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Expert Opinion on Drug Metabolism & Toxicology Volume 4, 2008 - Issue 5
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Review

Pharmacokinetic/pharmacodynamic modeling of cardiac toxicity in human acute overdoses: utility and limitations

Bruno Mégarbane Hôpital Lariboisière, Réanimation Médicale et Toxicologique, 2 rue Ambroise Paré, 75010, Paris, France +33 1 49 95 64 91; +33 1 49 95 65 78; [email protected]
, MD PhD,
Arsia Amir Aslani PRISM – Université Paris 1 Sorbonne, Paris, France
, PhD,
Nicolas Deye Hôpital Lariboisière, Réanimation Médicale et Toxicologique, 2 rue Ambroise Paré, 75010, Paris, France +33 1 49 95 64 91; +33 1 49 95 65 78; [email protected]
, MD &
Frédéric J Baud Hôpital Lariboisière, Réanimation Médicale et Toxicologique, 2 rue Ambroise Paré, 75010, Paris, France +33 1 49 95 64 91; +33 1 49 95 65 78; [email protected]
, MD
Pages 569-579 | Published online: 18 May 2008

Citations (7)

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Jérôme Liotier & François Coudoré. (2011) Drug monitoring of a case of citalopram overdosage. Drug and Chemical Toxicology 34:4, pages 420-423.
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Bruno Mégarbane, Vanessa Bloch, Deborah Hirt, Marcel Debray, Dabor Résiére, Nicolas Deye & Frédéric J. Baud. (2010) Blood concentrations are better predictors of chioroquine poisoning severity than plasma concentrations: a prospective study with modeling of the concentration/effect relationships. Clinical Toxicology 48:9, pages 904-915.
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Articles from other publishers (5)

Zofia Tylutki, Sebastian Polak & Barbara Wiśniowska. (2016) Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations. Current Pharmacology Reports 2:4, pages 171-177.
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TA Collins, L Bergenholm, T Abdulla, JWT Yates, N Evans, MJ Chappell & JT Mettetal. (2015) Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment. CPT: Pharmacometrics & Systems Pharmacology 4:3, pages 175-188.
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Jennifer Sorensen Forbey, Xinzhu Pu, Dong Xu, Knut Kielland & John Bryant. (2011) Inhibition of Snowshoe Hare Succinate Dehydrogenase Activity as a Mechanism of Deterrence for Papyriferic Acid in Birch. Journal of Chemical Ecology 37:12, pages 1285-1293.
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P. Timothy Pollak, Zulfikaral H. Verjee & Andrew W. Lyon. (2013) Risperidone‐Induced QT Prolongation Following Overdose Correlates With Serum Drug Concentration and Resolves Rapidly With No Evidence of Altered Pharmacokinetics. The Journal of Clinical Pharmacology 51:7, pages 1112-1115.
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N. Deye, B. Mégarbane & F. Baud. 2009. Insuffisance circulatoire aiguë. Insuffisance circulatoire aiguë 549 588 .

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