973
Views
90
CrossRef citations to date
0
Altmetric
Reviews

Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models

, , , & , PhD
Pages 579-589 | Published online: 23 Feb 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

A. K. M. Moyeenul Huq, Miah Roney, Abdul Rashid Issahaku, Suhaila Sapari, Fazira Ilyana Abdul Razak, Mahmoud E. S. Soliman, Mohd Fadhlizil Fasihi Mohd Aluwi & Saiful Nizam Tajuddin. (2023) Selected phytochemicals of Momordica charantia L. as potential anti-DENV-2 through the docking, DFT and molecular dynamic simulation. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
Read now
David Hernández-Silva, Francisca Alcaraz-Pérez, Horacio Pérez-Sánchez & Maria Luisa Cayuela. (2023) Virtual screening and zebrafish models in tandem, for drug discovery and development. Expert Opinion on Drug Discovery 18:8, pages 903-915.
Read now
Liwen Han, Qing Xia, Lei Zhang, Xuanming Zhang, Xiaobin Li, Shanshan Zhang, Lizhen Wang, Changxiao Liu & Kechun Liu. (2022) Induction of developmental toxicity and cardiotoxicity in zebrafish embryos/larvae by acetyl-11-keto-β-boswellic acid (AKBA) through oxidative stress. Drug and Chemical Toxicology 45:1, pages 143-150.
Read now
Wen-Wen Shen, Hai-Xia Zhang, Shou-Bei Qiu, Ying-Jie Wei, Fen-Xia Zhu, Jing Wang, Dan-Dan Wang, Xiao-Bin Jia, Dao-Quan Tang & Bin Chen. (2018) Biotransformation of ginsenosides F4 and Rg6 in zebrafish. Journal of Asian Natural Products Research 20:7, pages 686-696.
Read now
Helinor J. Johnston, Rachel Verdon, Suzanne Gillies, David M. Brown, Teresa F. Fernandes, Theodore B. Henry, Adriano G. Rossi, Lang Tran, Carl Tucker, Charles R. Tyler & Vicki Stone. (2018) Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials. Critical Reviews in Toxicology 48:3, pages 252-271.
Read now
John Fawell & Choon Nam Ong. (2012) Emerging Contaminants and the Implications for Drinking Water. International Journal of Water Resources Development 28:2, pages 247-263.
Read now
Guang Hu, Shiu On Siu, Shang Li, Ivan Keung Chu, Yiu Wa Kwan, Shun Wan Chan, George Pak-Heng Leung, Ru Yan & Simon Ming-Yuen Lee. (2012) Metabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae. Xenobiotica 42:3, pages 294-303.
Read now

Articles from other publishers (83)

Ha-Na Oh, Donggon Yoo, Seungmin Park, Sangwoo Lee & Woo-Keun Kim. (2024) Assessment of poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride-induced developmental neurotoxicity via oxidative stress mechanism: Integrative approaches with neuronal cells and zebrafish. Journal of Hazardous Materials 465, pages 133146.
Crossref
Jie Gu, Liguo Guo, Jun Hu, Guixiang Ji & Daqiang Yin. (2023) Potential adverse outcome pathway (AOP) of emamectin benzoate mediated cardiovascular toxicity in zebrafish larvae (Danio rerio). Science of The Total Environment 900, pages 165787.
Crossref
Pooja C. Asani, Zoya Alam & Raju Poddar. (2023) Exploring the impact of PVC and PVA microplastics on zebrafish tissue using multi-spectral imaging, Optical Coherence Tomography (OCT) and biospeckle OCT (bOCT). Chemosphere 341, pages 140088.
Crossref
Chao Chen, Yuhua Zuo, Hongmei Hu, Xue Li, Li Zhang, Dou Yang, Fasheng Liu, Xinjun Liao, Guanghua Xiong, Zigang Cao, Zilin Zhong, Yanlong Bi, Huiqiang Lu & Jianjun Chen. (2023) Hepatic lipid metabolism disorders and immunotoxicity induced by cysteamine in early developmental stages of zebrafish. Toxicology 493, pages 153555.
