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New toxicity profile for novel immunotherapy agents: focus on immune-checkpoint inhibitors

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Anna M Czarnecka & Piotr Rutkowski. (2020) An update on the safety of nivolumab for the treatment of advanced melanoma. Expert Opinion on Drug Safety 19:4, pages 409-421.
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Debora Basile, Silvio Ken Garattini, Marta Bonotto, Elena Ongaro, Mariaelena Casagrande, Monica Cattaneo, Valentina Fanotto, Elisa De Carlo, Fotios Loupakis, Federica Urbano, Francesca V. Negri, Nicoletta Pella, Marco Russano, Oronzo Brunetti, Mario Scartozzi, Daniele Santini, Nicola Silvestris, Andrea Casadei Gardini, Marco Puzzoni, Lorenzo Calvetti, Nadia Cardarelli & Giuseppe Aprile. (2017) Immunotherapy for colorectal cancer: where are we heading?. Expert Opinion on Biological Therapy 17:6, pages 709-721.
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Tomohide Tsukahara, Makoto Emori, Kenji Murata, Emi Mizushima, Yuji Shibayama, Terufumi Kubo, Takayuki Kanaseki, Yoshihiko Hirohashi, Toshihiko Yamashita, Noriyuki Sato & Toshihiko Torigoe. (2016) The future of immunotherapy for sarcoma. Expert Opinion on Biological Therapy 16:8, pages 1049-1057.
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Articles from other publishers (39)

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Matteo Santoni, Javier Molina-Cerrillo, Giorgio Santoni, Elaine T. Lam, Francesco Massari, Veronica Mollica, Giulia Mazzaschi, Bernardo L. Rapoport, Enrique Grande & Sebastiano Buti. (2023) Role of Clock Genes and Circadian Rhythm in Renal Cell Carcinoma: Recent Evidence and Therapeutic Consequences. Cancers 15:2, pages 408.
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Cihan Erol & Mehmet Ali Nahit Sendur. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 13 .
Thomas K. Le, Isabelle Brown, Rebecca Goldberg, Matthew T. Taylor, Junwen Deng, Varsha Parthasarathy, Zachary A. Bordeaux, Martin Prince Alphonse, Madan M. Kwatra, Vivek Naranbhai, Alexander Gusev, Jihad Alhariri, Nicole R. LeBoeuf, Kerry L. Reynolds, Laura C. Cappelli, Jarushka Naidoo, Julie R. Brahmer, Sewon Kang, Yevgeniy R. Semenov & Shawn G. Kwatra. (2022) Cutaneous Toxicities Associated with Immune Checkpoint Inhibitors: An Observational, Pharmacovigilance Study. Journal of Investigative Dermatology 142:11, pages 2896-2908.e4.
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Gianluca Nazzaro, Stefano Buffon, Serena Giacalone, Carlo Alberto Maronese & Angelo Valerio Marzano. (2022) Skin manifestations associated with checkpoint inhibitors. JEADV Clinical Practice 1:2, pages 73-87.
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Wei Yang, Xiaofeng Xu, Dajing Xia, Huaichong Wang, Jing Jiang & Guoliang Yang. (2022) Toxic epidermal necrolysis associated with chemoimmunotherapy for lymphoma: case report and literature review. Immunotherapy 14:5, pages 275-282.
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Yanhong Zhang, Changli Yue, Anna M. Krichevsky & Igor Garkavtsev. (2022) Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD‐L1. Molecular Oncology.
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Xiang Li, Li-Xin Qu, Yu-Mei Ren & Chang Hu. (2021) Case Report: A Case Report and Literature Review on Severe Bullous Skin Reaction Induced by anti-PD-1 Immunotherapy in a Cervical Cancer Patient. Frontiers in Pharmacology 12.
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Silpita Paul & Gaurisankar Sa. (2021) Curcumin as an Adjuvant to Cancer Immunotherapy. Frontiers in Oncology 11.
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Xin Shou, Yuxiao Liu, Dan Wu, Hui Zhang, Yuanjin Zhao, Weijian Sun & Xian Shen. (2021) Black phosphorus quantum dots doped multifunctional hydrogel particles for cancer immunotherapy. Chemical Engineering Journal 408, pages 127349.
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Sabina Y. van der Zanden, Jolien J. Luimstra, Jacques Neefjes, Jannie Borst & Huib Ovaa. (2020) Opportunities for Small Molecules in Cancer Immunotherapy. Trends in Immunology 41:6, pages 493-511.
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Avishek Bhuniya, Ipsita Guha, Nilanjan Ganguly, Akata Saha, Shayani Dasgupta, Partha Nandi, Arnab Das, Sarbari Ghosh, Tithi Ghosh, Enamul Haque, Saptak Banerjee, Anamika Bose & Rathindranath Baral. (2020) NLGP Attenuates Murine Melanoma and Carcinoma Metastasis by Modulating Cytotoxic CD8+ T Cells. Frontiers in Oncology 10.
