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Review

Time-dependent CYP inhibition

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Pages 51-66 | Published online: 01 Feb 2007

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Eva Ayet, Sandra Yeste, Raquel F. Reinoso, María José Pretel, Ariadna Balada & Maria Teresa Serafini. (2021) Preliminary in vitro approach to evaluate the drug-drug interaction potential of EST73502, a dual µ-opioid receptor partial agonist and σ1 receptor antagonist. Xenobiotica 51:5, pages 501-512.
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Robert J Riley & Claire E Wilson. (2015) Cytochrome P450 time-dependent inhibition and induction: advances in assays, risk analysis and modelling. Expert Opinion on Drug Metabolism & Toxicology 11:4, pages 557-572.
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Han Kiat Ho, James Chun Yip Chan, Klarissa D. Hardy & Eric Chun Yong Chan. (2015) Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinib. Drug Metabolism Reviews 47:1, pages 21-28.
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David M Stresser, Jialin Mao, Jane R Kenny, Barry C Jones & Kenneth Grime. (2014) Exploring concepts of in vitro time-dependent CYP inhibition assays. Expert Opinion on Drug Metabolism & Toxicology 10:2, pages 157-174.
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Peter Ballard, Patrick Brassil, Khanh H. Bui, Hugues Dolgos, Carl Petersson, Anders Tunek & Peter J. H. Webborn. (2012) The right compound in the right assay at the right time: an integrated discovery DMPK strategy. Drug Metabolism Reviews 44:3, pages 224-252.
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Howard J. Burt, Aleksandra Galetin & J. Brian Houston. (2010) IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4. Xenobiotica 40:5, pages 331-343.
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Zhi-Wei Zhou & Shu-Feng Zhou. (2009) Application of mechanism-based CYP inhibition for predicting drug–drug interactions. Expert Opinion on Drug Metabolism & Toxicology 5:6, pages 579-605.
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Masoud Jamei, Steve Marciniak, Kairui Feng, Adrian Barnett, Geoffrey Tucker & Amin Rostami-Hodjegan. (2009) The Simcyp® Population-based ADME Simulator. Expert Opinion on Drug Metabolism & Toxicology 5:2, pages 211-223.
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Ping Zhao. (2008) The use of hepatocytes in evaluating time-dependent inactivation of P450 in vivo. Expert Opinion on Drug Metabolism & Toxicology 4:2, pages 151-164.
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K. Venkatakrishnan, R. S. Obach & A. Rostami-Hodjegan. (2007) Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug–drug interaction risk assessment. Xenobiotica 37:10-11, pages 1225-1256.
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N. J. Hewitt, E. L. Lecluyse & S. S. Ferguson. (2007) Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and correlations. Xenobiotica 37:10-11, pages 1196-1224.
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