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Detecting reactive drug metabolites for reducing the potential for drug toxicity

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Chaitanya K. Jaladanki, Anuj Gahlawat, Gajanan Rathod, Hardeep Sandhu, Kousar Jahan & Prasad V. Bharatam. (2020) Mechanistic studies on the drug metabolism and toxicity originating from cytochromes P450. Drug Metabolism Reviews 52:3, pages 366-394.
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Chunyong He & Hong Wan. (2018) Drug metabolism and metabolite safety assessment in drug discovery and development. Expert Opinion on Drug Metabolism & Toxicology 14:10, pages 1071-1085.
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Fan He, Fenglian Zeng, Xiaohong Situ, Runmin He, Wei Zheng, Yongzhuang Chen, Dinghong Ou & Yilu Chen. (2023) Detection and identification of imperatorin metabolites in rat, dog, monkey, and human liver microsomes by ultra‐high‐performance liquid chromatography combined with high‐resolution mass spectrometry and Compound Discoverer software. Biomedical Chromatography.
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Chunyong He, Yuchang Mao & Hong Wan. (2023) Preclinical evaluation of chemically reactive metabolites and mitigation of bioactivation in drug discovery. Drug Discovery Today 28:7, pages 103621.
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Aizhen Hu, Qingwang Liu & Jing Ouyang. (2022) Identification and characterization of the metabolites of moscatilin in mouse, rat, dog, monkey and human hepatocytes by LC–Orbitrap–MS/MS combined with diagnostic fragment ions and accurate mass measurements. Biomedical Chromatography 37:4.
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Min Liu, Jie Jiang, Jie Zheng, Tao Huan, Bei Gao, Xunchang Fei, Yulan Wang & Mingliang Fang. (2021) RTP: One Effective Platform to Probe Reactive Compound Transformation Products and Its Applications for a Reactive Plasticizer BADGE. Environmental Science & Technology 55:23, pages 16034-16043.
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Qingping Wang & Chuang Lu. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 207 233 .
Noah R. Flynn, Michael D. Ward, Mary A. Schleiff, Corentine M. C. Laurin, Rohit Farmer, Stuart J. Conway, Gunnar Boysen, S. Joshua Swamidass & Grover P. Miller. (2021) Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors. Metabolites 11:6, pages 390.
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Agnieszka Potęga, Szymon Paczkowski, Ewa Paluszkiewicz & Zofia Mazerska. (2021) Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053. Journal of Pharmaceutical and Biomedical Analysis 197, pages 113970.
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Grzegorz M. Popowicz. 2021. Encyclopedia of Molecular Pharmacology. Encyclopedia of Molecular Pharmacology 1169 1179 .
André Guillouzo & Christiane Guguen-Guillouzo. (2020) Antibiotics-induced oxidative stress. Current Opinion in Toxicology 20-21, pages 23-28.
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Na Liu, Hongqiang Liu, Wucheng Zhang & Huijie Yao. (2020) Metabolic profiles of ribociclib in rat and human liver microsomes using liquid chromatography combined with electrospray ionization high‐resolution mass spectrometry. Biomedical Chromatography 34:3.
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Zi-Tian WU, Zhuo-Qing LI, Wei SHI, Ling-Li WANG, Yan JIANG, Ping LI & Hui-Jun LI. (2020) The crucial role of metabolic regulation in differential hepatotoxicity induced by furanoids in Dioscorea bulbifera. Chinese Journal of Natural Medicines 18:1, pages 57-69.
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Kaushik Mitra. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters 487 506 .
Grzegorz M. Popowicz. 2020. Encyclopedia of Molecular Pharmacology. Encyclopedia of Molecular Pharmacology 1 10 .
Yi-Kun Wang, Xiao-Nan Yang, Xu Zhu, Xue-Rong Xiao, Xiu-Wei Yang, Hong-Bo Qin, Frank J. Gonzalez & Fei Li. (2019) Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity. Journal of Agricultural and Food Chemistry 67:29, pages 8243-8252.