Crossref
Michael G. Morash, Morgan W. Kirzinger, J.C. Achenbach, Ananda B. Venkatachalam, Joëlle Pinsonnault Cooper, Deborah E. Ratzlaff, Cindy L.A. Woodland & Lee D. Ellis. (2023) The contribution of larval zebrafish transcriptomics to chemical risk assessment. Regulatory Toxicology and Pharmacology 138, pages 105336.
Crossref
Helinor J Johnston, Suzanne L J Gillies, Rachel Verdon, Vicki Stone, Theodore Henry, Lang Tran, Carl Tucker, Adriano G Rossi & Charles R Tyler. (2023) Application of transgenic zebrafish for investigating inflammatory responses to nanomaterials: Recommendations for new users. F1000Research 12, pages 51.
Crossref
Katharina Brotzmann, Sylvia E. Escher, Paul Walker & Thomas Braunbeck. (2022) Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues. Archives of Toxicology 96:11, pages 3033-3051.
Crossref
Ha-Na Oh, Donggon Yoo, Seungmin Park, Sangwoo Lee & Woo-Keun Kim. (2022) Developmental neurotoxicity induced by glutaraldehyde in neuron/astrocyte co-cultured cells and zebrafish. Ecotoxicology and Environmental Safety 242, pages 113891.
Crossref
Chenqinyao Li, Changqing Zhang, Chengyue Zhu, Jie Zhang, Qing Xia, Kechun Liu & Yun Zhang. (2022) Inflammation aggravated the hepatotoxicity of triptolide by oxidative stress, lipid metabolism disorder, autophagy, and apoptosis in zebrafish. Frontiers in Pharmacology 13.
Crossref
Marja Driessen, Suzanne van der Plas - Duivesteijn, Anne S. Kienhuis, Evert-Jan van den Brandhof, Marianne Roodbergen, Bob van de Water, Herman P. Spaink, Magnus Palmblad, Leo T.M. van der Ven & Jeroen L.A. Pennings. (2022) Identification of proteome markers for drug-induced liver injury in zebrafish embryos. Toxicology 477, pages 153262.
Crossref
Leo T.M. Van Der Ven, Paul Van Ommeren, Edwin P. Zwart, Eric R. Gremmer, Hennie M. Hodemaekers, Harm J. Heusinkveld, Jacob D. van Klaveren & Emiel Rorije. (2022) Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action. Environmental Health Perspectives 130:4.
Crossref
Rebecca von Hellfeld, Pauline Pannetier & Thomas Braunbeck. (2021) Specificity of time- and dose-dependent morphological endpoints in the fish embryo acute toxicity (FET) test for substances with diverse modes of action: the search for a “fingerprint”. Environmental Science and Pollution Research 29:11, pages 16176-16192.
Crossref
Michael K. Danquah & Jaison Jeevanandam. 2022. Emerging Nanomedicines for Diabetes Mellitus Theranostics. Emerging Nanomedicines for Diabetes Mellitus Theranostics 173 198 .
Amin Nozari, Selena Do & Vance L. Trudeau. (2021) Applications of the SR4G Transgenic Zebrafish Line for Biomonitoring of Stress-Disrupting Compounds: A Proof-of-Concept Study. Frontiers in Endocrinology 12.
Crossref
Sung-Joon ChoEugene ParkAndrew BakerAylin Y. Reid. (2021) Post-Traumatic Epilepsy in Zebrafish Is Drug-Resistant and Impairs Cognitive Function. Journal of Neurotrauma 38:22, pages 3174-3183.
Crossref
Yan-Qiu Liang, Yanjie Situ, Linchun Xie, Jialiang Huo, Zhongdian Dong, Chengyong Li & Zhong Lin. (2021) Exposure of adult zebrafish to androstenedione alters thyroid hormone levels and the transcriptional expression of genes related to the hypothalamus-pituitary-thyroid axis. Aquaculture Reports 21, pages 100966.
Crossref
Valentina Naef, Maria Marchese, Asahi Ogi, Gianluca Fichi, Daniele Galatolo, Rosario Licitra, Stefano Doccini, Tiziano Verri, Francesco Argenton, Federica Morani & Filippo M. Santorelli. (2021) Efficient Neuroprotective Rescue of Sacsin-Related Disease Phenotypes in Zebrafish. International Journal of Molecular Sciences 22:16, pages 8401.
