Citations (117)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (12)
Abhishek Kumar Verma, Sk. Faisal Ahmed, Md. Shahadat Hossain, Ali Asger Bhojiya, Ankita Mathur, Sudhir K. Upadhyay, Abhishek K. Srivastava, Naveen Kumar Vishvakarma, Mayadhar Barik, Md. Mizanur Rahaman & Newaz Mohammed Bahadur. (2022) Molecular docking and simulation studies of flavonoid compounds against PBP-2a of methicillin‐resistant Staphylococcus aureus . Journal of Biomolecular Structure and Dynamics 40:21, pages 10561-10577.
Read now
Read now
M. R. Lauro, C. Carbone, F. Sansone, B. Ruozi, R. Chillemi, S. Sciuto, R. P. Aquino & G. Puglisi. (2016) Innovative oral spray-dried Idebenone systems to improve patient compliance. Drug Development and Industrial Pharmacy 42:7, pages 1127-1136.
Read now
Read now
Corrado Blandizzi, Giuseppe Claudio Viscomi & Carmelo Scarpignato. (2015) Impact of crystal polymorphism on the systemic bioavailability of rifaximin, an antibiotic acting locally in the gastrointestinal tract, in healthy volunteers. Drug Design, Development and Therapy 9, pages 1-11.
Read now
Read now
Sue May Lim, Zyu Wenn Pang, Hwei Yuin Tan, Mohsin Shaikh, Gorajana Adinarayana & Sanjay Garg. (2015) Enhancement of docetaxel solubility using binary and ternary solid dispersion systems. Drug Development and Industrial Pharmacy 41:11, pages 1847-1855.
Read now
Read now
Shashank Jain, Niketkumar Patel & Senshang Lin. (2015) Solubility and dissolution enhancement strategies: current understanding and recent trends. Drug Development and Industrial Pharmacy 41:6, pages 875-887.
Read now
Read now
Andreas Mats Svennebring. (2015) Investigation of the prerequisites for the optimization of specific plasma protein binding as a strategy for the reduction of first-pass hepatic metabolism. Xenobiotica 45:4, pages 286-301.
Read now
Read now
Tjerk Bueters, Sanja Juric, Anna-Karin Sohlenius-Sternbeck, Yin Hu & Johan Bylund. (2013) Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human. Xenobiotica 43:7, pages 607-616.
Read now
Read now
Luana Perioli & Cinzia Pagano. (2012) Inorganic matrices: an answer to low drug solubility problem. Expert Opinion on Drug Delivery 9:12, pages 1559-1572.
Read now
Read now
John A Arnott & Sonia Lobo Planey. (2012) The influence of lipophilicity in drug discovery and design. Expert Opinion on Drug Discovery 7:10, pages 863-875.
Read now
Read now
Alexei Merzlikine, Charles Rotter, Brian Rago, Julie Poe, Curt Christoffersen, V. Hayden Thomas, Matthew Troutman & Ayman El-Kattan. (2009) Effect of chitosan glutamate, carbomer 974P, and EDTA on the in vitro Caco-2 permeability and oral pharmacokinetic profile of acyclovir in rats. Drug Development and Industrial Pharmacy 35:9, pages 1082-1091.
Read now
Read now
Jianling Wang, Laszlo Urban & Dejan Bojanic. (2007) Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety. Expert Opinion on Drug Metabolism & Toxicology 3:5, pages 641-665.
Read now
Read now
Susan Hurst, Cho-Ming Loi, Joanne Brodfuehrer & Ayman El-Kattan. (2007) Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans. Expert Opinion on Drug Metabolism & Toxicology 3:4, pages 469-489.
Read now
Read now
Articles from other publishers (105)
Homa Rezaei, Elaheh Rahimpour, Fleming Martinez & Abolghasem Jouyban. (2023) Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures. Heliyon 9:6, pages e17402.
Crossref
Crossref
Lin-Jie Wang, Yi-Chao Su, Peng-Tu Zhang, Xin Ji & Jin-Ze Du. (2023) Enhancing Solubility and Dissolution Behavior of Finasteride Using Solid Dispersion Technique by Carrier Screening and the New Preparation Instrument. Journal of Pharmaceutical Innovation.
Crossref
Crossref
Caroline Rynn, Arthur Van De Vyver, Antje Walz, Carina Cantrill & Matthias Wittwer. 2023. Inducing Targeted Protein Degradation. Inducing Targeted Protein Degradation
313
336
.
Timothy J. Carlson. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development
175
187
.
