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Current toxicological aspects on drug and chemical transport and metabolism across the human placental barrier

, MSC PhD, &
Pages 1263-1275 | Published online: 11 Jul 2012

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Luana C. Crocoli, Rafael A. Menck & Sidnei Moura. (2023) Pesticides analysis in alternative biological matrices. Drug and Chemical Toxicology 46:4, pages 809-824.
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Ekaterina Chelysheva, Anna Turkina, Evgenia Polushkina, Roman Shmakov, Alexey Zeifman, Sergey Aleshin, Igor Shokhin, Dorel Guranda, Oksana Oksenjuk, Sergey Mordanov, Khamida Kazakbaeva & Ghermes Chilov. (2018) Placental transfer of tyrosine kinase inhibitors used for chronic myeloid leukemia treatment. Leukemia & Lymphoma 59:3, pages 733-738.
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George Vasios, Aggeliki Kosmidi, Olga-Ioanna Kalantzi, Anna Tsantili-Kakoulidou, Nikolaos Kavantzas, Stamatios Theocharis & Constantinos Giaginis. (2016) Simple physicochemical properties related with lipophilicity, polarity, molecular size and ionization status exert significant impact on the transfer of drugs and chemicals into human breast milk. Expert Opinion on Drug Metabolism & Toxicology 12:11, pages 1273-1278.
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M. Xu, B. Liu, M-f. Wu, H-t. Chen, K. Cianflone & Z-l. Wang. (2015) Relationships among acylation-stimulating protein, insulin resistance, lipometabolism, and fetal growth in gestational diabetes mellitus women. Journal of Obstetrics and Gynaecology 35:4, pages 341-345.
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Aikaterini Berdiaki & Dragana Nikitovic. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 125 138 .
Khairulanwar Burhanuddin & Raj Badhan. (2022) Optimising Fluvoxamine Maternal/Fetal Exposure during Gestation: A Pharmacokinetic Virtual Clinical Trials Study. Metabolites 12:12, pages 1281.
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Negisa Seyed Toutounchi, Saskia Braber, Belinda van‘t Land, Suzan Thijssen, Johan Garssen, Gert Folkerts & Astrid Hogenkamp. (2022) Deoxynivalenol exposure during pregnancy has adverse effects on placental structure and immunity in mice model. Reproductive Toxicology 112, pages 109-118.
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Donghui Ma, Yao Lu, Yong Liang, Ting Ruan, Juan Li, Chunyan Zhao, Yawei Wang & Guibin Jiang. (2021) A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms. Environmental Science & Technology 56:10, pages 6014-6026.
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Fentahun Adane, Kaleab Asres, Wondwossen Ergete, Samuel Woldekidan & Girma Seyoum. (2022) The Developmental Toxicity of Thymus schimperi Essential Oil in Rat Embryos and Fetuses. Journal of Toxicology 2022, pages 1-13.
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I-Hsin Lin, Ling Yang, Jeffrey W. Dalley & Tung-Hu Tsai. (2022) Trans-placental transfer of nicotine: Modulation by organic cation transporters. Biomedicine & Pharmacotherapy 145, pages 112489.
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Gaëlle Deval, Sonja Boland, Thierry Fournier & Ioana Ferecatu. (2021) On Placental Toxicology Studies and Cerium Dioxide Nanoparticles. International Journal of Molecular Sciences 22:22, pages 12266.
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Juan I. Di Filippo, Mariela Bollini & Claudio N. Cavasotto. (2021) A Machine Learning Model to Predict Drug Transfer Across the Human Placenta Barrier. Frontiers in Chemistry 9.
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Hui Chen, Wei Zhou, James C.W. Lam, Jiali Ge, Juan Li & Lixi Zeng. (2020) Blood partitioning and whole-blood-based maternal transfer assessment of chlorinated paraffins in mother-infant pairs from South China. Environment International 142, pages 105871.
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Chia-Chi Wang, Pinpin Lin, Che-Yu Chou, Shan-Shan Wang & Chun-Wei Tung. (2020) Prediction of human fetal–maternal blood concentration ratio of chemicals. PeerJ 8, pages e9562.
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Shiming Song, Yuan He, Yingyan Huang, Xiongfei Huang, Yuankai Guo, Hongkai Zhu, Kurunthachalam Kannan & Tao Zhang. (2020) Occurrence and transfer of benzophenone-type ultraviolet filters from the pregnant women to fetuses. Science of The Total Environment 726, pages 138503.
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Kamisha L. Johnson-DavisKelly Doyle. (2020) Therapeutic Drug Monitoring in Pregnant Patients. Therapeutic Drug Monitoring 42:2, pages 172-180.
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Shanshan Yin, Jianyun Zhang, Fangjie Guo, Giulia Poma, Adrian Covaci & Weiping Liu. (2020) Transplacental transfer mechanism of organochlorine pesticides: An in vitro transcellular transport study. Environment International 135, pages 105402.
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Natasha R. Catlin, Andrea Z. Mitchell, Michael J. Potchoiba, Denise M. O'Hara, Mengmeng Wang, Minlei Zhang, Gerhard F. Weinbauer & Christopher J. Bowman. (2019) Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey . Birth Defects Research 112:1, pages 105-117.
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Marc Codaccioni, Frédéric Bois & Céline Brochot. (2019) Placental transfer of xenobiotics in pregnancy physiologically-based pharmacokinetic models: Structure and data. Computational Toxicology 12, pages 100111.
