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Expert Opinion on Drug Metabolism & Toxicology Volume 4, 2008 - Issue 10
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Drug Evaluation

Donepezil: potential neuroprotective and disease-modifying effects

Sandra A Jacobson Chief of Geriatric Psychopharmacology Research Cleo Roberts Center for Clinical Research, Sun Health Research Institute, 10515 W Santa Fe Drive, Sun City, AZ 85351, USA +1 623 875 6500; +1 623 875 6504; [email protected]
, MD &
Marwan N Sabbagh Director Cleo Roberts Center for Clinical Research, Sun Health Research Institute, 10515 W Santa Fe Drive, Sun City, AZ 85351, USA Funded by NIA ADCC P30 AG019610 and the Sun Health Research Institute
, MD
Pages 1363-1369 | Published online: 17 Sep 2008

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Darinka Dimitrova, Damianka Getova & Kremena Saracheva. (2023) Effects of 3 R , 16 S -2-hydroxyethyl apovincaminate (HEAPO), donepezil and galantamine on learning and memory retention in naïve Wistar rats . Acta Pharmaceutica 73:1, pages 91-105.
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Neha & Suhel Parvez. (2023) Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease. Ageing Research Reviews 85, pages 101815.
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Gizem Rüya Topal, Berrin Küçüktürkmen, Umut Can Öz, Erva Özkan, Filiz Bakar-Ates & Asuman Bozkır. (2023) Investigation on formulation parameters of donepezil HCl loaded solid lipid nanoparticles. Brazilian Journal of Pharmaceutical Sciences 59.
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Kholoud I. Eissa, Mona M. Kamel, Lamia W. Mohamed & Asmaa E. Kassab. (2022) Development of new Alzheimer's disease drug candidates using donepezil as a key model. Archiv der Pharmazie 356:1.
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Lupe Carolina Espinoza, Diana Guaya, Ana Cristina Calpena, Rodolfo Miguel Perotti, Lyda Halbaut, Lilian Sosa, Adriel Brito-Llera & Mireia Mallandrich. (2022) Comparative Study of Donepezil-Loaded Formulations for the Treatment of Alzheimer’s Disease by Nasal Administration. Gels 8:11, pages 715.
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Parham Pooladgar, Mehdi Sakhabakhsh, Arsia Taghva & Saeed Soleiman-Meigooni. (2022) Donepezil Beyond Alzheimer's Disease? A Narrative Review of Therapeutic Potentials of Donepezil in Different Diseases. Iranian Journal of Pharmaceutical Research 21:1.
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Jian Li, Chaojie Zheng, Qi Ge, Shaozhen Yan, Manish D Paranjpe, Shuo Hu & Yun Zhou. (2021) Association between long‐term donepezil treatment and brain regional amyloid and tau burden among individuals with mild cognitive impairment assessed using 18 F‐AV‐45 and 18 F‐AV‐1451 PET . Journal of Neuroscience Research 100:2, pages 670-680.
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Jan Korabecny, Katarina Spilovska, Eva Mezeiova, Ondrej Benek, Radomir Juza, Daniel Kaping & Ondrej Soukup. (2019) A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer’s Disease. Current Medicinal Chemistry 26:30, pages 5625-5648.
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Mohammad Mohajeri, Behzad Behnam, George E. Barreto & Amirhossein Sahebkar. (2019) Carbon nanomaterials and amyloid-beta interactions: potentials for the detection and treatment of Alzheimer's disease?. Pharmacological Research 143, pages 186-203.
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Qi Li, Siyu He, Yao Chen, Feng Feng, Wei Qu & Haopeng Sun. (2018) Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 158, pages 463-477.
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Zhengping Zhang, Rong Chen, Wenji An, Chunmei Wang, Gaoyong Liao, Xiaoliang Dong, Aijing Bi, Zhimin Yin & Lan Luo. (2015) A novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improves Aβ25–35-impaired mouse cognitive function. Psychopharmacology 233:4, pages 599-613.
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Eosu Kim, Minsun Park, Jihyeon Jeong, Hyunjeong Kim, Su Kyoung Lee, Eun Lee, Byoung Hoon Oh & Kee Namkoong. (2016) Cholinesterase Inhibitor Donepezil Increases Mitochondrial Biogenesis through AMP-Activated Protein Kinase in the Hippocampus. Neuropsychobiology 73:2, pages 81-91.
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