Crossref
Xin Huang, Fang Tang, Yuqing Hua & Xiao Li. (2021) In silico prediction of drug‐induced ototoxicity using machine learning and deep learning methods. Chemical Biology & Drug Design 98:2, pages 248-257.
Crossref
Deepak Kumar Khajuria & David Karasik. (2020) Novel model of restricted mobility induced osteopenia in zebrafish. Journal of Fish Biology 98:4, pages 1031-1038.
Crossref
Sheng‐Ya Guo, Yong Zhang, Xiao‐Yu Zhu, Jia‐Li Zhou, Jiao Li, Chun‐Qi Li & Li‐Ren Wu. (2020) Developmental neurotoxicity and toxic mechanisms induced by olaquindox in zebrafish. Journal of Applied Toxicology 41:4, pages 549-560.
Crossref
Katharina Brotzmann, André Wolterbeek, Dinant Kroese & Thomas Braunbeck. (2020) Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?. Archives of Toxicology 95:2, pages 641-657.
Crossref
Kun Wang, Qiushi Xu & Hanbing Zhong. (2021) The Bruton’s Tyrosine Kinase Inhibitor Ibrutinib Impairs the Vascular Development of Zebrafish Larvae. Frontiers in Pharmacology 11.
Crossref
Hidayah Dwi Renggani, Triana Hertianti & Retno Murwanti. (2021) Animal Models of Alcoholic Liver Disease for Hepatoprotective Activity Evaluation. BIO Web of Conferences 41, pages 07007.
Crossref
Al’aina Yuhainis Firus Khan, Qamar Uddin Ahmed, Tanzina Sharmin Nippun, Ayah Hilles, Tara K. Jalal, Lay Kek Teh, Mohd Zaki Salleh, Suzita Mohd Noor, Azman Seeni, Alfi Khatib & Ridhwan Abdul Wahab. (2020) Determination toxic effects of Hystrix Brachyura Bezoar extracts using cancer cell lines and embryo zebrafish (Danio rerio) models and identification of active principles through GC-MS analysis. Journal of Ethnopharmacology 262, pages 113138.
Crossref
Sung-Joon Cho, Eugene Park, Andrew Baker & Aylin Y. Reid. (2020) Age Bias in Zebrafish Models of Epilepsy: What Can We Learn From Old Fish?. Frontiers in Cell and Developmental Biology 8.
Crossref
Petrus J. Steenbergen, Jana Heigwer, Gunjan Pandey, Burkhard Tönshoff, Jochen Gehrig & Jens H. Westhoff. (2020) A Multiparametric Assay Platform for Simultaneous In Vivo Assessment of Pronephric Morphology, Renal Function and Heart Rate in Larval Zebrafish. Cells 9:5, pages 1269.
Crossref
Loutfy H. Madkour. 2020. Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms. Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms 623 644 .
Loutfy H. MadkourLoutfy H. Madkour. 2020. Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses. Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses 521 556 .
Dai-Yu Sun, Jia-Qi Wu, Zhi-Heng He, Ming-Fang He & Hong-Bin Sun. (2019) Cancer-associated fibroblast regulate proliferation and migration of prostate cancer cells through TGF-β signaling pathway. Life Sciences 235, pages 116791.
Crossref
Chongjun Zhao, Zhe Jia, Erwen Li, Xia Zhao, Ting Han, Jinghuan Tian, Farong Li, Dixin Zou & Ruichao Lin. (2019) Hepatotoxicity evaluation of Euphorbia kansui on zebrafish larvae in vivo. Phytomedicine 62, pages 152959.
Crossref
Samkele Zonyane, Longsheng Chen, Min-Jie Xu, Zhu-Nan Gong, Shuwen Xu & Nokwanda P. Makunga. (2019) Geographic-based metabolomic variation and toxicity analysis of Sutherlandia frutescens L. R.Br. – An emerging medicinal crop in South Africa. Industrial Crops and Products 133, pages 414-423.
