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Review

Genetic polymorphisms of drug-metabolizing enzymes and the susceptibility to antituberculosis drug-induced liver injury

Pages 1-8 | Published online: 01 Feb 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Dyah Aryani Perwitasari, Jarir Atthobari & Bob Wilffert. (2015) Pharmacogenetics of isoniazid-induced hepatotoxicity. Drug Metabolism Reviews 47:2, pages 222-228.
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S Hyder Hussaini & Elizabeth Anne Farrington. (2014) Idiosyncratic drug-induced liver injury: an update on the 2007 overview. Expert Opinion on Drug Safety 13:1, pages 67-81.
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Yong Zhou, Shizhen Qin & Kai Wang. (2013) Biomarkers of drug-induced liver injury. Current Biomarker Findings 3, pages 1-9.
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Articles from other publishers (42)

Fang Cheng, Xian-Gao Jiang, Shi-Lin Zheng, Te Wu, Qiang Zhang, Xin-Chun Ye, Saiduo Liu & Ji-Chan Shi. (2023) N-acetyltransferase 2 genetic polymorphisms and anti-tuberculosis-drug-induced liver injury: a correlation study. Frontiers in Pharmacology 14.
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Veronique Michaud, Lucy I. Darakjian, Pamela Dow & Jacques Turgeon. (2022) Role of Pharmacogenomics in Reducing the Risk of Drug-Related Iatrogenesis. Current Pharmacology Reports 8:2, pages 79-98.
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Chahra Chbili, Neila Fathallah, Chayma Laadhari, Bouraoui Ouni, Saad Saguem, Maha Ben Fredj, Ahmed Abdelghani, Helmi Ben Saad & Chaker Ben Salem. (2022) Glutathione-S-transferase genetic polymorphism and risk of hepatotoxicity to antitubercular drugs in a North-African population: A case-control study. Gene 809, pages 146019.
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Shao-Yu Tseng, Yi-Shin Huang, Tien-En Chang, Chin-Lin Perng & Yi-Hsiang Huang. (2021) Hepatotoxicity, efficacy and completion rate between 3 months of isoniazid plus rifapentine and 9 months of isoniazid in treating latent tuberculosis infection: A systematic review and meta-analysis. Journal of the Chinese Medical Association 84:11, pages 993-1000.
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Stella Rousset, Margaux Lafaurie, Hélène Guet-Revillet, Caroline Protin, Jean Le Grusse, Hélène Derumeaux, Peggy Gandia, Fatemeh Nourhashemi, Laurent Sailler, Agnès Sommet, Pierre Delobel & Guillaume Martin-Blondel. (2020) Safety of Pyrazinamide for the Treatment of Tuberculosis in Older Patients Over 75 Years of Age: A Retrospective Monocentric Cohort Study. Drugs & Aging 38:1, pages 43-52.
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Nuanjun Wichukchinda, Jirapa Pakdee, Punna Kunhapan, Wimala Imunchot, Licht Toyo-oka, Katsushi Tokunaga & Surakameth Mahasirimongkol. (2020) Haplotype-specific PCR for NAT2 diplotyping. Human Genome Variation 7:1.
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Supharat Suvichapanich, Sukanya Wattanapokayakit, Taisei Mushiroda, Hideki Yanai, Charoen Chuchottawon, Tassawan Kantima, Supalert Nedsuwan, Wimon Suwankesawong, Cholticha Sonsupap, Roongkarn Pannarunothai, Sukanya Tumpattanakul, Warawut Bamrungram, Achara Chaiwong, Surakameth Mahasirimongkol, Sasithorn Mameechai, Weerapat Panthong, Nantawan Klungtes, Amara Munsoo, Udomrat Chauychana, Molrudee Maneerat, Koya Fukunaga, Yosuke Omae & Katsushi Tokunaga. (2019) Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients . Antimicrobial Agents and Chemotherapy 63:8.
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Min Zhang, Shuqiang Wang, Bob Wilffert, Rongsheng Tong, Dick van Soolingen, Susan van den Hof & Jan‐Willem Alffenaar. (2018) The association between the NAT2 genetic polymorphisms and risk of DILI during anti‐TB treatment: a systematic review and meta‐analysis . British Journal of Clinical Pharmacology 84:12, pages 2747-2760.
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Supharat Suvichapanich, Koya Fukunaga, Hilyatuz Zahroh, Taisei Mushiroda, Surakameth Mahasirimongkol, Licht Toyo-oka, Usa Chaikledkaew, Jiraphun Jittikoon, Rika Yuliwulandari, Hideki Yanai, Sukanya Wattanapokayakit & Katsushi Tokunaga. (2018) NAT2 ultra-slow acetylator and risk of anti-tuberculosis drug-induced liver injury. Pharmacogenetics and Genomics 28:7, pages 167-176.
