Ganesh Moorthy, Gayle Pageau Pouliot, Lorraine Graham, Elizabeth Pilling, Lindsey Jung, Rachael Alcobi, Yali Zhu, Yan Li, Sharan Sidhu, Pablo Forte & Ganesh Mugundu. (2023) Comprehensive clinical pharmacology characterization of AZD4635 in healthy participants to support dosing considerations. British Journal of Clinical Pharmacology 89:9, pages 2775-2787.
Crossref
Elliot DavenportDaniela E. NegruGeoff BadmanDavid M. Lindsay & William J. Kerr. (2023) Robust and General Late-Stage Methylation of Aryl Chlorides: Application to Isotopic Labeling of Drug-like Scaffolds. ACS Catalysis 13:17, pages 11541-11547.
Crossref
R. Lock, P. J. H. Webborn, C. W. Vose & R. M. J. Ings. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry
265
297
.
Yuxuan Ding, Simon S. Pedersen, Alex Lin, Ruoyu Qian & Zachary T. Ball. (2022) Direct formation and site-selective elaboration of methionine sulfoximine in polypeptides. Chemical Science 13:47, pages 14101-14105.
Crossref
Ellen Cannady, Kishore Katyayan & Nita Patel. 2022. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology
51
76
.
Sheila Annie Peters. 2021. Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations. Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations
469
482
.
Mehr Fatima, Thomas Hausmaninger, Teemu Tomberg, Juho Karhu, Markku Vainio, Tuomas Hieta & Guillaume Genoud. (2021) Radiocarbon dioxide detection using cantilever-enhanced photoacoustic spectroscopy. Optics Letters 46:9, pages 2083.
Crossref
Simon S. Pedersen, Aske S. Donslund, Jesper H. Mikkelsen, Oskar S. Bakholm, Florian Papp, Kim B. Jensen, Magnus B. F. Gustafsson & Troels Skrydstrup. (2021) A Nickel(II)‐Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides. Chemistry – A European Journal 27:24, pages 7114-7123.
Crossref
Andrew McEwen. 2020. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology
773
806
.
Sheila Annie Peters & Hugues Dolgos. (2019) Requirements to Establishing Confidence in Physiologically Based Pharmacokinetic (PBPK) Models and Overcoming Some of the Challenges to Meeting Them. Clinical Pharmacokinetics 58:11, pages 1355-1371.
Crossref
Terry Podoll, Paul G. Pearson, Jerry Evarts, Tim Ingallinera, Elena Bibikova, Hao Sun, Mark Gohdes, Kristen Cardinal, Mitesh Sanghvi & J. Greg Slatter. (2019) Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans. Drug Metabolism and Disposition 47:2, pages 145-154.
Crossref
Dennis U. Nielsen, Karoline T. Neumann, Anders T. Lindhardt & Troels Skrydstrup. (2018)
Recent developments in carbonylation chemistry using [
13
C]CO, [
11
C]CO, and [
14
C]CO
. Journal of Labelled Compounds and Radiopharmaceuticals 61:13, pages 949-987.
Crossref
Nicole A. Kratochwil, Stephen R. Dueker, Dieter Muri, Claudia Senn, HyeJin Yoon, Byung-Yong Yu, Gwan-Ho Lee, Feng Dong & Michael B. Otteneder. (2018) Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies. PLOS ONE 13:10, pages e0205435.
Crossref
Andrew McEwen. 2017. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology
1
34
.
Gordon J. Dear & Andrew McEwen. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development
45
85
.
T. Bohnert, A. Patel, I. Templeton, Y. Chen, C. Lu, G. Lai, L. Leung, S. Tse, H. J. Einolf, Y.-H. Wang, M. Sinz, R. Stearns, R. Walsky, W. Geng, S. Sudsakorn, D. Moore, L. He, J. Wahlstrom, J. Keirns, R. Narayanan, D. Lang & X. Yang. (2016) Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions--an Industry Perspective. Drug Metabolism and Disposition 44:8, pages 1399-1423.