Israr Fatima, Hamza Ihsan, Muhammad Shareef Masoud, Saeeda Kalsoom, Sidra Aslam, Abdur Rehman, Usman Ali Ashfaq & Muhammad Qasim. (2022) Screening of drug candidates against Endothelin-1 to treat hypertension using computational based approaches: Molecular docking and dynamics simulation. PLOS ONE 17:8, pages e0269739.
Crossref
Crossref
Daniel Katz, Kate Fike, Justin Longenberger, Steve Placko, Laurence Philippe-Venec & Andrew Chervenak. (2022) AlphaLogD determination: An optimized Reversed-Phase Liquid Chromatography method to measure lipophilicity on neutral and basic small and Beyond-Rule-of-Five compounds. Journal of Chromatography A 1674, pages 463146.
Crossref
Crossref
Mubarak A. Alamri, Muhammad Usman Mirza, Muhammad Muzammal Adeel, Usman Ali Ashfaq, Muhammad Tahir ul Qamar, Farah Shahid, Sajjad Ahmad, Eid A. Alatawi, Ghadah M. Albalawi, Khaled S. Allemailem & Ahmad Almatroudi. (2022) Structural Elucidation of Rift Valley Fever Virus L Protein towards the Discovery of Its Potential Inhibitors. Pharmaceuticals 15:6, pages 659.
Crossref
Crossref
John Victor Napoleon, Satish Sagar, Sydney P. Kubica, Lidia Boghean, Smit Kour, Hannah M. King, Yogesh A. Sonawane, Ayrianne J. Crawford, Nagsen Gautam, Smitha Kizhake, Pawel A. Bialk, Eric Kmiec, Jayapal Reddy Mallareddy, Prathamesh P. Patil, Sandeep Rana, Sarbjit Singh, Janani Prahlad, Paul M. Grandgenett, Gloria E. O. Borgstahl, Gargi Ghosal, Yazen Alnouti, Michael A. Hollingsworth, Prakash Radhakrishnan & Amarnath Natarajan. (2022) Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth. Proceedings of the National Academy of Sciences 119:18.
Crossref
Crossref
Razan Haddad, Nasr Alrabadi, Bashar Altaani & Tonglei Li. (2022) Paclitaxel Drug Delivery Systems: Focus on Nanocrystals’ Surface Modifications. Polymers 14:4, pages 658.
Crossref
Crossref
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce, Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young & Alison D. Axtman. (2022) AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery. Alzheimer's & Dementia: Translational Research & Clinical Interventions 8:1.
Crossref
Crossref
Miah Roney, AKM Moyeenul Huq, Kamal Rullah, Hazrulrizawati Abd Hamid, Syahrul Imran, Md. Alimul Islam & Mohd Fadhlizil Fasihi Mohd Aluwi. (2021) Virtual Screening-Based Identification of Potent DENV-3 RdRp Protease Inhibitors via In-House Usnic Acid Derivative Database. Journal of Computational Biophysics and Chemistry 20:08, pages 797-814.
Crossref
Crossref
Alexia Grangeon, Valérie Clermont, Azemi Barama, Fleur Gaudette, Jacques Turgeon & Veronique Michaud. (2021) Determination of CYP450 Expression Levels in the Human Small Intestine by Mass Spectrometry-Based Targeted Proteomics. International Journal of Molecular Sciences 22:23, pages 12791.
Crossref
Crossref
Amritansh Bhanot & Sandeep Sundriyal. (2021) Physicochemical Profiling and Comparison of Research Antiplasmodials and Advanced Stage Antimalarials with Oral Drugs. ACS Omega 6:9, pages 6424-6437.
Crossref
Crossref
Robin A. Fairhurst, Thomas Knoepfel, Nicole Buschmann, Catherine Leblanc, Robert Mah, Milen Todorov, Pierre Nimsgern, Sebastien Ripoche, Michel Niklaus, Nicolas Warin, Van Huy Luu, Mario Madoerin, Jasmin Wirth, Diana Graus-Porta, Andreas Weiss, Michael Kiffe, Markus Wartmann, Jacqueline Kinyamu-Akunda, Dario Sterker, Christelle Stamm, Flavia Adler, Alexandra Buhles, Heiko Schadt, Philippe Couttet, Jutta Blank, Inga Galuba, Jörg Trappe, Johannes Voshol, Nils Ostermann, Chao Zou, Jörg Berghausen, Alberto Del Rio Espinola, Wolfgang Jahnke & Pascal Furet. (2020) Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4. Journal of Medicinal Chemistry 63:21, pages 12542-12573.
