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Promise and challenges in drug discovery and development of hybrid anticancer drugs

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Pages 1099-1111 | Published online: 30 Oct 2009

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Raju Samala, Satheesh Kumar Nukala, Narasimha Swamy Thirukovela, Gouthami Dasari & Srinivas Bandari. (2023) One-Pot Synthesis of Some New Phthalazine-Piperazine-1,2,4-Oxadiazole Hybrids: Anticancer Evaluation, Molecular Docking and ADMET Studies. Polycyclic Aromatic Compounds 43:10, pages 9175-9192.
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Srimathi Kurma, Satheesh Kumar Nukala, Narasimha Swamy Thirukovela, Vinitha Badithapuram, Gouthami Dasari & Srinivas Bandari. (2023) Design and Synthesis of Some New Quinoxaline-1,2,4-Oxadiazole-Amide Conjugates as EGFR Targeting Agents and ADMET Studies. Polycyclic Aromatic Compounds 0:0, pages 1-14.
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Subbareddy Lavunuri, Ratnakaram Venkata Nadh & Siva Kumar Rapeti. (2023) Anti-Proliferative, Anti-EGFR and In Silico Studies of a Series of New Imidazole Tethered 1,2,4-Oxadiazoles. Polycyclic Aromatic Compounds 0:0, pages 1-14.
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Claudiu T. Supuran. (2021) Multitargeting approaches involving carbonic anhydrase inhibitors: hybrid drugs against a variety of disorders. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1702-1714.
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Reem I Al-Wabli, Aliyah A Almomen, Maha S Almutairi, Adam B Keeton, Gary A Piazza & Mohamed I Attia. (2020) New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity. Drug Design, Development and Therapy 14, pages 483-495.
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Sumit Kumar, Nishant Verma, Nikhil Kumar, Alok Patel, Partha Roy, Vikas Pruthi & Naseem Ahmed. (2016) Design, synthesis, molecular docking, and biological studies of novel phytoestrogen-tanaproget hybrids. Synthetic Communications 46:5, pages 460-474.
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Alberto Leoni, Alessandra Locatelli, Rita Morigi & Mirella Rambaldi. (2016) 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008–2014). Expert Opinion on Therapeutic Patents 26:2, pages 149-173.
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Hala Bakr El-Nassan. (2015) Synthesis and antitumor activity of tetrahydrocarbazole hybridized with dithioate derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 30:2, pages 308-315.
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Sébastien Fortin & Gervais Bérubé. (2013) Advances in the development of hybrid anticancer drugs. Expert Opinion on Drug Discovery 8:8, pages 1029-1047.
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Varvara Pokrovskaya & Timor Baasov. (2010) Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance. Expert Opinion on Drug Discovery 5:9, pages 883-902.
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T. Shreedhar Reddy, Sanjay Rai & Shiva Kumar Koppula. Synthesis of 4-Azaindole-Thiazolidine-2,4-Dione Coupled 1,2,3-Triazoles as EGFR Directing Anticancer Agents. Polycyclic Aromatic Compounds 0:0, pages 1-13.
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Ana P. Francisco, Eduarda Mendes, Ana R. Santos & Maria J. Perry. (2019) Anticancer Triazenes: from Bioprecursors to Hybrid Molecules. Current Pharmaceutical Design 25:14, pages 1623-1642.
Crossref
Manohar Mantipally, Madhusudhana Reddy Gangireddy, Rambabu Gundla, Vishnu Nayak Badavath, Santhosh Reddy Mandha & Venkatanarayana Chowdary Maddipati. (2019) Rational design, molecular docking and synthesis of novel homopiperazine linked imidazo[1,2-a]pyrimidine derivatives as potent cytotoxic and antimicrobial agents. Bioorganic & Medicinal Chemistry Letters 29:16, pages 2248-2253.
Crossref
Jiliang Zhang, Shaojuan Zhang, Yang Liu, Meng Su, Xiaoxi Ling, Funan Liu, Yinghui Ge & Mingfeng Bai. (2018) Combined CB2 receptor agonist and photodynamic therapy synergistically inhibit tumor growth in triple negative breast cancer. Photodiagnosis and Photodynamic Therapy 24, pages 185-191.