Crossref
Han-Syuan Lin, Yi-Luen Huang, Yi-Rui Stefanie Wang, Eugene Hsiao, Tsu-An Hsu, Hui-Yi Shiao, Weir-Torn Jiaang, Bonifasius Putera Sampurna, Kuan-Hao Lin, Ming-Shun Wu, Gi-Ming Lai & Chiou-Hwa Yuh. (2019) Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index Than Sorafenib via Zebrafish Drug Screening Platform. Cancers 11:6, pages 739.
Crossref
Luana Mota Ferreira, Luiz Vinícius Costa da Rosa, Talise Ellwanger Müller, Charlene Cavalheiro de Menezes, Marcel Henrique Marcondes Sari, Vania Lucia Loro, Cristina Wayne Nogueira, Denis Broock Rosemberg & Letícia Cruz. (2019) Zebrafish exposure to diphenyl diselenide-loaded polymeric nanocapsules caused no behavioral impairments and brain oxidative stress. Journal of Trace Elements in Medicine and Biology 53, pages 62-68.
Crossref
Konstantin A. Demin, Anton M. Lakstygal, Polina A. Alekseeva, Maxim Sysoev, Murilo S. de Abreu, Erik T. Alpyshov, Nazar Serikuly, DongMei Wang, MengYao Wang, ZhiChong Tang, DongNi Yan, Tatyana V. Strekalova, Andrey D. Volgin, Tamara G. Amstislavskaya, JiaJia Wang, Cai Song & Allan V. Kalueff. (2019) The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models. Aquatic Toxicology 210, pages 44-55.
Crossref
Duo-qi Xu, Wen-fang Zhang, Jing Li, Ji-fen Wang, Shi-yang Qin & Jiang-hai Lu. (2019) Analysis of AMB-FUBINACA Biotransformation Pathways in Human Liver Microsome and Zebrafish Systems by Liquid Chromatography-High Resolution Mass Spectrometry. Frontiers in Chemistry 7.
Crossref
Jeongah Song, Kyung Jin Jung, Seok-joo Yoon, Kyuhong Lee & Bumseok Kim. (2019) Polyhexamethyleneguanidine phosphate induces cytotoxicity through disruption of membrane integrity. Toxicology 414, pages 35-44.
Crossref
Leonor Côrte-Real, Brittany Karas, Patrícia Gírio, Alexis Moreno, Fernando Avecilla, Fernanda Marques, Brian T. Buckley, Keith R. Cooper, Cathleen Doherty, Pierre Falson, M. Helena Garcia & Andreia Valente. (2019) Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand. European Journal of Medicinal Chemistry 163, pages 853-863.
Crossref
Raffaella Corvi, Horst Spielmann & Thomas Hartung. 2019. The History of Alternative Test Methods in Toxicology. The History of Alternative Test Methods in Toxicology 209 217 .
Marta d’Amora & Silvia Giordani. (2018) The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity. Frontiers in Neuroscience 12.
Crossref
Longsheng Chen, Minjie Xu, Zhunan Gong, Samkele Zonyane, Shuwen Xu & Nokwanda P. Makunga. (2018) Comparative cardio and developmental toxicity induced by the popular medicinal extract of Sutherlandia frutescens (L.) R.Br. detected using a zebrafish Tuebingen embryo model. BMC Complementary and Alternative Medicine 18:1.
Crossref
Zain Z. Zakaria, Fatiha M. Benslimane, Gheyath K. Nasrallah, Samar Shurbaji, Nadin N. Younes, Fatima Mraiche, Sahar I. Da’as & Huseyin C. Yalcin. (2018) Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity. BioMed Research International 2018, pages 1-10.
Crossref
Nurul Mohd Fuad, Jan Kaslin & Donald Wlodkowic. (2018) Lab-on-a-Chip imaging micro-echocardiography (iμEC) for rapid assessment of cardiovascular activity in zebrafish larvae. Sensors and Actuators B: Chemical 256, pages 1131-1141.
Crossref
JessicaR Morrice, CherylY Gregory-Evans & ChristopherA Shaw. (2018) Animal models of amyotrophic lateral sclerosis: A comparison of model validity. Neural Regeneration Research 13:12, pages 2050.
