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Expert Opinion on Drug Metabolism & Toxicology Volume 8, 2012 - Issue 6
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Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability – considerations for drug development

Yurong LaiPfizer Worldwide Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Eastern Point Road, Groton, CT 06340, USA+1 860 4413079; [email protected]
,
Manthena VarmaPfizer Worldwide Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Eastern Point Road, Groton, CT 06340, USA+1 860 4413079; [email protected]
,
Bo FengPfizer Worldwide Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Eastern Point Road, Groton, CT 06340, USA+1 860 4413079; [email protected]
,
Joel Clay StephensPfizer Worldwide Research and Development, PharmaTherapeutics Precision Medicine, Eastern Point Road, Groton, CT 06340, USA
,
Emi KimotoPfizer Worldwide Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Eastern Point Road, Groton, CT 06340, USA+1 860 4413079; [email protected]
,
Ayman El-KattanPfizer Worldwide Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Eastern Point Road, Groton, CT 06340, USA+1 860 4413079; [email protected]
,
Katsuomi IchikawaClinical Pharmacology, Pfizer Japan, Inc., Development Japan, 3-22-7, Yoyogi, Shibuya-ku, Tokyo 151-8589, Japan
,
Hironori KikkawaClinical Pharmacology, Pfizer Japan, Inc., Development Japan, 3-22-7, Yoyogi, Shibuya-ku, Tokyo 151-8589, Japan
,
Chiho OnoClinical Pharmacology, Pfizer Japan, Inc., Development Japan, 3-22-7, Yoyogi, Shibuya-ku, Tokyo 151-8589, Japan
,
Akiyuki SuzukiClinical Pharmacology, Pfizer Japan, Inc., Development Japan, 3-22-7, Yoyogi, Shibuya-ku, Tokyo 151-8589, Japan
,
Misaki SuzukiClinical Pharmacology, Pfizer Japan, Inc., Development Japan, 3-22-7, Yoyogi, Shibuya-ku, Tokyo 151-8589, Japan
,
Yuichi YamamotoClinical Pharmacology, Pfizer Japan, Inc., Development Japan, 3-22-7, Yoyogi, Shibuya-ku, Tokyo 151-8589, Japan
&
Larry TremainePfizer Worldwide Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Eastern Point Road, Groton, CT 06340, USA+1 860 4413079; [email protected]
 show all
Pages 723-743 | Published online: 18 Apr 2012

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Manthena V. S. Varma. (2023) Genetic variation in organic cation transporters and considerations in drug development. Expert Opinion on Drug Metabolism & Toxicology 19:3, pages 149-164.
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Cathrine F. Hjorth, Anja S. Nielsen, Henrik T. Sørensen, Timothy L. Lash, Per Damkier, Stephen Hamilton-Dutoit & Deirdre Cronin-Fenton. (2019) Multi-drug resistance protein 2 (MRP2) expression, adjuvant tamoxifen therapy, and risk of breast cancer recurrence: a Danish population-based nested case-control study. Acta Oncologica 58:2, pages 168-174.
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Nicholas Li-Xun Syn, Wei-Peng Yong, Soo-Chin Lee & Boon-Cher Goh. (2015) Genetic factors affecting drug disposition in Asian cancer patients. Expert Opinion on Drug Metabolism & Toxicology 11:12, pages 1879-1892.
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Seok Hwee Koo, Ying Li Lo, Jie Yin Yee & Edmund Jon Deoon Lee. (2015) Genetic and/or non-genetic causes for inter-individual and inter-cellular variability in transporter protein expression: implications for understanding drug efficacy and toxicity. Expert Opinion on Drug Metabolism & Toxicology 11:12, pages 1821-1837.
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Barbara Döring & Ernst Petzinger. (2014) Phase 0 and phase III transport in various organs: Combined concept of phases in xenobiotic transport and metabolism. Drug Metabolism Reviews 46:3, pages 261-282.
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Hugh A Barton, Yurong Lai, Theunis C Goosen, Hannah M Jones, Ayman F El-Kattan, James R Gosset, Jian Lin & Manthena V Varma. (2013) Model-based approaches to predict drug–drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond. Expert Opinion on Drug Metabolism & Toxicology 9:4, pages 459-472.
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