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Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review

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Miao Yan, Wenqun Li, Wen-Bo Li, Qi Huang, Jing Li, Hua-Lin Cai, Hui Gong, Bi-Kui Zhang & Yi-Kun Wang. (2023) Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice. Drug Metabolism Reviews 55:1-2, pages 94-106.
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Haochen Jiang, Ying Jin, Hao Yan, Zhifei Xu, Bo Yang, Qiaojun He & Peihua Luo. (2021) Hepatotoxicity of FDA-approved small molecule kinase inhibitors. Expert Opinion on Drug Safety 20:3, pages 335-348.
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Gloria Ravegnini, Giorgia Valori, Qianqian Zhang, Riccardo Ricci, Patrizia Hrelia & Sabrina Angelini. (2020) Pharmacogenetics in the treatment of gastrointestinal stromal tumors – an updated review. Expert Opinion on Drug Metabolism & Toxicology 16:9, pages 797-808.
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S. Cyrus Khojasteh, James P. Driscoll, Klarissa D. Jackson, Grover P. Miller, Kaushik Mitra, Ivonne M. C. M Rietjens & Donglu Zhang. (2020) Novel advances in biotransformation and bioactivation research—2019 year in review. Drug Metabolism Reviews 52:3, pages 333-365.
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Jonathan G. Stine & James H. Lewis. (2016) Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review. Expert Review of Gastroenterology & Hepatology 10:4, pages 517-536.
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Yee Hui Yeo, Walid Ayoub, Ju Dong Yang, Alexander Kuo & Hirsh D. Trivedi. (2023) Beyond the Checkpoint: Severe Axitinib-induced Liver Injury. ACG Case Reports Journal 10:11, pages e01177.
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Bethany D. Latham, D. Spencer Oskin, Rachel D. Crouch, Matthew J. Vergne & Klarissa D. Jackson. (2022) Cytochromes P450 2C8 and 3A Catalyze the Metabolic Activation of the Tyrosine Kinase Inhibitor Masitinib. Chemical Research in Toxicology 35:9, pages 1467-1481.
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Qi Zhao, Zhanxuan E. Wu, Bin Li & Fei Li. (2022) Recent advances in metabolism and toxicity of tyrosine kinase inhibitors. Pharmacology & Therapeutics 237, pages 108256.
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Zhe Wang, Xiaoyu Wang, Zhen Wang, Yuyi Feng, Yaqin Jia, Lili Jiang, Yangliu Xia, Jun Cao & Yong Liu. (2021) Comparison of Hepatotoxicity Associated With New BCR-ABL Tyrosine Kinase Inhibitors vs Imatinib Among Patients With Chronic Myeloid Leukemia. JAMA Network Open 4:7, pages e2120165.
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James H. Lewis, Hans Gelderblom, Michiel Sande, Silvia Stacchiotti, John H. Healey, William D. Tap, Andrew J. Wagner, Antonio Lopez Pousa, Mihaela Druta, Chia-Chi Lin, Hideo A. Baba, Youngsook Choi, Qiang Wang, Dale E. Shuster & Sebastian Bauer. (2021) Pexidartinib Long-Term Hepatic Safety Profile in Patients with Tenosynovial Giant Cell Tumors. The Oncologist 26:5, pages e863-e873.
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Camille Houron, Marie Danielou, Olivier Mir, Bernard Fromenty, Gabriel Perlemuter & Cosmin Sebastian Voican. (2021) Multikinase inhibitor-induced liver injury in patients with cancer: A review for clinicians. Critical Reviews in Oncology/Hematology 157, pages 103127.
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Hong Huang, Xue Bai & Lijun Yang. (2020) Intriguing generative metabolism discovery of reactive metabolite nitroso of lapatinib and relevant structural modification. International Journal of Quantum Chemistry 120:12.
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Wimonchat Tangamornsuksan, Chuenjid Kongkaew, C. N. Scholfield, Suphat Subongkot & Manupat Lohitnavy. (2019) HLA-DRB1*07:01 and lapatinib-induced hepatotoxicity: a systematic review and meta-analysis. The Pharmacogenomics Journal 20:1, pages 47-56.
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Jin Young Moon, Ji Min Han, Inyoung Seo & Hye Sun Gwak. (2019) Risk factors associated with the incidence and time to onset of lapatinib-induced hepatotoxicity. Breast Cancer Research and Treatment 178:1, pages 239-244.
