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An evaluation of the latest in vitro tools for drug metabolism studies

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Chunli Qi, Jiangnan Fu, Huinan Zhao, Huijie Xing, Dong Dong & Baojian Wu. (2019) Identification of UGTs and BCRP as potential pharmacokinetic determinants of the natural flavonoid alpinetin. Xenobiotica 49:3, pages 276-283.
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Érika Yoko Suzuki, Alice Simon, Thaisa Francielle Souza Domingos, Bárbara de Azevedo Abrahim Vieira, Alessandra Mendonça Teles de Souza, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Flávia Almada do Carmo & Lucio Mendes Cabral. (2023) Alternative Methods for Pulmonary-Administered Drugs Metabolism: A Breath of Change. Mini-Reviews in Medicinal Chemistry 23:2, pages 170-186.
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Ndeye F. Kane, Bushra H. Kiani, Matthew R. Desrosiers, Melissa J. Towler & Pamela J. Weathers. (2022) Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. Journal of Ethnopharmacology 298, pages 115587.
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Tracey Hurrell, Jerolen Naidoo & Janine Scholefield. (2022) Hepatic Models in Precision Medicine: An African Perspective on Pharmacovigilance. Frontiers in Genetics 13.
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Ge Zhao, Yue Tong, Fei Luan, Wenjing Zhu, Chenglin Zhan, Tiantian Qin, Weixiao An & Nan Zeng. (2022) Alpinetin: A Review of Its Pharmacology and Pharmacokinetics. Frontiers in Pharmacology 13.
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Sheng Yang, Yanping Cheng, Zaozao Chen, Tong Liu, Lihong Yin, Yuepu Pu & Geyu Liang. (2021) In vitro evaluation of nanoplastics using human lung epithelial cells, microarray analysis and co-culture model. Ecotoxicology and Environmental Safety 226, pages 112837.
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Dipali Sonawane, Anuradha Reddy, Tarang Jadav, Amit K Sahu, Rakesh K Tekade & Pinaki Sengupta. (2021) Advancements in practical and scientific bioanalytical approaches to metabolism studies in drug development. Bioanalysis 13:11, pages 913-930.
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Andreia Sofia Barros, Ana Costa & Bruno Sarmento. (2021) Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs. Advanced Drug Delivery Reviews 170, pages 386-395.
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Ponsiree Jithavech, Pahweenvaj Ratnatilaka Na Bhuket, Wiwat Supasena, Guanyinsheng Qiu, Shengqing Ye, Jie Wu, Tin Wui Wong & Pornchai Rojsitthisak. (2020) In Vitro Hepatic Metabolism of Curcumin Diethyl Disuccinate by Liver S9 from Different Animal Species. Frontiers in Pharmacology 11.
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Abdul Basit, Naveen K. Neradugomma, Christopher Wolford, Peter W. Fan, Bernard Murray, Ryan H. Takahashi, S. Cyrus Khojasteh, Bill J. Smith, Scott Heyward, Rheem A. Totah, Edward J. Kelly & Bhagwat Prasad. (2020) Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human. Molecular Pharmaceutics 17:11, pages 4114-4124.
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Xiaoni Ai, Lin Zhao, Yingyuan Lu, Yu Hou, Tian Lv, Yong Jiang, Pengfei Tu & Xiaoyu Guo. (2020) Integrated Array Chip for High-Throughput Screening of Species Differences in Metabolism. Analytical Chemistry 92:17, pages 11696-11704.
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Maciej Gawlik, Robert Skibiński & Łukasz Komsta. (2020) Characterization of lacosamide metabolites by UHPLC–ESI–HRMS method. Acta Chromatographica 32:2, pages 107-116.
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Camilla Bernasconi, Olavi Pelkonen, Tommy B. Andersson, Judy Strickland, Iwona Wilk-Zasadna, David Asturiol, Thomas Cole, Roman Liska, Andrew Worth, Ursula Müller-Vieira, Lysiane Richert, Christophe Chesne & Sandra Coecke. (2019) Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study. Toxicology in Vitro 60, pages 212-228.