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Shakuntala H. Mauzo, Michael T. Tetzlaff, Kelly Nelson, Rodabe Amaria, Sapna Patel, Phyu P. Aung, Priyadharsini Nagarajan, Carlos A. Torres‐Cabala, Adi Diab, Victor G. Prieto & Jonathan L. Curry. (2017) Regressed melanocytic nevi secondary to pembrolizumab therapy: an emerging melanocytic dermatologic effect from immune checkpoint antibody blockade. International Journal of Dermatology 58:9, pages 1045-1052.
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Rana Shafabakhsh, Mohammad Hossein Pourhanifeh, Hamid Reza Mirzaei, Amirhossein Sahebkar, Zatollah Asemi & Hamed Mirzaei. (2019) Targeting regulatory T cells by curcumin: A potential for cancer immunotherapy. Pharmacological Research 147, pages 104353.
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Elizabeth A. Blakeway, Noha Elshimy, Andrew Muinonen-Martin, Maria Marples, Bipin Mathew & Angana Mitra. (2019) Cutaneous lupus associated with pembrolizumab therapy for advanced melanoma: a report of three cases. Melanoma Research 29:3, pages 338-341.
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Yajaira Hernandez-SalasPhDPhD, Fernando Hernandez-TeranPhDPhD, Nagamani BalaguramyPhDPhD & Norma De La Fuente-SalcidoPhDPhD. (2019) Alternativa biotecnológica contra el cáncer: Parasporinas de Bacillus thuringiensis. Revista de Ingeniería Biomédica y Biotecnología, pages 8-17.
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John A. ThompsonBryan J. SchneiderJulie BrahmerStephanie AndrewsPhilippe ArmandShailender BhatiaLihua E. BuddeLuciano CostaMarianne DaviesDavid DunningtonMarc S. ErnstoffMatthew FrigaultBrianna HoffnerChristopher J. HoimesMario LacoutureFrederick LockeMatthew LunningNisha A. MohindraJarushka NaidooAnthony J. OlszanskiOlalekan OluwoleSandip P. PatelSunil ReddyMabel RyderBianca SantomassoScott ShoferJeffrey A. SosmanMomen WahidiYinghong Wang, Alyse Johnson-ChillaJillian L. Scavone. (2019) Management of Immunotherapy-Related Toxicities, Version 1.2019, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network 17:3, pages 255-289.
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Yong Li, Xiaosong Li, Austin Doughty, Connor West, Lu wang, Feifan Zhou, Robert E. Nordquist & Wei R. Chen. (2019) Phototherapy using immunologically modified carbon nanotubes to potentiate checkpoint blockade for metastatic breast cancer. Nanomedicine: Nanotechnology, Biology and Medicine.
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Yang Lu. (2019) FDG PET/CT Course of Pembrolizumab-Associated Multiorgan Sarcoidosis. Clinical Nuclear Medicine 44:2, pages 167-168.
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Wenhong Li, Zhigang Wei, Xia Yang, Guanghui Huang, Xiaoying Han, Yang Ni, Jiao Wang, Min Meng, Zhigeng Zou, Qiang Wen & Xin Ye. (2019) Salvage therapy of reactive capillary hemangiomas: Apatinib alleviates the unique adverse events induced by camrelizumab in non-small cell lung cancer. Journal of Cancer Research and Therapeutics 15:7, pages 1624.
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Lauren Penn, Lisa Rothman, Angela M. Sutton, Nooshin K. Brinster & Claudia I. Vidal. (2019) What’s New in Dermatopathology: Inflammatory Dermatoses. Advances in Anatomic Pathology 26:1, pages 40-55.
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Jeffrey Yang & Longqin Hu. (2019) Immunomodulators targeting the PD-1/PD-L1 protein-protein interaction: From antibodies to small molecules. Medicinal Research Reviews 39:1, pages 265-301.
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Michael T. Tetzlaff, Kelly C. Nelson, Adi Diab, Gregg A. Staerkel, Priyadharsini Nagarajan, Carlos A. Torres-Cabala, Beth A. Chasen, Jennifer A. Wargo, Victor G. Prieto, Rodabe N. Amaria & Jonathan L. Curry. (2018) Granulomatous/sarcoid-like lesions associated with checkpoint inhibitors: a marker of therapy response in a subset of melanoma patients. Journal for ImmunoTherapy of Cancer 6:1.
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Antonio Lopez-Beltran, Vanessa Henriques, Alessia Cimadamore, Matteo Santoni, Liang Cheng, Thomas Gevaert, Ana Blanca, Francesco Massari, Marina Scarpelli & Rodolfo Montironi. (2018) The Identification of Immunological Biomarkers in Kidney Cancers. Frontiers in Oncology 8.
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Celestine Trinidad, Kelly C. Nelson, Isabella C. Glitza Oliva, Carlos A. Torres-Cabala, Priyadharsini Nagarajan, Michael T. Tetzlaff, Doina Ivan, Wen-Jen Hwu, Victor G. Prieto, Jonathan L. Curry & Phyu P. Aung. (2018) Dermatologic toxicity from immune checkpoint blockade therapy with an interstitial granulomatous pattern. Journal of Cutaneous Pathology 45:7, pages 504-507.