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Julián G. Chamorro, Jorge P. Castagnino, Omar Aidar, Rosa M. Musella, Ana Frías, Mabel Visca, Mabel Nogueras, Lucas Costa, Alessandro Perez, Fabio Caradonna & Gabriela F. de Larrañaga. (2017) Effect of gene–gene and gene–environment interactions associated with antituberculosis drug-induced hepatotoxicity. Pharmacogenetics and Genomics 27:10, pages 363-371.
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Carlo J. Iasella, Heather J. Johnson & Michael A. Dunn. (2017) Adverse Drug Reactions. Clinics in Liver Disease 21:1, pages 73-87.
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Kashini Andrew, Nachamada Solomon Emmanuel, Deborah Chioma Ejiogu, Chinonso Nicodemus Chima, Fatima Mohammed Yahuza, Emmanuel Chukwuemeka Umeh & Philemon Paul Mshelia. (2017) Evaluation of Quantitative Phytochemicals, Liver Enzymes and Histological Changes in Isoniazid Induced Hepatotoxicity in Adult Male Wistar Rats Treated with Aqueous Extracts of <i>Brysocarpus coccineus</i>. Advances in Enzyme Research 05:03, pages 33-44.
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Zelalem Petros, Ming-Ta Michael Lee, Atsushi Takahashi, Yanfei Zhang, Getnet Yimer, Abiy Habtewold, Wondwossen Amogne, Getachew Aderaye, Ina Schuppe-Koistinen, Taisei Mushiroda, Eyasu Makonnen, Michiaki Kubo & Eleni Aklillu. (2016) Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity. BMC Genomics 17:1.
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Julián G. Chamorro, Jorge P. Castagnino, Rosa M. Musella, Mabel Nogueras, Ana Frías, Mabel Visca, Omar Aidar, Lucas Costa & Gabriela F. de Larrañaga. (2016) tagSNP rs1495741 as a useful molecular marker to predict antituberculosis drug-induced hepatotoxicity. Pharmacogenetics and Genomics 26:7, pages 357-361.
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Lei Cai, Mei-Hong Cai, Mei-Yan Wang, Yi-Feng Xu, Wen-Zhong Chen, Shen-Ying Qin, Chun-Ling Wan & Lin He. (2015) Meta-Analysis-Based Preliminary Exploration of the Connection between ATDILI and Schizophrenia by GSTM1/T1 Gene Polymorphisms. PLOS ONE 10:6, pages e0128643.
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Ru Chen, Jing Wang, Yuan Zhang, Shaowen Tang & Siyan Zhan. (2015) Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity. Archives of Toxicology 89:6, pages 883-897.
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Sang-Hoon KimSang-Heon KimJae-Hyoung LeeByoung-Hoon LeeHo Joo YoonDong Ho ShinSung Soo ParkSuk Bin JangJae-Seuk ParkYoung-Koo Jee. (2015) Superoxide Dismutase Gene (SOD1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis. Allergy, Asthma & Immunology Research 7:1, pages 88.
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Cristiana Perrotta, Paolo Pellegrino, Eliana Moroni, Clara De Palma, Davide Cervia, Piergiorgio Danelli & Emilio Clementi. (2015) Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug. Gastroenterology Research and Practice 2015, pages 1-9.
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Ayman M. Mahmoud, Mousa O. Germoush & Ayman S. Soliman. (2014) Berberine Attenuates Isoniazid-Induced Hepatotoxicity by Modulating Peroxisome Proliferator-Activated Receptor γ, Oxidative Stress and Inflammation. International Journal of Pharmacology 10:8, pages 451-460.
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Lan-Hui Chih, Angela W.F. On & Yi-Shin Huang. (2014) Correlation of antituberculosis drug-related liver injury and liver function monitoring: A 12-year experience of the Taiwan Drug Relief Foundation. Journal of Food and Drug Analysis 22:3, pages 356-362.
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Hsien-Chun Lin, Ming-Chih Yu, Hsing-Jin Liu & Kuan-Jen Bai. (2014) Impact of food intake on the pharmacokinetics of first-line antituberculosis drugs in Taiwanese tuberculosis patients. Journal of the Formosan Medical Association 113:5, pages 291-297.
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Dolores Njoku. (2014) Drug-Induced Hepatotoxicity: Metabolic, Genetic and Immunological Basis. International Journal of Molecular Sciences 15:4, pages 6990-7003.