Crossref
Yew Mun Lee, Caixia Li, Siew Hong Lam, Zhiyuan Gong & Qingsong Lin. 2018. Teratogenicity Testing. Teratogenicity Testing 443 459 .
Giovanna Medeiros Tavares de Oliveira, Elisa Magno Nunes de Oliveira, Talita Carneiro Brandão Pereira, Ricardo Meurer Papaléo & Maurício Reis Bogo. (2017) Implications of exposure to dextran-coated and uncoated iron oxide nanoparticles to developmental toxicity in zebrafish. Journal of Nanoparticle Research 19:12.
Crossref
Prabuddha Gupta, René Martin, Hans-Joachim Knölker, Deepak Nihalani & Deepak Kumar Sinha. (2017) Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos. PLOS ONE 12:7, pages e0180301.
Crossref
Malgorzata Kucinska, Marek Murias & Patrycja Nowak-Sliwinska. (2017) Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy. Mutation Research/Reviews in Mutation Research 773, pages 242-262.
Crossref
Normand Podechard, Martine Chevanne, Morgane Fernier, Arnaud Tête, Aurore Collin, Doris Cassio, Olivier Kah, Dominique Lagadic-Gossmann & Odile Sergent. (2017) Zebrafish larva as a reliable model for in vivo assessment of membrane remodeling involvement in the hepatotoxicity of chemical agents . Journal of Applied Toxicology 37:6, pages 732-746.
Crossref
K. V. Zolotarev, N. F. Belyaeva, A. N. Mikhailov & M. V. Mikhailova. (2017) Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos. Bulletin of Experimental Biology and Medicine 162:4, pages 445-450.
Crossref
Wenwen Shen, Yingjie Wei, Daoquan Tang, Xiaobin Jia & Bin Chen. (2017) Metabolite profiles of ginsenosides Rk1 and Rg5 in zebrafish using ultraperformance liquid chromatography/quadrupole?time-of-flight MS. Journal of Ginseng Research 41:1, pages 78-84.
Crossref
Qiyu Chen, Ai Jia, Shane A. Snyder, Zhiyuan Gong & Siew Hong Lam. (2016) Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chemosphere 144, pages 1162-1169.
Crossref
Natalie Mesens, Alexander D. Crawford, Aswin Menke, Pham Duc Hung, Freddy Van Goethem, Rik Nuyts, Erik Hansen, Andre Wolterbeek, Jacky Van Gompel, Peter De Witte & Camila V. Esguerra. (2015) Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?. Journal of Applied Toxicology 35:9, pages 1017-1029.
Crossref
Bin Chen, Yingjie Wei, Dandan Wang & Xiaobin Jia. (2014) Metabolism of ginsenosides Rk3 and Rh4 from steamed notoginseng in zebrafish by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry. Archives of Pharmacal Research 38:8, pages 1468-1476.
Crossref
Viviana E. Gallardo, Gaurav K. Varshney, Minnkyong Lee, Sujata Bupp, Lisha Xu, Paul Shinn, Nigel P. Crawford, James Inglese & Shawn M. Burgess. (2015) Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion. Disease Models & Mechanisms 8:6, pages 565-576.
Crossref
Locke Davenport Huyer, Miles Montgomery, Yimu Zhao, Yun Xiao, Genevieve Conant, Anastasia Korolj & Milica Radisic. (2015) Biomaterial based cardiac tissue engineering and its applications. Biomedical Materials 10:3, pages 034004.
Crossref
Ying Han, Jing-pu Zhang, Jian-qin Qian & Chang-qin Hu. (2015) Cardiotoxicity evaluation of anthracyclines in zebrafish ( Danio rerio ) . Journal of Applied Toxicology 35:3, pages 241-252.
Crossref
Tingting Liu, Ling-Ling Jiang, Ming-Fang He, Zhengang Zhu, De-bin Wang, Tian-Shun Song, Wei-min Tan, Pingkai Ouyang & Jingjing Xie. (2015) Green synthesis of reduced graphene oxide by a GRAS strain Bacillus subtilis 168 with high biocompatibility to zebrafish embryos. RSC Advances 5:74, pages 60024-60032.
