Advanced search
Publication Cover
Expert Opinion on Drug Metabolism & Toxicology Volume 7, 2011 - Issue 11
Submit an article Journal homepage
269
Views
21
CrossRef citations to date
0
Altmetric
Original Research

Effect of age on the pharmacokinetics of fimasartan (BR-A-657)

Hae Won Lee Kyungpook National University Graduate School and Hospital, Department of Biomedical Science and Clinical Trial Center, 200 Dongduk-Ro, Jung-gu, Daegu 700 721, Republic of Korea
,
Mi-sun Lim Kyungpook National University Graduate School and Hospital, Department of Biomedical Science and Clinical Trial Center, 200 Dongduk-Ro, Jung-gu, Daegu 700 721, Republic of Korea; Kyungpook National University School of Medicine, BK21 program, 101 Dongin-2ga, Jung-gu, Daegu 700 422, Republic of Korea
,
Sook Jin Seong Kyungpook National University Graduate School and Hospital, Department of Biomedical Science and Clinical Trial Center, 200 Dongduk-Ro, Jung-gu, Daegu 700 721, Republic of Korea; Kyungpook National University School of Medicine, BK21 program, 101 Dongin-2ga, Jung-gu, Daegu 700 422, Republic of Korea
,
Joomi Lee Kyungpook National University Graduate School and Hospital, Department of Biomedical Science and Clinical Trial Center, 200 Dongduk-Ro, Jung-gu, Daegu 700 721, Republic of Korea; Kyungpook National University School of Medicine, BK21 program, 101 Dongin-2ga, Jung-gu, Daegu 700 422, Republic of Korea
,
Jeonghyeon Park Kyungpook National University Graduate School and Hospital, Department of Biomedical Science and Clinical Trial Center, 200 Dongduk-Ro, Jung-gu, Daegu 700 721, Republic of Korea; Kyungpook National University School of Medicine, BK21 program, 101 Dongin-2ga, Jung-gu, Daegu 700 422, Republic of Korea
,
Jeong Ju Seo Kyungpook National University Graduate School and Hospital, Department of Biomedical Science and Clinical Trial Center, 200 Dongduk-Ro, Jung-gu, Daegu 700 721, Republic of Korea; Kyungpook National University School of Medicine, BK21 program, 101 Dongin-2ga, Jung-gu, Daegu 700 422, Republic of Korea
,
Joo-Youn Cho Seoul National University College of Medicine and Hospital, Department of Pharmacology and Clinical Pharmacology, 101 Daehang-ro, Jongno-gu, Seoul 110 744, Republic of Korea
,
Kyung-Sang Yu Seoul National University College of Medicine and Hospital, Department of Pharmacology and Clinical Pharmacology, 101 Daehang-ro, Jongno-gu, Seoul 110 744, Republic of Korea
&
Young-Ran Yoon Kyungpook National University Graduate School and Hospital, Department of Biomedical Science and Clinical Trial Center, 200 Dongduk-Ro, Jung-gu, Daegu 700 721, Republic of Korea; Kyungpook National University School of Medicine, BK21 program, 101 Dongin-2ga, Jung-gu, Daegu 700 422, Republic of Korea; Kyungpook National University School of Medicine and Hospital, Department of Molecular Medicine and Clinical Trial Center, 200 Dongduk-Ro, Jung-gu, Daegu 700 721, Republic of Korea+82 53 420 4950; +82 53 420 5218; [email protected]
(Associate Professor) show all
Pages 1337-1344 | Published online: 28 Sep 2011

Citations (21)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Woo Youl Kang, Sook Jin Seong, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Seungil Cho, Wang-Seob Shim, Kyung-Tae Lee, Eun Hee Kim, Dong Heon Yang, Hae Won Lee & Young-Ran Yoon. (2018) Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects. Drug Design, Development and Therapy 12, pages 3607-3615.
Read now
Ji-Yoon Lee, Young Jae Choi, Soo Jin Oh, Yong Ha Chi, Soo Heui Paik, Ki Ho Lee, Jae-Kyung Jung, Chang Seon Ryu, Kwon-Bok Kim, Dong-Hyun Kim, Young-Ran Yoon & Sang Kyum Kim. (2016) Characterization of fimasartan metabolites in human liver microsomes and human plasma. Xenobiotica 46:1, pages 40-51.
Read now
Eun-Sook Jeong, Yang-Weon Kim, Hyo-Ji Kim, Ho-Jung Shin, Jae-Gook Shin, Kwang Hee Kim, Yong Ha Chi, Soo Heui Paik & Dong-Hyun Kim. (2015) Glucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3. Xenobiotica 45:1, pages 10-18.
Read now
Tae Hwan Kim, Soyoung Shin, Mohammad Bashir, Yong Ha Chi, Soo Heui Paik, Joo Han Lee, Hyuk Joon Choi, Jin Ho Choi, Sun Dong Yoo, Jürgen B. Bulitta, Eunsook Ma, Sang Hoon Joo & Beom Soo Shin. (2014) Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats. Xenobiotica 44:10, pages 913-925.
Read now