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Yi-Shin Huang. (2014) Recent progress in genetic variation and risk of antituberculosis drug-induced liver injury. Journal of the Chinese Medical Association 77:4, pages 169-173.
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Yang Xiang, Long Ma, Weidong Wu, Wei Liu, Yongguang Li, Xia Zhu, Qian Wang, Jinfeng Ma, Mingqin Cao, Qian Wang, Xuemei Yao, Lei Yang, Atikaimu Wubuli, Corinne Merle, Paul Milligan, Ying Mao, Jiayi Gu & Xiumei Xin. (2014) The Incidence of Liver Injury in Uyghur Patients Treated for TB in Xinjiang Uyghur Autonomous Region, China, and Its Association with Hepatic Enzyme Polymorphisms NAT2, CYP2E1, GSTM1 and GSTT1. PLoS ONE 9:1, pages e85905.
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C. Li, J. Long, X. Hu & Y. Zhou. (2013) GSTM1 and GSTT1 genetic polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity: an updated meta-analysis. European Journal of Clinical Microbiology & Infectious Diseases 32:7, pages 859-868.
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Francisco Jose Forestiero, Leticia Cecon, Mario Hirouki Hirata, Fernando Fiuza de Melo, Rosilene Fressatti Cardoso, Alvaro Cerda & Rosario Dominguez Crespo Hirata. (2013) Relationship of NAT2, CYP2E1 and GSTM1/GSTT1 polymorphisms with mild elevation of liver enzymes in Brazilian individuals under anti-tuberculosis drug therapy. Clinica Chimica Acta 415, pages 215-219.
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Hui-Ru An, Xue-Qiong Wu, Zhong-Yuan Wang, Jun-Xian Zhang & Yan Liang. (2012) NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients. Clinical and Experimental Pharmacology and Physiology 39:6, pages 535-543.
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Yi-Shin Huang. (2012) Recent global endeavors in the detection and prevention of drug-induced liver injury. Journal of the Formosan Medical Association 111:5, pages 237-238.
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Sang-Heon KimYoung-Koo JeeJae-Hyung LeeByoung-Hoon LeeYoun-Seup KimJae-Seuk ParkSang-Hoon Kim. (2012) ABCC2 Haplotype is Associated With Antituberculosis Drug-Induced Maculopapular Eruption . Allergy, Asthma & Immunology Research 4:6, pages 362.
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Sang-Hoon Kim, Sang-Heon Kim, Jae-Hyung Lee, Byoung-Hoon Lee, Youn-Seup Kim, Jae-Seuk Park & Young-Koo Jee. (2012) Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs. Tuberculosis 92:1, pages 100-104.
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Indira Donepudi, Hatef Massoumi, T. S. Dharmarajan, T. S. Dharmarajan, T. S. Dharmarajan, T. S. Dharmarajan, C. S. Pitchumoni, C. S. Pitchumoni & C. S. Pitchumoni. 2012. Geriatric Gastroenterology. Geriatric Gastroenterology 409 420 .
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Thomas A. Baillie & Allan E. Rettie. (2011) Role of Biotransformation in Drug-Induced Toxicity: Influence of Intra- and Inter-Species Differences in Drug Metabolism. Drug Metabolism and Pharmacokinetics 26:1, pages 15-29.
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Patrick J. Shaw, Patricia E. Ganey & Robert A. Roth. (2010) Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity. Toxicological Sciences 118:1, pages 7-18.
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Stefan Russmann, Alexander Jetter & Gerd A. Kullak-Ublick. (2010) Pharmacogenetics of drug-induced liver injury. Hepatology 52:2, pages 748-761.
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Raquel L.F. Teixeira, Floriano P. SilvaJuniorJunior, Aline R. Silveira, Pedro H. Cabello, Leila Mendonça-Lima, Marcelo F. Rabahi, Afrânio L. Kritski, Fernanda C.Q. Mello, Philip N. Suffys, Antonio B. de Miranda & Adalberto R. Santos. (2010) Sequence analysis of NAT2 gene in Brazilians: Identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 683:1-2, pages 43-49.
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Yi-Shin Huang, Wei-Juin Su, Yi-Hsiang Huang, Chih-Yen Chen, Full-Young Chang, Han-Chieh Lin & Shou-Dong Lee. (2007) Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H:quinone oxidoreductase, glutathione S-transferase M1 and T1, and the susceptibility to drug-induced liver injury. Journal of Hepatology 47:1, pages 128-134.
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