624
Views
37
CrossRef citations to date
0
Altmetric
Reviews

The acute toxicity of local anesthetics

, PhD FANZCA FRCA (Emeritus Professor of Anaesthesia)
Pages 1313-1332 | Published online: 26 Aug 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Daniele Ribeiro de Araújo, Lígia Nunes de Morais Ribeiro & Eneida de Paula. (2019) Lipid-based carriers for the delivery of local anesthetics. Expert Opinion on Drug Delivery 16:7, pages 701-714.
Read now
Simon Dagenais, Richard Scranton, Andrew R. Joyce & Catherine C. Vick. (2018) A comparison of approaches to identify possible cases of local anesthetic systemic toxicity in the FDA Adverse Event Reporting System (FAERS) database. Expert Opinion on Drug Safety 17:6, pages 545-552.
Read now
Igor Dobrydnjov, Christian Anderberg, Christer Olsson, Olga Shapurova, Krister Angel & Stefan Bergman. (2011) Intraarticular vs. extraarticular ropivacaine infusion following high-dose local infiltration analgesia after total knee arthroplasty. Acta Orthopaedica 82:6, pages 692-698.
Read now

Articles from other publishers (34)

Chuang Wei, Zeyu Jiang, Congcong Li, Peifeng Li & Qinrui Fu. (2023) Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics. Advanced Functional Materials 33:26.
Crossref
Laurence E. Mather & Geoffrey T. Tucker. (2022) When Regional Anesthesia Met Pharmacokinetics. Anesthesiology 136:4, pages 588-593.
Crossref
Kelli Cristina Freitas Mariano, Juliana Zampoli Boava Papini, Naially Cardoso de Faria, Daniele Nicoli Cabral Heluany, Ana Luiza Lourençoni Botega, Cíntia Maria Saia Cereda, Eneida de Paula, Giovana Radomille Tófoli & Daniele Ribeiro de Araujo. (2021) Ropivacaine-Loaded Poloxamer Binary Hydrogels for Prolonged Regional Anesthesia: Structural Aspects, Biocompatibility, and Pharmacological Evaluation. BioMed Research International 2021, pages 1-12.
Crossref
Meredith Sheil, Michael Chambers, Adam Polkinghorne & Brendan Sharpe. (2021) Topical Application of Lidocaine and Bupivacaine to Disbudding Wounds in Dairy Calves: Safety, Toxicology and Wound Healing. Animals 11:3, pages 869.
Crossref
Liu Han, Qiang Zhuo, Ying Zhou & Yanning Qian. (2020) Propofol protects human cardiac cells against chemical hypoxiainduced injury by regulating the JNK signaling pathways. Experimental and Therapeutic Medicine.
Crossref
Taku Ukai, Hamahashi Kosuke, Goro Ebihara & Masahiko Watanabe. (2020) Comparison of periarticular multidrug infiltration and epidural catheter use in total knee arthroplasty: A prospective randomized controlled study. Journal of Orthopaedic Surgery 28:1, pages 230949902091066.
Crossref
Wenling Zhao, Peng Liang, Jin Liu, Huan Li, Daqing Liao, Xiangdong Chen, Qian Li & Cheng Zhou. (2019) Capsazepine prolongation of the duration of lidocaine block of sensory transmission in mice may be mediated by modulation of HCN channel currents. PeerJ 7, pages e7111.
Crossref
Véronique Peres‐Bachelot, Ellen Blanc, Nadia Oussaid, David Pérol, Anne Laure Daunizeau‐Walker, Stéphanie Pouderoux, Patrice Peyrat, Michel Rivoire & Aurélien Dupré. (2018) A 96‐hour continuous wound infiltration with ropivacaine reduces analgesic consumption after liver resection: A randomized, double‐blind, controlled trial. Journal of Surgical Oncology 119:1, pages 47-55.
Crossref
Marlis L. de Rezende. 2018. Textbook of Small Animal Emergency Medicine. Textbook of Small Animal Emergency Medicine 1263 1268 .