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Anagha Bangalore Kumar, Rachel Maus & Svetomir N. Markovic. (2018) Pharmacologic Modulation of Human Immunity in the Era of Immuno-oncology: Something Old, Something New. Mayo Clinic Proceedings 93:7, pages 917-936.
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Kimberly Shao, Suzanne McGettigan, Rosalie Elenitsas & Emily Y. Chu. (2018) Lupus-like cutaneous reaction following pembrolizumab: An immune-related adverse event associated with anti-PD-1 therapy. Journal of Cutaneous Pathology 45:1, pages 74-77.
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Michael T. Tetzlaff, Amir A. Jazaeri, Carlos A. Torres-Cabala, Brinda R. Korivi, Genie A. Landon, Priyadharsini Nagarajan, Adrienne Choksi, Leon Chen, Marc Uemura, Phyu P. Aung, Adi Diab, Padmanee Sharma, Michael A. Davies, Rodabe Amaria, Victor G. Prieto & Jonathan L. Curry. (2017) Erythema nodosum-like panniculitis mimicking disease recurrence: A novel toxicity from immune checkpoint blockade therapy-Report of 2 patients. Journal of Cutaneous Pathology 44:12, pages 1080-1086.
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Simone Negrini & Laurent Becquemont. (2017) HLA-associated drug hypersensitivity and the prediction of adverse drug reactions. Pharmacogenomics 18:15, pages 1441-1457.
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Chiara Ciccarese, Roberto Iacovelli, Emilio Bria, Alessandra Modena, Francesco Massari, Matteo Brunelli, Emanuela Fantinel, Davide Bimbatti, Giulia A Zamboni, Walter Artibani & Giampaolo Tortora. (2017) The incidence and relative risk of pulmonary toxicity in patients treated with anti-PD1/PD-L1 therapy for solid tumors: a meta-analysis of current studies. Immunotherapy 9:7, pages 579-587.
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Jessica C. Hassel, Lucie Heinzerling, Jens Aberle, Oliver Bähr, Thomas K. Eigentler, Marc-Oliver Grimm, Victor Grünwald, Jan Leipe, Niels Reinmuth, Julia K. Tietze, Jörg Trojan, Lisa Zimmer & Ralf Gutzmer. (2017) Combined immune checkpoint blockade (anti-PD-1/anti-CTLA-4): Evaluation and management of adverse drug reactions. Cancer Treatment Reviews 57, pages 36-49.
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Susanne Unverzagt, Ines Moldenhauer, Monika Nothacker, Dorothea Roßmeißl, Andreas V Hadjinicolaou, Frank Peinemann, Francesco Greco & Barbara Seliger. (2017) Immunotherapy for metastatic renal cell carcinoma. Cochrane Database of Systematic Reviews 2017:5.
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Roberto IacovelliChiara Ciccarese, Emanuela Fantinel, Davide Bimbatti, Mario Romano, Antonio Benito Porcaro, Salvatore Siracusano, Renzo Mazzarotto, Walter Artibani & Giampaolo Tortora. (2018) Renal Toxicity in Patients Treated with Anti-Pd-1 Targeted Agents for Solid Tumors. Journal of Onco-Nephrology 1:2, pages 132-142.
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Jonathan L. Curry, Michael T. Tetzlaff, Priyadharsini Nagarajan, Carol Drucker, Adi Diab, Sharon R. Hymes, Madeleine Duvic, Wen-Jen Hwu, Jennifer A. Wargo, Carlos A. Torres-Cabala, Ronald P. Rapini & Victor G. Prieto. (2017) Diverse types of dermatologic toxicities from immune checkpoint blockade therapy. Journal of Cutaneous Pathology 44:2, pages 158-176.
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Michael R. Yeaman & John P. HennesseyJr.Jr.. (2017) Innovative Approaches to Improve Anti-Infective Vaccine Efficacy. Annual Review of Pharmacology and Toxicology 57:1, pages 189-222.
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Letizia Procaccio, Marta Schirripa, Matteo Fassan, Loredana Vecchione, Francesca Bergamo, Alessandra Anna Prete, Rossana Intini, Chiara Manai, Vincenzo Dadduzio, Alice Boscolo, Vittorina Zagonel & Sara Lonardi. (2017) Immunotherapy in Gastrointestinal Cancers. BioMed Research International 2017, pages 1-17.
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Tomohide Tsukahara, Yoshihiko Hirohashi, Takayuki Kanaseki, Munehide Nakatsugawa, Terufumi Kubo, Noriyuki Sato & Toshihiko Torigoe. (2016) Peptide vaccination therapy: Towards the next generation. Pathology International 66:10, pages 547-553.
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Vincent Sibaud, Nicolas Meyer, Laurence Lamant, Emmanuelle Vigarios, Julien Mazieres & Jean Pierre Delord. (2016) Dermatologic complications of anti-PD-1/PD-L1 immune checkpoint antibodies. Current Opinion in Oncology 28:4, pages 254-263.
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