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Carlotta Figliola, Estelle Marchal, Brandon R. Groves & Alison Thompson. (2019) A step-wise synthetic approach is necessary to access γ-conjugates of folate: folate-conjugated prodigiosenes. RSC Advances 9:25, pages 14078-14092.
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Qingping Wang, Hanlan Liu, Marina Slavsky, Maria Fitzgerald, Chuang Lu & Thomas O'Shea. (2019) A high-throughput glutathione trapping assay with combined high sensitivity and specificity in high-resolution mass spectrometry by applying product ion extraction and data-dependent neutral loss. Journal of Mass Spectrometry 54:2, pages 158-166.
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Robert L. Smith, Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, Stephen S. Hecht, F. Peter Guengerich, Ivonne M. C. M. Rietjens, Maria Bastaki, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2018) The safety evaluation of food flavouring substances: the role of metabolic studies. Toxicology Research 7:4, pages 618-646.
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Ana L.A. Godinho, Inês L. Martins, João Nunes, Catarina Charneira, Jorge Grilo, Diogo M. Silva, Sofia A. Pereira, Karina Soto, M. Conceição Oliveira, M. Matilde Marques, Cristina C. Jacob & Alexandra M.M. Antunes. (2018) High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches. European Journal of Pharmaceutical Sciences 119, pages 70-82.
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Alf Claesson & Alexander Minidis. (2018) Systematic Approach to Organizing Structural Alerts for Reactive Metabolite Formation from Potential Drugs. Chemical Research in Toxicology 31:6, pages 389-411.
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Phil Jeffrey & Scott Summerfield. 2017. Pharmacology for Chemists: Drug Discovery in Context. Pharmacology for Chemists: Drug Discovery in Context 316 342 .
Tomoko Ogiyama, Mitsuhiro Yamaguchi, Nobuya Kurikawa, Shoko Honzumi, Koji Terayama, Nobumi Nagaoka, Yuka Yamamoto, Takako Kimura, Daisuke Sugiyama & Shin-ichi Inoue. (2017) Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor. Bioorganic & Medicinal Chemistry 25:17, pages 4817-4828.
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Jasleen Sodhi, Erlie Delarosa, Jason Halladay, James Driscoll, Teresa Mulder, Patrick Dansette & S. Khojasteh. (2017) Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms. International Journal of Molecular Sciences 18:7, pages 1553.
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Ravikiran Yerabolu, John Kong, Mckay Easton, Raghavendhar R. Kotha, Joann Max, Huaming Sheng, Minli Zhang, Chungang Gu & Hilkka I. Kenttämaa. (2017) Identification of Protonated Sulfone and Aromatic Carboxylic Acid Functionalities in Organic Molecules by Using Ion–Molecule Reactions Followed by Collisionally Activated Dissociation in a Linear Quadrupole Ion Trap Mass Spectrometer. Analytical Chemistry 89:14, pages 7398-7405.
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Andreas Brink, Axel P?hler, Christoph Funk, Franz Schuler & Simone Schadt. (2017) Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design. Drug Discovery Today 22:5, pages 751-756.
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Na Le Dang, Tyler B. Hughes, Grover P. Miller & S. Joshua Swamidass. (2017) Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes. Chemical Research in Toxicology 30:4, pages 1046-1059.
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Tomoko Ogiyama, Mitsuhiro Yamaguchi, Nobuya Kurikawa, Shoko Honzumi, Yuka Yamamoto, Daisuke Sugiyama, Hideo Takakusa & Shin-ichi Inoue. (2017) Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation. Bioorganic & Medicinal Chemistry 25:7, pages 2234-2243.
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Richard A. Thompson, Emre M. Isin, Monday O. Ogese, Jerome T. Mettetal & Dominic P. Williams. (2016) Reactive Metabolites: Current and Emerging Risk and Hazard Assessments. Chemical Research in Toxicology 29:4, pages 505-533.
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