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Jian Jiang, Jarno EJ Wolters, Simone G van Breda, Jos C Kleinjans & Theo M de Kok. (2015) Development of novel tools for the in vitro investigation of drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 11:10, pages 1523-1537.
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M José Gómez-Lechón, Laia Tolosa, Isabel Conde & M Teresa Donato. (2014) Competency of different cell models to predict human hepatotoxic drugs. Expert Opinion on Drug Metabolism & Toxicology 10:11, pages 1553-1568.
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Maria A Croyle. (2009) Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1189-1211.
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Yurong Lai. (2009) Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1175-1187.
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Gordon Liss & James H Lewis. (2009) Drug-induced liver injury: what was new in 2008?. Expert Opinion on Drug Metabolism & Toxicology 5:8, pages 843-860.
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Articles from other publishers (40)
In Young Kim, Jae Won Choi, Ik Hwan Kwon, Seonae Hwangbo, Song-Hwa Bae, Minjeong Kwak, Jaeseok Kim, Tae Geol Lee & Min Beom Heo. (2022) Variations in in vitro toxicity of silica nanoparticles according to scaffold type in a 3D culture system using a micropillar/microwell chip platform. Sensors and Actuators B: Chemical 369, pages 132328.
Crossref
Crossref
Hong Wei & Albert P. Li. (2022) Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone. Drug Metabolism and Disposition 50:2, pages 140-149.
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Christopher Hadjittofi, Michael Feretis, Jack Martin, Simon Harper & Emmanuel Huguet. (2021) Liver regeneration biology: Implications for liver tumour therapies. World Journal of Clinical Oncology 12:12, pages 1101-1156.
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Yi Chen, Dan Tang, Hongping Wu, Yuling Wu, Tianjie Yuan, Hongdan Zhang, Yingfu Jiao, Weifeng Yu & Hexin Yan. (2021) Assessment of long-term functional maintenance of primary human hepatocytes to predict drug-induced hepatoxicity in vitro. Archives of Toxicology 95:7, pages 2431-2442.
Crossref
Crossref
Saskia Floerl, Annett Kuehne & Yohannes Hagos. (2020) Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction. International Journal of Molecular Sciences 21:18, pages 6871.
Crossref
Crossref
Aida Rodriguez-Garcia, Jacqueline Oliva-Ramirez, Claudia Bautista-Flores & Samira Hosseini. (2020)
3D
In Vitro
Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment
. Advances in Polymer Technology 2020, pages 1-41.
Crossref
Crossref
Ume-Kulsoom Shah, Jefferson de Oliveira Mallia, Neenu Singh, Katherine E. Chapman, Shareen H. Doak & Gareth J.S. Jenkins. (2018) Reprint of: A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 834, pages 35-41.
Crossref
Crossref
Ume-Kulsoom Shah, Jefferson de Oliveira Mallia, Neenu Singh, Katherine E. Chapman, Shareen H. Doak & Gareth J.S. Jenkins. (2018) A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 825, pages 51-58.
Crossref
Crossref
Shamir Cassim, Valérie-Ann Raymond, Pascal Lapierre & Marc Bilodeau. (2017) From in vivo to in vitro: Major metabolic alterations take place in hepatocytes during and following isolation. PLOS ONE 12:12, pages e0190366.
Crossref
Crossref
Randy Strube, Johannes Haugstetter, Markus Furter, Andreia Fernandez, David Fluri & Jens M. Kelm. 2017. Technology Platforms for 3D Cell Culture. Technology Platforms for 3D Cell Culture
21
49
.
Joel G. Putnam, Justine E. Nelson, Eric M. Leis, Richard A. Erickson, Terrance D. Hubert & Jon J. Amberg. (2017) Using silver and bighead carp cell lines for the identification of a unique metabolite fingerprint from thiram-specific chemical exposure. Chemosphere 168, pages 1477-1485.
Crossref
Crossref
Marieke Teppner, Manfred Zell, Christophe Husser, Beat Ernst & Axel Pähler. (2016) Quantitative profiling of prostaglandins as oxidative stress biomarkers in vitro and in vivo by negative ion online solid phase extraction – Liquid chromatography–tandem mass spectrometry. Analytical Biochemistry 498, pages 68-77.
