250
Views
112
CrossRef citations to date
0
Altmetric
Review

Natural polyphenol disposition via coupled metabolic pathways

&
Pages 389-406 | Published online: 31 May 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Skyler H. Hoang, Kevin M. Tveter, Esther Mezhibovsky & Diana E. Roopchand. (2023) Proanthocyanidin B2 derived metabolites may be ligands for bile acid receptors S1PR2, PXR and CAR: an in silico approach. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-14.
Read now
Yang Li, Jinjin Xu, Chunxia Xu, Zifei Qin, Shishi Li, Liufang Hu, Zhihong Yao, Frank J. Gonzalez & Xinsheng Yao. (2020) Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells. Xenobiotica 50:8, pages 997-1008.
Read now
Liping Wang, Rongjin Sun, Qisong Zhang, Qing Luo, Sijing Zeng, Xiaoyan Li, Xia Gong, Yuhuan Li, Linlin Lu, Ming Hu & Zhongqiu Liu. (2019) An update on polyphenol disposition via coupled metabolic pathways. Expert Opinion on Drug Metabolism & Toxicology 15:2, pages 151-165.
Read now
Jason Walsh, Jordan Haddock, Jeffrey B. Blumberg, Diane L. McKay, Xiaoyong Wei, Gregory Dolnikowski & C.-Y. Oliver Chen. (2018) Identification of methylated metabolites of oat avenanthramides in human plasma using UHPLC QToF-MS. International Journal of Food Sciences and Nutrition 69:3, pages 377-383.
Read now
Guangyi Yang, Shufan Ge, Rashim Singh, Sumit Basu, Katherine Shatzer, Ming Zen, Jiong Liu, Yifan Tu, Chenning Zhang, Jinbao Wei, Jian Shi, Lijun Zhu, Zhongqiu Liu, Yuan Wang, Song Gao & Ming Hu. (2017) Glucuronidation: driving factors and their impact on glucuronide disposition. Drug Metabolism Reviews 49:2, pages 105-138.
Read now
Da Cheng Hao & Ling Yang. (2016) Drug metabolism and disposition diversity of Ranunculales phytometabolites: a systems perspective. Expert Opinion on Drug Metabolism & Toxicology 12:9, pages 1047-1065.
Read now
Shengpeng Wang, Jinming Zhang, Meiwan Chen & Yitao Wang. (2013) Delivering flavonoids into solid tumors using nanotechnologies. Expert Opinion on Drug Delivery 10:10, pages 1411-1428.
Read now
Matthias Unger. (2013) Pharmacokinetic drug interactions involving Ginkgo biloba. Drug Metabolism Reviews 45:3, pages 353-385.
Read now
José M. Estrela, Angel Ortega, Salvador Mena, Maria L. Rodriguez & Miguel Asensi. (2013) Pterostilbene: Biomedical applications. Critical Reviews in Clinical Laboratory Sciences 50:3, pages 65-78.
Read now
Miguel Asensi, Angel Ortega, Salvador Mena, Fatima Feddi & José M. Estrela. (2011) Natural polyphenols in cancer therapy. Critical Reviews in Clinical Laboratory Sciences 48:5-6, pages 197-216.
Read now
Dimitris Grigorakis, Vassiliki Bountziouka & Nick Kalogeropoulos. (2011) Alcohol Intake and Cardiovascular Disease Risk: Cheers, Tears, or Both?. Food Reviews International 27:3, pages 274-299.
Read now
Yin Cheong Wong, Li Zhang, Ge Lin & Zhong Zuo. (2009) Structure–activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases. Expert Opinion on Drug Metabolism & Toxicology 5:11, pages 1399-1419.
Read now

Articles from other publishers (99)

Gabriella Guelfi, Rolando Pasquariello, Polina Anipchenko, Camilla Capaccia, Georgia Pennarossa, Tiziana A. L. Brevini, Fulvio Gandolfi, Massimo Zerani & Margherita Maranesi. (2023) The Role of Genistein in Mammalian Reproduction. Molecules 28:21, pages 7436.
Crossref
Priaunsh Dutt, Yashika Shadija, Sneha Dokhale, Sweta Das, Shine Devarajan & Samiksha Garse. 2023. Polyphenols. Polyphenols 343 360 .
