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Expert Opinion on Drug Metabolism & Toxicology Volume 7, 2011 - Issue 5
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Drug Evaluations

Pharmacokinetic evaluation of decitabine for the treatment of leukemia

Jeffrey BryanThe University of Texas, M.D. Anderson Cancer Center, Department of Leukemia, 1515 Holcombe Blvd. Box 428. Houston, TX 77030, USA+1 713 792 4764; +1 713 794 4297; [email protected]
,
Hagop KantarjianThe University of Texas, M.D. Anderson Cancer Center, Department of Leukemia, 1515 Holcombe Blvd. Box 428. Houston, TX 77030, USA+1 713 792 4764; +1 713 794 4297; [email protected]
,
Guillermo Garcia-ManeroThe University of Texas, M.D. Anderson Cancer Center, Department of Leukemia, 1515 Holcombe Blvd. Box 428. Houston, TX 77030, USA+1 713 792 4764; +1 713 794 4297; [email protected]
&
Elias JabbourThe University of Texas, M.D. Anderson Cancer Center, Department of Leukemia, 1515 Holcombe Blvd. Box 428. Houston, TX 77030, USA+1 713 792 4764; +1 713 794 4297; [email protected]
, MD
Pages 661-672 | Published online: 18 Apr 2011

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Ratnam S. Seelan, Partha Mukhopadhyay, M. Michele Pisano & Robert M. Greene. (2018) Effects of 5-Aza-2′-deoxycytidine (decitabine) on gene expression. Drug Metabolism Reviews 50:2, pages 193-207.
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Yu Jing, Xue Shen, Qian Mei & Weidong Han. (2015) Spotlight on decitabine for myelodysplastic syndromes in Chinese patients. OncoTargets and Therapy 8, pages 2783-2790.
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Peter W Marks. (2012) Decitabine for acute myeloid leukemia. Expert Review of Anticancer Therapy 12:3, pages 299-305.
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Articles from other publishers (16)

Tomohiro Yabushita, Takumi Chinen, Atsuya Nishiyama, Shuhei Asada, Ruka Shimura, Tomoya Isobe, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Yosuke Tanaka, Tomofusa Fukuyama, Hitoshi Satoh, Keiko Kato, Kaori Saitoh, Takamasa Ishikawa, Tomoyoshi Soga, Yasuhito Nannya, Tatsuo Fukagawa, Makoto Nakanishi, Daiju Kitagawa, Toshio Kitamura & Susumu Goyama. (2023) Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment. Cell Reports 42:9, pages 113098.
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Xi Yang, Yanyan Yang, Junjie Guo, Yuanyuan Meng, Min Li, Panyu Yang, Xin Liu, Lynn Htet Htet Aung, Tao Yu & Yonghong Li. (2021) Targeting the epigenome in in-stent restenosis: from mechanisms to therapy. Molecular Therapy - Nucleic Acids 23, pages 1136-1160.
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Nicola Cook, Darren J. Parker, Eran Tauber, Bart A. Pannebakker & David M. Shuker. (2019) Validating the Demethylating Effects of 5-aza-2′-deoxycytidine in Insects Requires a Whole-Genome Approach. The American Naturalist 194:3, pages 432-438.
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Jeroen Roosendaal, Kai Wang, Hilde Rosing, Luc Lucas, Abadi Gebretensae, Aram Oganesian, Jan H.M. Schellens, Jos H. Beijnen & Zhongping (John) Lin. (2019) Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine. Journal of Chromatography B 1109, pages 132-141.
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Lauren B Levine, Julianna VF Roddy, Miryoung Kim, Junan Li, Gary Phillips & Alison R Walker. (2017) A comparison of toxicities in acute myeloid leukemia patients with and without renal impairment treated with decitabine. Journal of Oncology Pharmacy Practice 24:4, pages 290-298.
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Pin-Fang He, Jing-Dong Zhou, Dong-Ming Yao, Ji-Chun Ma, Xiang-Mei Wen, Zhi-Hui Zhang, Xin-Yue Lian, Zi-Jun Xu, Jun Qian & Jiang Lin. (2017) Efficacy and safety of decitabine in treatment of elderly patients with acute myeloid leukemia: A systematic review and meta-analysis. Oncotarget 8:25, pages 41498-41507.
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Rajnee Kanwal, Manish Datt, Xiaoqi Liu & Sanjay Gupta. (2016) Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases. PLOS ONE 11:9, pages e0162956.
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Yan Huang, Qiang Du, Weibao Wu, Feifei She & Yanling Chen. (2016) Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins. Molecular Medicine Reports 14:3, pages 2573-2581.
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No?l J.-M. Raynal & Jean-Pierre J. Issa. 2016. Drug Discovery in Cancer Epigenetics. Drug Discovery in Cancer Epigenetics 169 190 .
Ke Liu, Yanli Liu, Johnathan L. Lau & Jinrong Min. (2015) Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation. Pharmacology & Therapeutics 151, pages 121-140.
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Naveen Pemmaraju, Guillermo Garcia-Manero & Farhad Ravandi. 2015. Targeted Therapy of Acute Myeloid Leukemia. Targeted Therapy of Acute Myeloid Leukemia 441 458 .
Wenyi Hua, Thomas Ierardi, Michael Lesslie, Brian T. Hoffman & Daniel Mulvana. (2014) Development and validation of a HILIC–MS/MS method for quantification of decitabine in human plasma by using lithium adduct detection. Journal of Chromatography B 969, pages 117-122.
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Dongpo Li, Tianhong Zhang, Longfa Kou, Youxi Zhang, Jin Sun & Zhonggui He. (2013) Development of a Supercritical Fluid Chromatography-Tandem Mass Spectrometry Method for the Determination of Azacitidine in Rat Plasma and Its Application to a Bioavailability Study. Molecules 19:1, pages 342-351.
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Yannick Delpu, Pierre Cordelier, William Cho & Jérôme Torrisani. (2013) DNA Methylation and Cancer Diagnosis. International Journal of Molecular Sciences 14:7, pages 15029-15058.
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Marcela KrečmerováMiroslav Otmar. (2012) 5-azacytosine compounds in medicinal chemistry: current stage and future perspectives. Future Medicinal Chemistry 4:8, pages 991-1005.
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Matthias Schwab, Elke Schaeffeler & Hiltrud Brauch. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 365 378 .

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