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Assessment of the metabolism of therapeutic proteins and antibodies

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Jay Tibbitts, David Canter, Ryan Graff, Alison Smith & Leslie A. Khawli. (2016) Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development. mAbs 8:2, pages 229-245.
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Khandoker Asiqur Rahaman, Anca Raluca Muresan, Hophil Min, Junghyun Son, Min-Jung Kang & Oh-Seung Kwon. (2022) An approach for identifying in silico peptides against authentic metabolites: in vitro characterization of thymosin β4 metabolites. Journal of Pharmaceutical Investigation 52:5, pages 611-621.
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Wenying Jian, Cong Wei & and Jinping Gan. 2022. Bioanalytical Aspects in Biological Therapeutics. Bioanalytical Aspects in Biological Therapeutics 277 307 .
Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu & Xiaochun Zhu. (2022) A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation. Drug Metabolism and Disposition 50:6, pages 846-857.
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Marie de Bourayne, Sylvain Meunier, Samuel Bitoun, Evelyne Correia, Xavier Mariette, Hervé Nozach & Bernard Maillère. (2022) Pegylation Reduces the Uptake of Certolizumab Pegol by Dendritic Cells and Epitope Presentation to T-Cells. Frontiers in Immunology 13.
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Esther Kuilamu, Christopher Subasic, Gary J Cowin, Fiona Simpson, Rodney F Minchin & Lisa M Kaminskas. (2020) Cetuximab Exhibits Sex Differences in Lymphatic Exposure after Intravenous Administration in Rats in the Absence of Differences in Plasma Exposure. Pharmaceutical Research 37:11.
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Yue Huang, Christopher J. Del Nagro, Kemal Balic, William R. MylottJr.Jr., Omnia A. Ismaiel, Eric Ma, Morse Faria, Aaron M. Wheeler, Moucun Yuan, Michael P. Waldron, Marlking G. Peay, Diego F. Cortes, Lorin Roskos, Meina Liang & Anton I. Rosenbaum. (2020) Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody–Drug Conjugate. Analytical Chemistry 92:16, pages 11135-11144.
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Xiang Yu, Arthur Fridman, Ansuman Bagchi, Shiyao Xu, Kristen A. Kwasnjuk, Ping Lu & Mark T. Cancilla. (2020) Metabolite Identification of Therapeutic Peptides and Proteins by Top-down Differential Mass Spectrometry and Metabolite Database Matching. Analytical Chemistry 92:12, pages 8298-8305.
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Hussein M. Abdallah & Andy Z.X. Zhu. (2019) A Minimal Physiologically‐Based Pharmacokinetic Model Demonstrates Role of the Neonatal Fc Receptor (FcRn) Competition in Drug–Disease Interactions With Antibody Therapy. Clinical Pharmacology & Therapeutics 107:2, pages 423-434.
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Mark Ma, Kelly Colletti, Tong-Yuan Yang, Sheldon Leung, Susan Pederson, Charles S Hottenstein, Xiaohui Xu, Dominic Warrino & Eric Wakshull. (2019) Bioanalytical challenges and unique considerations to support pharmacokinetic characterization of bispecific biotherapeutics. Bioanalysis 11:5, pages 427-435.
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Cong Wei, Dian Su, Jian Wang, Wenying Jian & Donglu Zhang. (2018) LC–MS Challenges in Characterizing and Quantifying Monoclonal Antibodies (mAb) and Antibody-Drug Conjugates (ADC) in Biological Samples. Current Pharmacology Reports 4:1, pages 45-63.
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Parul Gupta, Jo-Ann Wentland, Mauricio Leal, Dangshe Ma, Rachel Roach, Antonio Esparza, Lindsay King, Mary E. Spilker, Cedo Bagi, Christopher T. Winkelmann & Anand Giddabasappa. (2017) Assessment of near-infrared fluorophores to study the biodistribution and tumor targeting of an IL13 receptor α2 antibody by fluorescence molecular tomography. Oncotarget 8:34, pages 57231-57245.
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Yongjun Xue, Priya Sriraman, Matthew V. Myers, Xiaomin Wang, Jian Chen, Brian Melo, Martha Vallejo, Stephen E. Maxwell & Sekhar Surapaneni. 2017. Protein Analysis using Mass Spectrometry. Protein Analysis using Mass Spectrometry 183 201 .
Majlinda Kullolli, Dan A. Rock & Ji Ma. (2016) Immuno-affinity Capture Followed by TMPP N-Terminus Tagging to Study Catabolism of Therapeutic Proteins. Journal of Proteome Research 16:2, pages 911-919.
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Jean Cornier, Andrew Owen, Arno Kwade & Marcel Van de Voorde. 2017. Pharmaceutical Nanotechnology: Innovation and Production. Pharmaceutical Nanotechnology: Innovation and Production 231 270 .
Manfred Zell, Christophe Husser, Roland F. Staack, Gregor Jordan, Wolfgang F. Richter, Simone Schadt & Axel Pähler. (2016) In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA. Analytical Chemistry 88:23, pages 11670-11677.
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Dhaval K. Shah. (2015) Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics. Journal of Pharmacokinetics and Pharmacodynamics 42:5, pages 553-571.
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E V Gurevich & V V Gurevich. (2015) Beyond traditional pharmacology: new tools and approaches. British Journal of Pharmacology 172:13, pages 3229-3241.
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