Mahendra P. Kapoor, Masamitsu Moriwaki, Kamiya Uguri, Kento Kito, Derek Timm & Aya Abe. (2023) Improved bioavailability of hesperetin 7-O-glucoside inclusion complex with β-cyclodextrin in Sprague-Dawley rats and healthy humans. Journal of Functional Foods 107, pages 105708.
Crossref
Ecaterina Isacescu, Paul Chiroi, Oana Zanoaga, Andreea Nutu, Liviuta Budisan, Radu Pirlog, Atanas G. Atanasov & Ioana Berindan-Neagoe. (2023) Melanoma Cellular Signaling Transduction Pathways Targeted by Polyphenols Action Mechanisms. Antioxidants 12:2, pages 407.
Crossref
Nitin Gupta, Shaloo Singh, Divya Chauhan, Ruchi Srivastava & Vipendra Kumar Singh. (2023) Exploring the Anticancer Potentials of Polyphenols: A Comprehensive Review of Patents in the Last Five Years. Recent Patents on Anti-Cancer Drug Discovery 18:1, pages 3-10.
Crossref
Angela Corvino, Elisa Magli, Massimiliano Minale, Andrea Autelitano, Valeria Valente & Giovanna Maria Pierantoni. (2022) Phloroglucinol-Derived Medications are Effective in Reducing Pain and Spasms of Urinary and Biliary Tracts: Results of Phase 3 Multicentre, Open-Label, Randomized, Comparative Studies of Clinical Effectiveness and Safety. Advances in Therapy 40:2, pages 619-640.
Crossref
Fereidoon Shahidi & Chandrika Sewwandi Dissanayaka. (2023) Phenolic-protein interactions: insight from in-silico analyses – a review. Food Production, Processing and Nutrition 5:1.
Crossref
Kenneth R. Olson, Paul J. DerryThomas A. KentKarl D. Straub. (2023) The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling. Antioxidants & Redox Signaling 38:1-3, pages 68-94.
Crossref
Aleksandra Bojarczuk & Magdalena Dzitkowska-Zabielska. (2022) Polyphenol Supplementation and Antioxidant Status in Athletes: A Narrative Review. Nutrients 15:1, pages 158.
Crossref
Ivonne Helena Valderrama, Sandra Milena Echeverry, Diana Patricia Rey, Ingrid Andrea Rodríguez, Fátima Regina Mena Barreto Silva, Geison M. Costa, Luis Fernando Ospina-Giraldo & Diana Marcela Aragón. (2022) Extract of Calyces from Physalis peruviana Reduces Insulin Resistance and Oxidative Stress in Streptozotocin-Induced Diabetic Mice. Pharmaceutics 14:12, pages 2758.
Crossref
Sarusha Santhiravel, Alaa El-Din A. Bekhit, Eresha Mendis, Joe L. Jacobs, Frank R. Dunshea, Niranjan Rajapakse & Eric N. Ponnampalam. (2022) The Impact of Plant Phytochemicals on the Gut Microbiota of Humans for a Balanced Life. International Journal of Molecular Sciences 23:15, pages 8124.
Crossref
Itziar Eseberri, Jenifer Trepiana, Asier Léniz, Iker Gómez-García, Helen Carr-Ugarte, Marcela González & María P. Portillo. (2022) Variability in the Beneficial Effects of Phenolic Compounds: A Review. Nutrients 14:9, pages 1925.
Crossref
Chi In Vong, Thirumurugan Rathinasabapathy, Marvin Moncada & Slavko Komarnytsky. (2022) All Polyphenols Are Not Created Equal: Exploring the Diversity of Phenolic Metabolites. Journal of Agricultural and Food Chemistry 70:7, pages 2077-2091.
Crossref
Roberto Arrigoni, Andrea Ballini, Luigi Santacroce, Stefania Cantore, Angelo Inchingolo, Francesco Inchingolo, Marina Di Domenico, Lucio Quagliuolo & Mariarosaria Boccellino. (2022) Another Look at Dietary Polyphenols: Challenges in Cancer Prevention and Treatment. Current Medicinal Chemistry 29:6, pages 1061-1082.
Crossref
Annaelle Hip Kam & Vidushi S. Neergheen. 2022. Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health. Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health 445 475 .