Crossref
Crossref
Sathish Dharani, Sogra F. Barakh Ali, Hamideh Afrooz, Mansoor A. Khan & Ziyaur Rahman. (2020) Studying effect of glyceryl palmitostearate amount, manufacturing method and stability on polymorphic transformation and dissolution of rifaximin tablets. International Journal of Pharmaceutics 589, pages 119785.
Crossref
Crossref
Eduard Wiedenbeck, Denis Gebauer & Helmut Cölfen. (2020)
Potentiometric Titration Method for the Determination of Solubility Limits and p
K
a
Values of Weak Organic Acids in Water
. Analytical Chemistry 92:14, pages 9511-9515.
Crossref
Crossref
Vincent Faugeras, Olivier Duclos, Didier Bazile & Abdou Rachid Thiam. (2020) Membrane determinants for the passive translocation of analytes through droplet interface bilayers. Soft Matter 16:25, pages 5970-5980.
Crossref
Crossref
Carina Cantrill, Prasoon Chaturvedi, Caroline Rynn, Jeannine Petrig Schaffland, Isabelle Walter & Matthias B. Wittwer. (2020) Fundamental aspects of DMPK optimization of targeted protein degraders. Drug Discovery Today 25:6, pages 969-982.
Crossref
Crossref
Gurdeep S. MinhasSimon Newstead. (2020) Recent advances in understanding prodrug transport through the SLC15 family of proton-coupled transporters. Biochemical Society Transactions 48:2, pages 337-346.
Crossref
Crossref
Chiara Borsari, Denise Rageot, Alix Dall’Asen, Thomas Bohnacker, Anna Melone, Alexander M. Sele, Eileen Jackson, Jean-Baptiste Langlois, Florent Beaufils, Paul Hebeisen, Doriano Fabbro, Petra Hillmann & Matthias P. Wymann. (2019) A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. Journal of Medicinal Chemistry 62:18, pages 8609-8630.
Crossref
Crossref
Yunhang Guo, Ye Liu, Nan Hu, Desheng Yu, Changyou Zhou, Gongyin Shi, Bo Zhang, Min Wei, Junhua Liu, Lusong Luo, Zhiyu Tang, Huipeng Song, Yin Guo, Xuesong Liu, Dan Su, Shuo Zhang, Xiaomin Song, Xing Zhou, Yuan Hong, Shuaishuai Chen, Zhenzhen Cheng, Steve Young, Qiang Wei, Haisheng Wang, Qiuwen Wang, Lei Lv, Fan Wang, Haipeng Xu, Hanzi Sun, Haimei Xing, Na Li, Wei Zhang, Zhongbo Wang, Guodong Liu, Zhijian Sun, Dongping Zhou, Wei Li, Libin Liu, Lai Wang & Zhiwei Wang. (2019) Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase. Journal of Medicinal Chemistry 62:17, pages 7923-7940.
Crossref
Crossref
Sathish Dharani, Sogra F. Barakh Ali, Hamideh Afrooz, Mansoor A. Khan & Ziyaur Rahman. (2019) Development and Validation of a Discriminatory Dissolution Method for Rifaximin Products. Journal of Pharmaceutical Sciences 108:6, pages 2112-2118.
Crossref
Crossref
Ryo Mizoguchi, Haruka Waraya & Yutaka Hirakura. (2019) Application of Co-Amorphous Technology for Improving the Physicochemical Properties of Amorphous Formulations. Molecular Pharmaceutics 16:5, pages 2142-2152.
Crossref
Crossref
Gurdeep S. Minhas & Simon Newstead. (2019) Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters. Proceedings of the National Academy of Sciences 116:3, pages 804-809.
Crossref
Crossref
Hui Qiu, Lesley Liu-Bujalski, Richard D. Caldwell, Ariele Viacava Follis, Anna Gardberg, Andreas Goutopoulos, Roland Grenningloh, Jared Head, Theresa Johnson, Christopher C.V. Jones, Reinaldo Jones, Igor Mochalkin, Federica Morandi, Constantin Neagu, Justin Potnick & Brian Sherer. (2018) Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors. Bioorganic & Medicinal Chemistry Letters 28:20, pages 3307-3311.
Crossref
Crossref
Ryo Mizoguchi & Hidehiro Uekusa. (2018) Elucidating the Dehydration Mechanism of Ondansetron Hydrochloride Dihydrate with a Crystal Structure. Crystal Growth & Design 18:10, pages 6142-6149.