Crossref
Marja Driessen, Alexa P. Vitins, Jeroen L.A. Pennings, Anne S. Kienhuis, Bob van de Water & Leo T.M. van der Ven. (2015) A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen. Toxicology Letters 232:2, pages 403-412.
Crossref
Claudia Stark & Thomas Steger-Hartmann. 2016. New Approaches to Drug Discovery. New Approaches to Drug Discovery 261 283 .
Natalie Mesens. 2014. Predictive Toxicology. Predictive Toxicology 217 240 .
Anna Beker van Woudenberg, Cor Snel, Eke Rijkmans, Didima de Groot, Marga Bouma, Sanne Hermsen, Aldert Piersma, Aswin Menke & André Wolterbeek. (2014) Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs. Reproductive Toxicology 49, pages 101-116.
Crossref
Marja Driessen, Anne S. Kienhuis, Alexa P. Vitins, Jeroen L.A. Pennings, Tessa E. Pronk, Evert-Jan van den Brandhof, Marianne Roodbergen, Bob van de Water & Leo T.M.van der Ven. (2014) Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Toxicology Letters 230:1, pages 48-56.
Crossref
Varun Ahuja & Sharad Sharma. (2014) Drug safety testing paradigm, current progress and future challenges: an overview. Journal of Applied Toxicology 34:6, pages 576-594.
Crossref
Guogang Yuan, Yimei Wang, Xiaoyan Yuan, Tingfen Zhang, Jun Zhao, Liuyu Huang & Shuangqing Peng. (2014) T-2 toxin induces developmental toxicity and apoptosis in zebrafish embryos. Journal of Environmental Sciences 26:4, pages 917-925.
Crossref
Xiaoyan Zhang, Caixia Li & Zhiyuan Gong. (2014) Development of a Convenient In Vivo Hepatotoxin Assay Using a Transgenic Zebrafish Line with Liver-Specific DsRed Expression. PLoS ONE 9:3, pages e91874.
Crossref
Xiao-Ping Gao, Feng Feng, Xiao-Qi Zhang, Xiao-Xin Liu, Yu-Bin Wang, Jin-Xiong She, Zhi-Heng He & Ming-Fang He. (2014) Toxicity Assessment of 7 Anticancer Compounds in Zebrafish. International Journal of Toxicology 33:2, pages 98-105.
Crossref
Joshua K Robertson, Kestral Danzmann, Sherise Charles, Katherine Blake, Annia Olivares, Solape Bamikole, Meghan Olson & Terence J Van Raay. (2014) Targeting the Wnt pathway in zebrafish as a screening method to identify novel therapeutic compounds. Experimental Biology and Medicine 239:2, pages 169-176.
Crossref
Akihito YamashitaHiroshi InadaKazuhiro ChiharaToru YamadaJiro DeguchiHitoshi Funabashi. (2014) Improvement of the evaluation method for teratogenicity using zebrafish embryos. The Journal of Toxicological Sciences 39:3, pages 453-464.
Crossref
Joost van Delft, Karen Mathijs, Jan Polman, Maarten Coonen, Ewa Szalowska, Geert R. Verheyen, Freddy van Goethem, Marja Driessen, Leo van de Ven, Sreenivasa Ramaiahgari & Leo S. Price. 2014. Toxicogenomics-Based Cellular Models. Toxicogenomics-Based Cellular Models 193 212 .
Yvette Drabsch, Shuning He, Long Zhang, B Ewa Snaar-Jagalska & Peter ten Dijke. (2013) Transforming growth factor-? signalling controls human breast cancer metastasis in a zebrafish xenograft model. Breast Cancer Research 15:6.
Crossref
Anna Beker van Woudenberg, André Wolterbeek, Lindsey te Brake, Cor Snel, Aswin Menke, Carina Rubingh, Didima de Groot & Dinant Kroese. (2013) A category approach to predicting the developmental (neuro) toxicity of organotin compounds: The value of the zebrafish (Danio rerio) embryotoxicity test (ZET). Reproductive Toxicology 41, pages 35-44.
