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Review

Predictive models for oral drug absorption: from in silico methods to integrated dynamical models

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Pages 491-505 | Published online: 19 Oct 2007

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Saeed Alqahtani, Ishfaq Bukhari, Ahmed Albassam & Maha Alenazi. (2018) An update on the potential role of intestinal first-pass metabolism for the prediction of drug–drug interactions: the role of PBPK modeling. Expert Opinion on Drug Metabolism & Toxicology 14:6, pages 625-634.
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Saeed Alqahtani, Loqman A Mohamed & Amal Kaddoumi. (2013) Experimental models for predicting drug absorption and metabolism. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1241-1254.
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Kiyohiko Sugano. (2009) Introduction to computational oral absorption simulation. Expert Opinion on Drug Metabolism & Toxicology 5:3, pages 259-293.
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Aleksandra Galetin, Michael Gertz & J Brian Houston. (2008) Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 909-922.
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Rajat Garg & Anuj Garg. (2023) A Comprehensive Review on Recent Advances and Considerations for the Selection of Cell-based In-vitro Techniques for the Assessment of Permeability of Drug Molecules. Current Drug Delivery 20:5, pages 526-544.
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TIRTHA NANDI. (2023) IMPORTANCE OF SUFFICIENT TIME POINTS FOR EFFICIENT PHARMACOKINETIC (PK) COMPARTMENTAL MODELING. International Journal of Applied Pharmaceutics, pages 87-92.
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Jyothsna Gangolu, Sandyapakula Balaiah, Sisir Nandi & Harekrishna Roy. (2022) Optimization and Quest of HPMC loaded Stavudine Controlled Release Dosage Development by Central Composite Design utilizing Reduced Factorial Screening Technique. Brazilian Journal of Pharmaceutical Sciences 58.
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Jangampalli Adi Pradeepkiran, S.B. Sainath & K.V.L. Shrikanya. 2021. Brucella Melitensis. Brucella Melitensis 133 176 .
Navpreet Kaur, Poonam Singh Thakur, Ganesh Shete, Rahul Gangwal, Abhay T. Sangamwar & Arvind Kumar Bansal. (2020) Understanding the Oral Absorption of Irbesartan Using Biorelevant Dissolution Testing and PBPK Modeling. AAPS PharmSciTech 21:3.
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Ravishekar Kannan & Andrzej Przekwas. (2020) A multiscale absorption and transit model for oral drug delivery: Formulation and applications during fasting conditions. International Journal for Numerical Methods in Biomedical Engineering 36:3.
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Harekrishna Roy & Sisir Nandi. (2019) In-Silico Modeling in Drug Metabolism and Interaction: Current Strategies of Lead Discovery. Current Pharmaceutical Design 25:31, pages 3292-3305.
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Li Di. (2019) The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics. Current Drug Metabolism 20:2, pages 91-102.
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Navpreet Kaur, Ajit Narang & Arvind Kumar Bansal. (2018) Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption. European Journal of Pharmaceutics and Biopharmaceutics 129, pages 222-246.
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Patrick E. Trapa, Kevin Beaumont, Karen Atkinson, Heather Eng, Amanda King-Ahmad, Dennis O. Scott, Tristan S. Maurer & Li Di. (2017) In Vitro – In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein–Cannulated Monkey. Journal of Pharmaceutical Sciences 106:3, pages 898-905.
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Ahmad Y. Abuhelwa, Desmond B. Williams, Richard N. Upton & David J.R. Foster. (2017) Food, gastrointestinal pH, and models of oral drug absorption. European Journal of Pharmaceutics and Biopharmaceutics 112, pages 234-248.
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Sheila Annie Peters, Christopher R. Jones, Anna-Lena Ungell & Oliver J. D. Hatley. (2016) Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models. Clinical Pharmacokinetics 55:6, pages 673-696.
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Mary S. Kleppe, Kelly M. Forney-Stevens, Roy J. Haskell & Robin H. Bogner. (2015) Mathematical Models to Explore Potential Effects of Supersaturation and Precipitation on Oral Bioavailability of Poorly Soluble Drugs. The AAPS Journal 17:4, pages 902-917.