José Andrés Galeana-López, Bruno Gómez-Gil, Crisantema Hernández, Nayely Leyva-López, Cynthia E. Lizárraga-Velázquez & Tania Zenteno-Savín. (2021) Use of Corn Husk Meal in the Development of a Functional Diet for Nile tilapia (Oreochromis niloticus) Fingerlings: Effect on Growth Performance, Antioxidant Status and Intestinal Microbiota. Waste and Biomass Valorization 12:8, pages 4355-4365.
Crossref
Dunya Al Duhaidahawi, Samer A. Hasan & Haider F.S. Al Zubaidy. (2021) Flavonoids in the Treatment of Diabetes: Clinical Outcomes and Mechanism to Ameliorate Blood Glucose Levels. Current Diabetes Reviews 17:6.
Crossref
Emer Shannon, Michael Conlon & Maria Hayes. (2021) Seaweed Components as Potential Modulators of the Gut Microbiota. Marine Drugs 19:7, pages 358.
Crossref
Hui Cao, Oznur Saroglu, Ayse Karadag, Zoriţa Diaconeasa, Gianni Zoccatelli, Carlos Adam Conte‐Junior, Gustavo A. Gonzalez‐Aguilar, Juanying Ou, Weibin Bai, Cristina Mara Zamarioli, Luis Alexandre Pedro de Freitas, Avi Shpigelman, Pedro H. Campelo, Esra Capanoglu, Ching Lik Hii, Seid Mahdi Jafari, Yaping Qi, Pan Liao, Mingfu Wang, Liang Zou, Paula Bourke, Jesus Simal‐Gandara & Jianbo Xiao. (2021) Available technologies on improving the stability of polyphenols in food processing. Food Frontiers 2:2, pages 109-139.
Crossref
Gina Paola Domínguez Moré, María Isabel Cardona, Paula Michelle Sepúlveda, Sandra Milena Echeverry, Cláudia Maria Oliveira Simões & Diana Marcela Aragón. (2021) Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling. Pharmaceutics 13:4, pages 535.
Crossref
Arik Monash, Daniele Marciano, Arthur (Skip) Colvin, Rafi Fass, Yair Dvash & Osnat Rosen. (2021) Phosphorescent palladium-tetrabenzoporphyrin indicators for immunosensing of small molecules with a novel optical device. Talanta 224, pages 121927.
Crossref
Meiyan Wang, Hui Zhao, Xiang Wen, Chi‐Tang Ho & Shiming Li. (2020) Citrus flavonoids and the intestinal barrier: Interactions and effects. Comprehensive Reviews in Food Science and Food Safety 20:1, pages 225-251.
Crossref
Itziar Eseberri, Iñaki Milton‐Laskibar, Alfredo Fernández‐Quintela, Saioa Gómez‐Zorita & María P. Portillo. 2020. Dietary Polyphenols. Dietary Polyphenols 407 438 .
Brittany D. Needham, Rima Kaddurah-Daouk & Sarkis K. Mazmanian. (2020) Gut microbial molecules in behavioural and neurodegenerative conditions. Nature Reviews Neuroscience 21:12, pages 717-731.
Crossref
Zeynep Goktas, Yujiao Zu, Mehrnaz Abbasi, Shannon Galyean, Dayong Wu, Zhaoyang Fan & Shu Wang. (2020) Recent Advances in Nanoencapsulation of Phytochemicals to Combat Obesity and Its Comorbidities. Journal of Agricultural and Food Chemistry 68:31, pages 8119-8131.
Crossref
Abigail E. Cullen, Ann Marie Centner, Riley Deitado, Javier Fernandez & Gloria Salazar. (2020) The Impact of Dietary Supplementation of Whole Foods and Polyphenols on Atherosclerosis. Nutrients 12:7, pages 2069.
Crossref
Francesco Visioli, Alberto Davalos, María‐Carmen López de las Hazas, María Carmen Crespo & Joao Tomé‐Carneiro. (2019) An overview of the pharmacology of olive oil and its active ingredients. British Journal of Pharmacology 177:6, pages 1316-1330.
Crossref
Pooja Rathaur & Kaid Johar SR. (2020) Metabolism and Pharmacokinetics of Phytochemicals in the Human Body. Current Drug Metabolism 20:14, pages 1085-1102.