Crossref
Alaa A. Abd Elhameed, Nadia S. El-Gohary, Eman R. El-Bendary, Mona I. Shaaban & Said M. Bayomi. (2018) Synthesis and biological screening of new thiazolo[4,5-d]pyrimidine and dithiazolo[3,2-a:5′,4′-e]pyrimidinone derivatives as antimicrobial, antiquorum-sensing and antitumor agents. Bioorganic Chemistry 81, pages 299-310.
Crossref
Aitor Maestro, Endika Martín-Encinas, Concepción Alonso, Edorta Martinez de Marigorta, Gloria Rubiales, Javier Vicario & Francisco Palacios. (2018) Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives. European Journal of Medicinal Chemistry 158, pages 874-883.
Crossref
Diana Lamaa, Hsin-Ping Lin, Lena Zig, Cyril Bauvais, Guillaume Bollot, Jérôme Bignon, Helene Levaique, Olivier Pamlard, Joelle Dubois, Mehdi Ouaissi, Martin Souce, Athena Kasselouri, François Saller, Delphine Borgel, Chantal Jayat-Vignoles, Hazar Al-Mouhammad, Jean Feuillard, Karim Benihoud, Mouad Alami & Abdallah Hamze. (2018) Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso -Combretastatin A-4 . Journal of Medicinal Chemistry 61:15, pages 6574-6591.
Crossref
Ramesh Gondru, K Sirisha, Sneha Raj, Shravan Kumar Gunda, C Ganesh Kumar, Mukesh Pasupuleti & Rajitha Bavantula. (2018) Design, Synthesis, In Vitro Evaluation and Docking Studies of Pyrazole-Thiazole Hybrids as Antimicrobial and Antibiofilm Agents. ChemistrySelect 3:28, pages 8270-8276.
Crossref
N.S. El-Gohary & M.I. Shaaban. (2018) New pyrazolopyridine analogs: Synthesis, antimicrobial, antiquorum-sensing and antitumor screening. European Journal of Medicinal Chemistry 152, pages 126-136.
Crossref
Shalki Choudhary, Pankaj Kumar Singh, Himanshu Verma, Harpreet Singh & Om Silakari. (2018) Success stories of natural product-based hybrid molecules for multi-factorial diseases. European Journal of Medicinal Chemistry 151, pages 62-97.
Crossref
Larry Yet. 2018. Privileged Structures in Drug Discovery. Privileged Structures in Drug Discovery 15 58 .
Shadia A. Galal, Muhammad Khattab, Samia A. Shouman, Raghda Ramadan, Omaima M. Kandil, Omnia M. Kandil, Ashraf Tabll, Yasmine S. El Abd, Reem El-Shenawy, Yasmin M. Attia, Ahmed A. El-Rashedy & Hoda I. El Diwani. (2018) Part III: Novel checkpoint kinase 2 (Chk2) inhibitors; design, synthesis and biological evaluation of pyrimidine-benzimidazole conjugates. European Journal of Medicinal Chemistry 146, pages 687-708.
Crossref
Yun-Ta Lee, Feng-Yu Chiu, Indrajeet J. Barve & Chung-Ming Sun. (2018) Microwave-Assisted Synthesis of Benzimidazole-Linked Indoline and Indole Hybrids from C-2 Linked ( o -Aminobenzyl)benzimidazoles . Advanced Synthesis & Catalysis 360:3, pages 502-512.
Crossref
Jiabing Wang, Di Yun, Jiali Yao, Weitao Fu, Fangyan Huang, Liping Chen, Tao Wei, Cuijuan Yu, Haineng Xu, Xiaoou Zhou, Yanqing Huang, Jianzhang Wu, Peihong Qiu & Wulan Li. (2018) Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds. European Journal of Medicinal Chemistry 144, pages 493-503.