Crossref
Le Thuy Vuong, Qi Song, Hee Joo Lee, Ad F Roffel, Seok-Ho Shin, Young G Shin & Stephen R Dueker. (2016) Opportunities in low-level radiocarbon microtracing: applications and new technology. Future Science OA 2:1.
Crossref
Graham Lappin. (2016) Approaches to intravenous clinical pharmacokinetics: Recent developments with isotopic microtracers. The Journal of Clinical Pharmacology 56:1, pages 11-23.
Crossref
George S. Jackson, Jane A. Einstein, Tom Kubley, Berdine Martin, Connie M. Weaver & Marc Caffee. (2015) Biomedical graphite and CaF2 preparation and measurement at PRIME Lab. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 361, pages 358-362.
Crossref
Susan Ebeler & Alyson Mitchell. 2015. Cosmeceuticals and Active Cosmetics, Third Edition. Cosmeceuticals and Active Cosmetics, Third Edition
411
428
.
Damayanthi Devineni, Joseph Murphy, Shean-Sheng Wang, Hans Stieltjes, Paul Rothenberg, Ellen Scheers & Rao N.V.S. Mamidi. (2015) Absolute oral bioavailability and pharmacokinetics of canagliflozin: A microdose study in healthy participants. Clinical Pharmacology in Drug Development 4:4, pages 295-304.
Crossref
Graham Lappin. (2015) A historical perspective on radioisotopic tracers in metabolism and biochemistry. Bioanalysis 7:5, pages 531-540.
Crossref
Charles S. Elmore & Ryan A. Bragg. (2015) Isotope chemistry; a useful tool in the drug discovery arsenal. Bioorganic & Medicinal Chemistry Letters 25:2, pages 167-171.
Crossref
Susanna Tse, Louis Leung, Sangeeta Raje, Mark Seymour, Yoko Shishikura & R. Scott Obach. (2014)
Disposition and Metabolic Profiling of [
14
C]Cerlapirdine Using Accelerator Mass Spectrometry
. Drug Metabolism and Disposition 42:12, pages 2023-2032.
Crossref
Claire Beaumont, Graeme C. Young, Tom Cavalier & Malcolm A. Young. (2014) Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approaches. British Journal of Clinical Pharmacology 78:6, pages 1185-1200.
Crossref
Gérard Hopfgartner. 2013. Mass Spectrometry for Drug Discovery and Drug Development. Mass Spectrometry for Drug Discovery and Drug Development
1
35
.
Ethan Hoffmann, Jeff Wald, Siva Lavu, John Roberts, Claire Beaumont, Jon Haddad, Peter Elliott, Christoph Westphal & Eric Jacobson. (2013) Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man. British Journal of Clinical Pharmacology 75:1, pages 186-196.
Crossref
Fuyuki Tokanai, Kazuhiro Kato, Minoru Anshita, Hirohisa Sakurai, Akihiro Izumi, Teiko Toyoguchi, Takeshi Kobayashi, Hiroko Miyahara, Motonari Ohyama & Yasuharu Hoshino. (2016) Present Status of YU-AMS System. Radiocarbon 55:2, pages 251-259.
Crossref
Angela Dudda & Gert Ulrich Kuerzel. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
1053
1094
.
Hao Jiang, Jianing Zeng, Wenying Li, Marc Bifano, Huidong Gu, Craig Titsch, John Easter, Richard Burrell, Hamza Kandoussi, Anne-Françoise Aubry & Mark E. Arnold. (2012) Practical and Efficient Strategy for Evaluating Oral Absolute Bioavailability with an Intravenous Microdose of a Stable Isotopically-Labeled Drug Using a Selected Reaction Monitoring Mass Spectrometry Assay. Analytical Chemistry 84:22, pages 10031-10037.
