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Dawid Krenc & Kesara Na-Bangchang. (2022) Spectroscopic observations of β-eudesmol binding to human cytochrome P450 isoforms 3A4 and 1A2, but not to isoforms 2C9, 2C19, and 2D6. Xenobiotica 52:2, pages 199-208.
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Read now
Michael Murray. (2012) Toxicological Actions of Plant-Derived and Anthropogenic Methylenedioxyphenyl-Substituted Chemicals in Mammals and Insects. Journal of Toxicology and Environmental Health, Part B 15:6, pages 365-395.
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Articles from other publishers (41)
Peiqi Liu, Qian Li, Guanghao Zhu, Tiantian Zhang, Dongzhu Tu, Feng Zhang, Moshe Finel, Yuqi He & Guangbo Ge. (2024) Characterization of the glucuronidating pathway of pectolinarigenin, the major active constituent of the Chinese medicine Daji, in humans and its influence on biological activities. Journal of Ethnopharmacology 319, pages 117280.
Crossref
Crossref
Agnieszka Wiesner, Paweł Zagrodzki, Marek Jamrozik, Jacek Korchowiec, Monika Marcinkowska & Paweł Paśko. (2023) Chemometrics as a valuable tool for evaluating interactions between antiretroviral drugs and food. British Journal of Clinical Pharmacology 89:10, pages 2977-2991.
Crossref
Crossref
Rachael E. Tennant, David J. Ponting & Andrew Thresher. (2023) A deep dive into historical Ames study data for N-nitrosamine compounds. Regulatory Toxicology and Pharmacology 143, pages 105460.
Crossref
Crossref
Suman Chakravarti. (2023)
Computational Prediction of Metabolic α-Carbon Hydroxylation Potential of
N
-Nitrosamines: Overcoming Data Limitations for Carcinogenicity Assessment
. Chemical Research in Toxicology 36:6, pages 959-970.
Crossref
Crossref
Xilin Li, Yuan Le, Ji-Eun Seo, Xiaoqing Guo, Yuxi Li, Si Chen, Roberta A. Mittelstaedt, Nyosha Moore, Sharon Guerrero, Audrey Sims, Sruthi T. King, Aisar H. Atrakchi, Timothy J. McGovern, Karen L. Davis-Bruno, David A. Keire, Rosalie K. Elespuru, Robert H. Heflich & Nan Mei. (2023) Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays. Regulatory Toxicology and Pharmacology 141, pages 105410.
Crossref
Crossref
Jakub Kostal & Adelina Voutchkova-Kostal. (2023)
Quantum-Mechanical Approach to Predicting the Carcinogenic Potency of
N
-Nitroso Impurities in Pharmaceuticals
. Chemical Research in Toxicology 36:2, pages 291-304.
Crossref
Crossref
Monalisha Jena, Misbah Mukadam, Divya Telange, Ruchika Dolas & C.S. Ramaa. (2023) Nitrosamine Impurities: Assessing Concerns through Case Studies. Asian Journal of Chemistry 35:4, pages 794-804.
Crossref
Crossref
Robert Thomas, Rachael E. Tennant, Antonio Anax F. Oliveira & David J. Ponting. (2022) What Makes a Potent Nitrosamine? Statistical Validation of Expert-Derived Structure–Activity Relationships. Chemical Research in Toxicology 35:11, pages 1997-2013.
Crossref
Crossref
Yelena Guttman & Zohar Kerem. (2022) Computer-Aided (In Silico) Modeling of Cytochrome P450-Mediated Food–Drug Interactions (FDI). International Journal of Molecular Sciences 23:15, pages 8498.
Crossref
Crossref
Frank Bringezu & Stephanie Simon. (2022) Salmonella typhimurium TA100 and TA1535 and E. coli WP2 uvrA are highly sensitive to detect the mutagenicity of short Alkyl-N-Nitrosamines in the Bacterial Reverse Mutation Test. Toxicology Reports 9, pages 250-255.
Crossref
Crossref
Kevin P. Cross & David J. Ponting. (2021) Developing structure-activity relationships for N-nitrosamine activity. Computational Toxicology 20, pages 100186.
