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Exploring concepts of in vitro time-dependent CYP inhibition assays

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Sicong Li, Xuting Li, Dingsheng Yuan, Bin Wang, Rui Yang, Min Zhang, Jinliang Li & Fuqiang Zeng. (2021) Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo. Xenobiotica 51:9, pages 961-967.
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Anna-Karin Sohlenius-Sternbeck, Gabrielle Meyerson, Ann-Louise Hagbjörk, Sanja Juric & Ylva Terelius. (2018) A strategy for early-risk predictions of clinical drug–drug interactions involving the GastroPlusTM DDI module for time-dependent CYP inhibitors. Xenobiotica 48:4, pages 348-356.
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Yuta Tamemoto, Yukihiro Shibata, Natsumi Hashimoto, Hiromi Sato & Akihiro Hisaka. (2023) Involvement of multiple cytochrome P450 isoenzymes in drug interactions between ritonavir and direct oral anticoagulants. Drug Metabolism and Pharmacokinetics, pages 100498.
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Elma Mons, Sander Roet, Robbert Q. Kim & Monique P. C. Mulder. (2022) A Comprehensive Guide for Assessing Covalent Inhibition in Enzymatic Assays Illustrated with Kinetic Simulations. Current Protocols 2:6.
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Jiangnan Dong, Su Li & Guangxuan Liu. (2021) Binimetinib Is a Potent Reversible and Time-Dependent Inhibitor of Cytochrome P450 1A2. Chemical Research in Toxicology 34:4, pages 1169-1174.
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Rodrigo Moreira da Silva, Daniel Blascke Carrão, Maísa Daniela Habenschus, Paula Christine Jimenez, Norberto Peporine Lopes, William Fenical, Letícia Vera Costa-Lotufo & Anderson Rodrigo Moraes de Oliveira. (2020) Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes. Toxicology in Vitro 65, pages 104820.
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Saneesh Kumar, Patrick J. Bouic & Bernd Rosenkranz. (2020) In Vitro Assessment of the Interaction Potential of Ocimum basilicum (L.) Extracts on CYP2B6, 3A4, and Rifampicin Metabolism. Frontiers in Pharmacology 11.
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Yu Fen Zheng, Soo Hyeon Bae, Zhouchi Huang, Soon Uk Chae, Seong Jun Jo, Hyung Joon Shim, Chae Bin Lee, Doyun Kim, Hunseung Yoo & Soo Kyung Bae. (2020) Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 Is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone. Pharmaceutics 12:4, pages 328.
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Jaydeep Yadav, Erickson Paragas, Ken Korzekwa & Swati Nagar. (2020) Time-dependent enzyme inactivation: Numerical analyses of in vitro data and prediction of drug-drug interactions. Pharmacology & Therapeutics 206, pages 107449.
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Daniel Blascke Carrão, Maísa Daniela Habenchus, Nayara Cristina Perez de Albuquerque, Rodrigo Moreira da Silva, Norberto Peporine Lopes & Anderson Rodrigo Moraes de Oliveira. (2019) In vitro inhibition of human CYP2D6 by the chiral pesticide fipronil and its metabolite fipronil sulfone: Prediction of pesticide-drug interactions. Toxicology Letters 313, pages 196-204.
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Dan Lou, Su-su Bao, Ying-hui Li, Qian-meng Lin, Su-fen Yang & Jia-yang He. (2019) Inhibitory Mechanisms of Myricetin on Human and Rat Liver Cytochrome P450 Enzymes. European Journal of Drug Metabolism and Pharmacokinetics 44:5, pages 611-618.
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Yi Cheng, Shuowen Tang, Ang Chen, Yuanjin Zhang, Mingyao Liu & Xin Wang. (2019) Evaluation of the inhibition risk of shikonin on human and rat UDP-glucuronosyltransferases (UGT) through the cocktail approach. Toxicology Letters 312, pages 214-221.
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Jelle Reinen, Martijn Smit & Mira Wenker. (2018) Evaluation of Strategies for the Assessment of Drug–Drug Interactions Involving Cytochrome P450 Enzymes. European Journal of Drug Metabolism and Pharmacokinetics 43:6, pages 737-750.
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Su-su Bao, Jian Wen, Xiang Zheng, Quan Zhou, Gao-er Qu, Ming-jing Chen & Guo-xin Hu. (2018) Evaluation of the inhibition effects of apatinib on human and rat cytochrome P450. Toxicology Letters 297, pages 1-7.
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Kelli Melville, Thalia Rodriguez & Hana M. Dobrovolny. (2018) Investigating Different Mechanisms of Action in Combination Therapy for Influenza. Frontiers in Pharmacology 9.
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Phil Jeffrey & Scott Summerfield. 2017. Pharmacology for Chemists: Drug Discovery in Context. Pharmacology for Chemists: Drug Discovery in Context 316 342 .
Shaheed Rehman, In Kim, Min Choi, Seung Kim, Yonghui Zhang & Hye Yoo. (2017) Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules 22:7, pages 1241.
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Bianca M. Liederer, Xingrong Liu, Simon Wong & Daniel R. Mudra. 2017. Translating Molecules into Medicines. Translating Molecules into Medicines 165 230 .
Ang Chen, Xiaojing Zhou, Shuowen Tang, Mingyao Liu & Xin Wang. (2016) Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Scientific Reports 6:1.
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Jialin Mao, Suzanne Tay, Cyrus S. Khojasteh, Yuan Chen, Cornelis E. C. A. Hop & Jane R. Kenny. (2016) Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma. Pharmaceutical Research 33:5, pages 1204-1219.
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Dominik Dahlinger, Sabrina Duechting, Daniela Nuecken, Konrad Sydow, Uwe Fuhr & Sebastian Frechen. (2016) Development and validation of an in vitro, seven-in-one human cytochrome P450 assay for evaluation of both direct and time-dependent inhibition. Journal of Pharmacological and Toxicological Methods 77, pages 66-75.
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Kaisa A. Salminen, Minna Rahnasto-Rilla, Raija Väänänen, Peter Imming, Achim Meyer, Aline Horling, Antti Poso, Tuomo Laitinen, Hannu Raunio & Maija Lahtela-Kakkonen. (2015) Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis. Drug Metabolism and Disposition 43:12, pages 1891-1904.
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