Crossref
López-Yerena, Vallverdú-Queralt, Mols, Augustijns, Lamuela-Raventós & Escribano-Ferrer. (2020) Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats. Pharmaceutics 12:2, pages 134.
Crossref
Robert A. Ronzio. 2020. Textbook of Natural Medicine. Textbook of Natural Medicine 731 751.e12 .
Gabriele Serreli & Monica Deiana. (2019) In vivo formed metabolites of polyphenols and their biological efficacy . Food & Function 10:11, pages 6999-7021.
Crossref
Wilhelmina Kalt. (2019) Anthocyanins and Their C6-C3-C6 Metabolites in Humans and Animals. Molecules 24:22, pages 4024.
Crossref
Suramya Waidyanatha, Esra Mutlu, Seth Gibbs, Billie Stiffler, Jon Andre, Brian Burback & Cynthia V. Rider. (2019) Systemic exposure to Ginkgo biloba extract in male F344/NCrl rats: Relevance to humans. Food and Chemical Toxicology 131, pages 110586.
Crossref
S. Franklyn De Silva & Jane Alcorn. (2019) Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets. Pharmaceuticals 12:2, pages 68.
Crossref
Justine Renaud & Maria-Grazia Martinoli. (2019) Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases. International Journal of Molecular Sciences 20:8, pages 1883.
Crossref
Zhenzhen Guo, Yanmei Lou, Muyan Kong, Qing Luo, Zhongqiu Liu & Jinjun Wu. (2019) A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine. International Journal of Molecular Sciences 20:6, pages 1463.
Crossref
Sheila C. Oliveira-Alves, Ana Teresa Serra & Maria R. Bronze. 2019. Nutraceuticals and Natural Product Pharmaceuticals. Nutraceuticals and Natural Product Pharmaceuticals 197 233 .
Da-Cheng Hao. 2019. Ranunculales Medicinal Plants. Ranunculales Medicinal Plants 175 221 .
Jung Bae Park, Doyun Kim, Jee Sun Min, Su Jeong, Doo-Yeoun Cho, Yu Fen Zheng, Kee Dong Yoon & Soo Kyung Bae. (2018) Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food and Chemical Toxicology 120, pages 651-661.
Crossref
Jingjing Chai, Ping Jiang, Pengjie Wang, Yumeng Jiang, Dan Li, Weier Bao, Bingxue Liu, Bin Liu, Liyun Zhao, Willem Norde, Qipeng Yuan, Fazheng Ren & Yuan Li. (2018) The intelligent delivery systems for bioactive compounds in foods: Physicochemical and physiological conditions, absorption mechanisms, obstacles and responsive strategies. Trends in Food Science & Technology 78, pages 144-154.
Crossref
Shamsher Singh & Puneet Kumar. (2018) Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences. Neuroscience Research 133, pages 38-47.
Crossref
Monica Isgut, Mukkavilli Rao, Chunhua Yang, Vangala Subrahmanyam, Padmashree C. G. Rida & Ritu Aneja. (2018) Application of Combination High-Throughput Phenotypic Screening and Target Identification Methods for the Discovery of Natural Product-Based Combination Drugs. Medicinal Research Reviews 38:2, pages 504-524.
Crossref
Benson O.A. Botchway, Masania K. Moore, Faith O. Akinleye, Ishwari C. Iyer & Marong Fang. (2018) Nutrition: Review on the Possible Treatment for Alzheimer’s Disease. Journal of Alzheimer's Disease 61:3, pages 867-883.
Crossref
Amandeep K. Sandhu, Marshall G. Miller, Nopporn Thangthaeng, Tammy M. Scott, Barbara Shukitt-Hale, Indika Edirisinghe & Britt Burton-Freeman. (2018) Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults. Food & Function 9:1, pages 96-106.
Crossref
Pallavi Kesavan, Antara Banerjee, Anushka Banerjee, Ramachandran Murugesan, Francesco Marotta & Surajit Pathak. 2018. Polyphenols: Mechanisms of Action in Human Health and Disease. Polyphenols: Mechanisms of Action in Human Health and Disease 221 235 .