Crossref
Alessio Nocentini, Silvia Bua, Carrie L. Lomelino, Robert McKenna, Marta Menicatti, Gianluca Bartolucci, Barbara Tenci, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Paola Gratteri & Claudiu T. Supuran. (2017) Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. ACS Medicinal Chemistry Letters 8:12, pages 1314-1319.
Crossref
Vinayak Botla, NavyaSree Pilli, Dhevendar Koude, Sunil Misra & Chandrasekharam Malapaka. (2017) Molecular Engineering of Tetracyclic 2,3-Dihydro-1 H -benzo[2,3]-benzofuro[4,5-e][1,3]oxazine Derivatives: Evaluation for Potential Anticancer Agents . Archiv der Pharmazie 350:10, pages 1700169.
Crossref
Ella Lineham, John Spencer & Simon J Morley. (2017) Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers. Future Medicinal Chemistry 9:13, pages 1539-1555.
Crossref
Shadia A. Galal, Ahmed S. Abdelsamie, Samia A. Shouman, Yasmin M. Attia, Hamed I. Ali, Ashraf Tabll, Reem El-Shenawy, Yasmine S. El Abd, Mamdouh M. Ali, Abeer E. Mahmoud, Abeer H. Abdel-Halim, Amal A. Fyiad, Adel S. Girgis & Hoda I. El-Diwani. (2017) Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs. European Journal of Medicinal Chemistry 134, pages 392-405.
Crossref
Chunmei Li & Furen Zhang. (2017) Efficient synthesis of novel furo[2,3-d]pyrimidine derivatives under catalyst-free conditions. Tetrahedron Letters 58:16, pages 1572-1575.
Crossref
Guohui Sun, Tengjiao Fan, Lijiao Zhao, Yue Zhou & Rugang Zhong. (2017) The potential of combi-molecules with DNA-damaging function as anticancer agents. Future Medicinal Chemistry 9:4, pages 403-435.
Crossref
Heba A.H. Elshemy & Mohamed A. Zaki. (2017) Design and synthesis of new coumarin hybrids and insight into their mode of antiproliferative action. Bioorganic & Medicinal Chemistry 25:3, pages 1066-1075.
Crossref
Rui Pinheiro, Cláudia Braga, Gisela Santos, Maria R. Bronze, Maria J. Perry, Rui Moreira, Dora Brites & Ana S. Falcão. (2016) Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?. ACS Chemical Neuroscience 8:1, pages 50-59.
Crossref
M. Sambaiah, K. Raghavulu, K. Shiva Kumar, Satyanarayana Yennam & Manoranjan Behera. (2017) Synthesis of novel fused chromone–pyrimidine hybrids and 2,4,5-trisubstituted pyrimidine derivatives via ANRORC rearrangement. New Journal of Chemistry 41:18, pages 10020-10026.
Crossref
Tomislav Gregorić, Mirela Sedić, Petra Grbčić, Andrea Tomljenović Paravić, Sandra Kraljević Pavelić, Mario Cetina, Robert Vianello & Silvana Raić-Malić. (2017) Novel pyrimidine-2,4-dione–1,2,3-triazole and furo[2,3-d]pyrimidine-2-one–1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation. European Journal of Medicinal Chemistry 125, pages 1247-1267.
Crossref
Bishoy El-Aarag, Tomonari Kasai, Junko Masuda, Hussein Agwa, Magdy Zahran & Masaharu Seno. (2017) Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2. Biomedicine & Pharmacotherapy 85, pages 549-555.
Crossref
Qingjie Zhao & Guozheng Huang. 2017. Design of Hybrid Molecules for Drug Development. Design of Hybrid Molecules for Drug Development 193 218 .
Jayant Sindhu, Harjinder Singh, J. M. Khurana, Jitender Kumar Bhardwaj, Priyanka Saraf & Chetan Sharma. (2016) Synthesis and biological evaluation of some functionalized 1H-1,2,3-triazole tethered pyrazolo[3,4-b]pyridin-6(7H)-ones as antimicrobial and apoptosis inducing agents. Medicinal Chemistry Research 25:9, pages 1813-1830.
