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Intestinal transporters: enhanced absorption through P-glycoprotein-related drug interactions

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Mohammad Feyzizadeh, Ashkan Barfar, Zeinab Nouri, Muhammad Sarfraz, Parvin Zakeri-Milani & Hadi Valizadeh. (2022) Overcoming multidrug resistance through targeting ABC transporters: lessons for drug discovery. Expert Opinion on Drug Discovery 17:9, pages 1013-1027.
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Yunliang Guo, Xuyan Mao, Jing Zhang, Peng Sun, Haiyang Wang, Yue Zhang, Yingjuan Ma, Song Xu, Renjun Lv & Xueping Liu. (2019) Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution. Drug Delivery 26:1, pages 1191-1205.
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Wei Xiong, Wei Sang, Ke Gang Linghu, Zhang Feng Zhong, Wai San Cheang, Juan Li, Yuan Jia Hu, Hua Yu & Yi Tao Wang. (2018) Dual-functional Brij-S20-modified nanocrystal formulation enhances the intestinal transport and oral bioavailability of berberine. International Journal of Nanomedicine 13, pages 3781-3793.
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Deqing Sun, Aiying Xue, Bin Zhang, Xia Xue, Jie Zhang & Wenjie Liu. (2016) Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology. Drug Design, Development and Therapy 10, pages 2029-2039.
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Mehri Niazi, Parvin Zakeri-Milani, Saeedeh Najafi Hajivar, Mehdi Soleymani Goloujeh, Nasrin Ghobakhlou, Javid Shahbazi Mojarrad & Hadi Valizadeh. (2016) Nano-based strategies to overcome p-glycoprotein-mediated drug resistance. Expert Opinion on Drug Metabolism & Toxicology 12:9, pages 1021-1033.
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Articles from other publishers (48)

Florina Veider, Soheil Haddadzadegan, Eva Sanchez Armengol, Flavia Laffleur, Gergely Kali & Andreas Bernkop-Schnürch. (2024) Inhibition of P-glycoprotein-mediated efflux by thiolated cyclodextrins. Carbohydrate Polymers 327, pages 121648.
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Jéssica Veiga-Matos, Ana I. Morales, Marta Prieto, Fernando Remião & Renata Silva. (2023) Study Models of Drug–Drug Interactions Involving P-Glycoprotein: The Potential Benefit of P-Glycoprotein Modulation at the Kidney and Intestinal Levels. Molecules 28:22, pages 7532.
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Giordana Salvi de Souza, Dimitri B.A. Mantovani, Pascalle Mossel, Bartholomeus C.M. Haarman, Ana Maria Marques da Silva, Hendrikus H. Boersma, Cristiane R.G. Furini, Adriaan A. Lammertsma, Charalampos Tsoumpas & Gert Luurtsema. (2023) Oral administration of PET tracers: Current status. Journal of Controlled Release 357, pages 591-605.
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Su-Jin Lee, Seul-A Joo, Heejeong Kim, Yunjong Lee, Suk-Jae Chung, Yoon-Jee Chae & Han-Joo Maeng. (2023) Involvement of CYP3A4 and MDR1 in altered metabolism and transport of indinavir in 1,25(OH)2D3-treated Caco-2 cells. European Journal of Pharmaceutical Sciences 183, pages 106396.
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Mohamed R. Abdelaal, Esraa Ibrahim, Mohamed R. Elnagar, Sameh H. Soror & Hesham Haffez. (2022) Augmented Therapeutic Potential of EC-Synthetic Retinoids in Caco-2 Cancer Cells Using an In Vitro Approach. International Journal of Molecular Sciences 23:16, pages 9442.
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Maisarah Azman, Akmal H. Sabri, Qonita Kurnia Anjani, Mohd Faiz Mustaffa & Khuriah Abdul Hamid. (2022) Intestinal Absorption Study: Challenges and Absorption Enhancement Strategies in Improving Oral Drug Delivery. Pharmaceuticals 15:8, pages 975.
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Wojciech Szlasa, Natalia Janicka, Natalia Sauer, Olga Michel, Bernadetta Nowak, Jolanta Saczko & Julita Kulbacka. (2022) Chemotherapy and Physical Therapeutics Modulate Antigens on Cancer Cells. Frontiers in Immunology 13.