Zhaoyu Wang, Yao Lan, MingHao Chen, Cailing Wen, Yanxian Hu, Zhongqiu Liu & Ling Ye. (2017) Eriodictyol, Not Its Glucuronide Metabolites, Attenuates Acetaminophen-Induced Hepatotoxicity. Molecular Pharmaceutics 14:9, pages 2937-2951.
Crossref
Wilhelmina Kalt, Jane E. McDonald, Yan Liu & Sherry A. E. Fillmore. (2017) Flavonoid Metabolites in Human Urine during Blueberry Anthocyanin Intake. Journal of Agricultural and Food Chemistry 65:8, pages 1582-1591.
Crossref
Ra?l Dom?nguez-Perles, David Au??n, Federico Ferreres & Angel Gil-Izquierdo. (2015) Gender differences in plasma and urine metabolites from Sprague?Dawley rats after oral administration of normal and high doses of hydroxytyrosol, hydroxytyrosol acetate, and DOPAC. European Journal of Nutrition 56:1, pages 215-224.
Crossref
Hitomi OzawaAtsushi ImaizumiYoshihiko SumiTadashi HashimotoMasashi Kanai, Yuji Makino, Takanori Tsuda, Nobuaki Takahashi & Hideaki Kakeya. (2017) Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 40:9, pages 1515-1524.
Crossref
R. Domínguez-Perles, D. Auñón, F. Ferreres & A. Gil-Izquierdo. (2017) Physiological linkage of gender, bioavailable hydroxytyrosol derivatives, and their metabolites with systemic catecholamine metabolism. Food & Function 8:12, pages 4570-4581.
Crossref
Wilhelmina Kalt, Jane E. McDonald, Melinda R. Vinqvist-Tymchuk, Yan Liu & Sherry A. E. Fillmore. (2017) Human anthocyanin bioavailability: effect of intake duration and dosing. Food & Function 8:12, pages 4563-4569.
Crossref
Shufan Ge, Yifan Tu & Ming Hu. (2016) Challenges and Opportunities with Predicting In Vivo Phase II Metabolism via Glucuronidation From In Vitro Data. Current Pharmacology Reports 2:6, pages 326-338.
Crossref
Chung-Ping Yu, Chi-Sheng Shia, Hui-Ju Lin, Yow-Wen Hsieh, Shiuan-Pey Lin & Yu-Chi Hou. (2016) Analysis of the pharmacokinetics and metabolism of aloe-emodin following intravenous and oral administrations in rats. Biomedical Chromatography 30:10, pages 1641-1647.
Crossref
Swati Pund, Amita Joshi & Vandana Patravale. 2016. Nutraceuticals. Nutraceuticals 481 534 .
A. Gioxari, D.A.A. Kogiannou, N. Kalogeropoulos & A.C. Kaliora. 2016. Encyclopedia of Food and Health. Encyclopedia of Food and Health 339 345 .
Peimin Dai, Feifei Luo, Ying Wang, Huangyu Jiang, Liping Wang, Guiyu Zhang, Lijun Zhu, Ming Hu, Xinchun Wang, Linlin Lu & Zhongqiu Liu. (2015) Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes. Biopharmaceutics & Drug Disposition 36:9, pages 622-635.
Crossref
Wan Li, Hua Sun, Xingwang Zhang, Huan Wang & Baojian Wu. (2015) Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). Biochemical Pharmacology 98:1, pages 203-214.
Crossref
Mitchell H. Keylor, Bryan S. Matsuura & Corey R. J. Stephenson. (2015) Chemistry and Biology of Resveratrol-Derived Natural Products. Chemical Reviews 115:17, pages 8976-9027.
Crossref
Peimin Dai, Lijun Zhu, Feifei Luo, Linlin Lu, Qiang Li, Liping Wang, Ying Wang, Xinchun Wang, Ming Hu & Zhongqiu Liu. (2015) Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids. The AAPS Journal 17:3, pages 723-736.
Crossref
Qiang Li, Liping Wang, Peimin Dai, Xuejun Zeng, Xiaoxiao Qi, Lijun Zhu, Tongmeng Yan, Ying Wang, Linlin Lu, Ming Hu, Xinchun Wang & Zhongqiu Liu. (2015) A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5?-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats. Journal of Chromatography A 1395, pages 116-128.
