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Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects

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Pages 847-863 | Published online: 21 Nov 2007

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Tewes Tralau & Andreas Luch. (2013) The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications. Expert Opinion on Drug Metabolism & Toxicology 9:12, pages 1541-1554.
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Santosh Kumar. (2010) Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation. Expert Opinion on Drug Metabolism & Toxicology 6:2, pages 115-131.
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Articles from other publishers (25)

Panpan Wei, Chuanbo Zhang, Xueke Bian & Wenyu Lu. (2022) Metabolic Engineering of Saccharomyces cerevisiae for Heterologous Carnosic Acid Production. Frontiers in Bioengineering and Biotechnology 10.
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Natalie Jay, Sean R. Duffy & D. Fernando Estrada. (2022) Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding. Biochemistry 61:2, pages 57-66.
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David C Lamb, Tatiana Y Hargrove, Bin Zhao, Zdzislaw Wawrzak, Jared V Goldstone, William David Nes, Steven L Kelly, Michael R Waterman, John J Stegeman & Galina I Lepesheva. (2021) Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases. Molecular Biology and Evolution 38:3, pages 952-967.
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Gamal Awad & Alain Garnier. (2021) Promising optimization of bacterial cytochrome P450BM3 enzyme production by engineered Escherichia coli BL21. Biocatalysis and Agricultural Biotechnology 31, pages 101917.
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Kaiprathu Anjali, Naragalu J. Venkatesha, Jayaraj Christopher & Ayyamperumal Sakthivel. (2020) Rhodium porphyrin molecule-based catalysts for the hydrogenation of biomass derived levulinic acid to biofuel additive γ-valerolactone. New Journal of Chemistry 44:26, pages 11064-11075.
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Hyun A. Park & Kwon-Young Choi. (2020) α, ω-Oxyfunctionalization of C12 alkanes via whole-cell biocatalysis of CYP153A from Marinobacter aquaeolei and a new CYP from Nocardia farcinica IFM10152. Biochemical Engineering Journal 156, pages 107524.
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A. V. Kuzikov, R. A. Masamrekh, A. I. Archakov & V. V. Shumyantseva. (2018) Methods for Determination of Functional Activity of Cytochrome P450 Isoenzymes. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 12:3, pages 220-240.
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A.V. Kuzikov, R.A. Masamrekh, A.I. Archakov & V.V. Shumyantseva. (2018) Methods for determining of cytochrome P450 isozymes functional activity. Biomeditsinskaya Khimiya 64:2, pages 149-168.
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Anja Greule, Jeanette E. Stok, James J. De Voss & Max J. Cryle. (2018) Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism. Natural Product Reports 35:8, pages 757-791.
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Alexander V. LyubimovEugene G. Hrycay & Stelvio M. Bandiera. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 36 .
Lea Talmann, Jochen Wiesner & Andreas Vilcinskas. (2017) Strategies for the construction of insect P450 fusion enzymes. Zeitschrift für Naturforschung C 72:9-10, pages 405-415.
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Patrick J. Bakkes, Jan L. Riehm, Tanja Sagadin, Ansgar Rühlmann, Peter Schubert, Stefan Biemann, Marco Girhard, Michael C. Hutter, Rita Bernhardt & Vlada B. Urlacher. (2017) Engineering of versatile redox partner fusions that support monooxygenase activity of functionally diverse cytochrome P450s. Scientific Reports 7:1.
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Sebastian Schulz, Dominik Schumacher, Daniel Raszkowski, Marco Girhard & Vlada B. Urlacher. (2016) Fusion to Hydrophobin HFBI Improves the Catalytic Performance of a Cytochrome P450 System. Frontiers in Bioengineering and Biotechnology 4.
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Patrick J. Bakkes, Stefan Biemann, Ansgar Bokel, Marc Eickholt, Marco Girhard & Vlada B. Urlacher. (2015) Design and improvement of artificial redox modules by molecular fusion of flavodoxin and flavodoxin reductase from Escherichia coli. Scientific Reports 5:1.
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Peter Hlavica. 2015. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 247 297 .
Marco Girhard, Patrick J. Bakkes, Osama Mahmoud & Vlada B. Urlacher. 2015. Cytochrome P450. Cytochrome P450 451 520 .
Kwon-Young Choi, EunOk Jung, Hyungdon Yun, Yung-Hun Yang & Byung-Gee Kim. (2014) Engineering class I cytochrome P450 by gene fusion with NADPH-dependent reductase and S. avermitilis host development for daidzein biotransformation. Applied Microbiology and Biotechnology 98:19, pages 8191-8200.
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Rita Bernhardt & Vlada B. Urlacher. (2014) Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations. Applied Microbiology and Biotechnology 98:14, pages 6185-6203.
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Giovanna Di Nardo & Gianfranco Gilardi. (2012) Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites. International Journal of Molecular Sciences 13:12, pages 15901-15924.
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Daniela Gamenara, Gustavo A. Seoane, Patricia Saenz‐Méndez & Pablo Domínguez de María. 2012. Redox Biocatalysis. Redox Biocatalysis 1 85 .
Christopher J. C. Whitehouse, Stephen G. Bell & Luet-Lok Wong. (2012) P450 BM3 (CYP102A1): connecting the dots . Chem. Soc. Rev. 41:3, pages 1218-1260.
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Cassy M. Spiller & Peter Koopman. 2011. Cell Cycle in Development. Cell Cycle in Development 269 308 .
Kirsty J McLean, James Belcher, Max D Driscoll, Christine C Fernandez, Duyet Le Van, Soi Bui, Marina Golovanova & Andrew W Munro. (2010) The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention . Future Medicinal Chemistry 2:8, pages 1339-1353.
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Alexander Combes, Cassy Spiller & Peter Koopman. 2010. Oogenesis. Oogenesis 27 79 .
Kwon-Young Choi, Changhyun Roh, Bishnu P. Pandey, Nahum Lee, Taejin Kim, Seungkee Kim & Byung-Gee Kim. (2008) Functional expression of cytochrome P450s in Escherichia coli for the biotransformation of daidzein to produce ortho-specific monohydroxylation. Journal of Biotechnology 136, pages S70.
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