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Iron-based phosphate binders – a new element in management of hyperphosphatemia

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J. Bover, P. Ureña-Torres, M. J. Lloret, C. Ruiz-García, I. DaSilva, M. M. Diaz-Encarnacion, C. Mercado, S. Mateu, E. Fernández & J. Ballarin. (2016) Integral pharmacological management of bone mineral disorders in chronic kidney disease (part I): from treatment of phosphate imbalance to control of PTH and prevention of progression of cardiovascular calcification. Expert Opinion on Pharmacotherapy 17:9, pages 1247-1258.
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Mark Sampson, Nuno Faria & Jonathan J Powell. (2021) Efficacy and safety of PT20, an iron-based phosphate binder, for the treatment of hyperphosphataemia: a randomized, double-blind, placebo-controlled, dose-ranging, Phase IIb study in patients with haemodialysis-dependent chronic kidney disease. Nephrology Dialysis Transplantation 36:8, pages 1399-1407.
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Min Li, Xianlin Fan, Qian Mao, Qing Li, Xiujuan Zhang, Gaohong He, Shufen Zhang & Wenjun Zhang. (2021) The hollow core-shell ferric oxide entrapped chitosan microcapsules as phosphate binders for phosphorus removal in vitro. Carbohydrate Polymers 257, pages 117621.
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Jürgen Floege. (2019) Phosphate binders in chronic kidney disease: an updated narrative review of recent data. Journal of Nephrology 33:3, pages 497-508.
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Yalda Rahbar Saadat, Bahram Niknafs, Seyed Mahdi Hosseiniyan Khatibi, Mohammadreza Ardalan, Hasan Majdi, Zahra Bahmanpoor, Sima Abediazar & Sepideh Zununi Vahed. (2020) Gut microbiota; an overlooked effect of phosphate binders. European Journal of Pharmacology 868, pages 172892.
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Tomas Ganz, Avi Bino & Isidro B. Salusky. (2019) Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate). Drugs 79:9, pages 957-968.
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Wen Jen Lin & Shu An Lee. (2019) A novel iron-conjugated acid-modified chitosan derivatives as an oral phosphate binding agent to improve phosphorus adsorption efficacy in vitro and in vivo, synthesis and their characterization. Carbohydrate Polymers 212, pages 378-386.
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Guus A. M. Kortman, Dorien Reijnders & Dorine W. Swinkels. (2017) Oral iron supplementation: Potential implications for the gut microbiome and metabolome in patients with CKD. Hemodialysis International 21, pages S28-S36.
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Jung-Heun Ha, Caglar Doguer, Xiaoyu Wang, Shireen R. Flores & James F. Collins. (2016) High-Iron Consumption Impairs Growth and Causes Copper-Deficiency Anemia in Weanling Sprague-Dawley Rats. PLOS ONE 11:8, pages e0161033.
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