Crossref
Crossref
Stephan Kirchner & Patrick Schnider. 2021. The Medicinal Chemist's Guide to Solving ADMET Challenges. The Medicinal Chemist's Guide to Solving ADMET Challenges
331
363
.
Risto O. Juvonen, Mira Ahinko, Elmeri M. Jokinen, Juhani Huuskonen, Hannu Raunio & Olli T. Pentikäinen. (2021) Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling. ACS Omega 6:17, pages 11286-11296.
Crossref
Crossref
Junhao Li, Yang Zhou, Yun Tang, Weihua Li & Yaoquan Tu. (2020) Dissecting the Structural Plasticity and Dynamics of Cytochrome P450 2B4 by Molecular Dynamics Simulations. Journal of Chemical Information and Modeling 60:10, pages 5026-5035.
Crossref
Crossref
Qing-Qing He, Yue Chen, Qi-Hang Zhou, Feng Zhang, Yi-Nan Wang, Chao-Ran Wang, Yu-Qi He, Xin-Miao Liang, Guang-Bo Ge & Ling Yang. (2020) Deciphering the metabolic fates of a green fluorescent protein (GFP)-like fluorophore: Metabolite identification, isoenzyme contribution and species differences. Dyes and Pigments 181, pages 108571.
Crossref
Crossref
Risto Olavi Juvonen, Elmeri Matias Jokinen, Adeel Javaid, Marko Lehtonen, Hannu Raunio & Olli Taneli Pentikäinen. (2020)
Inhibition of human CYP1 enzymes by a classical inhibitor α‐naphthoflavone and a novel inhibitor
N
‐(3, 5‐dichlorophenyl)cyclopropanecarboxamide: An in vitro and in silico study
. Chemical Biology & Drug Design 95:5, pages 520-533.
Crossref
Crossref
Michiko Watanabe, Takamitsu Sasaki, Jun-ichi Takeshita, Madoka Kushida, Yuki Shimizu, Hitomi Oki, Yoko Kitsunai, Haruka Nakayama, Hitomi Saruhashi, Rui Ogura, Ryota Shizu, Takuomi Hosaka & Kouichi Yoshinari. (2020) Application of cytochrome P450 reactivity on the characterization of chemical compounds and its association with repeated-dose toxicity. Toxicology and Applied Pharmacology 388, pages 114854.
Crossref
Crossref
Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu & Dong-Qing Wei. (2019) Survey of Machine Learning Techniques for Prediction of the Isoform Specificity of Cytochrome P450 Substrates. Current Drug Metabolism 20:3, pages 229-235.
Crossref
Crossref
Eleni A. Rekka, Panos N. Kourounakis & Maria Pantelidou. (2019) Xenobiotic Metabolising Enzymes: Impact on Pathologic Conditions, Drug Interactions and Drug Design. Current Topics in Medicinal Chemistry 19:4, pages 276-291.
Crossref
Crossref
Sang-Bum Kim, Kyu-Sang Kim, Dae-Duk Kim & In-Soo Yoon. (2019) Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases. Biomedicine & Pharmacotherapy 110, pages 111-117.
Crossref
Crossref
Ken-ichi Umehara, Felix Huth, Helen Gu, Hilmar Schiller, Tycho Heimbach & Handan He. (2017) Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) – a comparison with the chemical inhibition method. Drug Metabolism and Personalized Therapy 32:4.
Crossref
Crossref
F. L. Wood, J. B. Houston & D. Hallifax. (2017) Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology. Drug Metabolism and Disposition 45:11, pages 1178-1188.
Crossref
Crossref
Lydia Benkaidali, François André, Gautier Moroy, Bahoueddine Tangour, François Maurel & Michel Petitjean. (2017) The Cytochrome P450 3A4 has three Major Conformations: New Clues to Drug Recognition by this Promiscuous Enzyme. Molecular Informatics 36:10.
Crossref
Crossref
Shu-Ting Pan, Danfeng Xue, Zhi-Ling Li, Zhi-Wei Zhou, Zhi-Xu He, Yinxue Yang, Tianxin Yang, Jia-Xuan Qiu & Shu-Feng Zhou. (2016) Computational Identification of the Paralogs and Orthologs of Human Cytochrome P450 Superfamily and the Implication in Drug Discovery. International Journal of Molecular Sciences 17:7, pages 1020.