Articles from other publishers (17)

Hae-Young Lee, Kwang-il Kim, Sang Hyun Ihm, Moo-Yong Rhee, Il Suk Sohn, Sungha Park, Eun-Seok Jeon, Jong-Min Song, Wook Bum Pyun, Ki-Chul Sung, Moo Hyun Kim, Sang-Hyun Kim, Seok-Yeon Kim, Shin-Jae Kim, Eung Ju Kim, Jinho Shin, Sung Yun Lee, Kook-Jin Chun, Jin-Ok Jeong, Shung Chull Chae, Ki Dong Yoo, Young Jin Choi, Yong Hwan Park & Cheol-Ho Kim. (2021) A Randomized, Double-blind, Active-controlled, Two Parallel-Group, Optional Titration, Multicenter, Phase IIIb Study to Evaluate the Efficacy and Safety of Fimasartan Versus Perindopril Monotherapy With and Without a Diuretic Combination in Elderly Patients With Essential Hypertension. Clinical Therapeutics 43:10, pages 1746-1756.
Crossref
Jong-Ho Kim, I-Rang Lim, Hyung Joon Joo, Chi-Yeon Park, Seung-Cheol Choi, Han Saem Jeong & Soon Jun Hong. (2019) Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice. Molecular Medicine 25:1.
Crossref
Young Jae Choi, Ji-Yoon Lee, Chang Seon Ryu, Yong Ha Chi, Soo Heui Paik & Sang Kyum Kim. (2018) Role of cytochrome P450 enzymes in fimasartan metabolism in vitro. Food and Chemical Toxicology 115, pages 375-384.
Crossref
Hae-Young Lee, Cheol-Ho Kim, Jae-Kwan Song, Shung Chull Chae, Myung Ho Jeong, Dong-Soo Kim & Byung-Hee Oh. (2017) 24-Hour blood pressure response to lower dose (30 mg) fimasartan in Korean patients with mild to moderate essential hypertension. The Korean Journal of Internal Medicine 32:6, pages 1025-1036.
Crossref
Jürgen B. Bulitta, Soo Heui Paik, Yong Ha Chi, Tae Hwan Kim, Soyoung Shin, Cornelia B. Landersdorfer, Yuanyuan Jiao, Rajbharan Yadav & Beom Soo Shin. (2017) Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling. European Journal of Pharmaceutical Sciences 107, pages 32-44.
Crossref
Choon OK KimSangil JeonSeunghoon HanTaegon HongMin Soo ParkYoung-Ran YoonDong-Seok Yim. (2017) Decreased potency of fimasartan in liver cirrhosis was quantified using mixed-effects analysis. Translational and Clinical Pharmacology 25:1, pages 43.
Crossref
Yong-Jik Lee, Yoo-Na Jang, Yoon-Mi Han, Hyun-Min Kim, Jong-Min Jeong & Hong Seog Seo. (2017) Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPAR δ Regulation in Hyperlipidemic and Hypertensive Conditions . PPAR Research 2017, pages 1-14.
Crossref
Tae Hwan Kim, Min Gi Kim, Soyoung Shin, Yong-Ha Chi, Soo-Heui Paik, Joo-Han Lee, Sun Dong Yoo, Yu Seok Youn, Jürgen B. Bulitta, Sang Hoon Joo, Seok Won Jeong, Kwon-Yeon Weon & Beom Soo Shin. (2016) Placental transfer and mammary excretion of a novel angiotensin receptor blocker fimasartan in rats. BMC Pharmacology and Toxicology 17:1.
Crossref
Jong-Lyul Ghim, Soo Heui Paik, M. Hasanuzzaman, Yong Ha Chi, Hyang-Ki Choi, Dong-Hyun Kim & Jae-Gook Shin. (2016) Absolute bioavailability and pharmacokinetics of the angiotensin II receptor antagonist fimasartan in healthy subjects. The Journal of Clinical Pharmacology 56:5, pages 576-580.
Crossref
