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Considering CYP1A2 phenotype and genotype for optimizing the dose of olanzapine in the management of schizophrenia

, , , , , , (Associate Clinical Professor) & show all
Pages 1115-1137 | Published online: 04 May 2013

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Yeo-Jung Kwon, Sangyun Shin & Young-Jin Chun. (2021) Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes. Archives of Pharmacal Research 44:1, pages 63-83.
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M. Martinez-Matilla, A. Blanco-Verea, M. Santori, J. Ansede-Bermejo, E. Ramos-Luis, R. Gil, AM. Bermejo, F. Lotufo-Neto, MH. Hirata, F. Brisighelli, M. Paramo, A. Carracedo & M. Brion. (2019) Genetic susceptibility in pharmacodynamic and pharmacokinetic pathways underlying drug-induced arrhythmia and sudden unexplained deaths. Forensic Science International: Genetics 42, pages 203-212.
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Thomas M. Polasek, Geoffrey T. Tucker, Michael J. Sorich, Michael D. Wiese, Titus Mohan, Amin Rostami-Hodjegan, Porntipa Korprasertthaworn, Vidya Perera & Andrew Rowland. (2018) Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation. British Journal of Clinical Pharmacology 84:3, pages 462-476.
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A S Darwich, K Ogungbenro, A A Vinks, J R Powell, J-L Reny, N Marsousi, Y Daali, D Fairman, J Cook, L J Lesko, J S McCune, C A J Knibbe, S N de Wildt, J S Leeder, M Neely, A F Zuppa, P Vicini, L Aarons, T N Johnson, J Boiani & A Rostami-Hodjegan. (2017) Why Has Model-Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future. Clinical Pharmacology & Therapeutics 101:5, pages 646-656.
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Anyue Yin, Dewei Shang, Yuguan Wen, Liang Li, Tianyan Zhou & Wei Lu. (2016) Population pharmacokinetics analysis of olanzapine for Chinese psychotic patients based on clinical therapeutic drug monitoring data with assistance of meta-analysis. European Journal of Clinical Pharmacology 72:8, pages 933-944.
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Michael W. Jann & W. Klugh Kennedy. 2016. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents 139 175 .
Fabian Czerwensky, Stefan Leucht & Werner Steimer. (2015) CYP1A2*1D and *1F Polymorphisms Have a Significant Impact on Olanzapine Serum Concentrations. Therapeutic Drug Monitoring 37:2, pages 152-160.
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Vidya Perera, Robert R. Bies, Gary Mo, Michael J. Dolton, Vaughan J. Carr, Andrew J. McLachlan, Richard O. Day, Thomas M. Polasek & Alan Forrest. (2014) Optimal sampling of antipsychotic medicines: a pharmacometric approach for clinical practice. British Journal of Clinical Pharmacology 78:4, pages 800-814.
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Daniel C. Javitt. (2014) Current and Emergent Treatments for Symptoms and Neurocognitive Impairment in Schizophrenia. Current Treatment Options in Psychiatry 1:2, pages 107-120.
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Vidya Perera, Annette S. Gross, Alan Forrest, Cornelia B. Landersdorfer, Hongmei Xu, Sihem Ait-Oudhia & Andrew J. McLachlan. (2013) A Pharmacometric Approach to Investigate the Impact of Methylxanthine Abstinence and Caffeine Consumption on CYP1A2 Activity. Drug Metabolism and Disposition 41:11, pages 1957-1966.
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