Crossref
Xingwang Zhang, Dong Dong, Huailing Wang, Zhiguo Ma, Yifei Wang & Baojian Wu. (2015) Stable Knock-down of Efflux Transporters Leads to Reduced Glucuronidation in UGT1A1-Overexpressing HeLa Cells: The Evidence for Glucuronidation-Transport Interplay. Molecular Pharmaceutics 12:4, pages 1268-1278.
Crossref
Enxi Quan, Huailing Wang, Dong Dong, Xingwang Zhang & Baojian Wu. (2015) Characterization of Chrysin Glucuronidation in UGT1A1-Overexpressing HeLa Cells: Elucidating the Transporters Responsible for Efflux of Glucuronide. Drug Metabolism and Disposition 43:4, pages 433-443.
Crossref
Hui-Ping Chang, Lee-Yan Sheen & Yen-Ping Lei. (2015) The protective role of carotenoids and polyphenols in patients with head and neck cancer. Journal of the Chinese Medical Association 78:2, pages 89-95.
Crossref
Loai Basheer & Zohar Kerem. (2015) Interactions between CYP3A4 and Dietary Polyphenols. Oxidative Medicine and Cellular Longevity 2015, pages 1-15.
Crossref
Guiyuan He, Shixuan Zhang, Liang Xu, Yangliu Xia, Ping Wang, Shiyang Li, Liangliang Zhu, Hongxi Xu, Guangbo Ge & Ling Yang. (2015) C-8 Mannich base derivatives of baicalein display improved glucuronidation stability: exploring the mechanism by experimentation and theoretical calculations. RSC Advances 5:109, pages 89818-89826.
Crossref
Torsten Bohn. (2014) Dietary factors affecting polyphenol bioavailability. Nutrition Reviews 72:7, pages 429-452.
Crossref
Sushma R. Gundala, Rao Mukkavilli, Chunhua Yang, Pooja Yadav, Vibha Tandon, Subrahmanyam Vangala, Satya Prakash & Ritu Aneja. (2014) Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract. Carcinogenesis 35:6, pages 1320-1329.
Crossref
Wilhelmina Kalt, Yan Liu, Jane E. McDonald, Melinda R. Vinqvist-Tymchuk & Sherry A. E. Fillmore. (2014) Anthocyanin Metabolites Are Abundant and Persistent in Human Urine. Journal of Agricultural and Food Chemistry 62:18, pages 3926-3934.
Crossref
Laura Rubió, Alba Macià, Anna Castell-Auví, Montserrat Pinent, M. Teresa Blay, Anna Ardévol, Maria-Paz Romero & Maria-José Motilva. (2014) Effect of the co-occurring olive oil and thyme extracts on the phenolic bioaccesibility and bioavailability assessed by in vitro digestion and cell models. Food Chemistry 149, pages 277-284.
Crossref
Mehdi El Arbi, Jérémie Théolier, Pascal Pigeon, Karim Jellali, Fatma Trigui, Siden Top, Sami Aifa, Ismail Fliss, Gérard Jaouen & Riadh Hammami. (2014) Antibacterial properties and mode of action of new triaryl butene citrate compounds. European Journal of Medicinal Chemistry 76, pages 408-413.
Crossref
R. Albajes, C. Cantero-Martínez, T. Capell, P. Christou, A. Farre, J. Galceran, F. López-Gatius, S. Marin, O. Martín-Belloso, Ma.-J. Motilva, C. Nogareda, J. Peman, J. Puy, J. Recasens, I. Romagosa, Ma.-P. Romero, V. Sanchis, R. Savin, G. A. Slafer, R. Soliva-Fortuny, I. Viñas & J. Voltas. (2013) Building bridges: an integrated strategy for sustainable food production throughout the value chain. Molecular Breeding 32:4, pages 743-770.
Crossref
Dongjie Wang, Barbara A. Williams, Mario G. Ferruzzi & Bruce R. D’Arcy. (2013) Microbial metabolites, but not other phenolics derived from grape seed phenolic extract, are transported through differentiated Caco-2 cell monolayers. Food Chemistry 138:2-3, pages 1564-1573.
Crossref
Robert A. Ronzio. 2013. Textbook of Natural Medicine. Textbook of Natural Medicine 891 914 .