Crossref
Crossref
Yu Zhang, Beth A Lorsbach, Scott Castetter, William T Lambert, Jeremy Kister, Nick X Wang, Carla J R Klittich, Joshua Roth, Thomas C Sparks & Mike R Loso. (2018) Physicochemical property guidelines for modern agrochemicals. Pest Management Science 74:9, pages 1979-1991.
Crossref
Crossref
Iqbal Azad, Malik Nasibullah, Tahmeena Khan, Firoj Hassan & Yusuf Akhter. (2018) Exploring the novel heterocyclic derivatives as lead molecules for design and development of potent anticancer agents. Journal of Molecular Graphics and Modelling 81, pages 211-228.
Crossref
Crossref
Jingbo Zhu, Jing Wang, Yan Ding, Baoyue Liu & Wei Xiao. (2018) A systems-level approach for investigating organophosphorus pesticide toxicity. Ecotoxicology and Environmental Safety 149, pages 26-35.
Crossref
Crossref
Qi Qi, Obiamaka Obianyo, Yuhong Du, Haian Fu, Shiyong Li & Keqiang Ye. (2017) Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis. Journal of Medicinal Chemistry 60:17, pages 7244-7255.
Crossref
Crossref
Ken A. Brameld, Timothy D. Owens, Erik Verner, Eleni Venetsanakos, J. Michael Bradshaw, Vernon T. Phan, Danny Tam, Kwan Leung, Jin Shu, Jacob LaStant, David G. Loughhead, Tony Ton, Dane E. Karr, Mary E. Gerritsen, David M. Goldstein & Jens Oliver Funk. (2017)
Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-
d
]pyrimidin-7(8
H
)-one (PRN1371) for the Treatment of Solid Tumors
. Journal of Medicinal Chemistry 60:15, pages 6516-6527.
Crossref
Crossref
Anna Nilsson, Alexandra Peric, Marie Strimfors, Richard J. A. Goodwin, Martin A. Hayes, Per E. Andrén & Constanze Hilgendorf. (2017) Mass Spectrometry Imaging proves differential absorption profiles of well-characterised permeability markers along the crypt-villus axis. Scientific Reports 7:1.
Crossref
Crossref
Boryana Nikolova-Mladenova, Georgi Momekov, Darvin Ivanov & Adriana Bakalova. (2017) Design and drug-like properties of new 5-methoxysalicylaldehyde based hydrazones with anti-breast cancer activity. Journal of Applied Biomedicine 15:3, pages 233-240.
Crossref
Crossref
Manthena V. Varma, Yurong Lai & Ayman F. El-Kattan. (2017) Molecular properties associated with transporter-mediated drug disposition. Advanced Drug Delivery Reviews 116, pages 92-99.
Crossref
Crossref
Natalia Khuri, Arik A. Zur, Matthias B. Wittwer, Lawrence Lin, Sook Wah Yee, Andrej Sali & Kathleen M. Giacomini. (2017) Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1. Journal of Chemical Information and Modeling 57:6, pages 1402-1413.
Crossref
Crossref
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment
331
346
.
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment
269
307
.
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment
173
201
.
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment
139
171
.
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment
35
76
.
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment
387
430
.
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment
357
376
.
Francesca Curreli, Young Do Kwon, Dmitry S. Belov, Ranjith R. Ramesh, Alexander V. Kurkin, Andrea Altieri, Peter D. Kwong & Asim K. Debnath. (2017) Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120. Journal of Medicinal Chemistry 60:7, pages 3124-3153.
Crossref
Crossref
Janett Müller, Markus Keiser, Marek Drozdzik & Stefan Oswald. (2017) Expression, regulation and function of intestinal drug transporters: an update. Biological Chemistry 398:2, pages 175-192.
Crossref
Crossref
Dev Prasad, Akash Jain & Sudhakar Garad. 2017. Poorly Soluble Drugs. Poorly Soluble Drugs
125
186
.
Ayman F. El-Kattan, Manthena V. Varma, Stefan J. Steyn, Dennis O. Scott, Tristan S. Maurer & Arthur Bergman. (2016) Projecting ADME Behavior and Drug-Drug Interactions in Early Discovery and Development: Application of the Extended Clearance Classification System. Pharmaceutical Research 33:12, pages 3021-3030.
Crossref
Crossref
Edwin Chiu Yuen Chow, Arjang Talattof, Eleftheria Tsakalozou, Jianghong Fan, Liang Zhao & Xinyuan Zhang. (2016) Using Physiologically Based Pharmacokinetic (PBPK) Modeling to Evaluate the Impact of Pharmaceutical Excipients on Oral Drug Absorption: Sensitivity Analyses. The AAPS Journal 18:6, pages 1500-1511.