Crossref
Crossref
Avanthika Venkatachalam, Abhinav Parashar & Kelath Murali Manoj. (2016) Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme ‘active site’ pocket plays a relatively ‘passive role’ in some enzyme-substrate interactions. In Silico Pharmacology 4:1.
Crossref
Crossref
Hannu Raunio, Mira Kuusisto, Risto O. Juvonen & Olli T. Pentikäinen. (2015) Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes. Frontiers in Pharmacology 6.
Crossref
Crossref
Iwona Wilk-Zasadna, Camilla Bernasconi, Olavi Pelkonen & Sandra Coecke. (2015) Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data. Toxicology 332, pages 8-19.
Crossref
Crossref
Tao Zhang & Dongqing Wei. 2015. Advance in Structural Bioinformatics. Advance in Structural Bioinformatics
327
339
.
Kouta Toshimoto, Naomi Wakayama, Makiko Kusama, Kazuya Maeda, Yuichi Sugiyama & Yutaka Akiyama. (2014) In Silico Prediction of Major Drug Clearance Pathways by Support Vector Machines with Feature-Selected Descriptors. Drug Metabolism and Disposition 42:11, pages 1811-1819.
Crossref
Crossref
Mohsen Sharifi & Taravat Ghafourian. (2013) Estimation of Biliary Excretion of Foreign Compounds Using Properties of Molecular Structure. The AAPS Journal 16:1, pages 65-78.
Crossref
Crossref
J.L. Rourke & C.J. Sinal. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology
490
502
.
Philip C. BurchamPhilip C. Burcham. 2014. An Introduction to Toxicology. An Introduction to Toxicology
53
90
.
Maris Lapins, Apilak Worachartcheewan, Ola Spjuth, Valentin Georgiev, Virapong Prachayasittikul, Chanin Nantasenamat & Jarl E. S. Wikberg. (2013) A Unified Proteochemometric Model for Prediction of Inhibition of Cytochrome P450 Isoforms. PLoS ONE 8:6, pages e66566.
Crossref
Crossref
Maria S. Zharkova, Boris N. Sobolev, Nina Yu. Oparina, Alexander V. Veselovsky & Alexander I. Archakov. (2013) Prediction of amino acid residues participated in substrate recognition by cytochrome P450 subfamilies with broad substrate specificity. Journal of Molecular Recognition 26:2, pages 86-91.
Crossref
Crossref
P Beswick & A Naylor. 2013. Drug Discovery and Development. Drug Discovery and Development
119
134
.
Thomas G. Osimitz. 2010. Handbook of Green Chemistry. Handbook of Green Chemistry
501
524
.
Thomas G. Osimitz & John L. Nelson. 2010. Handbook of Green Chemistry. Handbook of Green Chemistry
47
75
.
Johannes Kirchmair, Mark J. Williamson, Jonathan D. Tyzack, Lu Tan, Peter J. Bond, Andreas Bender & Robert C. Glen. (2012) Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms. Journal of Chemical Information and Modeling 52:3, pages 617-648.
Crossref
Crossref
Svava Ósk Jónsdóttir, Tine Ringsted, Nikolai G. Nikolov, Marianne Dybdahl, Eva Bay Wedebye & Jay R. Niemelä. (2012) Identification of cytochrome P450 2D6 and 2C9 substrates and inhibitors by QSAR analysis. Bioorganic & Medicinal Chemistry 20:6, pages 2042-2053.
Crossref
Crossref
Paul B. Watkins. 2011. Schiff's Diseases of the Liver. Schiff's Diseases of the Liver
784
801
.
Iosif Vranakis, Pieter-Jan De Bock, Anastasia Papadioti, Georgios Samoilis, Yannis Tselentis, Kris Gevaert, Georgios Tsiotis & Anna Psaroulaki. (2011)
Unraveling Persistent Host Cell Infection with
Coxiella burnetii
by Quantitative Proteomics
. Journal of Proteome Research 10:9, pages 4241-4251.
Crossref
Crossref