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Pavlo V. Zadorozhnii, Vadym V. Kiselev & Aleksandr V. Kharchenko. (2022) In Silico ADME Profiling of Salubrinal and Its Analogues. Future Pharmacology 2:2, pages 160-197.
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Christel A. S. Bergström & René Holm. 2022. Oral Drug Delivery for Modified Release Formulations. Oral Drug Delivery for Modified Release Formulations 87 102 .
Andaleeb Sajid, Sabrina Lusvarghi & Suresh V. Ambudkar. 2022. Drug Transporters. Drug Transporters 199 211 .
Nermin E. Eleraky, Mahmoud M. Omar, Hemat A. Mahmoud & Heba A. Abou-Taleb. (2020) Nanostructured Lipid Carriers to Mediate Brain Delivery of Temazepam: Design and In Vivo Study. Pharmaceutics 12:5, pages 451.
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Sahar A. Harby, Rasha A. Nassra, Jaidaa F. Mekky, Samia M. Ali & Cherine A. Ismail. (2020) Correlation of levetiracetam concentration in peripheral blood mononuclear cells with clinical efficacy: A sensitive monitoring biomarker in patients with epilepsy. Seizure 78, pages 71-77.
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A. S. Moskalev, E. M. Barysheva, V. O. Soldatov, O. G. Frolova, O. V. Bobyntseva, T. A. Samgina, M. I. Churnosov, V. P. Ivanov, A. V. Polonikov & O. Yu. Bushueva. (2020) Association of C3435T (rs1045642) Polymorphism of the MDR1 Gene with the Increased Risk of Colorectal Cancer in Russian Females from Central Russia. Russian Journal of Genetics 55:12, pages 1514-1519.
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Clarissa Feltrin & Cláudia Maria Oliveira Simões. (2019) Reviewing the mechanisms of natural product-drug interactions involving efflux transporters and metabolic enzymes. Chemico-Biological Interactions 314, pages 108825.
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Yuhua Li, Qiang Meng, Mengbi Yang, Dongyang Liu, Xiangyu Hou, Lan Tang, Xin Wang, Yuanfeng Lyu, Xiaoyan Chen, Kexin Liu, Ai-Ming Yu, Zhong Zuo & Huichang Bi. (2019) Current trends in drug metabolism and pharmacokinetics. Acta Pharmaceutica Sinica B 9:6, pages 1113-1144.
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Luping Zhou, Lulu Chen, Yaqin Wang, Jie Huang, Guoping Yang, Zhirong Tan, Yicheng Wang, Jianwei Liao, Gan Zhou, Kai Hu, Zhenyu Li & Dongsheng Ouyang. (2019) Impact of NR1I2, adenosine triphosphate–binding cassette transporters genetic polymorphisms on the pharmacokinetics of ginsenoside compound K in healthy Chinese volunteers. Journal of Ginseng Research 43:3, pages 460-474.
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Xiangyang Li, Jianxin Yang, Yijie Qiao, Yabin Duan, Yuanyao Xin, Yongqiong Nian, Lin Zhu & Guiqin Liu. (2019) Effects of Radiation on Drug Metabolism: A Review. Current Drug Metabolism 20:5, pages 350-360.
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Yang Mai, Liu Dou, Christine M. Madla, Sudaxshina Murdan & Abdul W. Basit. (2019) Sex-Dependence in the Effect of Pharmaceutical Excipients: Polyoxyethylated Solubilising Excipients Increase Oral Drug Bioavailability in Male but Not Female Rats. Pharmaceutics 11:5, pages 228.
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Xin Tian, Yuanyuan Chang, Jingyao Wei, Ruijuan Liu, Li Wang, Ji Zhang & Xiaojian Zhang. (2019) Baicalin reduces ciclosporin bioavailability by inducing intestinal p-glycoprotein in rats. Journal of Pharmacy and Pharmacology 71:5, pages 788-796.
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Xu Zhang, Xiao Cheng, Yali Wu, Di Feng, Yifan Qian, Liping Chen, Bo Yang & Mancang Gu. (2019) In Vitro and In Situ Characterization of the Intestinal Absorption of Capilliposide B and Capilliposide C from Lysimachia capillipes Hemsl. Molecules 24:7, pages 1227.