Crossref
Crossref
Muhammad Tahir ul Q, Saleha Kiran, Usman Ali Ashfaq, Muhammad Rizwan Javed, Farooq Anwar, Muhammad Amjad Ali & Anwar ul Hassan Gilani. (2016) Discovery of Novel Dengue NS2B/NS3 Protease Inhibitors Using
Pharmacophore Modeling and Molecular Docking Based Virtual
Screening of the ZINC Database. International Journal of Pharmacology 12:6, pages 621-632.
Crossref
Crossref
Christopher R. Jones, Oliver J. D. Hatley, Anna-Lena Ungell, Constanze Hilgendorf, Sheila Annie Peters & Amin Rostami-Hodjegan. (2016) Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination. The AAPS Journal 18:3, pages 589-604.
Crossref
Crossref
Lauri Paasonen, Shweta Sharma, Gary B. Braun, Venkata Ramana Kotamraju, Thomas D. Y. Chung, Zhi-Gang She, Kazuki N. Sugahara, Marjo Yliperttula, Bainan Wu, Maurizio Pellecchia, Erkki Ruoslahti & Tambet Teesalu. (2016) New p32/gC1qR Ligands for Targeted Tumor Drug Delivery. ChemBioChem 17:7, pages 570-575.
Crossref
Crossref
Greg Russell-JonesAoife M O’Mahony, Brendan T Griffin & Caitriona M O’Driscoll. 2016. Advances and Challenges in Oral Delivery of Macromolecules. Advances and Challenges in Oral Delivery of Macromolecules
8
27
.
Feng Chen, Qi Wen, Jun Jiang, Hai-Long Li, Yin-Feng Tan, Yong-Hui Li & Nian-Kai Zeng. (2016) Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?. Journal of Ethnopharmacology 179, pages 253-264.
Crossref
Crossref
Andreas Svennebring. (2016)
The connection Between Plasma Protein Binding and Acute Toxicity as Determined by the LD
50
Value
. Drug Development Research 77:1, pages 3-11.
Crossref
Crossref
Kim Huard, Janice Brown, Jessica C. Jones, Shawn Cabral, Kentaro Futatsugi, Matthew Gorgoglione, Adhiraj Lanba, Nicholas B. Vera, Yimin Zhu, Qingyun Yan, Yingjiang Zhou, Cecile Vernochet, Keith Riccardi, Angela Wolford, David Pirman, Mark Niosi, Gary Aspnes, Michael Herr, Nathan E. Genung, Thomas V. Magee, Daniel P. Uccello, Paula Loria, Li Di, James R. Gosset, David Hepworth, Timothy Rolph, Jeffrey A. Pfefferkorn & Derek M. Erion. (2015) Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5). Scientific Reports 5:1.
Crossref
Crossref
Alison Kamil, C‐Y. Oliver Chen & Jeffrey B. Blumberg. 2015. Nanotechnology and Functional Foods. Nanotechnology and Functional Foods
158
174
.
M Sundqvist, A Lundahl, MB Någård, U Bredberg & P Gennemark. (2015) Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction. CPT: Pharmacometrics & Systems Pharmacology 4:4, pages 243-254.
Crossref
Crossref
Andreas M Svennebring. (2015)
How to report and discuss ADME data in medicinal chemistry publications:
in vitro
data or
in vivo
extrapolations?
. Future Medicinal Chemistry 7:3, pages 259-267.
Crossref
Crossref
Katharina Maisel, Laura Ensign, Mihika Reddy, Richard Cone & Justin Hanes. (2015) Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse. Journal of Controlled Release 197, pages 48-57.
Crossref
Crossref
Gerhard Gross. 2015. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry
631
655
.
Roy J. Haskell, Kimberly A. Foster, Ching Kim Tye & Michael Morgen. 2015. Discovering and Developing Molecules with Optimal Drug-Like Properties. Discovering and Developing Molecules with Optimal Drug-Like Properties
95
140
.
Sudhakar Garad & Akash Jain. 2015. Discovering and Developing Molecules with Optimal Drug-Like Properties. Discovering and Developing Molecules with Optimal Drug-Like Properties
3
47
.
Ketan Patel, Anand Patil, Miten Mehta, Vikram Gota & Pradeep Vavia. (2014) Oral delivery of paclitaxel nanocrystal (PNC) with a dual Pgp-CYP3A4 inhibitor: Preparation, characterization and antitumor activity. International Journal of Pharmaceutics 472:1-2, pages 214-223.
