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Drug Evaluation

Tocilizumab for treating rheumatoid arthritis: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy

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Monika Tomaszewska-Kiecana, Martin Ullmann, Corinne Petit-Frere, Joëlle Monnet, Christos Dagres & Andras Illes. (2023) Pharmacokinetics of a proposed tocilizumab biosimilar (MSB11456) versus US-licensed tocilizumab: results of a randomized, double-blind, single-intravenous dose study in healthy adults. Expert Review of Clinical Immunology 19:4, pages 439-446.
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Stephanie Si & David T Teachey. (2020) Spotlight on Tocilizumab in the Treatment of CAR-T-Cell-Induced Cytokine Release Syndrome: Clinical Evidence to Date. Therapeutics and Clinical Risk Management 16, pages 705-714.
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Karin A van Schie, Gerrit-Jan Wolbink & Theo Rispens. (2015) Cross-reactive and pre-existing antibodies to therapeutic antibodies—Effects on treatment and immunogenicity. mAbs 7:4, pages 662-671.
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Articles from other publishers (27)

Kenji Takami & Shigeyoshi Tsuji. (2023) Real-world retention rates of biologics in patients with rheumatoid arthritis. Scientific Reports 13:1.
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Hongtao Guo, Li Li, Bin Liu, Peipei Lu, Zhiwen Cao, Xinyu Ji, Li Li, Guilin Ouyang, Zhixin Nie, Aiping Lyu & Cheng Lu. (2023) Inappropriate treatment response to DMARDs: A pathway to difficult-to-treat rheumatoid arthritis. International Immunopharmacology 122, pages 110655.
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Abdul Naeem, Lubna Meraj, Nadia Shams, Mehr Fatima Rizvi, Muhammad Kamal & Muhammad Amir. (2023) Effectiveness of Tocilizumab in reducing inflammatory response associated with COVID-19 pneumonia at Islamabad Medical Complex, Islamabad. Journal of Rawalpindi Medical College 27:1.
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Xiaoran Cui, Jinko Sawashita, Jian Dai, Chang Liu, Yuichi Igarashi, Masayuki Mori, Hiroki Miyahara & Keiichi Higuchi. (2022) Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway. Disease Models & Mechanisms 15:3.
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Wael Hafez, Mohamad Azzam Ziade, Arun Arya, Husam Saleh, Mahmoud Abdelshakor, Osman Fadl Alla, Pragati Agrawal, Sara Ali, Srinivasa Raghu Rao, Subrata Gupta, Ikram Abdelli, Honeymol Sebastian, Mohamed Ali, Muneir Gador, Ziad Al Baha & Ahmed Abdelrahman. (2022) Treatment Outcomes of Tocilizumab in Critically-Ill COVID-19 Patients, Single-Centre Retrospective Study. Antibiotics 11:2, pages 241.
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Ming-Yue Wu, Er-Jin Wang, Du Feng, Min Li, Richard D. Ye & Jia-Hong Lu. (2021) Pharmacological insights into autophagy modulation in autoimmune diseases. Acta Pharmaceutica Sinica B 11:11, pages 3364-3378.
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Justyna Olszewska-Parasiewicz, Łukasz Szarpak, Sylwester Rogula, Aleksandra Gąsecka, Urszula Szymańska, Maria Kwiatkowska, Milosz J. Jaguszewski, Radosław Sierpiński, Artur Zaczyński, Waldemar Wierzba & Dariusz A. Kosior. (2021) Statins in COVID-19 Therapy. Life 11:6, pages 565.
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Linlin Chen, Hong Zhang, Mengyi Chi, Quanjun Yang & Cheng Guo. 2021. Background and Management of Muscular Atrophy. Background and Management of Muscular Atrophy.
Ricardo de las Cuevas Allende, Lucía Díaz de Entresotos & Susana Conde Díez. (2021) Anemia de las enfermedades crónicas: fisiopatología, diagnóstico y tratamiento. Medicina Clínica 156:5, pages 235-242.
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Ricardo de las Cuevas Allende, Lucía Díaz de Entresotos & Susana Conde Díez. (2021) Anaemia of chronic diseases: Pathophysiology, diagnosis and treatment. Medicina Clínica (English Edition) 156:5, pages 235-242.
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Marie Lund Bay, Sarah Heywood, Anne‐Sophie Wedell‐Neergaard, Tim Schauer, Louise Lang Lehrskov, Regitse Højgaard Christensen, Grit Elster Legård, Peter Østrup Jensen, Rikke Krogh‐Madsen & Helga Ellingsgaard. (2020) Human immune cell mobilization during exercise: effect of IL‐6 receptor blockade. Experimental Physiology 105:12, pages 2086-2098.
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Chu Lin, Hongyu Ji, Xiaoling Cai, Wenjia Yang, Fang Lv & Linong Ji. (2020) The association between the biological disease-modifying anti-rheumatic drugs and the incidence of diabetes: A systematic review and meta-analysis. Pharmacological Research 161, pages 105216.
