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In vitro cell culture models to study the corneal drug absorption

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Pages 559-578 | Published online: 08 Mar 2011

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Vrinda Gote, Michael Ansong & Dhananjay Pal. (2020) Prodrugs and nanomicelles to overcome ocular barriers for drug penetration. Expert Opinion on Drug Metabolism & Toxicology 16:10, pages 885-906.
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Chris MacDonald, Di Shao, Angus Oli & Remigius U. Agu. (2013) Characterization of Calu-3 cell monolayers as a model of bronchial epithelial transport: organic cation interaction studies. Journal of Drug Targeting 21:1, pages 97-106.
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Saumyakanti Giri, Hemant Badwaik & Tapan Kumar Giri. (2023) Breaking the ocular barrier through nano-lipid carriers to treat intraocular diseases. Journal of Drug Delivery Science and Technology 87, pages 104867.
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Van Nguyen Tran, Ondřej Strnad, Jáchym Šuman, Tereza Veverková, Adéla Sukupová, Pavel Cejnar, Radovan Hynek, Olga Kronusová, Josef Šach, Petr Kaštánek, Tomáš Ruml & Jitka Viktorová. (2023) Cannabidiol nanoemulsion for eye treatment – Anti-inflammatory, wound healing activity and its bioavailability using in vitro human corneal substitute. International Journal of Pharmaceutics 643, pages 123202.
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Inès De Hoon, Rabah Boukherroub, Stefaan C. De Smedt, Sabine Szunerits & Félix Sauvage. (2023) In Vitro and Ex Vivo Models for Assessing Drug Permeation across the Cornea . Molecular Pharmaceutics 20:7, pages 3298-3319.
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Liping Li, Fan Jia, Youxiang Wang, Jiamin Liu, Yi Tian, Xinghuai Sun, Yuan Lei & Jian Ji. (2023) Trans-corneal drug delivery strategies in the treatment of ocular diseases. Advanced Drug Delivery Reviews 198, pages 114868.
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Azadeh Izadyari Aghmiuni & Saeed Heidari Keshel. 2023. Principles of Human Organs-on-Chips. Principles of Human Organs-on-Chips 315 369 .
Patrizia Chetoni, Susi Burgalassi, Erica Zucchetti, Carlotta Granchi, Filippo Minutolo, Silvia Tampucci & Daniela Monti. (2022) MAGL inhibitor NanoMicellar formulation (MAGL-NanoMicellar) for the development of an antiglaucoma eye drop. International Journal of Pharmaceutics 625, pages 122078.
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Susi Burgalassi, Erica Zucchetti, Leonardo Ling, Patrizia Chetoni, Silvia Tampucci & Daniela Monti. (2022) Hydrogels as Corneal Stroma Substitutes for In Vitro Evaluation of Drug Ocular Permeation. Pharmaceutics 14:4, pages 850.
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Agnė Žiniauskaitė, Vytautas Cėpla, Tadas Jelinskas, Romuald Eimont, Artūras Ulčinas, Rūta Aldonytė, Ramūnas Valiokas, Giedrius Kalesnykas & Jenni J. Hakkarainen. (2021) Introducing an Efficient In Vitro Cornea Mimetic Model for Testing Drug Permeability. Sci 3:3, pages 30.
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Yulia Kaluzhny & Mitchell Klausner. (2021) In vitro reconstructed 3D corneal tissue models for ocular toxicology and ophthalmic drug development. In Vitro Cellular & Developmental Biology - Animal 57:2, pages 207-237.
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Laura García-Posadas & Yolanda Diebold. (2020) Three-Dimensional Human Cell Culture Models to Study the Pathophysiology of the Anterior Eye. Pharmaceutics 12:12, pages 1215.
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Lucy Urwin, Katarzyna Okurowska, Grace Crowther, Sanhita Roy, Prashant Garg, Esther Karunakaran, Sheila MacNeil, Lynda J. Partridge, Luke R. Green & Peter N. Monk. (2020) Corneal Infection Models: Tools to Investigate the Role of Biofilms in Bacterial Keratitis. Cells 9:11, pages 2450.
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Thalita Pedon de Araujo Cardoso, Juliana Kishishita, Asley Thalia Medeiros Souza, Jeymesson Raphael Cardoso Vieira, Cristiane Moutinho Lagos de Melo, Davi Pereira de Santana & Leila Bastos Leal. (2020) A proposed eye ex vivo permeation approach to evaluate pesticides: Case dimethoate. Toxicology in Vitro 66, pages 104833.
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Anju Sharma, Mukesh S. Patil, Pravin Pawar, A.A. Shirkhedkar & Inderbir Singh. 2020. Bioadhesives in Drug Delivery. Bioadhesives in Drug Delivery 171 211 .
Maud Gorbet, Dana Toameh, Cameron Postnikoff & Robert Pintwala. 2020. Handbook of Biomaterials Biocompatibility. Handbook of Biomaterials Biocompatibility 681 699 .
Marina Juretić, Biserka Cetina-Čižmek, Jelena Filipović-Grčić, Anita Hafner, Jasmina Lovrić & Ivan Pepić. (2018) Biopharmaceutical evaluation of surface active ophthalmic excipients using in vitro and ex vivo corneal models. European Journal of Pharmaceutical Sciences 120, pages 133-141.
