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The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs

, PhD (Senior Lecturer) & , PhD (Associate-Professor)
Pages 267-285 | Published online: 06 Jan 2013

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Hao Ye, Hui Ng, Sugunadevi Sakkiah, Weigong Ge, Roger Perkins, Weida Tong & Huixiao Hong. (2016) Pathway Analysis Revealed Potential Diverse Health Impacts of Flavonoids that Bind Estrogen Receptors. International Journal of Environmental Research and Public Health 13:4, pages 373.
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Torsten Bohn, Gordon J. McDougall, Amparo Alegría, Marie Alminger, Eva Arrigoni, Anna‐Marja Aura, Catarina Brito, Antonio Cilla, Sedef N. El, Sibel Karakaya, Marie C. Martínez‐Cuesta & Claudia N. Santos. (2015) Mind the gap—deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites—a position paper focusing on carotenoids and polyphenols. Molecular Nutrition & Food Research 59:7, pages 1307-1323.
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Sanjay K. Nigam. (2014) What do drug transporters really do?. Nature Reviews Drug Discovery 14:1, pages 29-44.
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Selvi Durmus, Jeroen J.M.A. Hendrikx & Alfred H. Schinkel. 2015. ABC Transporters and Cancer. ABC Transporters and Cancer 1 41 .
Kee W. Tan, Janine Cooney, Dwayne Jensen, Yan Li, James W. Paxton, Nigel P. Birch & Arjan Scheepens. (2014) Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Molecular Nutrition & Food Research 58:11, pages 2099-2110.
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M.A. Nguyen, P. Staubach, S. Wolffram & P. Langguth. (2014) Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans – Implications for the evaluation of transporter-mediated flavonoid–drug interactions. European Journal of Pharmaceutical Sciences 61, pages 54-60.
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Yury S. Tarahovsky, Yuri A. Kim, Elena A. Yagolnik & Eugeny N. Muzafarov. (2014) Flavonoid–membrane interactions: Involvement of flavonoid–metal complexes in raft signaling. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:5, pages 1235-1246.
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C.P. Yu, Y.W. Hsieh, S.P. Lin, Y.C. Chi, P. Hariharan, P.D.L. Chao & Y.C. Hou. (2014) Potential modulation on P-glycoprotein and CYP3A by soymilk and miso: In vivo and ex-vivo studies. Food Chemistry 149, pages 25-30.
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Uwe Wenzel. (2013) Flavonoids as drugs at the small intestinal level. Current Opinion in Pharmacology 13:6, pages 864-868.
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