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Louise L Lehrskov, Sasha Kjeldsen, Mark P Lyngbæk, Regitse Højgaard Chirstensen, Anne-Sophie Wedell-Neergaard, Line Søderlund, Niklas Rye Jørgensen, Rikke Krogh-Madsen, Nicolai J Wewer Albrechtsen & Helga Ellingsgaard. (2020) Interleukin-6 May Not Affect Bone Resorption Marker CTX or Bone Formation Marker P1NP in Humans. Journal of the Endocrine Society 4:9.
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Hamidreza Samaee, Monireh Mohsenzadegan, Shahram Ala, Shahnam Sedigh Maroufi & Parisa Moradimajd. (2020) Tocilizumab for treatment patients with COVID-19: recommended medication for novel disease. International Immunopharmacology, pages 107018.
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Louise Lang Lehrskov, Regitse Højgaard Christensen, Anne-Sophie Wedell-Neergaard, Grit Elster Legaard, Emma Dorph, Monica Korsager Larsen, Marie Henneberg, Natja Launbo, Sabrina Ravn Fagerlind, Sidsel Kofoed Seide, Stine Nymand, Maria Ball, Nicole Vinum, Camilla Dahl, Nicolai Jacob Wewer Albrechtsen, Jens Juul Holst, Mathias Ried-Larsen, Jaya Birgitte Rosenmeier, Rikke Krogh-Madsen, Kristian Karstoft, Bente Klarlund Pedersen & Helga Ellingsgaard. (2019) Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial. Frontiers in Physiology 10.
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Alberto Jiménez Morales, Mar Maldonado-Montoro, Juan Enrique Martínez de la Plata, Cristina Pérez Ramírez, Abdelali Daddaoua, Carolina Alarcón Payer, Manuela Expósito Ruiz & Carlos García Collado. (2019) FCGR2A/FCGR3A Gene Polymorphisms and Clinical Variables as Predictors of Response to Tocilizumab and Rituximab in Patients With Rheumatoid Arthritis. The Journal of Clinical Pharmacology 59:4, pages 517-531.
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Yan Xu, Chuanpu Hu, Yanli Zhuang, Benjamin Hsu, Zhenhua Xu & Honghui Zhou. (2018) Confirmatory Population Pharmacokinetic Analysis for Sirukumab, a Human Monoclonal Antibody Targeting Interleukin-6, in Patients With Moderately to Severely Active Rheumatoid Arthritis. The Journal of Clinical Pharmacology 58:7, pages 939-951.
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Hwiwon Lee, Suk Ho Bhang, Jeong Ho Lee, Hyemin Kim & Sei Kwang Hahn. (2017) Tocilizumab–Alendronate Conjugate for Treatment of Rheumatoid Arthritis. Bioconjugate Chemistry 28:4, pages 1084-1092.
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Debbie M. Roeleveld, Renoud J. Marijnissen, Birgitte Walgreen, Monique M. Helsen, Liduine van den Bersselaar, Fons A. van de Loo, Peter L. van Lent, Peter M. van der Kraan, Wim B. van den Berg & Marije I. Koenders. (2017) Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis. PLOS ONE 12:2, pages e0171757.
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T. Dimitroulas, A. Sandoo, S. Skeoch, M. O’Sullivan, M. Yessirkepov, L. Ayvazyan, A.Y. Gasparyan, G. Metsios & G.D. Kitas. 2017. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases 129 165 .
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M. Lepetit & D.-A. Laplaud. (2016) Effetti collaterali delle bioterapie nella sclerosi multipla e nelle malattie correlate. EMC - Neurologia 16:3, pages 1-10.
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Teresa A. Zimmers, Melissa L. Fishel & Andrea Bonetto. (2016) STAT3 in the systemic inflammation of cancer cachexia. Seminars in Cell & Developmental Biology 54, pages 28-41.
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Weirong Wang, Thomas S. McIntosh, Xiling Jiang, Rajitha Doddareddy, Elayne C. Dell & Honghui Zhou. (2015) Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model. Pharmaceutical Research 33:4, pages 1040-1049.
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Steffanie L. Furtek, Donald S. Backos, Christopher J. Matheson & Philip Reigan. (2016) Strategies and Approaches of Targeting STAT3 for Cancer Treatment. ACS Chemical Biology 11:2, pages 308-318.
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Lifeng Wang, Fu-Sheng Wang & M. Eric Gershwin. (2015) Human autoimmune diseases: a comprehensive update. Journal of Internal Medicine 278:4, pages 369-395.
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Kazuko Uno, Kazuyuki Yoshizaki, Mitsuhiro Iwahashi, Jiro Yamana, Seizo Yamana, Miki Tanigawa & Katsumi Yagi. (2015) Pretreatment Prediction of Individual Rheumatoid Arthritis Patients’ Response to Anti-Cytokine Therapy Using Serum Cytokine/Chemokine/Soluble Receptor Biomarkers. PLOS ONE 10:7, pages e0132055.
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