Crossref
Crossref
Bradley Croy Doak, Bjӧrn Over, Fabrizio Giordanetto & Jan Kihlberg. (2014) Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates. Chemistry & Biology 21:9, pages 1115-1142.
Crossref
Crossref
Kwok Chow. 2014. Therapeutic Delivery Solutions. Therapeutic Delivery Solutions
67
104
.
Corrado Blandizzi, Giuseppe Claudio Viscomi, Antonio Marzo & Carmelo Scarpignato. (2014) Is generic rifaximin still a poorly absorbed antibiotic? A comparison of branded and generic formulations in healthy volunteers. Pharmacological Research 85, pages 39-44.
Crossref
Crossref
Essa Hu, Kristin Andrews, Samer Chmait, Xiaoning Zhao, Carl Davis, Silke Miller, Geraldine Hill Della Puppa, Mary Dovlatyan, Hang Chen, Dianna Lester-Zeiner, Jessica Able, Christopher Biorn, Ji Ma, Jianxia Shi, James Treanor & Jennifer R. Allen. (2014)
Discovery of Novel Imidazo[4,5-
b
]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)
. ACS Medicinal Chemistry Letters 5:6, pages 700-705.
Crossref
Crossref
Christopher G. Nasveschuk, Alexandre Gagnon, Shivani Garapaty-Rao, Srividya Balasubramanian, Robert Campbell, Christina Lee, Feng Zhao, Louise Bergeron, Richard Cummings, Patrick Trojer, James E. Audia, Brian K. Albrecht & Jean-Christophe P. Harmange. (2014) Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2. ACS Medicinal Chemistry Letters 5:4, pages 378-383.
Crossref
Crossref
Tycho Heimbach, Rakesh Gollen & Handan He. 2014. Predictive ADMET. Predictive ADMET
319
352
.
Andrés Olivares-Morales, Oliver J. D. Hatley, David Turner, Aleksandra Galetin, Leon Aarons & Amin Rostami-Hodjegan. (2013) The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data. Pharmaceutical Research 31:3, pages 720-730.
Crossref
Crossref
Erik J. Hicken, Fred P. Marmsater, Mark C. Munson, Stephen T. Schlachter, John E. Robinson, Shelley Allen, Laurence E. Burgess, Robert Kirk DeLisle, James P. Rizzi, George T. Topalov, Qian Zhao, Julie M. Hicks, Nicholas C. Kallan, Eugene Tarlton, Andrew Allen, Michele Callejo, April Cox, Sumeet Rana, Nathalie Klopfenstein, Richard Woessner & Joseph P. Lyssikatos. (2013)
Discovery of a Novel Class of Imidazo[1,2-
a
]Pyridines with Potent PDGFR Activity and Oral Bioavailability
. ACS Medicinal Chemistry Letters 5:1, pages 78-83.
Crossref
Crossref
Afjal H. Miah, Royston C. B. Copley, Daniel O'Flynn, Jonathan M. Percy & Panayiotis A. Procopiou. (2014) Lead identification and structure–activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists. Organic & Biomolecular Chemistry 12:11, pages 1779.
Crossref
Crossref
Richard B. Silverman & Mark W. Holladay. 2014. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action
19
122
.
Ketan Patel, Vidur Sarma & Pradeep Vavia. (2013) Design and evaluation of Lumefantrine – Oleic acid self nanoemulsifying ionic complex for enhanced dissolution. DARU Journal of Pharmaceutical Sciences 21:1.
Crossref
Crossref
Frank BoehmRose Hayeshi, Boitumelo Semete, Lonji Kalombo, Yolandy Lemmer, Lebogang Katata & Hulda Swai. 2013. Nanomedical Device and Systems Design. Nanomedical Device and Systems Design
491
516
.
Wendy Lee, Daniel F. Ortwine, Philippe Bergeron, Kevin Lau, Lichuan Lin, Shiva Malek, Jim Nonomiya, Zhonghua Pei, Kirk D. Robarge, Stephen Schmidt, Steve Sideris & Joseph P. Lyssikatos. (2013) A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors. Bioorganic & Medicinal Chemistry Letters 23:18, pages 5097-5104.
Crossref
Crossref
Scott L. Childs, Praveen Kandi & Sreenivas Reddy Lingireddy. (2013) Formulation of a Danazol Cocrystal with Controlled Supersaturation Plays an Essential Role in Improving Bioavailability. Molecular Pharmaceutics 10:8, pages 3112-3127.