Crossref
Crossref
Linfeng Li, Qiong Zhou, Ty C. Voss, Kevin L. Quick & Daniel V. LaBarbera. (2016) High-throughput imaging: Focusing in on drug discovery in 3D. Methods 96, pages 97-102.
Crossref
Crossref
Stefan O. Mueller, André Guillouzo, Philip G. Hewitt & Lysiane Richert. (2015) Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project. Toxicology in Vitro 30:1, pages 19-26.
Crossref
Crossref
Jessica J.W. Broeders, Céline Parmentier, Germaine L. Truisi, Rozenn Jossé, Eliane Alexandre, Camille C. Savary, Philip G. Hewitt, Stefan O. Mueller, André Guillouzo, Lysiane Richert, Jan C.H. van Eijkeren, Joop L.M. Hermens & Bas J. Blaauboer. (2015) Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure. Toxicology in Vitro 30:1, pages 52-61.
Crossref
Crossref
Kathleen A. Fitzgerald, Meenakshi Malhotra, Caroline M. Curtin, Fergal J. O' Brien & Caitriona M. O' Driscoll. (2015) Life in 3D is never flat: 3D models to optimise drug delivery. Journal of Controlled Release 215, pages 39-54.
Crossref
Crossref
Germaine L. Truisi, Emma Di Consiglio, Céline Parmentier, Camille C. Savary, Giuliana Pomponio, Frederic Bois, Birthe Lauer, Rozenn Jossé, Philip G. Hewitt, Stefan O. Mueller, Lysiane Richert, André Guillouzo & Emanuela Testai. (2015) Understanding the biokinetics of ibuprofen after single and repeated treatments in rat and human in vitro liver cell systems. Toxicology Letters 233:2, pages 172-186.
Crossref
Crossref
Céline Parmentier, Germaine L. Truisi, Konrad Moenks, Sven Stanzel, Arno Lukas, Annette Kopp-Schneider, Eliane Alexandre, Philip G. Hewitt, Stefan O. Mueller & Lysiane Richert. (2013) Transcriptomic Hepatotoxicity Signature of Chlorpromazine after Short- and Long-Term Exposure in Primary Human Sandwich Cultures. Drug Metabolism and Disposition 41:10, pages 1835-1842.
Crossref
Crossref
Naila Naz, Federico Moriconi, Shakil Ahmad, Ahmad Amanzada, Sajjad Khan, Sabine Mihm, Guiliano Ramadori & Ihtzaz Ahmed Malik. (2013) Ferritin L is the Sole Serum Ferritin Constituent and a Positive Hepatic Acute-Phase Protein. Shock 39:6, pages 520-526.
Crossref
Crossref
Patrina Gunness, Daniel Mueller, Valery Shevchenko, Elmar Heinzle, Magnus Ingelman-Sundberg & Fozia Noor. (2013) 3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies. Toxicological Sciences 133:1, pages 67-78.
Crossref
Crossref
Shuyan Lu, Bart Jessen, Christopher Strock & Yvonne Will. (2012) The contribution of physicochemical properties to multiple in vitro cytotoxicity endpoints. Toxicology in Vitro 26:4, pages 613-620.
Crossref
Crossref
W. Griffith Humphreys. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development
55
65
.
Rajarshi Pal, Murali Krishna Mamidi, Anjan Kumar Das, Pawan Kumar Gupta & Ramesh Bhonde. (2012) A Simple and economical route to generate functional hepatocyte-like cells from hESCs and their application in evaluating alcohol induced liver damage. Journal of Cellular Biochemistry 113:1, pages 19-30.
Crossref
Crossref
Ana B. Blázquez, Javier Cuesta & Cristobalina Mayorga. (2011) Role of dendritic cells in drug allergy. Current Opinion in Allergy & Clinical Immunology 11:4, pages 279-284.
Crossref
Crossref
M. Ann Mongan & Hisham K. Hamadeh. 2011. Applications of Toxicogenomics in Safety Evaluation and Risk Assessment. Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
147
176
.
Hong YangCharles M. RothMarianthi G. Ierapetritou. (2011) Analysis of Amino Acid Supplementation Effects on Hepatocyte Cultures Using Flux Balance Analysis. OMICS: A Journal of Integrative Biology 15:7-8, pages 449-460.
