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Expert Opinion on Drug Metabolism & Toxicology Volume 8, 2012 - Issue 9
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Bioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates

James J CaliPromega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA+1 608 443 3503; +1 608 298 4818; [email protected]
, PhD (Director of Research) ,
Dongping MaPromega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA
, MS (Senior Scientist) ,
Monika G WoodPromega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA
, MS (Senior Scientist) ,
Poncho L MeisenheimerPromega Biosciences, 277 Granada Drive, San Luis Obispo, CA 93401, USA
, PhD (Director of Chemistry Research) &
Dieter H KlaubertPromega Biosciences, 277 Granada Drive, San Luis Obispo, CA 93401, USA
, PhD (Director of Chemistry, Advanced Technologies)
Pages 1115-1130 | Published online: 11 Jun 2012

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Jie Zhao, David Machalz, Sijie Liu, Clemens Alexander Wolf, Gerhard Wolber, Maria Kristina Parr & Matthias Bureik. (2022) Metabolism of the antipsychotic drug olanzapine by CYP3A43. Xenobiotica 52:4, pages 413-425.
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Tewes Tralau & Andreas Luch. (2013) The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications. Expert Opinion on Drug Metabolism & Toxicology 9:12, pages 1541-1554.
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Articles from other publishers (24)

Ziru Dai, Yue Wu, Yuan Xiong, Jingjing Wu, Min Wang, Xiao Sun, Xinxin Ding, Ling Yang, Xiaobo Sun & Guangbo Ge. (2023) CYP1A inhibitors: Recent progress, current challenges, and future perspectives. Medicinal Research Reviews 44:1, pages 169-234.
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Rong-Jing He, Zhen-Hao Tian, Jian Huang, Meng-Ru Sun, Feng Wei, Chun-Yu Li, Hai-Rong Zeng, Feng Zhang, Xiao-Qing Guan, Yan Feng, Xiang-Ming Meng, Hui Yang & Guang-Bo Ge. (2023) Rationally Engineered CYP3A4 Fluorogenic Substrates for Functional Imaging Analysis and Drug–Drug Interaction Studies. Journal of Medicinal Chemistry 66:10, pages 6743-6755.
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Elizabeth M.J. Gillam & Valerie M. Kramlinger. (2023) Opportunities for Accelerating Drug Discovery and Development by Using Engineered Drug-Metabolizing Enzymes. Drug Metabolism and Disposition 51:3, pages 392-402.
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Jie Zhao, Xue Zhang, Yueyin Wang, Huimin Huang, Shishir Sharma, Sangeeta Shrestha Sharma, Clemens Alexander Wolf, Sijie Liu, Gerhard Wolber, Erik J. Sorensen & Matthias Bureik. (2022) Exploring the Chemical Space of Proluciferins as Probe Substrates for Human Cytochrome P450 Enzymes. Applied Biochemistry and Biotechnology 195:2, pages 1042-1058.
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Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation 551 569 .
Qiang Jin, JingJing Wu, Yue Wu, Hongxin Li, Moshe Finel, Dandan Wang & Guangbo Ge. (2022) Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives. Acta Pharmaceutica Sinica B 12:3, pages 1068-1099.
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Hannah M. Work, Sylvie E. Kandel & Jed N. Lampe. (2021) Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening. Scientific Reports 11:1.
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Shishir Sharma, Sangeeta Shrestha Sharma, Xue Zhang, Jan‐Philipp Bureik, Erik J. Sorensen & Matthias Bureik. (2021) Conversion of five proluciferin esters by human cytochrome P450 enzymes. Biotechnology Journal 16:7.
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Lei Feng, Jing Ning, Xiangge Tian, Chao Wang, Zhenlong Yu, Xiaokui Huo, Tian Xie, Baojing Zhang, Tony D. James & Xiaochi Ma. (2021) Fluorescent probes for the detection and imaging of Cytochrome P450. Coordination Chemistry Reviews 437, pages 213740.