Crossref
Dmytro Havrylyuk, Olexandra Roman & Roman Lesyk. (2016) Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids. European Journal of Medicinal Chemistry 113, pages 145-166.
Crossref
Riham F. George, Marwa A. Fouad & Iman E.O. Gomaa. (2016) Synthesis and cytotoxic activities of some pyrazoline derivatives bearing phenyl pyridazine core as new apoptosis inducers. European Journal of Medicinal Chemistry 112, pages 48-59.
Crossref
Saadia Leeza Zaidi, Subhash M. Agarwal, Porntip Chavalitshewinkoon-Petmitr, Thidarat Suksangpleng, Kamal Ahmad, Fernando Avecilla & Amir Azam. (2016) Thienopyrimidine sulphonamide hybrids: design, synthesis, antiprotozoal activity and molecular docking studies. RSC Advances 6:93, pages 90371-90383.
Crossref
Han Wei, Jinlan Ruan & Xiaojian Zhang. (2016) Coumarin–chalcone hybrids: promising agents with diverse pharmacological properties. RSC Advances 6:13, pages 10846-10860.
Crossref
Atulya Nagarsenkar, Santosh Kumar Prajapti, Sravanthi Devi Guggilapu, Swetha Birineni, Sudha Sravanti Kotapalli, Ramesh Ummanni & Bathini Nagendra Babu. (2016) Investigation of triazole-linked indole and oxindole glycoconjugates as potential anticancer agents: novel Akt/PKB signaling pathway inhibitors. MedChemComm 7:4, pages 646-653.
Crossref
Surendra R. Punganuru, Hanumantha Rao Madala, Sanjay N. Venugopal, Ramakrishna Samala, Constantinos Mikelis & Kalkunte S. Srivenugopal. (2016) Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties. European Journal of Medicinal Chemistry 107, pages 233-244.
Crossref
Temilolu Idowu, Pranati Samadder, Gilbert Arthur & Frank Schweizer. (2016) Design, synthesis and antitumor properties of glycosylated antitumor ether lipid (GAEL)- chlorambucil-hybrids. Chemistry and Physics of Lipids 194, pages 139-148.
Crossref
Jure Vajs, Ivana Steiner, Anamaria Brozovic, Andrej Pevec, Andreja Ambriović-Ristov, Marija Matković, Ivo Piantanida, Damijana Urankar, Maja Osmak & Janez Košmrlj. (2015) The 1,3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity. Journal of Inorganic Biochemistry 153, pages 42-48.
Crossref
Stavros E. Bariamis, George E. Magoulas, Katerina Grafanaki, Eleni Pontiki, Theodore Tsegenidis, Constantinos M. Athanassopoulos, George Maroulis, Dionissios Papaioannou & Dimitra Hadjipavlou-Litina. (2015) Synthesis and biological evaluation of new C-10 substituted dithranol pleiotropic hybrids. Bioorganic & Medicinal Chemistry 23:22, pages 7251-7263.
Crossref
Rahmi Kasımoğulları, Hamdiye Duran, Ayşe Şahin Yağlıoğlu, Samet Mert & İbrahim Demirtaş. (2015) Design, synthesis, characterization, and antiproliferative activity of novel pyrazole-3-carboxylic acid derivatives. Monatshefte für Chemie - Chemical Monthly 146:10, pages 1743-1749.
Crossref
Vandana Srivastava & Hoyun Lee. (2015) Chloroquine-based hybrid molecules as promising novel chemotherapeutic agents. European Journal of Pharmacology 762, pages 472-486.
Crossref
T. Srinivasa Reddy, Hitesh Kulhari, V. Ganga Reddy, Vipul Bansal, Ahmed Kamal & Ravi Shukla. (2015) Design, synthesis and biological evaluation of 1,3-diphenyl-1 H -pyrazole derivatives containing benzimidazole skeleton as potential anticancer and apoptosis inducing agents. European Journal of Medicinal Chemistry 101, pages 790-805.