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Edmund S. Kostewicz, Leon Aarons, Martin Bergstrand, Michael B. Bolger, Aleksandra Galetin, Oliver Hatley, Masoud Jamei, Richard Lloyd, Xavier Pepin, Amin Rostami-Hodjegan, Erik Sjögren, Christer Tannergren, David B. Turner, Christian Wagner, Werner Weitschies & Jennifer Dressman. (2014) PBPK models for the prediction of in vivo performance of oral dosage forms. European Journal of Pharmaceutical Sciences 57, pages 300-321.
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Hannah K. Batchelor, Nikoletta Fotaki & Sandra Klein. (2014) Paediatric oral biopharmaceutics: Key considerations and current challenges. Advanced Drug Delivery Reviews 73, pages 102-126.
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C. Markopoulos, F. Thoenen, D. Preisig, M. Symillides, M. Vertzoni, N. Parrott, C. Reppas & G. Imanidis. (2014) Biorelevant media for transport experiments in the Caco-2 model to evaluate drug absorption in the fasted and the fed state and their usefulness. European Journal of Pharmaceutics and Biopharmaceutics 86:3, pages 438-448.
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Aleksandra Galetin. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 255 288 .
Naresh Pavurala & Luke E.K. Achenie. (2013) A mechanistic approach for modeling oral drug delivery. Computers & Chemical Engineering 57, pages 196-206.
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Ryusuke Takano, Makoto Kataoka & Shinji Yamashita. (2012) Integrating drug permeability with dissolution profile to develop IVIVC. Biopharmaceutics & Drug Disposition 33:7, pages 354-365.
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Peng Zou, Yanke Yu, Nan Zheng, Yongsheng Yang, Hayley J. Paholak, Lawrence X. Yu & Duxin Sun. (2012) Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation. The AAPS Journal 14:2, pages 262-281.
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. 2012. Pharmacokinetics and Metabolism in Drug Design. Pharmacokinetics and Metabolism in Drug Design 41 59 .
Alexander V. LyubimovTonika Bohnert & Chandra Prakash. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 42 .
John C. Lipscomb, Sami Haddad, Torka Poet & Kannan Krishnan. 2012. New Technologies for Toxicity Testing. New Technologies for Toxicity Testing 76 95 .
John A. Roush. (2011) Evaluation of gastrointestinal motility directly from human pharmacokinetic data. International Journal of Pharmaceutics 419:1-2, pages 43-51.
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Miguel Ángel Cabrera‐Pérez & Isabel González‐álvarez. 2011. Oral Bioavailability. Oral Bioavailability 519 534 .
Yi Gao, Robert A. Carr, Julie K. Spence, Weili W. Wang, Teresa M. Turner, John M. Lipari & Jonathan M. Miller. (2010) A pH-Dilution Method for Estimation of Biorelevant Drug Solubility along the Gastrointestinal Tract: Application to Physiologically Based Pharmacokinetic Modeling. Molecular Pharmaceutics 7:5, pages 1516-1526.
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Mark McAllister. (2010) Dynamic Dissolution: A Step Closer to Predictive Dissolution Testing?. Molecular Pharmaceutics 7:5, pages 1374-1387.
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A. Guerra, N.E. Campillo & J.A. Páez. (2010) Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European Journal of Medicinal Chemistry 45:3, pages 930-940.
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Aleksandra Galetin, Michael Gertz & J. Brian Houston. (2010) Contribution of Intestinal Cytochrome P450-Mediated Metabolism to Drug-Drug Inhibition and Induction Interactions. Drug Metabolism and Pharmacokinetics 25:1, pages 28-47.
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J. Brian Houston & Aleksandra Galetin. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 169 215 .
Aleksandra Galetin & J. Brian Houston. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 315 343 .
Weili Huang, Sau Lawrence Lee & Lawrence X. Yu. (2009) Mechanistic Approaches to Predicting Oral Drug Absorption. The AAPS Journal 11:2, pages 217-224.
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Masoud Jamei, Gemma L. Dickinson & Amin Rostami-Hodjegan. (2009) A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates. Drug Metabolism and Pharmacokinetics 24:1, pages 53-75.
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Lana X. Garmire & C. Anthony Hunt. (2008) In Silico Methods for Unraveling the Mechanistic Complexities of Intestinal Absorption: Metabolism-Efflux Transport Interactions. Drug Metabolism and Disposition 36:7, pages 1414-1424.
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