Xiangbiao Yan, Yu Li, Xuechang Han, Xu Dong, Yajie Zhang & Qunzhi Xing. (2018) Ropivacaine regulates the expression and function of heme oxygenase-1. Biomedicine & Pharmacotherapy 103, pages 284-289.
Crossref
Vaughn E. Nossaman & Bobby D. Nossaman. 2018. Essentials of Regional Anesthesia. Essentials of Regional Anesthesia 297 315 .
Cristiane Neves Alessi Pissulin, Ana Angélica Henrique Fernandes, Alejandro Manuel Sanchez Orellana, Renata Calciolari Rossi e Silva & Selma Maria Michelin Matheus. (2017) Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine. Journal of Photochemistry and Photobiology B: Biology 168, pages 30-39.
Crossref
Manuel J. Richter, Ralf Ewert, Christian Warnke, Henning Gall, Simon Classen, Friedrich Grimminger, Eckhard Mayer, Werner Seeger & Hossein-Ardeschir Ghofrani. (2016) Procedural safety of a fully implantable intravenous prostanoid pump for pulmonary hypertension. Clinical Research in Cardiology 106:3, pages 174-182.
Crossref
Alessandra C.S. Akkari, Juliana Z. Boava Papini, Gabriella K. Garcia, Margareth K.K. Dias Franco, Leide P. Cavalcanti, Antonio Gasperini, Melissa Inger Alkschbirs, Fabiano Yokaichyia, Eneida de Paula, Giovana R. Tófoli & Daniele R. de Araujo. (2016) Poloxamer 407/188 binary thermosensitive hydrogels as delivery systems for infiltrative local anesthesia: Physico-chemical characterization and pharmacological evaluation. Materials Science and Engineering: C 68, pages 299-307.
Crossref
Richard N. Yu, Constance S. Houck, Alfonso Casta & Richard H. Blum. (2016) Institutional Policy Changes to Prevent Cardiac Toxicity Associated With Bupivacaine Penile Blockade in Infants. A & A Case Reports 7:3, pages 71-75.
Crossref
Ming-Zhu Zhai, Huang-Hui Wu, Jun-Bin Yin, Yuan-Yuan Cui, Xiao-Peng Mei, Han Zhang, Xia Zhu, Xue-Feng Shen, Alan David Kaye & Guo-Zhong Chen. (2015) Dexmedetomidine Dose-Dependently Attenuates Ropivacaine-Induced Seizures and Negative Emotions Via Inhibiting Phosphorylation of Amygdala Extracellular Signal-Regulated Kinase in Mice. Molecular Neurobiology 53:4, pages 2636-2646.
Crossref
Olcay Guler, Serhat Mutlu, Mehmet Isyar, Harun Mutlu, Ahmet M. Bulbul & Mahir Mahirogullari. (2015) Efficacy of periarticular injection applied trough knee other than posterior capsule in simultaneous bilateral total knee arthroplasty. Journal of Orthopaedics 12:4, pages 205-210.
Crossref
Zahida Mamou, Jacques Descotes, Philippe Chevalier, Bernard Bui-Xuan, Caroline Romestaing & Quadiri Timour. (2015) Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions?. Fundamental & Clinical Pharmacology 29:5, pages 439-449.
Crossref
Eva Rioja Garcia. 2015. Veterinary Anesthesia and Analgesia. Veterinary Anesthesia and Analgesia 332 354 .
Yuanjun Teng, Jin Jiang, Shaolong Chen, Lianggong Zhao, Zhaohui Cui, Md Shahidur Khan, Wenjia Du, Xuren Gao, Jing Wang & Yayi Xia. (2013) Periarticular multimodal drug injection in total knee arthroplasty. Knee Surgery, Sports Traumatology, Arthroscopy 22:8, pages 1949-1957.
Crossref
Lyubov Chaykovska, Linus Blohmé, Dieter Mayer, Steffen Gloekler, Zoran Rancic, Christian A.P. Schmidt, Roberto Tunesi, Frank Veith, Mario Lachat & Dominique Bettex. (2014) Paraincisional Subcutaneous Infusion of Ropivacaine after Open Abdominal Vascular Surgery Shows Significant Advantages. Annals of Vascular Surgery 28:4, pages 837-844.
