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Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics

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Pages 1021-1033 | Published online: 04 Aug 2008

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Graham Lappin, Mark Seymour, Graeme Young, David Higton & Howard M Hill. (2011) AMS method validation for quantitation in pharmacokinetic studies with concomitant extravascular and intravenous administration. Bioanalysis 3:4, pages 393-405.
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Crossref
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Crossref
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Angus N. R. Nedderman & Don K. Walker. 2011. Pharmacokinetics in Drug Development. Pharmacokinetics in Drug Development 131 143 .
Graham Lappin. 2011. Pharmacokinetics in Drug Development. Pharmacokinetics in Drug Development 115 130 .
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Crossref
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Crossref
Stephen R DuekerPeter N LohstrohJason A GiacomoLe T VuongBradly D KeckJohn S Vogel. (2010) Early human ADME using microdoses and microtracers: bioanalytical considerations. Bioanalysis 2:3, pages 441-454.
Crossref
Paul T HendersonChong-xian Pan. (2010) Human microdosing for the prediction of patient response. Bioanalysis 2:3, pages 373-376.
Crossref
John S VogelJason A Giacomo, Tim Schulze-KönigBradly D Keck, Peter Lohstroh & Stephen Dueker. (2010) Accelerator mass spectrometry best practices for accuracy and precision in bioanalytical 14 C measurements . Bioanalysis 2:3, pages 455-468.
Crossref
Ali Arjomand. (2010) Accelerator mass spectrometry-enabled studies: current status and future prospects. Bioanalysis 2:3, pages 519-541.
Crossref
Kin Y. TamAlex Avdeef, Oksana Tsinman & Na Sun. (2009) The Permeation of Amphoteric Drugs through Artificial Membranes − An in Combo Absorption Model Based on Paracellular and Transmembrane Permeability. Journal of Medicinal Chemistry 53:1, pages 392-401.
Crossref
Graham Lappin. 2010. Clinical Pharmacology: Current Topics and Case Studies. Clinical Pharmacology: Current Topics and Case Studies 157 166 .
Paul de KoningJames Keirns. (2009) Clinical pharmacology, biomarkers and personalized medicine: education please. Biomarkers in Medicine 3:6, pages 685-700.
Crossref
Gerhard GrossIan Wilson. (2009) Issues in the safety testing of metabolites. Future Medicinal Chemistry 1:8, pages 1381-1390.
Crossref
Laurent Leclercq, Filip Cuyckens, Geert S. J. Mannens, Ronald de Vries, Philip Timmerman & David C. Evans. (2009) Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development. Chemical Research in Toxicology 22:2, pages 280-293.
Crossref
Shelby Anderson, Debra Luffer-Atlas & Mary Pat Knadler. (2009) Predicting Circulating Human Metabolites: How Good Are We?. Chemical Research in Toxicology 22:2, pages 243-256.
Crossref
E. Hywel Evans, Jason A. Day, Christopher D. Palmer & Clare M. M. Smith. (2009) Atomic Spectrometry Update. Advances in atomic spectrometry and related techniques. Journal of Analytical Atomic Spectrometry 24:6, pages 711.
Crossref
Andrew Taylor, Simon Branch, Martin P. Day, Marina Patriarca & Mark White. (2009) Atomic Spectrometry Update. Clinical and biological materials, foods and beverages. Journal of Analytical Atomic Spectrometry 24:4, pages 535.
Crossref
Thomas N. Thompson. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 459 474 .

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