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Editorial

Drug hybridization strategies: before or after lead identification?

Pages 605-609 | Published online: 06 May 2009

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. 2016. Microbial Biotechnology. Microbial Biotechnology 27 62 .
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Crossref
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Crossref
Jayant Sindhu, Harjinder Singh, J.M. Khurana, Chetan Sharma & K.R. Aneja. (2015) Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation. Chinese Chemical Letters 26:1, pages 50-54.
Crossref
Jayant Sindhu, Harjinder Singh, J.M. Khurana, Chetan Sharma & K.R. Aneja. (2014) WITHDRAWN: Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation. Chinese Chemical Letters.
Crossref
Koneni V. Sashidhara, Ranga Prasad Dodda, Ravi Sonkar, Gopala Reddy Palnati & Gitika Bhatia. (2014) Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents. European Journal of Medicinal Chemistry 81, pages 499-509.
Crossref
Juan Sun, Ming-Hui Li, Xin-Yi Wang, Yang Zhang, Rong-Ju Yuan, Han-Yu Liu & Hai-Liang Zhu. (2013) Vanillin derivatives as the selective small molecule inhibitors of FtsZ. Medicinal Chemistry Research 23:6, pages 2985-2994.
Crossref
Rômulo F. S. Canto, Flavio A. R. Barbosa, Vanessa Nascimento, Aldo S. de Oliveira, Inês M. C. Brighente & Antonio Luiz Braga. (2014) Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. Org. Biomol. Chem. 12:21, pages 3470-3477.
Crossref
Bao-Le Zhang, En Zhang, Lu-Ping Pang, Li-Xing Song, Ya-Fei Li, Bin Yu & Hong-Min Liu. (2013) Design and synthesis of novel D-ring fused steroidal heterocycles. Steroids 78:12-13, pages 1200-1208.
Crossref
Variam Ullas Jeankumar, Janupally Renuka, Peddi Santosh, Vijay Soni, Jonnalagadda Padma Sridevi, Priyanka Suryadevara, Perumal Yogeeswari & Dharmarajan Sriram. (2013) Thiazole?aminopiperidine hybrid analogues: Design and synthesis of novel Mycobacterium tuberculosis GyrB inhibitors. European Journal of Medicinal Chemistry 70, pages 143-153.
Crossref
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Crossref
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Crossref
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Crossref

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