609
Views
63
CrossRef citations to date
0
Altmetric
Reviews

Role of organic cation transporters in drug-induced toxicity

Pages 159-174 | Published online: 18 Jan 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Liping Li, Siyuan Sun, Yayun Weng, Feifeng Song, Sisi Zhou, Mengru Bai, Hui Zhou, Su Zeng & Huidi Jiang. (2016) Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3. Xenobiotica 46:2, pages 175-183.
Read now
S. A. Al-Abri, S. Hayashi, K. L. Thoren & K. R. Olson. (2013) Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs. Clinical Toxicology 51:5, pages 444-447.
Read now
Eva Ramboer, Tamara Vanhaecke, Vera Rogiers & Mathieu Vinken. (2013) Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters. Drug Metabolism Reviews 45:2, pages 196-217.
Read now
Xiaoyan Chu, Kelly Bleasby & Raymond Evers. (2013) Species differences in drug transporters and implications for translating preclinical findings to humans. Expert Opinion on Drug Metabolism & Toxicology 9:3, pages 237-252.
Read now
Maria Luisa Lucero, Ana Gonzalo, Alvaro Ganza, Nerea Leal, Itziar Soengas, Eniko Ioja, Szilvia Gedey, Mirza Jahic & Dallas Bednarczyk. (2012) Interactions of bilastine, a new oral H1 antihistamine, with human transporter systems. Drug and Chemical Toxicology 35:sup1, pages 8-17.
Read now
Christopher A Koczor, Rebecca A Torres & William Lewis. (2012) The role of transporters in the toxicity of nucleoside and nucleotide analogs. Expert Opinion on Drug Metabolism & Toxicology 8:6, pages 665-676.
Read now
Alexander M Cressman, Vanja Petrovic & Micheline Piquette-Miller. (2012) Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response. Expert Review of Clinical Pharmacology 5:1, pages 69-89.
Read now

Articles from other publishers (56)

Barbara Vuic, Tina Milos, Lucija Tudor, Matea Nikolac Perkovic, Marcela Konjevod, Gordana Nedic Erjavec, Vladimir Farkas, Suzana Uzun, Ninoslav Mimica & Dubravka Svob Strac. (2023) Pharmacogenomics of Dementia: Personalizing the Treatment of Cognitive and Neuropsychiatric Symptoms. Genes 14:11, pages 2048.
Crossref
Elena Puris, Gert Fricker & Mikko Gynther. (2023) The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy. Pharmaceutics 15:2, pages 364.
Crossref
Sara Ahmed Eltayeb, Giuliano Ciarimboli, Katrin Beul, Giovana Seno Di Marco & Vivien Barz. (2022) Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives. International Journal of Molecular Sciences 23:3, pages 1090.
Crossref
Douglas B. Kell. (2021) The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes. Molecules 26:18, pages 5629.
Crossref
Carla Varrica, Helena Sofia Dias, Catarina Reis, Manuela Carvalheiro & Sandra Simões. (2021) Targeted delivery in scleroderma fibrosis. Autoimmunity Reviews 20:2, pages 102730.
Crossref
Nida Sohail, Khan Hira, Junaid Ahmed Kori, Hafiza Farhat, Faizah Urooj, Waqas Khan, Viqar Sultana, Muhammad Shaiq Ali & Syed Ehteshamul-Haque. (2020) Nephroprotective effect of ethanol extract and fractions of a sea lettuce, Ulva fasciata against cisplatin-induced kidney injury in rats. Environmental Science and Pollution Research 28:8, pages 9448-9461.
Crossref
Miljan N. M. Milunović, Oleg Palamarciuc, Angela Sirbu, Sergiu Shova, Dan Dumitrescu, Dana Dvoranová, Peter Rapta, Tatsiana V. Petrasheuskaya, Eva A. Enyedy, Gabriella Spengler, Marija Ilic, Harald H. Sitte, Gert Lubec & Vladimir B. Arion. (2020) Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters. Biomolecules 10:9, pages 1213.
Crossref
Benjamin K. Gersten, Tracy S. Fitzgerald, Katharine A. Fernandez & Lisa L. Cunningham. (2020) Ototoxicity and Platinum Uptake Following Cyclic Administration of Platinum-Based Chemotherapeutic Agents. Journal of the Association for Research in Otolaryngology 21:4, pages 303-321.
Crossref
Frenzel, Köppen, Bauer, Karst, Schröter, Tzvetkov & Ciarimboli. (2019) Effects of Single Nucleotide Polymorphism Ala270Ser (rs316019) on the Function and Regulation of hOCT2. Biomolecules 9:10, pages 578.
