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Expert Opinion on Drug Metabolism & Toxicology Volume 8, 2012 - Issue 12
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Original Research

Validated in vitro/in vivo correlation of prolonged-release oxycodone/naloxone with differing dissolution rates in relation to gastrointestinal transit times

Gill E MundinMundipharma Research Ltd, Cambridge Science Park, Milton Road, Cambridge, CB4 0GW, UK;Functional Director of Analytical & Pharmaceutical Sciences, Mundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany+49 6431 701 780; +49 6431 701 8780; [email protected]
,
Kevin J SmithMundipharma Research Ltd, Cambridge Science Park, Milton Road, Cambridge, CB4 0GW, UK;Functional Director of Analytical & Pharmaceutical Sciences, Mundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany+49 6431 701 780; +49 6431 701 8780; [email protected]
,
Jana MysickaBioVista GmbH, Ruechligweg 101, CH-4125 Riehen, Switzerland;Functional Director of Analytical & Pharmaceutical Sciences, Mundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany+49 6431 701 780; +49 6431 701 8780; [email protected]
,
Gerhard HeunMundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany;Functional Director of Analytical & Pharmaceutical Sciences, Mundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany+49 6431 701 780; +49 6431 701 8780; [email protected]
,
Mathias KrämerMundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany;Functional Director of Analytical & Pharmaceutical Sciences, Mundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany+49 6431 701 780; +49 6431 701 8780; [email protected]
,
Udo HahnMundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany;Functional Director of Analytical & Pharmaceutical Sciences, Mundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany+49 6431 701 780; +49 6431 701 8780; [email protected]
&
Christian LeunerMundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany;Functional Director of Analytical & Pharmaceutical Sciences, Mundipharma Research GmbH & Co. KG, Höhenstrasse 10, D-65549 Limburg Lahn, Germany+49 6431 701 780; +49 6431 701 8780; [email protected]
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Pages 1495-1503 | Published online: 01 Oct 2012

Citations (7)

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Read on this site (3)

Marival Bermejo, Barbara Sanchez-Dengra, Marta Gonzalez-Alvarez & Isabel Gonzalez-Alvarez. (2020) Oral controlled release dosage forms: dissolution versus diffusion. Expert Opinion on Drug Delivery 17:6, pages 791-803.
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Antti Valtola, James D. Morse, Pawel Florkiewicz, Heidi Hautajärvi, Pasi Lahtinen, Tadeusz Musialowicz, Brian J. Anderson, Veli-Pekka Ranta & Hannu Kokki. (2020) Bioavailability of oxycodone by mouth in coronary artery bypass surgery patients – a randomized trial. Journal of Drug Assessment 9:1, pages 117-128.
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Ignacio González-García, Victor Mangas-Sanjuán, Matilde Merino-Sanjuán & Marival Bermejo. (2015) In vitro–in vivo correlations: general concepts, methodologies and regulatory applications. Drug Development and Industrial Pharmacy 41:12, pages 1935-1947.
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Articles from other publishers (4)

Yan Li, Duxin Sun, Maria Palmisano & Simon Zhou. (2016) Slow drug delivery decreased total body clearance and altered bioavailability of immediate‐ and controlled‐release oxycodone formulations. Pharmacology Research & Perspectives 4:1.
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M. Blagden, J. Hafer, H. Duerr, M. Hopp & B. Bosse. (2014) Long‐term evaluation of combined prolonged‐release oxycodone and naloxone in patients with moderate‐to‐severe chronic pain: pooled analysis of extension phases of two Phase III trials. Neurogastroenterology & Motility 26:12, pages 1792-1801.
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Celeste B. Burness & Gillian M. Keating. (2014) Oxycodone/Naloxone Prolonged-Release: A Review of Its Use in the Management of Chronic Pain While Counteracting Opioid-Induced Constipation. Drugs 74:3, pages 353-375.
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Richard J. Bodnar. (2013) Endogenous opiates and behavior: 2012. Peptides 50, pages 55-95.
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