Ji Yeon Hyun, Hyun-Ju Kim, Mi-Ri Gwon, Hae Won Lee, Sook Jin Seong & Young-Ran Yoon. (2015) Fully Validated Ultra-performance Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Fimasartan in Human Plasma. Analytical Sciences 31:12, pages 1335-1339.
Crossref
Hae-Young Lee, Yong-Jin Kim, Taehoon Ahn, Ho-Joong Youn, Shung Chull Chae, Hong Seog Seo, Ki-Sik Kim, Moo-Yong Rhee, Dong-Ju Choi, Jae-Joong Kim, Kook-Jin Chun, Byung-Su Yoo, Jong-Seon Park, Seok-Kyu Oh, Dong-Soo Kim, Jun Kwan, Youngkeun Ahn, Jeong Bae Park, Jin-ok Jeong, Min-Soo Hyon, Eun-Joo Cho, Kyoo-Rok Han, Doo-Il Kim, Seung-Jae Joo, Jin-Ho Shin, Ki-Chul Sung & Eun-Seok Jeon. (2015) A Randomized, Multicenter, Double-blind, Placebo-controlled, 3 × 3 Factorial Design, Phase II Study to Evaluate the Efficacy and Safety of the Combination of Fimasartan/Amlodipine in Patients With Essential Hypertension. Clinical Therapeutics 37:11, pages 2581-2596.e3.
Crossref
Tae Hwan Kim, Soyoung Shin, Cornelia B. Landersdorfer, Yong Ha Chi, Soo Heui Paik, Jayhyuk Myung, Rajbharan Yadav, Stefan Horkovics-Kovats, Jürgen B. Bulitta & Beom Soo Shin. (2015) Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans. The AAPS Journal 17:5, pages 1210-1223.
Crossref
Choon Ok Kim, Hae Wan Lee, Eun Sil Oh, Sook Jin Seong, Do Young Kim, Joomi Lee, Sang-Hoon Ahn, Young-Ran Yoon, Chang-Min Cho & Min Soo Park. (2013) Influence of Hepatic Dysfunction on the Pharmacokinetics and Safety of Fimasartan. Journal of Cardiovascular Pharmacology 62:6, pages 524-529.
Crossref
Jin Han, Sung-Ji Park, Vu Thi Thu, Sung-Ryul Lee, Le Thanh Long, Hyoung Kyu Kim, Nari Kim, Seung Woo Park, Eun-Seok Jeon, Eun-Ji Kim, Chang-Hwan Yoon, Goo-Young Cho & Dong-Ju Choi. (2013) Effects of the novel angiotensin II receptor type I antagonist, fimasartan on myocardial ischemia/reperfusion injury. International Journal of Cardiology 168:3, pages 2851-2859.
Crossref
Jongtae Lee, Seunghoon Han, Sangil Jeon, Taegon Hong & Dong-Seok Yim. (2012) Pharmacokinetic–pharmacodynamic model of fimasartan applied to predict the influence of a high fat diet on its blood pressure-lowering effect in healthy subjects. European Journal of Clinical Pharmacology 69:1, pages 11-20.
Crossref
Namyi Gu, Bo-Hyung Kim, Kyoung Soo Lim, Sung Eun Kim, Won Seok Nam, Seo Hyun Yoon, Joo-Youn Cho, Sang-Goo Shin, In-Jin Jang & Kyung-Sang Yu. (2012) The Effect of Fimasartan, an Angiotensin Receptor Type 1 Blocker, on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Korean Male Volunteers: A One-Sequence, Two-Period Crossover Clinical Trial. Clinical Therapeutics 34:7, pages 1592-1600.
Crossref
Tae Woo Kim, Byoung Wook Yoo, Joon Kwang Lee, Ji Han Kim, Kyung-Tae Lee, Yong Ha Chi & Jae Yeol Lee. (2012) Synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives as losartan analogue for new angiotensin II receptor type 1 (AT1) antagonists. Bioorganic & Medicinal Chemistry Letters 22:4, pages 1649-1654.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.