Crossref
Loana Musso, Sabrina Dallavalle & Franco Zunino. (2015) Perspectives in the development of hybrid bifunctional antitumour agents. Biochemical Pharmacology 96:4, pages 297-305.
Crossref
Paula Morales, Sandra Blasco-Benito, Clara Andradas, María Gómez-Cañas, Juana María Flores, Pilar Goya, Javier Fernández-Ruiz, Cristina Sánchez & Nadine Jagerovic. (2015) Selective, Nontoxic CB 2 Cannabinoid o -Quinone with in Vivo Activity against Triple-Negative Breast Cancer . Journal of Medicinal Chemistry 58:5, pages 2256-2264.
Crossref
Li-Ying Ma, Bo Wang, Lu-Ping Pang, Miao Zhang, Sai-Qi Wang, Yi-Chao Zheng, Kun-Peng Shao, Deng-Qi Xue & Hong-Min Liu. (2015) Design and synthesis of novel 1,2,3-triazole–pyrimidine–urea hybrids as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 25:5, pages 1124-1128.
Crossref
Anil Rana, Jimi Marin Alex, Monika Chauhan, Gaurav Joshi & Raj Kumar. (2014) A review on pharmacophoric designs of antiproliferative agents. Medicinal Chemistry Research 24:3, pages 903-920.
Crossref
Melanie Lödige & Luisa Hiersch. (2015) Design and Synthesis of Novel Hybrid Molecules against Malaria. International Journal of Medicinal Chemistry 2015, pages 1-23.
Crossref
A N Tevyashova, E N Olsufyeva & M N Preobrazhenskaya. (2015) Design of dual action antibiotics as an approach to search for new promising drugs. Russian Chemical Reviews 84:1, pages 61-97.
Crossref
K. Easwaramoorthi, A. Jeya Rajendran, K. Chennakesava Rao, Y. Arun, C. Balachandran, P. T. Perumal, Nobuhiko Emi, S. M. Mahalingam, V. Duraipandiyan & N. A. Al-Dhabi. (2015) Synthesis of novel 1,4-disubstituted 1,2,3-triazolo-bosentan derivatives – evaluation of antimicrobial and anticancer activities and molecular docking. RSC Advances 5:127, pages 105266-105278.
Crossref
Li-Ying Ma, Lu-Ping Pang, Bo Wang, Miao Zhang, Biao Hu, Deng-Qi Xue, Kun-Peng Shao, Bao-Le Zhang, Ying Liu, En Zhang & Hong-Min Liu. (2014) Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents. European Journal of Medicinal Chemistry 86, pages 368-380.
Crossref
Bishoy Y.A. El-Aarag, Tomonari Kasai, Magdy A.H. Zahran, Nadia I. Zakhary, Tsukasa Shigehiro, Sreeja C. Sekhar, Hussein S. Agwa, Akifumi Mizutani, Hiroshi Murakami, Hiroki Kakuta & Masaharu Seno. (2014) In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs. International Immunopharmacology 21:2, pages 283-292.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Kimatrai Salvador, Mariem Chayah, M. Encarnacion Camacho, Filippo Prencipe, Ernest Hamel, Francesca Consolaro, Giuseppe Basso & Giampietro Viola. (2014) Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents. European Journal of Medicinal Chemistry 81, pages 394-407.
Crossref
Kunal Nepali, Sahil Sharma, Manmohan Sharma, P.M.S. Bedi & K.L. Dhar. (2014) Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids. European Journal of Medicinal Chemistry 77, pages 422-487.
Crossref
Tamilselvan Rajasekaran, Govindaraju Karthik, B. Sridhar, S. Kiran Kumar & Basi V. Subba Reddy. (2014) Highly Diastereoselective Reaction of α‐Diazoesters with Aryl Alcohols and Isatin Imines: Rapid Access to Oxindole‐Derived α‐Alkoxy‐β‐amino Acid Derivatives with Two Adjacent Quaternary Carbon Centers. European Journal of Organic Chemistry 2014:11, pages 2221-2224.