Crossref
Crossref
Garrett C. Moraski, Lowell D. Markley, Jeffrey Cramer, Philip A. Hipskind, Helena Boshoff, Mai A. Bailey, Torey Alling, Juliane Ollinger, Tanya Parish & Marvin J. Miller. (2013)
Advancement of Imidazo[1,2-
a
]pyridines with Improved Pharmacokinetics and nM Activity vs.
Mycobacterium tuberculosis
. ACS Medicinal Chemistry Letters 4:7, pages 675-679.
Crossref
Crossref
Claudio F. Sturino, Yves Bousquet, Clint A. James, Patrick DeRoy, Martin Duplessis, Paul J. Edwards, Ted Halmos, Joannie Minville, Louis Morency, Sébastien Morin, Bounkham Thavonekham, Martin Tremblay, Jianmin Duan, Maria Ribadeneira, Michel Garneau, Alex Pelletier, Sonia Tremblay, Louie Lamorte, Richard Bethell, Michael G. Cordingley, Daniel Rajotte & Bruno Simoneau. (2013) Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: In vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors. Bioorganic & Medicinal Chemistry Letters 23:13, pages 3967-3975.
Crossref
Crossref
Flavia P. Bruno, Mino R. Caira, Eliseo Ceballos Martin, Gustavo A. Monti & Norma R. Sperandeo. (2013) Characterization and structural analysis of the potent antiparasitic and antiviral agent tizoxanide. Journal of Molecular Structure 1036, pages 318-325.
Crossref
Crossref
A.S. Paulino, G.S. Rauber, C.E.M Campos, M.H.P Maurício, R.R. de Avillez, S.L. Cuffini & S.G. Cardoso. (2013) Hollow crystal anti-solvent preparation process as a promising technique to improve dissolution of poorly soluble drugs. Journal of Crystal Growth 366, pages 76-81.
Crossref
Crossref
Johan Bylund & Tjerk Bueters. (2013) Presystemic Metabolism of AZ’0908, A Novel mPGES-1 Inhibitor: An In Vitro and In Vivo Cross-Species Comparison. Journal of Pharmaceutical Sciences 102:3, pages 1106-1115.
Crossref
Crossref
Danielle NewbyAlex A. FreitasTaravat Ghafourian. (2013) Coping with Unbalanced Class Data Sets in Oral Absorption Models. Journal of Chemical Information and Modeling 53:2, pages 461-474.
Crossref
Crossref
Maryam Salahinejad, Tu C. Le & David A. Winkler. (2013) Capturing the Crystal: Prediction of Enthalpy of Sublimation, Crystal Lattice Energy, and Melting Points of Organic Compounds. Journal of Chemical Information and Modeling 53:1, pages 223-229.
Crossref
Crossref
Jan Hüsch, Kathleen Gerbeth, Gert Fricker, Constanze Setzer, Jürgen Zirkel, Herbert Rebmann, Manfred Schubert-Zsilavecz & Mona Abdel-Tawab. (2012)
Effect of Phospholipid-Based Formulations of
Boswellia serrata
Extract on the Solubility, Permeability, and Absorption of the Individual Boswellic Acid Constituents Present
. Journal of Natural Products 75:10, pages 1675-1682.
Crossref
Crossref
Alexander V. LyubimovManthena V. S. Varma, Zaher A. Radi, Charles J. Rotter, John Litchfield & Ayman F. El‐Kattan. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
18
.
Sandhya Kortagere, Markus Lill & John Kerrigan. 2012. Computational Toxicology. Computational Toxicology
21
48
.
Ndidi C. Ngwuluka, Viness Pillay, Yahya E. Choonara, Girish Modi, Dinesh Naidoo, Lisa C. du Toit, Pradeep Kumar, Valence M.K. Ndesendo & Riaz A. Khan. (2011) Fabrication, Modeling and Characterization of Multi-Crosslinked Methacrylate Copolymeric Nanoparticles for Oral Drug Delivery. International Journal of Molecular Sciences 12:9, pages 6194-6225.
Crossref
Crossref
Miki Susanto Park & Jae H. Chang. 2011. Oral Bioavailability. Oral Bioavailability
63
75
.
Ayman El‐Kattan, Susan Hurst, Joanne Brodfuehrer & Cho‐Ming Loi. 2011. Oral Bioavailability. Oral Bioavailability
253
265
.
Laszlo Urban, Jianling Wang, Dejan Bojanic & Susan Ward. 2010. Predictive Toxicology in Drug Safety. Predictive Toxicology in Drug Safety
183
203
.