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Marie‐Noëlle Paludetto, Florent Puisset, Etienne Chatelut & Cécile Arellano. (2019) Identifying the reactive metabolites of tyrosine kinase inhibitors in a comprehensive approach: Implications for drug‐drug interactions and hepatotoxicity. Medicinal Research Reviews 39:6, pages 2105-2152.
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Alberto Carretero-González, Javier Salamanca Santamaría, Daniel Castellano & Guillermo de Velasco. (2019) Three case reports. Medicine 98:47, pages e18098.
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Artem Lysenko, Alok Sharma, Keith A Boroevich & Tatsuhiko Tsunoda. (2018) An integrative machine learning approach for prediction of toxicity-related drug safety. Life Science Alliance 1:6, pages e201800098.
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Verena Schöning, Stephan Krähenbühl & Jürgen Drewe. (2018) The hepatotoxic potential of protein kinase inhibitors predicted with Random Forest and Artificial Neural Networks. Toxicology Letters 299, pages 145-148.
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Jun Zhang, Lijun Ren, Xi Yang, Matthew White, James Greenhaw, Tashika Harris, Qiangen Wu, Matthew Bryant, Thomas Papoian, William Mattes & Qiang Shi. (2018) Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicology Letters 291, pages 138-148.
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Dominique Béchade, Camille Chakiba, Marie Desjardin, Yves Bécouarn & Marianne Fonck. (2018) Toxicité hépatique des inhibiteurs des tyrosines kinases : mécanismes en cause et conséquences pratiques. Bulletin du Cancer 105:3, pages 290-298.
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Cécile Mingard, Franziska Paech, Jamal Bouitbir & Stephan Krähenbühl. (2018) Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines. Journal of Applied Toxicology 38:3, pages 418-431.
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Nelia Hernandez. (2017) Hepatotoxicity of New Antitumor Agents. Current Hepatology Reports 16:4, pages 293-297.
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Jun Zhang, Alec Salminen, Xi Yang, Yong Luo, Qiangen Wu, Matthew White, James Greenhaw, Lijun Ren, Matthew Bryant, William Salminen, Thomas Papoian, William Mattes & Qiang Shi. (2016) Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria. Archives of Toxicology 91:8, pages 2921-2938.
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Franziska Paech, Jamal Bouitbir & Stephan Krähenbühl. (2017) Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis. Frontiers in Pharmacology 8.
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Ivo Vrobel, David Friedecký, Edgar Faber, Lukáš Najdekr, Kateřina Mičová, Radana Karlíková & Tomáš Adam. (2017) Novel sulphur-containing imatinib metabolites found by untargeted LC-HRMS analysis. European Journal of Pharmaceutical Sciences 104, pages 335-343.
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Chalermrat Bunchorntavakul & K. Rajender Reddy. (2017) Drug Hepatotoxicity. Clinics in Liver Disease 21:1, pages 115-134.
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Tamara Alempijevic, Simon Zec & Tomica Milosavljevic. (2017) Drug-induced liver injury: Do we know everything?. World Journal of Hepatology 9:10, pages 491.
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Jacqueline L. Olin, J. Andrew Woods & Stuart J. Garner. (2017) Delayed Presentation of Hepatocellular Liver Injury After Nintedanib Administration. American Journal of Therapeutics 24:1, pages e107-e108.
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Kai Qu, Tian Liu, Ting Lin, Xing Zhang, Ruixia Cui, Sinan Liu, Fandi Meng, Jingyao Zhang, Minghui Tai, Yong Wan & Chang Liu. (2016) Tyrosine kinase inhibitors: friends or foe in treatment of hepatic fibrosis?. Oncotarget 7:41, pages 67650-67660.
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Yakov M. Koen, Nadezhda A. Galeva, Imir G. Metushi, Jack Uetrecht & Robert P. Hanzlik. (2016) Protein Targets of Isoniazid-Reactive Metabolites in Mouse Liver in Vivo . Chemical Research in Toxicology 29:6, pages 1064-1072.
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Emanuel Raschi. (2015) Drug- and herb-induced liver injury: Progress, current challenges and emerging signals of post-marketing risk. World Journal of Hepatology 7:13, pages 1761.
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Maria Salvado. (2015) Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient. World Journal of Gastroenterology 21:36, pages 10475.
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