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Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity

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John C. Lindon. 2018. Modern Magnetic Resonance. Modern Magnetic Resonance 2163 2187 .
David J. Craik & Hayden Peacock. 2018. Modern Magnetic Resonance. Modern Magnetic Resonance 1971 1981 .
Weiping Zhang, Lihong Chen, Hui Feng, Wei Wang, Yi Cai, Fen Qi, Xiaofang Tao, Jun Liu, Yujun Shen, Xiaofei Ren, Xi Chen, Jianming Xu & Yuxian Shen. (2017) Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response. Free Radical Biology and Medicine 112, pages 24-35.
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David J Craik & Hayden Peacock. 2017. Modern Magnetic Resonance. Modern Magnetic Resonance 1 11 .
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