Crossref
Anna Hucke, Markus M. Rinschen, Oliver B. Bauer, Michael Sperling, Uwe Karst, Christina Köppen, Karolin Sommer, Rita Schröter, Cecilia Ceresa, Alessia Chiorazzi, Annalisa Canta, Sara Semperboni, Paola Marmiroli, Guido Cavaletti, Stefan Schlatt, Eberhard Schlatter, Hermann Pavenstädt, Barbara Heitplatz, Veerle Van Marck, Alex Sparreboom, Vivien Barz, Arne Knief, Dirk Deuster, Antoinette am Zehnhoff-Dinnesen & Giuliano Ciarimboli. (2019) An integrative approach to cisplatin chronic toxicities in mice reveals importance of organic cation-transporter-dependent protein networks for renoprotection. Archives of Toxicology 93:10, pages 2835-2848.
Crossref
Martin Valis, David Herman, Nela Vanova, Jiri Masopust, Oldrich Vysata, Jakub Hort, Zbysek Pavelek, Blanka Klimova, Kamil Kuca, Jan Misik & Jana Zdarova Karasova. (2019) The Concentration of Memantine in the Cerebrospinal Fluid of Alzheimer’s Disease Patients and Its Consequence to Oxidative Stress Biomarkers. Frontiers in Pharmacology 10.
Crossref
Birgit Deutsch, Claudia Neumeister, Ulrich Schwantes, Martin F. Fromm & Jörg König. (2019) Interplay of the Organic Cation Transporters OCT1 and OCT2 with the Apically Localized Export Protein MATE1 for the Polarized Transport of Trospium. Molecular Pharmaceutics 16:2, pages 510-517.
Crossref
Saliha Harrach, Vivien Barz, Thomas Pap, Hermann Pavenstädt, Eberhard Schlatter, Bayram Edemir, Jörg Distler, Giuliano Ciarimboli & Jessica Bertrand. (2019) Notch Signaling Activity Determines Uptake and Biological Effect of Imatinib in Systemic Sclerosis Dermal Fibroblasts. Journal of Investigative Dermatology 139:2, pages 439-447.
Crossref
Sarah Aldobeaban, Bandr Mzahim & Abdussalam Ali Alshehri. (2018) Recurrent hypoglycemia secondary to metformin toxicity in the absence of co-ingestions: a case report. Journal of Medical Case Reports 12:1.
Crossref
Michele Fedecostante, Koen G. C. Westphal, Michele F. Buono, Natalia Sanchez Romero, Martijn J. Wilmer, Janis Kerkering, Pedro Miguel Baptista, Joost G. Hoenderop & Rosalinde Masereeuw. (2018) Recellularized Native Kidney Scaffolds as a Novel Tool in Nephrotoxicity Screening. Drug Metabolism and Disposition 46:9, pages 1338-1350.
Crossref
Joanne Y.-C. Soo, Jitske Jansen, Rosalinde Masereeuw & Melissa H. Little. (2018) Advances in predictive in vitro models of drug-induced nephrotoxicity. Nature Reviews Nephrology 14:6, pages 378-393.
Crossref
Anna Hucke, Ga Young Park, Oliver B. Bauer, Georg Beyer, Christina Köppen, Dorothea Zeeh, Christoph A. Wehe, Michael Sperling, Rita Schröter, Marta Kantauskaitè, Yohannes Hagos, Uwe Karst, Stephen J. Lippard & Giuliano Ciarimboli. (2018) Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations. Frontiers in Chemistry 6.
Crossref
A. Gessner, J. König & M. F. Fromm. (2018) Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO). Scientific Reports 8:1.
Crossref
Qing Li, Zhi Ye, Peng Zhu, Dong Guo, Hong Yang, Jin Huang, Wei Zhang, James E. Polli & Yan Shu. (2018) Indinavir Alters the Pharmacokinetics of Lamivudine Partially via Inhibition of Multidrug and Toxin Extrusion Protein 1 (MATE1). Pharmaceutical Research 35:1.
Crossref
Anton Ivanyuk, Françoise Livio, Jérôme Biollaz & Thierry Buclin. (2017) Renal Drug Transporters and Drug Interactions. Clinical Pharmacokinetics 56:8, pages 825-892.
Crossref
Saliha Harrach, Bayram Edemir, Christian Schmidt-Lauber, Thomas Pap, Jessica Bertrand & Giuliano Ciarimboli. (2017) Importance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts. Scientific Reports 7:1.