Crossref
Crossref
W. Griffith Humphreys. (2011) Overview of strategies for addressing BRIs in drug discovery: Impact on optimization and design. Chemico-Biological Interactions 192:1-2, pages 56-59.
Crossref
Crossref
Katrin ZeilingerThomas SchreiterMalin DarnellTherese SöderdahlMarc LübberstedtBirgitta DillnerDaniel KnobelochAndreas K. NüsslerJörg C. GerlachTommy B. Andersson. (2011)
Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological
In Vitro
Studies
. Tissue Engineering Part C: Methods 17:5, pages 549-556.
Crossref
Crossref
Marco Parolini, Andrea Binelli & Alfredo Provini. (2010) Assessment of the Potential Cyto–Genotoxicity of the Nonsteroidal Anti-Inflammatory Drug (NSAID) Diclofenac on the Zebra Mussel (Dreissena polymorpha). Water, Air, & Soil Pollution 217:1-4, pages 589-601.
Crossref
Crossref
A. Y. AU, J. M. HASENWINKEL & C. G. FRONDOZA. (2011) Silybin inhibits interleukin-1β-induced production of pro-inflammatory mediators in canine hepatocyte cultures. Journal of Veterinary Pharmacology and Therapeutics 34:2, pages 120-129.
Crossref
Crossref
Jinghai James Xu & Keith Hoffmaster. 2011. ADMET for Medicinal Chemists. ADMET for Medicinal Chemists
353
377
.
Arefeh Ghodsizadeh, Adeleh Taei, Mehdi Totonchi, Ali Seifinejad, Hamid Gourabi, Behshad Pournasr, Nasser Aghdami, Reza Malekzadeh, Navid Almadani, Ghasem Hosseini Salekdeh & Hossein Baharvand. (2010) Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells. Stem Cell Reviews and Reports 6:4, pages 622-632.
Crossref
Crossref
Bridget C. Fox, Alison S. Devonshire, Maaike E. Schutte, Carole A. Foy, Jesus Minguez, Stefan Przyborski, Daniel Maltman, Maria Bokhari & Damian Marshall. (2010) Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers. Toxicology in Vitro 24:7, pages 1962-1970.
Crossref
Crossref
Hua Liu, Zhaohui Ye, Yonghak Kim, Saul Sharkis & Yoon-Young Jang. (2010) Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes. Hepatology 51:5, pages 1810-1819.
Crossref
Crossref
Josef S. Ozer, Raj Chetty, Gerry Kenna, Joe Palandra, Yiqun Zhang, Anne Lanevschi, Nandan Koppiker, Bernard E. Souberbielle & Shashi K. Ramaiah. (2010) Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury. Regulatory Toxicology and Pharmacology 56:3, pages 237-246.
Crossref
Crossref
Miloň Tichý, Adéla Pokorná, Iveta Hanzlíková, Jana Nerudová, Jana Tumová & Rút Uzlová. (2010) Primary rat hepatocytes in chemical testing and QSAR predictive applicability. Toxicology in Vitro 24:1, pages 240-244.
Crossref
Crossref
María José Gómez-Lechón, José V. Castell & María Teresa Donato. 2010. Hepatocytes. Hepatocytes
389
415
.
Zhihua Song, Jun Cai, Yanxia Liu, Dongxin Zhao, Jun Yong, Shuguang Duo, Xijun Song, Yushan Guo, Yang Zhao, Han Qin, Xiaolei Yin, Chen Wu, Jie Che, Shichun Lu, Mingxiao Ding & Hongkui Deng. (2009) Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Research 19:11, pages 1233-1242.
Crossref
Crossref
Gregor Tuschl, Jens Hrach, Yvonne Walter, Philip G. Hewitt & Stefan O. Mueller. (2009) Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug–drug interaction studies. Chemico-Biological Interactions 181:1, pages 124-137.
Crossref
Crossref
Birthe Lauer, Gregor Tuschl, Margret Kling & Stefan O. Mueller. (2009) Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chemico-Biological Interactions 179:1, pages 17-24.
Crossref
Crossref