Crossref
Richard A. Graham, Cornelis E. C. A. Hop, Marie T. Borin, Bert L. Lum, Dawn Colburn, Ilsung Chang, Young G. Shin, Vikram Malhi, Jennifer A. Low & Mark J. Dresser. (2012) Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects. British Journal of Clinical Pharmacology 74:5, pages 788-796.
Crossref
Jean-Pierre Delord, Jaafar Bennouna, Loïc Mourey, Joël Bougaret, Maud Brandely-Talbot & Pierre Ferré. (2012) Vinflunine Oral Pharmacokinetics and Absolute Bioavailability of Soft and Hard Gelatin Capsules. Clinical Pharmacokinetics 51:6, pages 357-364.
Crossref
Xiaomin Wang, Voon Ong & Mark Seymour. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development
331
338
.
Natalia Penner, Lin Xu & Chandra Prakash. (2012) Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?. Chemical Research in Toxicology 25:3, pages 513-531.
Crossref
Alexander V. LyubimovShelby Anderson, Debra Luffer‐Atlas & Mary Pat Knadler. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
27
.
Alexander V. LyubimovBenny M. Amore. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
39
.
Sergei F. Boulyga. (2011) Mass spectrometric analysis of long-lived radionuclides in bio-assays. International Journal of Mass Spectrometry 307:1-3, pages 200-210.
Crossref
Stephen R. Dueker, Le T. Vuong, Peter N. Lohstroh, Jason A. Giacomo & John S. Vogel. (2011) Quantifying exploratory low dose compounds in humans with AMS. Advanced Drug Delivery Reviews 63:7, pages 518-531.
Crossref
Claudia C. Wagner & Oliver Langer. (2011) Approaches using molecular imaging technology — use of PET in clinical microdose studies. Advanced Drug Delivery Reviews 63:7, pages 539-546.
Crossref
John S. Vogel, Peter Lohstroh, Brad Keck & Stephen R. Dueker. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition
525
566
.
Graham Lappin, Mark Seymour, Graeme Young, David Higton & Howard M Hill. (2011) AMS method validation for quantitation in pharmacokinetic studies with concomitant extravascular and intravenous administration. Bioanalysis 3:4, pages 393-405.
Crossref
Claudia C. Wagner, Marie Simpson, Markus Zeitlinger, Martin Bauer, Rudolf Karch, Aiman Abrahim, Thomas Feurstein, Matthias Schütz, Kurt Kletter, Markus Müller, Graham Lappin & Oliver Langer. (2011) A Combined Accelerator Mass Spectrometry-Positron Emission Tomography Human Microdose Study with 14C- and 11C-Labelled Verapamil. Clinical Pharmacokinetics 50:2, pages 111-120.
Crossref
Gordon J Dear, Claire Beaumont, Andrew Roberts, Bianca Squillaci, Steve Thomas, Mike Nash & Donna Fraser. (2011) Approaches for the rapid identification of drug metabolites in early clinical studies. Bioanalysis 3:2, pages 197-213.
Crossref
Thomas A. Baillie & Allan E. Rettie. (2011) Role of Biotransformation in Drug-Induced Toxicity: Influence of Intra- and Inter-Species Differences in Drug Metabolism. Drug Metabolism and Pharmacokinetics 26:1, pages 15-29.
Crossref
Tim Schulze-König, Lukas Wacker & Hans-Arno Synal. (2011) Direct radiocarbon analysis of exhaled air. J. Anal. At. Spectrom. 26:2, pages 287-292.
Crossref
Ulrich Kuerzel, Volker Krone, Manfred Zimmer & Gareth Shackleton. 2011. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology
73
103
.
Angus N. R. Nedderman & Don K. Walker. 2011. Pharmacokinetics in Drug Development. Pharmacokinetics in Drug Development
131
143
.
Graham Lappin. 2011. Pharmacokinetics in Drug Development. Pharmacokinetics in Drug Development
115
130
.
