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Expert Opinion on Drug Discovery Volume 4, 2009 - Issue 11
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Advances in fragment-based drug discovery platforms

Masaya Orita Drug Discovery Research, Astellas Pharma, Inc., 21 Miyukigaoka Tsukuba, Ibaraki 305-8585, Japan +81 29 863 6768; +81 29 856 2558; [email protected]
,
Masaichi Warizaya Drug Discovery Research, Astellas Pharma, Inc., 21 Miyukigaoka Tsukuba, Ibaraki 305-8585, Japan +81 29 863 6768; +81 29 856 2558; [email protected]
,
Yasushi Amano Drug Discovery Research, Astellas Pharma, Inc., 21 Miyukigaoka Tsukuba, Ibaraki 305-8585, Japan +81 29 863 6768; +81 29 856 2558; [email protected]
,
Kazuki Ohno Drug Discovery Research, Astellas Pharma, Inc., 21 Miyukigaoka Tsukuba, Ibaraki 305-8585, Japan +81 29 863 6768; +81 29 856 2558; [email protected]
&
Tatsuya Niimi Drug Discovery Research, Astellas Pharma, Inc., 21 Miyukigaoka Tsukuba, Ibaraki 305-8585, Japan +81 29 863 6768; +81 29 856 2558; [email protected]
Pages 1125-1144 | Published online: 30 Oct 2009

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Hidekazu Hiroaki. (2013) Recent applications of isotopic labeling for protein NMR in drug discovery. Expert Opinion on Drug Discovery 8:5, pages 523-536.
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Zenon D Konteatis. (2010) In silico fragment-based drug design. Expert Opinion on Drug Discovery 5:11, pages 1047-1065.
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Hongyu Zhao & Irini Akritopoulou-Zanze. (2010) When analoging is not enough: scaffold discovery in medicinal chemistry. Expert Opinion on Drug Discovery 5:2, pages 123-134.
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Articles from other publishers (23)

Yao-Chao Yan, Wei Wu, Guang-Yi Huang, Wen-Chao Yang, Qiong Chen, Ren-Yu Qu, Hong-Yan Lin & Guang-Fu Yang. (2022) Pharmacophore-Oriented Discovery of Novel 1,2,3-Benzotriazine-4-one Derivatives as Potent 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. Journal of Agricultural and Food Chemistry 70:22, pages 6644-6657.
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Ren‐Yu Qu, Jing‐Fang Yang, Qiong Chen, Cong‐Wei Niu, Zhen Xi, Wen‐Chao Yang & Guang‐Fu Yang. (2020) Fragment‐based discovery of flexible inhibitor targeting wild‐type acetohydroxyacid synthase and P197L mutant. Pest Management Science 76:10, pages 3403-3412.
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Hidekazu Hiroaki & Daisuke Kohda. 2018. Experimental Approaches of NMR Spectroscopy. Experimental Approaches of NMR Spectroscopy 579 600 .
Juliana da Fonseca Rezende e Mello, Renan Augusto Gomes, Drielli Gomes Vital-Fujii, Glaucio Monteiro Ferreira & Gustavo Henrique Goulart Trossini. (2017) Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design 90:6, pages 1067-1078.
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H. Chen, X. Zhou, Y. Gao, H. Chen & J. Zhou. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 212 232 .
Rongsheng Ma, Pengchao Wang, Jihui Wu & Ke Ruan. (2016) Process of Fragment-Based Lead Discovery—A Perspective from NMR. Molecules 21:7, pages 854.
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Lucy A. Woods, Olan Dolezal, Bin Ren, John H. Ryan, Thomas S. Peat & Sally-Ann Poulsen. (2016) Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination. Journal of Medicinal Chemistry 59:5, pages 2192-2204.
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Christina E. Faller, E. Prabhu Raman, Alexander D. MacKerellJr.Jr. & Olgun Guvench. 2015. Fragment-Based Methods in Drug Discovery. Fragment-Based Methods in Drug Discovery 75 87 .
Pierangelo Fabbrizzi, Francesca Bianchini, Gloria Menchi, Silvia Raspanti, Antonio Guarna & Andrea Trabocchi. (2014) Combination of click chemistry and sulfonamides to develop three-armed triazole compounds. Tetrahedron 70:35, pages 5439-5449.
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Laurent Hoffer, Jean-Paul Renaud & Dragos Horvath. (2013) In Silico Fragment-Based Drug Discovery: Setup and Validation of a Fragment-to-Lead Computational Protocol Using S4MPLE. Journal of Chemical Information and Modeling 53:4, pages 836-851.
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Sally-Ann Poulsen. (2013) Fragment Screening by Native State Mass Spectrometry. Australian Journal of Chemistry 66:12, pages 1495.
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P Beswick & A Naylor. 2013. Drug Discovery and Development. Drug Discovery and Development 119 134 .
Ge-Fei Hao, Fu Wang, Hui Li, Xiao-Lei Zhu, Wen-Chao Yang, Li-Shar Huang, Jia-Wei Wu, Edward A. Berry & Guang-Fu Yang. (2012) Computational Discovery of Picomolar Q o Site Inhibitors of Cytochrome bc 1 Complex . Journal of the American Chemical Society 134:27, pages 11168-11176.
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Ewa SwiezewskaWojciech Schlif. 2012. Nuclear Magnetic Resonance. Nuclear Magnetic Resonance 1 37 .
Xuqing Zhang, Fengbing Song, Gee-Hong Kuo, Amy Xiang, Alan C. Gibbs, Marta C. Abad, Weimei Sun, Lawrence C. Kuo & Zhihua Sui. (2011) Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors. Bioorganic & Medicinal Chemistry Letters 21:16, pages 4762-4767.
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James Lanter, Xuqing Zhang & Zhihua Sui. 2011. Fragment-Based Drug Design - Tools, Practical Approaches, and Examples. Fragment-Based Drug Design - Tools, Practical Approaches, and Examples 421 445 .
Masaya Orita, Kazuki Ohno, Masaichi Warizaya, Yasushi Amano & Tatsuya Niimi. 2011. Fragment-Based Drug Design - Tools, Practical Approaches, and Examples. Fragment-Based Drug Design - Tools, Practical Approaches, and Examples 383 419 .
Lawrence C. Kuo. 2011. Fragment-Based Drug Design - Tools, Practical Approaches, and Examples. Fragment-Based Drug Design - Tools, Practical Approaches, and Examples 159 168 .
Brett A. Tounge & Michael H. Parker. 2011. Fragment-Based Drug Design - Tools, Practical Approaches, and Examples. Fragment-Based Drug Design - Tools, Practical Approaches, and Examples 3 20 .
Didier Rognan. 2012. Fragment-Based Drug Discovery and X-Ray Crystallography. Fragment-Based Drug Discovery and X-Ray Crystallography 201 222 .
Robert J. Falconer & Brett M. Collins. (2011) Survey of the year 2009: applications of isothermal titration calorimetry. Journal of Molecular Recognition 24:1, pages 1-16.
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Nyssa Drinkwater, Hoan Vu, Kimberly M. LovellKevin R. CriscioneBrett M. Collins, Thomas E. PrisinzanoSally-Ann Poulsen, Michael J. McLeishGary L. GrunewaldJennifer L. Martin. (2010) Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochemical Journal 431:1, pages 51-61.
Crossref
Sabine Schultes, Chris de Graaf, Eric E.J. Haaksma, Iwan J.P. de Esch, Rob Leurs & Oliver Krämer. (2010) Ligand efficiency as a guide in fragment hit selection and optimization. Drug Discovery Today: Technologies 7:3, pages e157-e162.
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