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Expert Opinion on Drug Metabolism & Toxicology Volume 8, 2012 - Issue 9
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Probe ADME and Test Hypotheses: a PATH beyond clearance in vitro–in vivo correlations in early drug discovery

Leslie C BellNovartis Institutes for Biomedical Research, Metabolism and Pharmacokinetics, 250 Massachusetts Avenue, Cambridge, MA 02139, USA;[email protected]
&
Jianling WangNovartis Institutes for Biomedical Research, Metabolism and Pharmacokinetics, 250 Massachusetts Avenue, Cambridge, MA 02139, USA;[email protected]
Pages 1131-1155 | Published online: 11 Jun 2012

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F. Zhang, M. Bartels, A. Clark, T. Erskine, T. Auernhammer, B. Bhhatarai, D. Wilson & S. Marty. (2018) Performance evaluation of the GastroPlusTM software tool for prediction of the toxicokinetic parameters of chemicals. SAR and QSAR in Environmental Research 29:11, pages 875-893.
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Chunyong He & Hong Wan. (2018) Drug metabolism and metabolite safety assessment in drug discovery and development. Expert Opinion on Drug Metabolism & Toxicology 14:10, pages 1071-1085.
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Articles from other publishers (10)

Yu Yuan, Guangpeng Meng, Yuanbo Li & Chunjie Wu. (2022) Study on In Vitro Metabolism and In Vivo Pharmacokinetics of Beauvericin. Toxins 14:7, pages 477.
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Zeyun Li, Songfeng Zhao, Yongliang Yuan, Lizhen Zhang, Zhizhen Song, Xin Tian & Xiaojian Zhang. (2019) In vitro metabolic profiles of motolimod by using liquid chromatography tandem mass spectrometry: Metabolic stability, metabolite characterization and species comparison. Journal of Pharmaceutical and Biomedical Analysis 167, pages 90-99.
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Bianca M. Liederer, Xingrong Liu, Simon Wong & Daniel R. Mudra. 2017. Translating Molecules into Medicines. Translating Molecules into Medicines 165 230 .
Martin Perreault, René Maltais, Raphaël Dutour & Donald Poirier. (2016) Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133. Steroids 115, pages 105-113.
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Y He, J R Chevillet, G Liu, T K Kim & K Wang. (2015) The effects of microRNA on the absorption, distribution, metabolism and excretion of drugs. British Journal of Pharmacology 172:11, pages 2733-2747.
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Susan M. Jenkins & Dawn D. Parker. 2015. Discovering and Developing Molecules with Optimal Drug-Like Properties. Discovering and Developing Molecules with Optimal Drug-Like Properties 141 175 .
Leslie Bell, Suzanne Skolnik & Dallas Bednarczyk. 2014. Predictive ADMET. Predictive ADMET 63 88 .
Kevin Beaumont, James R. Gosset & Chris E. Keefer. 2014. Predictive ADMET. Predictive ADMET 291 318 .
Julien Burton, Joachim Petit, Emeric Danloy, Gerald M. Maggiora & Daniel P. Vercauteren. (2013) Rough Set Theory as an Interpretable Method for Predicting the Inhibition of Cytochrome P450 1A2 and 2D6. Molecular Informatics 32:7, pages 579-589.
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Frank Barile. 2013. Principles of Toxicology Testing, Second Edition. Principles of Toxicology Testing, Second Edition 23 43 .

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