Crossref
Sang-Hee ParkSang-Hyun KwakKyung-Yeon YooHyun-Jung LeeKeun-Bae YookSeok-Jai Kim. (2014) Lipid Emulsion in the Successful Resuscitation of Local Anesthetic Toxicity after Ankle Block. Korean Journal of Critical Care Medicine 29:3, pages 234.
Crossref
Thomas M. Halaszynski. 2014. Orofacial Pain. Orofacial Pain 65 79 .
Jin Jiang, Yuanjun Teng, Zhenzhen Fan, Md Shahidur Khan, Zhaohui Cui & Yayi Xia. (2013) The Efficacy of Periarticular Multimodal Drug Injection for Postoperative Pain Management in Total Knee or Hip Arthroplasty. The Journal of Arthroplasty 28:10, pages 1882-1887.
Crossref
Dmitrii V. Kalinin, Vladimir I. Pantsurkin, Boris Ya. Syropyatov, Svetlana A. Kalinina, Irina P. Rudakova, Mikhail I. Vakhrin & Anton V. Dolzhenko. (2013) Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides. European Journal of Medicinal Chemistry 63, pages 144-150.
Crossref
Sai Li, Xiao Bin Fu, Li Liu, Nuo Lan, Weng Qi Meng, Jing Zheng Zhang, Wen Cui & Yi Liu. (2013) Synthesis of Ropivacaine under Ultrasound Irradiation. Advanced Materials Research 634-638, pages 1152-1156.
Crossref
T. Corsini, P. Cuvillon, A. Forgeot, C. Chapelle, P. Seffert & C. Chauleur. (2013) Infiltration peropératoire de lévobupivacaïne après césariennes : étude randomisée en double insu contre placebo. Annales Françaises d'Anesthésie et de Réanimation 32:1, pages 25-30.
Crossref
François Gaudreault, Pierre Drolet, Michel Fallaha & France Varin. (2012) A population pharmacokinetic model for the complex systemic absorption of ropivacaine after femoral nerve block in patients undergoing knee surgery. Journal of Pharmacokinetics and Pharmacodynamics 39:6, pages 635-642.
Crossref
Andreas Mazarakis & Nicholas G. Kounis. (2012) Commentary on: Shields LB, Rolf CM, Davis GJ, Hunsaker JC 3rd. Sudden and unexpected death in three cases of Ehlers‐Danlos syndrome type IV. J Forensic Sci 2010;55(6):1641–5. Journal of Forensic Sciences 57:3, pages 839-840.
Crossref
Geoffrey T. Tucker & Laurence E. Mather. (2012) Dr. Daniel C. Moore—In Appreciation. Regional Anesthesia and Pain Medicine 37:2, pages 236.
Crossref
Mary E. Crawford. 2012. Lower Extremity Soft Tissue & Cutaneous Plastic Surgery. Lower Extremity Soft Tissue & Cutaneous Plastic Surgery 45 51 .
Bryan Fritz, Marlene Barnhouse, Usha Ramadhyani & Bobby Nossaman. 2012. Essentials of Regional Anesthesia. Essentials of Regional Anesthesia 665 688 .
Brigitte M. Richard, Douglas E. Rickert, Paul E. Newton, Laura R. Ott, Dean Haan, Abram N. Brubaker, Phaedra I. Cole, Paul E. Ross, Marlon C. Rebelatto & Keith G. Nelson. (2011) Safety Evaluation of EXPAREL (DepoFoam Bupivacaine) Administered by Repeated Subcutaneous Injection in Rabbits and Dogs: Species Comparison. Journal of Drug Delivery 2011, pages 1-14.
Crossref
Yao-min Zhu, Zu-yi Yuan, Hui Wu, Dan-dan Zhou & Gui-xia Jing. (2011) Midazolam in rabbits terminates dysrhythmias caused by intracerebroventricular ropivacaine. Journal of Zhejiang University SCIENCE B 12:8, pages 668-676.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.