Crossref
Ulf Schulze, Sabine Brast, Alexander Grabner, Christian Albiker, Beatrice Snieder, Svenja Holle, Eberhard Schlatter, Rita Schröter, Hermann Pavenstädt, Edwin Herrmann, Carsten Lambert, Gilles A. Spoden, Luise Florin, Paul Saftig & Giuliano Ciarimboli. (2016) Tetraspanin CD63 controls basolateral sorting of organic cation transporter 2 in renal proximal tubules. The FASEB Journal 31:4, pages 1421-1433.
Crossref
Ludmila V. Puchkova, Alexey N. Skvortsov, Paolo Rusconi, Ekaterina Yu. Ilyechova & Massimo Broggini. (2016) In vivo effect of copper status on cisplatin-induced nephrotoxicity. BioMetals 29:5, pages 841-849.
Crossref
David J. Wagner, Tao Hu & Joanne Wang. (2016) Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics. Pharmacological Research 111, pages 237-246.
Crossref
Anna Hucke & Giuliano Ciarimboli. (2016) The Role of Transporters in the Toxicity of Chemotherapeutic Drugs: Focus on Transporters for Organic Cations. The Journal of Clinical Pharmacology 56, pages S157-S172.
Crossref
Marilyn E. Morris & Xiaowen Guan. 2016. Drug Delivery. Drug Delivery 62 102 .
Q. Li, H. Yang, D. Guo, T. Zhang, J. E. Polli, H. Zhou & Y. Shu. (2016) Effect of Ondansetron on Metformin Pharmacokinetics and Response in Healthy Subjects. Drug Metabolism and Disposition 44:4, pages 489-494.
Crossref
Ivan Sabolić, Davorka Breljak & Tvrtko Smital. 2016. Organic Cation Transporters. Organic Cation Transporters 217 242 .
Trine Eggen & Cathrine Lillo. 2016. Organic Cation Transporters. Organic Cation Transporters 243 256 .
Giuliano Ciarimboli. 2016. Organic Cation Transporters. Organic Cation Transporters 1 47 .
Dan C. Li, Colin G. Nichols & Monica Sala-Rabanal. (2015) Role of a Hydrophobic Pocket in Polyamine Interactions with the Polyspecific Organic Cation Transporter OCT3. Journal of Biological Chemistry 290:46, pages 27633-27643.
Crossref
Victoria Hellberg, Caroline Gahm, Wei Liu, Hans Ehrsson, Helge Rask‐Andersen & Göran Laurell. (2015) Immunohistochemical localization of OCT2 in the cochlea of various species. The Laryngoscope 125:9.
Crossref
Yuan Zhang, Liang Tao, Lixia Fan, Yuexia Peng, Kefan Yang, Yifan Zhao, Qi Song & Qin Wang. (2015) Different gap junction-propagated effects on cisplatin transfer result in opposite responses to cisplatin in normal cells versus tumor cells. Scientific Reports 5:1.
Crossref
František Trejtnar, Jana Mandíková, Jana Kočíncová & Marie Volková. (2014) Renal Handling of Amphotericin B and Amphotericin B-Deoxycholate and Potential Renal Drug-Drug Interactions with Selected Antivirals. Antimicrobial Agents and Chemotherapy 58:10, pages 5650-5657.
Crossref
Yohannes Hagos, Waja Wegner, Annett Kuehne, Saskia Floerl, Venkata V.V.R. Marada, Gerhard Burckhardt & Maja Henjakovic. (2014) HNF4? Induced Chemosensitivity to Oxaliplatin and 5-FU Mediated by OCT1 and CNT3 in Renal Cell Carcinoma. Journal of Pharmaceutical Sciences 103:10, pages 3326-3334.
Crossref
Eberhard Schlatter, Philipp Klassen, Vivian Massmann, Svenja K. Holle, Denise Guckel, Bayram Edemir, Hermann Pavenstädt & Giuliano Ciarimboli. (2013) Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules. Pflügers Archiv - European Journal of Physiology 466:8, pages 1581-1589.
Crossref
Lorena Pochini, Angela Seidita, Cristina Sensi, Mariafrancesca Scalise, Ivano Eberini & Cesare Indiveri. (2014) Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling. Biochemical Pharmacology 89:3, pages 422-430.
Crossref
Christoph A. Wehe, Georg Beyer, Michael Sperling, Giuliano Ciarimboli & Uwe Karst. (2014) Assessing the intracellular concentration of platinum in medulloblastoma cell lines after Cisplatin incubation. Journal of Trace Elements in Medicine and Biology 28:2, pages 166-172.