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Ana Costa, Cristiane de Souza Carvalho-Wodarz, Vítor Seabra, Bruno Sarmento & Claus-Michael Lehr. (2019) Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier. Acta Biomaterialia 91, pages 235-247.
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Xingxing Diao & Marilyn A. Huestis. (2019) New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites. Frontiers in Chemistry 7.
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Tracey Hurrell, Charis-Patricia Segeritz, Ludovic Vallier, Kathryn S. Lilley & Allan D. Cromarty. (2019) A proteomic time course through the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. Scientific Reports 9:1.
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Tracey Hurrell, Andrea Antonio Ellero, Zelie Flavienne Masso & Allan Duncan Cromarty. (2018) Characterization and reproducibility of HepG2 hanging drop spheroids toxicology in vitro. Toxicology in Vitro 50, pages 86-94.
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Zifei Qin, Shishi Li, Zhihong Yao, Xiaodan Hong, Baojian Wu, Kristopher W. Krausz, Frank J. Gonzalez, Hao Gao & Xinsheng Yao. (2018) Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides. Food & Function 9:3, pages 1410-1423.
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X Diao & MA Huestis. (2017) Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites. Clinical Pharmacology & Therapeutics 101:2, pages 239-253.
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T. Hartung. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 150 155 .
Giovanni Ugolini, Daniela Cruz-Moreira, Roberta Visone, Alberto Redaelli & Marco Rasponi. (2016) Microfabricated Physiological Models for In Vitro Drug Screening Applications. Micromachines 7:12, pages 233.
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Ana Ferreira, Márcio Rodrigues, Amílcar Falcão & Gilberto Alves. (2016) A Rapid and Sensitive HPLC–DAD Assay to Quantify Lamotrigine, Phenytoin and Its Main Metabolite in Samples of Cultured HepaRG Cells. Journal of Chromatographic Science 54:8, pages 1352-1358.
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Qingping Wang & Meng Li. 2016. Drug Delivery. Drug Delivery 164 185 .
Ana Ferreira, Márcio Rodrigues, Amílcar Falcão & Gilberto Alves. (2016) HPLC–DAD Method for the Quantification of Carbamazepine, Oxcarbazepine and their Active Metabolites in HepaRG Cell Culture Samples. Chromatographia 79:9-10, pages 581-590.
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Madison Davis & Brendan D. Stamper. (2016) TAMH: A Useful In Vitro Model for Assessing Hepatotoxic Mechanisms. BioMed Research International 2016, pages 1-9.
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Edward J. Kelly & Jenna L. Voellinger. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 177 201 .
Hua Sun, Xiaotong Zhou, Xingwang Zhang & Baojian Wu. (2015) Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling. Journal of Agricultural and Food Chemistry 63:26, pages 6001-6008.
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Hua Sun, Zhiguo Ma, Danyi Lu & Baojian Wu. (2015) Regio- and Isoform-Specific Glucuronidation of Psoralidin: Evaluation of 3-O-Glucuronidation as a Functional Marker for UGT1A9. Journal of Pharmaceutical Sciences 104:7, pages 2369-2377.
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Xingwang Zhang, Dong Dong, Huailing Wang, Zhiguo Ma, Yifei Wang & Baojian Wu. (2015) Stable Knock-down of Efflux Transporters Leads to Reduced Glucuronidation in UGT1A1-Overexpressing HeLa Cells: The Evidence for Glucuronidation-Transport Interplay. Molecular Pharmaceutics 12:4, pages 1268-1278.
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Enxi Quan, Huailing Wang, Dong Dong, Xingwang Zhang & Baojian Wu. (2015) Characterization of Chrysin Glucuronidation in UGT1A1-Overexpressing HeLa Cells: Elucidating the Transporters Responsible for Efflux of Glucuronide. Drug Metabolism and Disposition 43:4, pages 433-443.
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Ndeye F. Kane, Bushra H. Kiani, Matthew R. Desrosiers, Melissa J. Towler & Pamela Weathers. (2022) Artemisia Extracts Differ from Artemisinin Effects on Human Hepatic CYP450s 2B6 and 3A4 In Vitro. SSRN Electronic Journal.
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