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Expert Opinion on Drug Metabolism & Toxicology Volume 3, 2007 - Issue 4
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Review

In vitro models for processes involved in intestinal absorption

Florian Nigsch University of Cambridge, Unilever Centre for Molecular Science Informatics, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK +44 1223 763 073; +44 1223 763 076; [email protected]
,
Werner Klaffke Unilever Food and Health Research Institute, Olivier van Noortlaan 120, 3133 AC Vlaardingen, The Netherlands
&
Silvia Miret Unilever Food and Health Research Institute, Olivier van Noortlaan 120, 3133 AC Vlaardingen, The Netherlands
Pages 545-556 | Published online: 19 Oct 2007

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Saeed Alqahtani, Ishfaq Bukhari, Ahmed Albassam & Maha Alenazi. (2018) An update on the potential role of intestinal first-pass metabolism for the prediction of drug–drug interactions: the role of PBPK modeling. Expert Opinion on Drug Metabolism & Toxicology 14:6, pages 625-634.
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Saeed Alqahtani, Loqman A Mohamed & Amal Kaddoumi. (2013) Experimental models for predicting drug absorption and metabolism. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1241-1254.
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Olavi Pelkonen, Jaime Kapitulnik, Ursula Gundert-Remy, AlanR. Boobis & Armel Stockis. (2008) Local Kinetics and Dynamics of Xenobiotics. Critical Reviews in Toxicology 38:8, pages 697-720.
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Q. Shi, J.-C. Carrillo, M. Penman, J. Manton, E. Fioravanzo, R. Powrie, C.R. Elcombe, T. Borsboom-Patel, Y. Tian, H. Shen & P.J. Boogaard. (2022) P17-17 Assessment of the intestinal absorption of higher olefins by the everted gut sac model in combination with in silicon newapproach methodologies. Toxicology Letters 368, pages S233-S234.
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Vincent Faugeras, Olivier Duclos, Didier Bazile & Abdou Rachid Thiam. (2022) Impact of Cyclization and Methylation on Peptide Penetration through Droplet Interface Bilayers. Langmuir 38:18, pages 5682-5691.
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Sheila Annie Peters. 2021. Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations. Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations 129 167 .
Jaime L. Korner, Elanna B. Stephenson & Katherine S. Elvira. (2020) A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes. Lab on a Chip 20:11, pages 1898-1906.
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Andrea Sacchetti. (2013) Cancer cell killing by Celecoxib: Reality or just in vitro precipitation‐related artifact?. Journal of Cellular Biochemistry 114:6, pages 1434-1444.
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Sheila Annie Peters. 2012. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations 43 88 .
Kevin J. Randall, John Turton & John R. Foster. (2011) Explant culture of gastrointestinal tissue: a review of methods and applications. Cell Biology and Toxicology 27:4, pages 267-284.
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E. NEIRINCKX, C. VERVAET, J. MICHIELS, S. DE SMET, W. VAN DEN BROECK, J. P. REMON, P. DE BACKER & S. CROUBELS. (2011) Feasibility of the Ussing chamber technique for the determination of in vitro jejunal permeability of passively absorbed compounds in different animal species. Journal of Veterinary Pharmacology and Therapeutics 34:3, pages 290-297.
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Laura Turco, Tiziana Catone, Francesca Caloni, Emma Di Consiglio, Emanuela Testai & Annalaura Stammati. (2011) Caco-2/TC7 cell line characterization for intestinal absorption: How reliable is this in vitro model for the prediction of the oral dose fraction absorbed in human?. Toxicology in Vitro 25:1, pages 13-20.
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Isabella De Angelis & Laura Turco. (2011) Caco‐2 Cells as a Model for Intestinal Absorption. Current Protocols in Toxicology 47:1.
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Pilar Prieto, Sebastian Hoffmann, Valentina Tirelli, Francesco Tancredi, Isabel González, Marival Bermejo & Isabella De Angelis. (2010) An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity. Alternatives to Laboratory Animals 38:5, pages 367-386.
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Guus S. M. J. E. Duchateau & Werner Klaffke. (2008) Product Composition, Structure, and Bioavailability. Food Biophysics 3:2, pages 207-212.
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David S. Palmer, Antonio Llinàs, Iñaki Morao, Graeme M. Day, Jonathan M. Goodman, Robert C. Glen & John B. O. Mitchell. (2008) Predicting Intrinsic Aqueous Solubility by a Thermodynamic Cycle. Molecular Pharmaceutics 5:2, pages 266-279.
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