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Drug Evaluations

Prucalopride: evaluation of the pharmacokinetics, pharmacodynamics, efficacy and safety in the treatment of chronic constipation

, MD PhD & , MD PhD
Pages 1327-1335 | Published online: 18 Sep 2012

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Vincenzo Savarino, Elisa Marabotto, Patrizia Zentilin, Maria Giulia Demarzo, Nicola de Bortoli & Edoardo Savarino. (2021) Pharmacological Management of Gastro-Esophageal Reflux Disease: An Update of the State-of-the-Art. Drug Design, Development and Therapy 15, pages 1609-1621.
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Sheetal Makwana, Veerabhadragouda B. Patil, Madhavi Patel, Jatin Upadhyay & Anamik Shah. (2021) A Validated Stability-Indicating Method for Separation of Prucalopride Drug by HPLC: Method Transfer to UPLC. Analytical Chemistry Letters 11:4, pages 580-595.
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Gabrio Bassotti, Dario Gambaccini & Massimo Bellini. (2016) Prucalopride succinate for the treatment of constipation: an update. Expert Review of Gastroenterology & Hepatology 10:3, pages 291-300.
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Emanuel Raschi & Fabrizio De Ponti. (2014) Lubiprostone: pharmacokinetic, pharmacodynamic, safety and regulatory aspects in the treatment of constipation-predominant irritable bowel syndrome. Expert Opinion on Drug Metabolism & Toxicology 10:2, pages 293-305.
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Daniël Robin Hoekman & Marc Alexander Benninga. (2013) Functional constipation in childhood: current pharmacotherapy and future perspectives. Expert Opinion on Pharmacotherapy 14:1, pages 41-51.
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Articles from other publishers (22)

Priya Bisht, Neha Dagar, Nitesh Kumar, Ravichandiran Velayutham & Somasundaram Arumugam. (2023) Potential Targets in Constipation Research: A Review. Current Drug Targets 24:3, pages 247-260.
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Giovanni Barbara, Cesare Cremon, Massimo Bellini, Maura Corsetti, Giovanni Di Nardo, Francesca Falangone, Lorenzo Fuccio, Francesca Galeazzi, Paola Iovino, Giovanni Sarnelli, Edoardo Vincenzo Savarino, Vincenzo Stanghellini, Annamaria Staiano, Cristina Stasi, Cesare Tosetti, Rossella Turco, Enzo Ubaldi, Rocco Maurizio Zagari, Letizia Zenzeri & Giovanni Marasco. (2023) Italian guidelines for the management of irritable bowel syndrome. Digestive and Liver Disease 55:2, pages 187-207.
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Gregory S. SayukScott A. WaldmanDarren M. Brenner. (2022) Mechanisms of Action of Current Pharmacologic Options for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation. American Journal of Gastroenterology 117:4S, pages S6-S13.
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Micaela Atkins, Ingrid Guerrero López & Braden Kuo. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 57 75 .
Neha R. Santucci & Ajay Kaul. 2022. Pediatric Neurogastroenterology. Pediatric Neurogastroenterology 317 332 .
Florencia Carbone, Tim Vanuytsel & Jan Tack. (2021) The effect of prucalopride on gastric sensorimotor function and satiation in healthy volunteers. Neurogastroenterology & Motility 33:8.
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Ziye Zhou, Chenxiang Wang, Xuyong Zheng, Xuben Yu, Chao Yu, Dongchuan Zhang, Yan Xia, Huafang Chen, Xiaoxiao Huang & Xiuhua Zhang. (2019) Pharmacokinetics, Bioequivalence, and Safety Studies of Prucalopride in Healthy Chinese Subjects. Clinical Pharmacology in Drug Development 9:6, pages 671-676.
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Rachel M. Gwynne & Joel C. Bornstein. (2019) Luminal 5‐HT 4 receptors—A successful target for prokinetic actions . Neurogastroenterology & Motility 31:10.
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Florencia Carbone, Karen Van den Houte, Egbert Clevers, Christopher N. Andrews, Athanassos Papathanasopoulos, Lieselot Holvoet, Lukas Van Oudenhove, Philip Caenepeel, Joris Arts, Tim Vanuytsel & Jan Tack. (2019) Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study. American Journal of Gastroenterology 114:8, pages 1265-1274.
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Magnus Simrén & Jan Tack. (2018) New treatments and therapeutic targets for IBS and other functional bowel disorders. Nature Reviews Gastroenterology & Hepatology 15:10, pages 589-605.
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Lawrence Hookey, Melissa Kelley, Katherine Marchut, Jordan Green & Robert Bechara. (2018) Colon Capsule Visualization Is Not Enhanced with Prucalopride: A Randomized Controlled Trial. Journal of the Canadian Association of Gastroenterology 1:1, pages 20-25.
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Kelly Conlon, Joris H. De Maeyer, Chris Bruce, Jan A. J. Schuurkes, Lee Christie, James McRedmond, Katayoun Derakhchan & Paul R. Wade. (2018) Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist. Journal of Pharmacology and Experimental Therapeutics 364:2, pages 156-169.
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Anam Omer & Eamonn M.M. Quigley. (2017) An update on prucalopride in the treatment of chronic constipation. Therapeutic Advances in Gastroenterology 10:11, pages 877-887.
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Muhammad S Sajid, Madhu Hebbar, Mirza K Baig, Andy Li & Zinu Philipose. (2016) Use of Prucalopride for Chronic Constipation: A Systematic Review and Meta-analysis of Published Randomized, Controlled Trials. Journal of Neurogastroenterology and Motility 22:3, pages 412-422.
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Satish S. C. Rao, Kulthep Rattanakovit & Tanisa Patcharatrakul. (2016) Diagnosis and management of chronic constipation in adults. Nature Reviews Gastroenterology & Hepatology 13:5, pages 295-305.
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Lawrence Szarka. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology 1154 1195 .
MeiYun Ke, Jan Tack, Eamonn M M Quigley, Duowu Zou, Suck Chei Choi, Somchai Leelakusolvong, Andy Liu & JinYong Kim. (2014) Effect of Prucalopride in the Treatment of Chronic Constipation in Asian and Non-Asian Women: A Pooled Analysis of 4 Randomized, Placebo-controlled Studies. Journal of Neurogastroenterology and Motility 20:4, pages 458-468.
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A. Shin, M. Camilleri, G. Kolar, P. Erwin, C. P. West & M. H. Murad. (2013) Systematic review with meta‐analysis: highly selective 5‐HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation. Alimentary Pharmacology & Therapeutics 39:3, pages 239-253.
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Ali Dabbagh. 2014. Postoperative Critical Care for Cardiac Surgical Patients. Postoperative Critical Care for Cardiac Surgical Patients 257 294 .
Gillian M. Keating. (2013) Prucalopride: A Review of Its Use in the Management of Chronic Constipation. Drugs 73:17, pages 1935-1950.
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G. Bassotti & M. Bellini. (2013) The use of prucalopride in real life for the treatment of constipation subtypes: ups and downs. Techniques in Coloproctology 17:5, pages 475-476.
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Miriam Góngora-Benítez, Judit Tulla-Puche & Fernando Albericio. (2013) Constella™(EU)–Linzess™(USA): the last milestone in the long journey of the peptide linaclotide and its implications for the future of peptide drugs. Future Medicinal Chemistry 5:3, pages 291-300.
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