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Jingjing Wu, Xiaoqing Guan, Ziru Dai, Rongjing He, Xinxin Ding, Ling Yang & Guangbo Ge. (2021) Molecular probes for human cytochrome P450 enzymes: Recent progress and future perspectives. Coordination Chemistry Reviews 427, pages 213600.
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Jingyao Liu, David Machalz, Gerhard Wolber, Erik J. Sorensen & Matthias Bureik. (2020) New Proluciferin Substrates for Human CYP4 Family Enzymes. Applied Biochemistry and Biotechnology 193:1, pages 218-237.
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Yanan Sun, David Machalz, Gerhard Wolber, Maria Kristina Parr & Matthias Bureik. (2020) Functional Expression of All Human Sulfotransferases in Fission Yeast, Assay Development, and Structural Models for Isoforms SULT4A1 and SULT6B1. Biomolecules 10:11, pages 1517.
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Shishir Sharma, Pradeepraj Durairaj & Matthias Bureik. (2020) Rapid and convenient biotransformation procedure for human drug metabolizing enzymes using permeabilized fission yeast cells. Analytical Biochemistry 607, pages 113704.
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Pradeepraj Durairaj, Linbing Fan, Sangeeta Shrestha Sharma, Zhao Jie & Matthias Bureik. (2020) Identification of new probe substrates for human CYP20A1. Biological Chemistry 401:3, pages 361-365.
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Sandra Ortega Ugalde, Dongping Ma, James J. Cali & Jan N.M. Commandeur. (2019) Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis. SLAS Discovery 24:7, pages 745-754.
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Pradeepraj Durairaj, Linbing Fan, David Machalz, Gerhard Wolber & Matthias Bureik. (2019) Functional characterization and mechanistic modeling of the human cytochrome P450 enzyme CYP4A22. FEBS Letters 593:16, pages 2214-2225.
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Pradeepraj Durairaj, Linbing Fan, Wei Du, Shabir Ahmad, Dawit Mebrahtu, Shishir Sharma, Rana Azeem Ashraf, Jiaxin Liu, Qian Liu & Matthias Bureik. (2019) Functional expression and activity screening of all human cytochrome P450 enzymes in fission yeast. FEBS Letters 593:12, pages 1372-1380.
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Linbing Fan, Jan Felix Joseph, Pradeepraj Durairaj, Maria Kristina Parr & Matthias Bureik. (2019) Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1. Biological Chemistry 400:5, pages 625-628.
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Michael Crosby & David S. Riddick. (2019) Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice . Drug Metabolism and Disposition 47:3, pages 279-282.
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Qi Yan, David Machalz, Andy Zöllner, Erik J. Sorensen, Gerhard Wolber & Matthias Bureik. (2017) Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast. Biochemical Pharmacology 146, pages 174-187.
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Cindy Yanfei Li, Soowan Lee, Sara Cade, Li-Jung Kuo, Irvin R. Schultz, Deepak K. Bhatt, Bhagwat Prasad, Theo K. Bammler & Julia Yue Cui. (2017) Novel Interactions between Gut Microbiome and Host Drug-Processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals Polybrominated Diphenyl Ethers. Drug Metabolism and Disposition 45:11, pages 1197-1214.
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Johannes T.-H. Yeh, Kwangho Nam, Joshua T.-H. Yeh & Norbert Perrimon. (2017) eUnaG: a new ligand-inducible fluorescent reporter to detect drug transporter activity in live cells. Scientific Reports 7:1.
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Shayne Cox Gad. 2016. Drug Safety Evaluation. Drug Safety Evaluation 503 521 .
Chunja Lee, Xinxin Ding & David S. Riddick. (2013) Downregulation of Mouse Hepatic CYP3A Protein by 3-Methylcholanthrene Does Not Require Cytochrome P450-Dependent Metabolism. Drug Metabolism and Disposition 41:10, pages 1782-1786.
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