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Nicole Beißner, Antonio Bolea Albero, Jendrik Füller, Thomas Kellner, Lothar Lauterboeck, Jinghu Liang, Markus Böl, Birgit Glasmacher, Christel C. Müller-Goymann & Stephan Reichl. (2018) Improved in vitro models for preclinical drug and formulation screening focusing on 2D and 3D skin and cornea constructs. European Journal of Pharmaceutics and Biopharmaceutics 126, pages 57-66.
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Masanobu Mizuta, Takashi Kurita, Emily E. Kimball & Bernard Rousseau. (2017) Structurally and functionally characterized in vitro model of rabbit vocal fold epithelium. Tissue and Cell 49:3, pages 427-434.
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Marina Juretić, Bisera Jurišić Dukovski, Iva Krtalić, Stephan Reichl, Biserka Cetina-Čižmek, Jelena Filipović-Grčić, Jasmina Lovrić & Ivan Pepić. (2017) HCE-T cell-based permeability model: A well-maintained or a highly variable barrier phenotype?. European Journal of Pharmaceutical Sciences 104, pages 23-30.
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Abhirup Mandal, Rohit Bisht, Ilva D. Rupenthal & Ashim K. Mitra. (2017) Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies. Journal of Controlled Release 248, pages 96-116.
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Christian Kölln & Stephan Reichl. (2016) Cytochrome P450 Activity in Ex Vivo Cornea Models and a Human Cornea Construct. Journal of Pharmaceutical Sciences 105:7, pages 2204-2212.
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Christian Kölln & Stephan Reichl. (2016) Expression of glutathione transferases in corneal cell lines, corneal tissues and a human cornea construct. International Journal of Pharmaceutics 506:1-2, pages 371-381.
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Rakesh K. Tekade & Muktika Tekade. 2016. Nano-Biomaterials For Ophthalmic Drug Delivery. Nano-Biomaterials For Ophthalmic Drug Delivery 211 230 .
Jessica Verstraelen & Stephan Reichl. (2015) Upregulation of P-glycoprotein expression by ophthalmic drugs in different corneal in-vitro models. Journal of Pharmacy and Pharmacology 67:5, pages 605-615.
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Saman Mohammadi, Lyndon Jones & Maud Gorbet. (2014) Extended Latanoprost Release from Commercial Contact Lenses: In Vitro Studies Using Corneal Models. PLoS ONE 9:9, pages e106653.
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Saman Mohammadi, Cameron Postnikoff, Ann M. Wright & Maud Gorbet. (2014) Design and Development of an In Vitro Tear Replenishment System. Annals of Biomedical Engineering 42:9, pages 1923-1931.
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Cameron K. Postnikoff, Robert Pintwala, Sara Williams, Ann M. Wright, Denise Hileeto & Maud B. Gorbet. (2014) Development of a Curved, Stratified, In Vitro Model to Assess Ocular Biocompatibility. PLoS ONE 9:5, pages e96448.
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Ivan Pepić, Jasmina Lovrić, Biserka Cetina-Čižmek, Stephan Reichl & Jelena Filipović-Grčić. (2014) Toward the practical implementation of eye-related bioavailability prediction models. Drug Discovery Today 19:1, pages 31-44.
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Hideyuki Miyashita, Seiichi Yokoo, Satoru Yoshida, Tetsuya Kawakita, Satoru Yamagami, Kazuo Tsubota & Shigeto Shimmura. (2013) Long-Term Maintenance of Limbal Epithelial Progenitor Cells Using Rho Kinase Inhibitor and Keratinocyte Growth Factor. Stem Cells Translational Medicine 2:10, pages 758-765.
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Kouichi Kawazu, Shinobu Fujii, Kazuhito Yamada, Katsuhiko Shinomiya, Osamu Katsuta & Yoshihide Horibe. (2013) Characterization of monocarboxylate uptake and immunohistochemical demonstration of monocarboxylate transporters in cultured rabbit corneal epithelial cells. Journal of Pharmacy and Pharmacology 65:3, pages 328-336.
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Jessica Verstraelen & Stephan Reichl. (2013) Expression analysis of MDR1, BCRP and MRP3 transporter proteins in different in vitro and ex vivo cornea models for drug absorption studies. International Journal of Pharmaceutics 441:1-2, pages 765-775.
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Leandro Teixeira & Richard R. Dubielzig. 2013. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 2095 2185 .
Stephan Reichl & Karin Becker. (2012) Cultivation of RPMI 2650 cells as an in-vitro model for human transmucosal nasal drug absorption studies: optimization of selected culture conditions. Journal of Pharmacy and Pharmacology 64:11, pages 1621-1630.
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Matthias Hahne, Michaela Zorn-Kruppa, Gustavo Guzman, Johanna M. Brandner, Eleonore Haltner-Ukomado, Hermann Wätzig & Stephan Reichl. (2012) Prevalidation of a Human Cornea Construct as an Alternative to Animal Corneas for In Vitro Drug Absorption Studies. Journal of Pharmaceutical Sciences 101:8, pages 2976-2988.
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Christian KöllnStephan Reichl. (2012) mRNA Expression of Metabolic Enzymes in Human Cornea, Corneal Cell Lines, and Hemicornea Constructs. Journal of Ocular Pharmacology and Therapeutics 28:3, pages 271-277.
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Matthias Hahne & Stephan Reichl. (2011) Development of a serum-free human cornea construct for in vitro drug absorption studies: The influence of varying cultivation parameters on barrier characteristics. International Journal of Pharmaceutics 416:1, pages 268-279.
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