Crossref
Sashi Nadanaciva, Michael D. Aleo, Christopher J. Strock, Donald B. Stedman, Huijun Wang & Yvonne Will. (2013) Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes. Toxicology and Applied Pharmacology 272:2, pages 272-280.
Crossref
Ingrid W.T. Selderslaghs, Jef Hooyberghs, Ronny Blust & Hilda E. Witters. (2013) Assessment of the developmental neurotoxicity of compounds by measuring locomotor activity in zebrafish embryos and larvae. Neurotoxicology and Teratology 37, pages 44-56.
Crossref
Randall T. Peterson & Calum A. MacRae. (2013) Changing the scale and efficiency of chemical warfare countermeasure discovery using the zebrafish. Drug Discovery Today: Disease Models 10:1, pages e37-e42.
Crossref
Xiaoyan Zhang & Zhiyuan Gong. (2013) Fluorescent Transgenic Zebrafish Tg(nkx2.2a:mEGFP) Provides a Highly Sensitive Monitoring Tool for Neurotoxins. PLoS ONE 8:2, pages e55474.
Crossref
Jian-Hui He, Sheng-Ya Guo, Feng Zhu, Jun-Jing Zhu, Yun-Xiang Chen, Chang-Jiang Huang, Ji-Min Gao, Qiao-Xiang Dong, Yao-Xian Xuan & Chun-Qi Li. (2013) A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity. Journal of Pharmacological and Toxicological Methods 67:1, pages 25-32.
Crossref
Robert M Littleton, Matthew Miller & Jay R Hove. (2012) Whole plant based treatment of hypercholesterolemia with Crataegus laevigata in a zebrafish model. BMC Complementary and Alternative Medicine 12:1.
Crossref
Uwe Strähle, Stefan Scholz, Robert Geisler, Petra Greiner, Henner Hollert, Sepand Rastegar, Axel Schumacher, Ingrid Selderslaghs, Carsten Weiss, Hilda Witters & Thomas Braunbeck. (2012) Zebrafish embryos as an alternative to animal experiments—A commentary on the definition of the onset of protected life stages in animal welfare regulations. Reproductive Toxicology 33:2, pages 128-132.
Crossref
David Mandrell, Lisa Truong, Caleb Jephson, Mushfiqur R. Sarker, Aaron Moore, Christopher Lang, Michael T. Simonich & Robert L. Tanguay. (2012) Automated Zebrafish Chorion Removal and Single Embryo Placement: Optimizing Throughput of Zebrafish Developmental Toxicity Screens. SLAS Technology 17:1, pages 66-74.
Crossref
Konstantin V. Zolotarev, Valentina N. Kashirtseva, Alexey V. Mishin, Natalya F. Belyaeva, Natalya V. Medvedeva & Olga M. Ipatova. (2012) Assessment of Toxicity of Cdse/Cds/Zns/S,S-Dihydrolipoic Acid/Polyacrylic Acid Quantum Dots at Danio rerio Embryos and Larvae . ISRN Nanotechnology 2012, pages 1-5.
Crossref
Xiaoqian Huang, Li Zhou & Zhiyuan Gong. (2012) Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes . Future Oncology 8:1, pages 21-28.
Crossref
Hendrian Sukardi, Xiaoyan Zhang, Eei Yin Lui, Choong Yong Ung, Sinnakaruppan Mathavan, Zhiyuan Gong & Siew Hong Lam. (2012) Liver X receptor agonist T0901317 induced liver perturbation in zebrafish: Histological, gene set enrichment and expression analyses. Biochimica et Biophysica Acta (BBA) - General Subjects 1820:1, pages 33-43.
Crossref
Siew Hong Lam, Mya Myintzu Hlaing, Xiaoyan Zhang, Chuan Yan, Zhenghua Duan, Lin Zhu, Choong Yong Ung, Sinnakaruppan Mathavan, Choon Nam Ong & Zhiyuan Gong. (2011) Toxicogenomic and Phenotypic Analyses of Bisphenol-A Early-Life Exposure Toxicity in Zebrafish. PLoS ONE 6:12, pages e28273.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.