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Expert Opinion on Drug Metabolism & Toxicology Volume 3, 2007 - Issue 1
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Drug Evaluation

A brief review of the pharmacologic and therapeutic aspects of memantine in Alzheimer’s disease

Frederick Schmitt University of Kentucky, Sanders-Brown Center on Aging, and Department of Neurology, and Departments of Psychiatry, Psychology, and Behavioural Sciences, 800 S. Limestone Street, Lexington, KY 40536-0230, USA. [email protected]
,
Melody Ryan University of Kentucky, Department of Neurology, and Department of Pharmacy Practice and Science, 800 S. Limestone Street, Lexington, KY 40536-0230, USA
&
Gregory Cooper University of Kentucky, Sanders-Brown Center on Aging, and Department of Neurology, 800 S. Limestone Street, Lexington, KY 40536-0230, USA; Lexington Clinic, Division of Neurology, Lexington, KY, USA
Pages 135-141 | Published online: 01 Feb 2007

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Rose M Santangelo, Timothy M Acker, Sommer S Zimmerman, Brooke M Katzman, Katie L Strong, Stephen F Traynelis & Dennis C Liotta. (2012) Novel NMDA receptor modulators: an update. Expert Opinion on Therapeutic Patents 22:11, pages 1337-1352.
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Ging-Yuek Robin Hsiung & Howard H Feldman. (2008) Pharmacological treatment in moderate-to-severe Alzheimer's disease. Expert Opinion on Pharmacotherapy 9:15, pages 2575-2582.
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David B Hogan. (2007) Progress update: Pharmacological treatment of Alzheimer’s disease. Neuropsychiatric Disease and Treatment 3:5, pages 569-578.
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Articles from other publishers (19)

Atsushi Kawase, Akira Kazaoka, Hiroaki Shimada & Masahiro Iwaki. (2021) Increased brain penetration of diphenhydramine and memantine in rats with adjuvant-induced arthritis. Brain Research 1768, pages 147581.
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Hilda Martínez-Coria, Isabel Arrieta-Cruz, María-Esther Cruz & HéctorE López-Valdés. (2021) Physiopathology of ischemic stroke and its modulation using memantine: evidence from preclinical stroke. Neural Regeneration Research 16:3, pages 433.
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Abdur Rahman, Sara Al-Qenaie, Muddanna S. Rao, Khalid M. Khan & Gilles J. Guillemin. (2019) Memantine Is Protective against Cytotoxicity Caused by Lead and Quinolinic Acid in Cultured Rat Embryonic Hippocampal Cells. Chemical Research in Toxicology 32:6, pages 1134-1143.
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Shahrina Alam, Kaelyn Skye Lingenfelter, Aaron M. Bender & Craig W. Lindsley. (2017) Classics in Chemical Neuroscience: Memantine. ACS Chemical Neuroscience 8:9, pages 1823-1829.
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Eunji Kim, Hae Ju Ko, Se Jin Jeon, Sunhee Lee, Hyung Eun Lee, Ha Neul Kim, Eun-Rhan Woo & Jong Hoon Ryu. (2016) The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice. Pharmacology Biochemistry and Behavior 142, pages 85-90.
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Xiaochuan Wang, Julie Blanchard, Inge Grundke-Iqbal & Khalid Iqbal. (2015) Memantine Attenuates Alzheimer’s Disease-Like Pathology and Cognitive Impairment. PLOS ONE 10:12, pages e0145441.
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Güliz Armagan, Ayşegül Keser, Çiğdem Atalayın & Taner Dagcı. (2015) Tideglusib protects neural stem cells against NMDA receptor overactivation. Pharmacological Reports 67:5, pages 823-831.
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Cristina Hernández, Olga Simó-Servat & Rafael Simó. (2014) Somatostatin and diabetic retinopathy: current concepts and new therapeutic perspectives. Endocrine 46:2, pages 209-214.
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T. Freret, J.-M. Billard, P. Schumann-Bard, P. Dutar, F. Dauphin, M. Boulouard & V. Bouet. (2012) Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan. Neurobiology of Aging 33:5, pages 1005.e1-1005.e10.
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Mohammed Filali, Robert Lalonde & Serge Rivest. (2011) Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer’s disease. Neuropharmacology 60:6, pages 930-936.
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Valentine Bouet, Thomas Freret, Patrick Dutar, Jean-Marie Billard & Michel Boulouard. (2011) Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals. Mechanisms of Ageing and Development 132:5, pages 240-248.
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Akhlaq A. FarooquiAkhlaq A. Farooqui. 2010. Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases. Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases 325 382 .
Roland Jakob-Roetne & Helmut Jacobsen. (2009) Alzheimer's Disease: From Pathology to Therapeutic Approaches. Angewandte Chemie International Edition 48:17, pages 3030-3059.
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Roland Jakob-Roetne & Helmut Jacobsen. (2009) Die Alzheimer-Demenz: von der Pathologie zu therapeutischen Ansätzen. Angewandte Chemie 121:17, pages 3074-3105.
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M. S. Song, G. Rauw, G. B. Baker & S. Kar. (2008) Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation. European Journal of Neuroscience 28:10, pages 1989-2002.
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Jee Hee Lee, Eun Ok Lee, JiHee Lee Kang & Young Hae Chong. (2008) Concomitant degradation of -catenin and GSK-3 potently contributes to glutamate-induced neurotoxicity in rat hippocampal slice cultures. Journal of Neurochemistry 106:3, pages 1066-1077.
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Ming-Yan Liu, Sheng-Nan Meng, Hui-Zhe Wu, Shuang Wang & Min-Jie Wei. (2008) Pharmacokinetics of single-dose and multiple-dose memantine in healthy chinese volunteers using an analytic method of liquid chromatography-tandem mass spectrometry. Clinical Therapeutics 30:4, pages 641-653.
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D. Jantas, M. Pytel, J.W. Mozrzymas, M. Leskiewicz, M. Regulska, L. Antkiewicz-Michaluk & W. Lason. (2008) The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells. Neurochemistry International 52:4-5, pages 864-877.
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Akhlaq A. Farooqui, Wei-Yi Ong & Lloyd A. Horrocks. 2008. Neurochemical Aspects of Excitotoxicity. Neurochemical Aspects of Excitotoxicity 241 260 .

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