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Expert Opinion on Drug Metabolism & Toxicology Volume 6, 2010 - Issue 10
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The effect of liver disease on inhibitory and plasma protein-binding displacement interactions: an update

Pietro Palatini University of Padova, Department of Pharmacology and Anesthesiology, Largo E. Meneghetti 2, 35131 Padova, Italy +39 49 8275077, +39 49 8275093, [email protected]
, PhD (Professor) ,
Rocco Orlando University of Padova, Department of Medical and Surgical Sciences, Padova, Italy
, MD &
Sara De Martin University of Padova, Department of Pharmacology and Anesthesiology, Largo E. Meneghetti 2, 35131 Padova, Italy
, PhD
Pages 1215-1230 | Published online: 07 Jul 2010

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Jianzhen Ye, Guangrui Deng & Feng Gao. (2018) Theoretical overview of clinical and pharmacological aspects of the use of etelcalcetide in diabetic patients undergoing hemodialysis. Drug Design, Development and Therapy 12, pages 901-909.
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Mario Pellegatti, Sabrina Pagliarusco, Lara Solazzo & Dimitri Colato. (2011) Plasma protein binding and blood-free concentrations: which studies are needed to develop a drug?. Expert Opinion on Drug Metabolism & Toxicology 7:8, pages 1009-1020.
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Articles from other publishers (9)

Katia Sayaf, Daniela Gabbia, Francesco Paolo Russo & Sara De Martin. (2022) The Role of Sex in Acute and Chronic Liver Damage. International Journal of Molecular Sciences 23:18, pages 10654.
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Daniela Gabbia, Marco Roverso, Maria Guido, Diana Sacchi, Michela Scaffidi, Maria Carrara, Genny Orso, Francesco Paolo Russo, Annarosa Floreani, Sara Bogialli & Sara De Martin. (2019) Western Diet-Induced Metabolic Alterations Affect Circulating Markers of Liver Function before the Development of Steatosis. Nutrients 11:7, pages 1602.
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Ruben van der Galiën, Rob ter Heine, Rick Greupink, Stein J. Schalkwijk, Antonius E. van Herwaarden, Angela Colbers & David M. Burger. (2018) Pharmacokinetics of HIV-Integrase Inhibitors During Pregnancy: Mechanisms, Clinical Implications and Knowledge Gaps. Clinical Pharmacokinetics 58:3, pages 309-323.
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Jennifer J. Kiser, Darlene Lu, Susan L. Rosenkranz, Gene D. Morse, Robin DiFrancesco, Kenneth E. Sherman & Adeel A. Butt. (2017) Boceprevir and Antiretroviral Pharmacokinetic Interactions in HIV/HCV Co-infected Persons: AIDS Clinical Trials Group Study A5309s. Drugs in R&D 17:4, pages 557-567.
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R. Sane & M. Sinz. 2017. Drug Metabolism in Diseases. Drug Metabolism in Diseases 1 19 .
Sara De Martin, Daniela Gabbia, Giovanna Albertin, Maria Martina Sfriso, Claudia Mescoli, Laura Albertoni, Giovanna Paliuri, Sergio Bova & Pietro Palatini. (2014) Differential Effect of Liver Cirrhosis on the Pregnane X Receptor–Mediated Induction of CYP3A1 and 3A2 in the Rat. Drug Metabolism and Disposition 42:10, pages 1617-1626.
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Maura Floreani, Sara De Martin, Daniela Gabbia, Massimo Barbierato, Alberto Nassi, Claudia Mescoli, Rocco Orlando, Sergio Bova, Paolo Angeli, Elisabetta Gola, Antonietta Sticca & Pietro Palatini. (2013) Severe Liver Cirrhosis Markedly Reduces AhR-Mediated Induction of Cytochrome P450 in Rats by Decreasing the Transcription of Target Genes. PLoS ONE 8:4, pages e61983.
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Gabriella Fanali, Alessandra di Masi, Viviana Trezza, Maria Marino, Mauro Fasano & Paolo Ascenzi. (2012) Human serum albumin: From bench to bedside. Molecular Aspects of Medicine 33:3, pages 209-290.
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Albert Wolthuis. (2011) Impact of disease on interferences in blood bioanalysis. Bioanalysis 3:19, pages 2223-2231.
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