Lorna H. Mitchell, Theodore R. Johnson, Guang Wei Lu, Daniel Du, Kaushik Datta, Felicity Grzemski, Veerabahu Shanmugasundaram, Julie Spence, Kim Wade, Zhi Wang, Kevin Sun, Kristin Lin, Lain-Yen Hu, Karen Sexton, Neil Raheja, Catherine Kostlan & David Pocalyko. (2010) Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery. Journal of Medicinal Chemistry 53:11, pages 4422-4427.
Crossref
Crossref
Sandhya Kortagere & Sean Ekins. (2010) Troubleshooting computational methods in drug discovery. Journal of Pharmacological and Toxicological Methods 61:2, pages 67-75.
Crossref
Crossref
Jie Jack Li, Lorna H. Mitchell & Robert L. Dow. (2010) Thyroid receptor agonists for the treatment of androgenetic alopecia. Bioorganic & Medicinal Chemistry Letters 20:1, pages 306-308.
Crossref
Crossref
Frank Lovering, Jack Bikker & Christine Humblet. (2009) Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success. Journal of Medicinal Chemistry 52:21, pages 6752-6756.
Crossref
Crossref
Jianling Wang & Suzanne Skolnik. (2009) Recent Advances in Physicochemical and ADMET Profiling in Drug Discovery. Chemistry & Biodiversity 6:11, pages 1887-1899.
Crossref
Crossref
Tycho Heimbach, Suresh B. Lakshminarayana, Wenyu Hu & Handan He. (2009) Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data. The AAPS Journal 11:3.
Crossref
Crossref
G.S.M.J.E. Duchateau & W. Klaffke. 2009. Designing Functional Foods. Designing Functional Foods
647
675
.
Ayman El‐Kattan, Chris Holliman & Lucinda H. Cohen. 2008. Mass Spectrometry in Drug Metabolism and Pharmacokinetics. Mass Spectrometry in Drug Metabolism and Pharmacokinetics
87
121
.
Jie Jack Li, Donna M. Iula, Maria N. Nguyen, Lain-Yen Hu, Danielle Dettling, Theodore R. Johnson, Daniel Y. Du, Veerabahu Shanmugasundaram, Jennifer A. Van Camp, Zhi Wang, William G. Harter, Wen-Song Yue, Mark L. Boys, Kimberly J. Wade, Elena M. Drummond, Brian M. Samas, Bruce A. Lefker, Garrett S. Hoge, Mark J. Lovdahl, Jeffrey Asbill, Matthew Carroll, Mary Ann Meade, Susan M. Ciotti & Theresa Krieger-Burke. (2008)
Rational Design and Synthesis of 4-((1
R
,2
R
)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications
. Journal of Medicinal Chemistry 51:21, pages 7010-7014.
Crossref
Crossref
David J. Livingstone & Han van de Waterbeemd. 2008. Drug Bioavailability. Drug Bioavailability
433
451
.
Qun Dang, Srinivas Rao Kasibhatla, Tao Jiang, Kevin Fan, Yan Liu, Frank Taplin, William Schulz, Daniel K. Cashion, K. Raja Reddy, Paul D. van Poelje, James M. Fujitaki, Scott C. Potter & Mark D. Erion. (2008) Discovery of Phosphonic Diamide Prodrugs and Their Use for the Oral Delivery of a Series of Fructose 1,6-Bisphosphatase Inhibitors. Journal of Medicinal Chemistry 51:14, pages 4331-4339.
Crossref
Crossref
Jarkko Rautio, Hanna Kumpulainen, Tycho Heimbach, Reza Oliyai, Dooman Oh, Tomi Järvinen & Jouko Savolainen. (2008) Prodrugs: design and clinical applications. Nature Reviews Drug Discovery 7:3, pages 255-270.
Crossref
Crossref
CHAD L. STONER, MATTHEW D. TROUTMAN & CAROLINE E. LAVERTY. 2008. Cancer Drug Design and Discovery. Cancer Drug Design and Discovery
131
153
.
David A. Favor, Douglas S. Johnson, James J. Powers, Tingsheng Li & Rambabu Madabattula. (2007) Synthesis of chromanyl and dihydrobenzofuranyl piperazines. Tetrahedron Letters 48:17, pages 3039-3041.
Crossref
Crossref
Christopher Seadeek, Howard Ando, Shobha N. Bhattachar, Tycho Heimbach, Jason L. Sonnenberg & Anthony C. Blackburn. (2007) Automated approach to couple solubility with final pH and crystallinity for pharmaceutical discovery compounds. Journal of Pharmaceutical and Biomedical Analysis 43:5, pages 1660-1666.
Crossref
Crossref