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Review

The use of isotopes in the determination of absolute bioavailability of drugs in humans

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Pages 419-427 | Published online: 30 May 2006

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Elena Guerini, Simone Schadt, Gerard Greig, Ruth Haas, Christophe Husser, Manfred Zell, Christoph Funk, Thomas Hartung, Andreas Gloge & Navita L. Mallalieu. (2017) A double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]-basimglurant and absolute bioavailability after oral administration and concomitant intravenous microdose administration of [13C6]-labeled basimglurant in humans. Xenobiotica 47:2, pages 144-153.
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Nicolas Hohmann, Walter E. Haefeli & Gerd Mikus. (2016) CYP3A activity: towards dose adaptation to the individual. Expert Opinion on Drug Metabolism & Toxicology 12:5, pages 479-497.
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Graham Lappin, Robert Noveck & Tal Burt. (2013) Microdosing and drug development: past, present and future. Expert Opinion on Drug Metabolism & Toxicology 9:7, pages 817-834.
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Angus N.R. Nedderman, Gordon J. Dear, Stephanie North, R. Scott Obach & David Higton. (2011) From definition to implementation: a cross-industry perspective of past, current and future MIST strategies. Xenobiotica 41:8, pages 605-622.
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Anil S Modak. (2009) 13C breath tests in personalized medicine: fiction or reality?. Expert Review of Molecular Diagnostics 9:8, pages 805-815.
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Graham Lappin & R Colin Garner. (2008) The utility of microdosing over the past 5 years. Expert Opinion on Drug Metabolism & Toxicology 4:12, pages 1499-1506.
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Graham Lappin & Lloyd Stevens. (2008) Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics. Expert Opinion on Drug Metabolism & Toxicology 4:8, pages 1021-1033.
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Thomas Walle, Xia Wen & U Kristina Walle. (2007) Improving metabolic stability of cancer chemoprotective polyphenols. Expert Opinion on Drug Metabolism & Toxicology 3:3, pages 379-388.
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