Crossref
Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang & A. David Rodrigues. (2013) Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance. Drug Metabolism and Disposition 41:12, pages 2095-2103.
Crossref
Qing Li, Dong Guo, Zhongqi Dong, Wei Zhang, Lei Zhang, Shiew-Mei Huang, James E. Polli & Yan Shu. (2013) Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs). Toxicology and Applied Pharmacology 273:1, pages 100-109.
Crossref
Lorena Pochini, Mariafrancesca Scalise, Michele Galluccio & Cesare Indiveri. (2013) OCTN Cation Transporters in Health and Disease: Role as Drug Targets and Assay Development. SLAS Discovery 18:8, pages 851-867.
Crossref
F Sánchez-Jiménez, M V Ruiz-Pérez, J L Urdiales & M A Medina. (2013) Pharmacological potential of biogenic amine-polyamine interactions beyond neurotransmission. British Journal of Pharmacology 170:1, pages 4-16.
Crossref
Bidya Dhar Sahu, Madhusudana Kuncha, Uday Kumar Putcha & Ramakrishna Sistla. (2013) Effect of metformin against cisplatin induced acute renal injury in rats: A biochemical and histoarchitectural evaluation. Experimental and Toxicologic Pathology 65:6, pages 933-940.
Crossref
Cesare Indiveri, Michele Galluccio, Mariafrancesca Scalise & Lorena Pochini. (2012) Strategies of Bacterial Over Expression of Membrane Transporters Relevant in Human Health: The Successful Case of the Three Members of OCTN Subfamily. Molecular Biotechnology 54:2, pages 724-736.
Crossref
Sofia Waissbluth & Sam J. Daniel. (2013) Cisplatin-induced ototoxicity: Transporters playing a role in cisplatin toxicity. Hearing Research 299, pages 37-45.
Crossref
Monica Sala-Rabanal, Dan C. Li, Gregory R. Dake, Harley T. Kurata, Mikhail Inyushin, Serguei N. Skatchkov & Colin G. Nichols. (2013) Polyamine Transport by the Polyspecific Organic Cation Transporters OCT1, OCT2, and OCT3. Molecular Pharmaceutics 10:4, pages 1450-1458.
Crossref
Muriel Noetzli & Chin B. Eap. (2013) Pharmacodynamic, Pharmacokinetic and Pharmacogenetic Aspects of Drugs Used in the Treatment of Alzheimer’s Disease. Clinical Pharmacokinetics 52:4, pages 225-241.
Crossref
Douglas B. Kell, Paul D. Dobson, Elizabeth Bilsland & Stephen G. Oliver. (2013) The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Discovery Today 18:5-6, pages 218-239.
Crossref
Muriel Noetzli, Monia Guidi, Karsten Ebbing, Stephan Eyer, Laurence Wilhelm, Agnès Michon, Valérie Thomazic, Abdel-Messieh Alnawaqil, Sophie Maurer, Serge Zumbach, Panteleimon Giannakopoulos, Armin von Gunten, Chantal Csajka & Chin B. Eap. (2013) Population Pharmacokinetic Study of Memantine: Effects of Clinical and Genetic Factors. Clinical Pharmacokinetics 52:3, pages 211-223.
Crossref
Ting Chan. (2013) Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters. World Journal of Pharmacology 2:4, pages 115.
Crossref
Ikumi Tamai. (2012) Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21). Biopharmaceutics & Drug Disposition 34:1, pages 29-44.
Crossref
Lauren E. Kelly, Shirley Poon, Parvaz Madadi & Gideon Koren. (2012) Neonatal Benzodiazepines Exposure during Breastfeeding. The Journal of Pediatrics 161:3, pages 448-451.
Crossref
Lorena Pochini, Mariafrancesca Scalise, Michele Galluccio, Giovambattista Pani, Katherine A. Siminovitch & Cesare Indiveri. (2012) The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease. Biochimica et Biophysica Acta (BBA) - Biomembranes 1818:3, pages 559-565.
Crossref
Giuliano Ciarimboli. (2012) Membrane Transporters as Mediators of Cisplatin Effects and Side Effects. Scientifica 2012, pages 1-18.
Crossref
Collen Masimirembwa & Alice Matimba. 2012. Genomics Applications for the Developing World. Genomics Applications for the Developing World 161 182 .
Douglas B. Kell, Paul D. Dobson & Stephen G. Oliver. (2011) Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only. Drug Discovery Today 16:15-16, pages 704-714.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.