Laura Rubió, Rosa- M. Valls, Alba Macià, Anna Pedret, Montse Giralt, Maria-Paz Romero, Rafael de la Torre, Maria-Isabel Covas, Rosa Solà & Maria-José Motilva. (2012) Impact of olive oil phenolic concentration on human plasmatic phenolic metabolites. Food Chemistry 135:4, pages 2922-2929.
Crossref
Bijun Xia, Qiong Zhou, Zhijie Zheng, Ling Ye, Ming Hu & Zhongqiu Liu. (2012) A Novel Local Recycling Mechanism That Enhances Enteric Bioavailability of Flavonoids and Prolongs Their Residence Time in the Gut. Molecular Pharmaceutics 9:11, pages 3246-3258.
Crossref
P. Stanely Mainzen Prince & B. Sathya. (2012) Protective effects of quercetin on mitochondrial oxidative stress in isoproterenol induced myocardial infarcted rats: An in vivo and in vitro study. Food Research International 49:1, pages 233-241.
Crossref
Baojian Wu, Wen Jiang, Taijun Yin, Song Gao & Ming Hu. (2012) A New Strategy to Rapidly Evaluate Kinetics of Glucuronide Efflux by Breast Cancer Resistance Protein (BCRP/ABCG2). Pharmaceutical Research 29:11, pages 3199-3208.
Crossref
Mireia Urpi-Sarda, Joseph Rothwell, Christine Morand & Claudine Manach. 2012. Flavonoids and Related Compounds. Flavonoids and Related Compounds.
J. Debora van der Merwe, Elizabeth Joubert, Marena Manley, Dalene de Beer, Christiaan J. Malherbe & Wentzel C.A. Gelderblom. (2012) Mangiferin glucuronidation: Important hepatic modulation of antioxidant activity. Food and Chemical Toxicology 50:3-4, pages 808-815.
Crossref
Baojian Wu. (2012) Use of Physiologically Based Pharmacokinetic Models to Evaluate the Impact of Intestinal Glucuronide Hydrolysis on the Pharmacokinetics of Aglycone. Journal of Pharmaceutical Sciences 101:3, pages 1281-1301.
Crossref
Wen Jiang, Beibei Xu, Baojian Wu, Rong Yu & Ming Hu. (2012) UDP-Glucuronosyltransferase (UGT) 1A9-Overexpressing HeLa Cells Is an Appropriate Tool to Delineate the Kinetic Interplay between Breast Cancer Resistance Protein (BRCP) and UGT and to Rapidly Identify the Glucuronide Substrates of BCRP. Drug Metabolism and Disposition 40:2, pages 336-345.
Crossref
Baojian Wu. (2012) Pharmacokinetic Interplay of Phase II Metabolism and Transport: A Theoretical Study. Journal of Pharmaceutical Sciences 101:1, pages 381-393.
Crossref
Walter Brand, Berend Oosterhuis, Peter Krajcsi, Denis Barron, Fabiola Dionisi, Peter J. Bladeren, Ivonne M. C. M. Rietjens & Gary Williamson. (2011) Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells. Biopharmaceutics & Drug Disposition 32:9, pages 530-535.
Crossref
Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán & Juan C. Espín. (2011) Bioavailability of the Glucuronide and Sulfate Conjugates of Genistein and Daidzein in Breast Cancer Resistance Protein 1 Knockout Mice. Drug Metabolism and Disposition 39:11, pages 2008-2012.
Crossref
Baojian Wu, Kaustubh Kulkarni, Sumit Basu, Shuxing Zhang & Ming Hu. (2011) First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics. Journal of Pharmaceutical Sciences 100:9, pages 3655-3681.
Crossref
Rashim Singh & Ming Hu. 2011. Oral Bioavailability. Oral Bioavailability 91 109 .
Susan R. Mallery, Deric E. Budendorf, Matthew P. Larsen, Ping Pei, Meng Tong, Andrew S. Holpuch, Peter E. Larsen, Gary D. Stoner, Henry W. Fields, Kenneth K. Chan, Yonghua Ling & Zhongfa Liu. (2011) Effects of Human Oral Mucosal Tissue, Saliva, and Oral Microflora on Intraoral Metabolism and Bioactivation of Black Raspberry Anthocyanins. Cancer Prevention Research 4:8, pages 1209-1221.