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Jolien J. M. Freriksen, Minou van Seyen, Ali Judd, Diana M. Gibb, Intira J. Collins, Rick Greupink, Frans G. M. Russel, Joost P. H. Drenth, Angela Colbers & David M. Burger. (2019) Review article: direct-acting antivirals for the treatment of HCV during pregnancy and lactation - implications for maternal dosing, foetal exposure, and safety for mother and child. Alimentary Pharmacology & Therapeutics 50:7, pages 738-750.
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Michael Paulzen, Julia C. Stingl, Marc Augustin, Helena Saßmannshausen, Cordula Franz, Gerhard Gründer & Georgios Schoretsanitis. (2018) Comprehensive Measurements of Intrauterine and Postnatal Exposure to Lamotrigine. Clinical Pharmacokinetics 58:4, pages 535-543.
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M. Kadawathagedara, B. de Lauzon-Guillain & J. Botton. (2019) Environmental contaminants and child’s growth. Journal of Developmental Origins of Health and Disease 9:6, pages 632-641.
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Brooke L. Griffin, Rebecca H. Stone, Shareen Y. El-Ibiary, Sarah Westberg, Kayce Shealy, Alicia Forinash, Abigail Yancey, Kathleen Vest, Lamis R. Karaoui, Sally Rafie, Cheryl Horlen, Nicole Lodise, Nicole Cieri-Hutcherson, Sarah McBane & Anahit Simonyan. (2018) Guide for Drug Selection During Pregnancy and Lactation: What Pharmacists Need to Know for Current Practice. Annals of Pharmacotherapy 52:8, pages 810-818.
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Wei Wu. 2018. Pregnancy and Birth Outcomes. Pregnancy and Birth Outcomes.
Michael Paulzen, Tamme W. Goecke, Maxim Kuzin, Marc Augustin, Gerhard Gründer & Georgios Schoretsanitis. (2018) Pregnancy exposure to quetiapine – Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood and obstetrical outcomes. Schizophrenia Research 195, pages 252-257.
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Michael Paulzen, Tamme W. Goecke, Julia C. Stingl, Geer Janssen, Elmar Stickeler, Gerhard Gründer & Georgios Schoretsanitis. (2017) Pregnancy exposure to citalopram – Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood. Progress in Neuro-Psychopharmacology and Biological Psychiatry 79, pages 213-219.
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Michael Paulzen, Tamme W. Goecke, Elmar Stickeler, Gerhard Gründer & Georgios Schoretsanitis. (2017) Sertraline in pregnancy – Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood. Journal of Affective Disorders 212, pages 1-6.
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Michael Paulzen, Sarah E. Lammertz, Tanja Veselinovic, Tamme W. Goecke, Christoph Hiemke & Gerhard Gründer. (2015) Lamotrigine in pregnancy – therapeutic drug monitoring in maternal blood, amniotic fluid, and cord blood. International Clinical Psychopharmacology, pages 1.
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Yong-Hong Zhang, Zhi-Ning Xia, Li Yan & Shu-Shen Liu. (2015) Prediction of Placental Barrier Permeability: A Model Based on Partial Least Squares Variable Selection Procedure. Molecules 20:5, pages 8270-8286.
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Grace Ewing, Yekaterina Tatarchuk, Dina Appleby, Nadav Schwartz & Deborah Kim. (2015) Placental Transfer of Antidepressant Medications: Implications for Postnatal Adaptation Syndrome. Clinical Pharmacokinetics 54:4, pages 359-370.
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Hisham Mirghani, Nawal Osman, Subramanian Dhanasekaran, Hassan M. Elbiss & Gharid Bekdache. (2015) Transplacental transfer of 2-naphthol in human placenta. Toxicology Reports 2, pages 957-960.
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Fontoura Andrea, R. Ayres Lorena, Martins-Nagai Michelly, L. S. Dewulf Nathalie, dos Santos Vania, Z. Martinez Edson & R. L. Pereira Leonardo. (2014) Prevalence of medication use among low risk pregnant women: A drug utilization study. African Journal of Pharmacy and Pharmacology 8:36, pages 883-892.
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Graeme J. Moffat, Marc W. Retter, Gayle Kwon, Mark Loomis, M. Benjamin Hock, Colin Hall, Jeanine Bussiere, Elise M. Lewis & Gary J. Chellman. (2014) Placental Transfer of a Fully Human IgG2 Monoclonal Antibody in the Cynomolgus Monkey, Rat, and Rabbit: A Comparative Assessment from during Organogenesis to Late Gestation. Birth Defects Research Part B: Developmental and Reproductive Toxicology 101:2, pages 178-188.
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Claudia Göhner, Judit Svensson-Arvelund, Christiane Pfarrer, Jan-Dirk Häger, Marijke Faas, Jan Ernerudh, J. Mark Cline, Darlene Dixon, Eberhard Buse & Udo R. Markert. (2013) The Placenta in Toxicology. Part IV. Toxicologic Pathology 42:2, pages 345-351.
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T.A. Lewandowski. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
R. Bajoria, S. Sooranna & R. Chatterjee. (2013) Effect of lipid composition of cationic SUV liposomes on materno-fetal transfer of warfarin across the perfused human term placenta. Placenta 34:12, pages 1216-1222.
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