Z Tozuka, H Kusuhara, K Nozawa, Y Hamabe, I Ikushima, T Ikeda & Y Sugiyama. (2010) Microdose Study of 14C-Acetaminophen With Accelerator Mass Spectrometry to Examine Pharmacokinetics of Parent Drug and Metabolites in Healthy Subjects. Clinical Pharmacology & Therapeutics 88:6, pages 824-830.
Crossref
J. Greg Slatter. 2010. Biotransformation and Metabolite Elucidation of Xenobiotics. Biotransformation and Metabolite Elucidation of Xenobiotics
295
312
.
Stephen H. Curry & Robin Whelpton. 2010. Drug Disposition and Pharmacokinetics. Drug Disposition and Pharmacokinetics
269
278
.
Angus NR Nedderman & Pat Wright. (2010) Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis. Bioanalysis 2:7, pages 1235-1248.
Crossref
Shelby Anderson, Mary Pat Knadler & Debra Luffer-Atlas. (2010) Overview of metabolite safety testing from an industry perspective. Bioanalysis 2:7, pages 1249-1261.
Crossref
Stephen R DuekerPeter N LohstrohJason A GiacomoLe T VuongBradly D KeckJohn S Vogel. (2010) Early human ADME using microdoses and microtracers: bioanalytical considerations. Bioanalysis 2:3, pages 441-454.
Crossref
Paul T HendersonChong-xian Pan. (2010) Human microdosing for the prediction of patient response. Bioanalysis 2:3, pages 373-376.
Crossref
John S VogelJason A Giacomo, Tim Schulze-KönigBradly D Keck, Peter Lohstroh & Stephen Dueker. (2010)
Accelerator mass spectrometry best practices for accuracy and precision in bioanalytical
14
C measurements
. Bioanalysis 2:3, pages 455-468.
Crossref
Ali Arjomand. (2010) Accelerator mass spectrometry-enabled studies: current status and future prospects. Bioanalysis 2:3, pages 519-541.
Crossref
Kin Y. TamAlex Avdeef, Oksana Tsinman & Na Sun. (2009) The Permeation of Amphoteric Drugs through Artificial Membranes − An in Combo Absorption Model Based on Paracellular and Transmembrane Permeability. Journal of Medicinal Chemistry 53:1, pages 392-401.
Crossref
Graham Lappin. 2010. Clinical Pharmacology: Current Topics and Case Studies. Clinical Pharmacology: Current Topics and Case Studies
157
166
.
Paul de KoningJames Keirns. (2009) Clinical pharmacology, biomarkers and personalized medicine: education please. Biomarkers in Medicine 3:6, pages 685-700.
Crossref
Gerhard GrossIan Wilson. (2009) Issues in the safety testing of metabolites. Future Medicinal Chemistry 1:8, pages 1381-1390.
Crossref
Laurent Leclercq, Filip Cuyckens, Geert S. J. Mannens, Ronald de Vries, Philip Timmerman & David C. Evans. (2009) Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development. Chemical Research in Toxicology 22:2, pages 280-293.
Crossref
Shelby Anderson, Debra Luffer-Atlas & Mary Pat Knadler. (2009) Predicting Circulating Human Metabolites: How Good Are We?. Chemical Research in Toxicology 22:2, pages 243-256.
Crossref
E. Hywel Evans, Jason A. Day, Christopher D. Palmer & Clare M. M. Smith. (2009) Atomic Spectrometry Update. Advances in atomic spectrometry and related techniques. Journal of Analytical Atomic Spectrometry 24:6, pages 711.
Crossref
Andrew Taylor, Simon Branch, Martin P. Day, Marina Patriarca & Mark White. (2009) Atomic Spectrometry Update. Clinical and biological materials, foods and beverages. Journal of Analytical Atomic Spectrometry 24:4, pages 535.
Crossref
Thomas N. Thompson. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44
459
474
.