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Wei Xiong, Guan Ding Zhao, Xunqing Yin, Ke Gang Linghu, John M.T. Chu, Gordon T.C. Wong, Haifeng Li, Hua Yu & Yi Tao Wang. (2019) Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations. Carbohydrate Polymers 204, pages 89-96.
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Jyothshna Devi Katamreddy, Prasanna Raju Yalavarthi, Subba Rao D, Sowjanya Battu & Jaya Preethi Peesa. (2018) Biopharmaceutical insights of particulate emulsified systems - a prospective overview. Lipids in Health and Disease 17:1.
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Liu Dou, Yang Mai, Christine M. Madla, Mine Orlu & Abdul W. Basit. (2018) P-glycoprotein expression in the gastrointestinal tract of male and female rats is influenced differently by food. European Journal of Pharmaceutical Sciences 123, pages 569-575.
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Jessica Cusato, Amedeo De Nicolò, Lucio Boglione, Fabio Favata, Alessandra Ariaudo, Simone Mornese Pinna, Chiara Carcieri, Federica Guido, Valeria Avataneo, Giuseppe Cariti, Giovanni Di Perri & Antonio D’Avolio. (2018) Pharmacogenetics of the anti-HCV drug sofosbuvir: a preliminary study. Journal of Antimicrobial Chemotherapy 73:6, pages 1659-1664.
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Ahmed A. Abdulhussein Al-Ali, Jeffrey Rong Chao Quach, Christoffer Bundgaard, Bente Steffansen, René Holm & Carsten Uhd Nielsen. (2018) Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague-Dawley rats. International Journal of Pharmaceutics 543:1-2, pages 352-360.
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Zohaib Ahmed Bhutto, Fang He, Mire Zloh, Jing Yang, Jinhu Huang, Tingting Guo & Liping Wang. (2018) Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken. Scientific Reports 8:1.
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K.K. Wolf & M.F. Paine. 2018. Comprehensive Toxicology. Comprehensive Toxicology 74 98 .
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Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 331 346 .
Sarah Allegra, Giovanna Fatiguso, Andrea Calcagno, Lorena Baietto, Ilaria Motta, Fabio Favata, Jessica Cusato, Stefano Bonora, Giovanni Di Perri & Antonio D’Avolio. (2017) Role of vitamin D pathway gene polymorphisms on rifampicin plasma and intracellular pharmacokinetics. Pharmacogenomics 18:9, pages 865-880.
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Yuanjin Zhang, Zhiyang Zeng, Junfang Zhao, Dali Li, Mingyao Liu & Xin Wang. (2016) Measurement of Rhodamine 123 in Three-Dimensional Organoids: A Novel Model for P-Glycoprotein Inhibitor Screening. Basic & Clinical Pharmacology & Toxicology 119:4, pages 349-352.
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Shinhee Park, Sunny Lihua Cheng & Julia Yue Cui. (2016) Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine. Acta Pharmaceutica Sinica B 6:5, pages 475-491.
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Maite R. Arana, Guillermo N. Tocchetti, Juan P. Rigalli, Aldo D. Mottino & Silvina S.M. Villanueva. (2016) Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Impact on its function as membrane barrier. Pharmacological Research 109, pages 32-44.
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Sheila Annie Peters, Christopher R. Jones, Anna-Lena Ungell & Oliver J. D. Hatley. (2016) Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models. Clinical Pharmacokinetics 55:6, pages 673-696.
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C. D. van Beusekom, R. Lange & J. A. Schrickx. (2016) A functional model for feline P-glycoprotein. Journal of Veterinary Pharmacology and Therapeutics 39:1, pages 95-97.
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Natalícia de Jesus Antunes, Lauro Wichert-Ana, Eduardo Barbosa Coelho, Oscar Della Pasqua, Veriano Alexandre Junior, Osvaldo Massaiti Takayanagui, Eduardo Tozatto, Maria Paula Marques & Vera Lucia Lanchote. (2015) Influence of verapamil on the pharmacokinetics of oxcarbazepine and of the enantiomers of its 10-hydroxy metabolite in healthy volunteers. European Journal of Clinical Pharmacology 72:2, pages 195-201.
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