Crossref
Walter Brand, Beatriz Padilla, Peter J. van Bladeren, Gary Williamson & Ivonne M. C. M. Rietjens. (2010) The effect of co‐administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco‐2 cell monolayers. Molecular Nutrition & Food Research 54:6, pages 851-860.
Crossref
Walter Brand, Marelle G. Boersma, Hanneke Bik, Elisabeth F. Hoek-van den Hil, Jacques Vervoort, Denis Barron, Walter Meinl, Hansruedi Glatt, Gary Williamson, Peter J. van Bladeren & Ivonne M. C. M. Rietjens. (2010) Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples. Drug Metabolism and Disposition 38:4, pages 617-625.
Crossref
Chi-Sheng Shia, Yu-Chi Hou, Shang-Yuan Tsai, Pei-Hsun Huieh, Yann-Lii Leu & Pei-Dawn Lee Chao. (2010) Differences in pharmacokinetics and ex vivo antioxidant activity following intravenous and oral administrations of emodin to rats**Chi-Sheng Shia and Yu-Chi Hou contributed equally to this work.. Journal of Pharmaceutical Sciences 99:4, pages 2185-2195.
Crossref
A. Maestro, M. Terdoslavich, A. Vanzo, A. Kuku, F. Tramer, V. Nicolin, F. Micali, G. Decorti & S. Passamonti. (2009) Expression of bilitranslocase in the vascular endothelium and its function as a flavonoid transporter. Cardiovascular Research 85:1, pages 175-183.
Crossref
Umberto De Marchi, Lucia Biasutto, Spiridione Garbisa, Antonio Toninello & Mario Zoratti. (2009) Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1787:12, pages 1425-1432.
Crossref
Lan Tang, Rashim Singh, Zhongqiu Liu & Ming Hu. (2009) Structure and Concentration Changes Affect Characterization of UGT Isoform-Specific Metabolism of Isoflavones. Molecular Pharmaceutics 6:5, pages 1466-1482.
Crossref
Shih Peng Wong, Ping Shen, L. Lee, J. Li & E.L. Yong. (2009) Pharmacokinetics of prenylflavonoids and correlations with the dynamics of estrogen action in sera following ingestion of a standardized Epimedium extract. Journal of Pharmaceutical and Biomedical Analysis 50:2, pages 216-223.
Crossref
Stephen W. J. Wang, Kaustubh H. Kulkarni, Lan Tang, Jing Rong Wang, Taijun Yin, Tomo Daidoji, Hiroshi Yokota & Ming Hu. (2009) Disposition of Flavonoids via Enteric Recycling: UDP-Glucuronosyltransferase (UGT) 1As Deficiency in Gunn Rats Is Compensated by Increases in UGT2Bs Activities. Journal of Pharmacology and Experimental Therapeutics 329:3, pages 1023-1031.
Crossref
Stefano Petti & Crispian Scully. (2009) Polyphenols, oral health and disease: A review. Journal of Dentistry 37:6, pages 413-423.
Crossref
Walter Brand, Petronella A. I. van der Wel, Maarit J. Rein, Denis Barron, Gary Williamson, Peter J. van Bladeren & Ivonne M. C. M. Rietjens. (2008) Metabolism and Transport of the Citrus Flavonoid Hesperetin in Caco-2 Cell Monolayers. Drug Metabolism and Disposition 36:9, pages 1794-1802.
Crossref
Yong-mei Li, Xiao-mian Li, Guang-ming Li, Wen-cai Du, Jing Zhang, Wei-xia Li, Jianshe Xu, Ming Hu & Ze Zhu. (2008) In Vivo Pharmacokinetics of Hesperidin Are Affected by Treatment with Glucosidase-like BglA Protein Isolated from Yeasts. Journal of Agricultural and Food Chemistry 56:14, pages 5550-5557.
Crossref
Ritu Trivedi, Sudhir Kumar, Avinash Kumar, Jawed A. Siddiqui, Gaurav Swarnkar, Varsha Gupta, Amruta Kendurker, Anil Kumar Dwivedi, Jose R. Romero & Naibedya Chattopadhyay. (2008) Kaempferol has osteogenic effect in ovariectomized adult Sprague–Dawley rats. Molecular and Cellular Endocrinology 289:1-2, pages 85-93.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.