Crossref
Samet Mert, Ayşe Şahin Yağlıoğlu, Ibrahim Demirtas & Rahmi Kasımoğulları. (2013) Synthesis and antiproliferative activities of some pyrazole-sulfonamide derivatives. Medicinal Chemistry Research 23:3, pages 1278-1289.
Crossref
Soundararasu Senthilkumar, Sure Siva Prasad, Ponminor Senthil Kumar & Sundarababu Baskaran. (2014) A diversity oriented one-pot synthesis of novel iminosugar C-glycosides. Chemical Communications 50:13, pages 1549.
Crossref
Paula Morales, Diana Vara, María Goméz-Cañas, María C. Zúñiga, Claudio Olea-Azar, Pilar Goya, Javier Fernández-Ruiz, Inés Díaz-Laviada & Nadine Jagerovic. (2013) Synthetic cannabinoid quinones: Preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity. European Journal of Medicinal Chemistry 70, pages 111-119.
Crossref
Ying-Chao Duan, Yi-Chao Zheng, Xiao-Chen Li, Meng-Meng Wang, Xian-Wei Ye, Yuan-Yuan Guan, Gai-Zhi Liu, Jia-Xin Zheng & Hong-Min Liu. (2013) Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole–dithiocarbamate–urea hybrids. European Journal of Medicinal Chemistry 64, pages 99-110.
Crossref
L. W. Lawrence Woo, Paul M. Wood, Christian Bubert, Mark P. Thomas, Atul Purohit & Barry V. L. Potter. (2013) Synthesis and Structure–Activity Relationship Studies of Derivatives of the Dual Aromatase–Sulfatase Inhibitor 4‐{[(4‐Cyanophenyl)(4 H ‐1,2,4‐triazol‐4‐yl)amino]methyl}phenyl sulfamate . ChemMedChem 8:5, pages 779-799.
Crossref
Makoah N. Aminake, Aman Mahajan, Vipan Kumar, Renate Hans, Lubbe Wiesner, Dale Taylor, Carmen de Kock, Anne Grobler, Peter J. Smith, Marc Kirschner, Axel Rethwilm, Gabriele Pradel & Kelly Chibale. (2012) Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. Bioorganic & Medicinal Chemistry 20:17, pages 5277-5289.
Crossref
Gonzalo García, Isabel Serrano, Patricia Sánchez-Alonso, Manuel Rodríguez-Puyol, Ramón Alajarín, Mercedes Griera, Juan J. Vaquero, Diego Rodríguez-Puyol, Julio Álvarez-Builla & María L. Díez-Marqués. (2012) New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers. European Journal of Medicinal Chemistry 50, pages 90-101.
Crossref
Weihu Shang, Jinping Qiao, Chenxin Gu, Wei Yin, Jinglei Du, Wei Wang, Meilin Zhu, Mei Han & Weidong Lu. (2011) Anticancer activity of an extract from needles and twigs of Taxus cuspidata and its synergistic effect as a cocktail with 5-fluorouracil. BMC Complementary and Alternative Medicine 11:1.
Crossref
Gamal A. Elmegeed, Wagdy K.B. Khalil, Rafat M. Mohareb, Hanaa H. Ahmed, Mervat M. Abd-Elhalim & Ghada H. Elsayed. (2011) Cytotoxicity and gene expression profiles of novel synthesized steroid derivatives as chemotherapeutic anti-breast cancer agents. Bioorganic & Medicinal Chemistry 19:22, pages 6860-6872.
Crossref
Nouri Neamati. 2011. HIV‐1 Integrase. HIV‐1 Integrase 165 196 .
L.W. Lawrence Woo, Atul Purohit & Barry V.L. Potter. (2011) Development of steroid sulfatase inhibitors. Molecular and Cellular Endocrinology 340:2, pages 175-185.
Crossref
Alicia Merlino, Lucia Otero, Dinorah Gambino & E. Laura Coitiño. (2011) In search of patterns over physicochemical properties and pharmacological activities for a set of [MCl2(thiosemicarbazone)] complexes (M=Pt/Pd): Support for multiple mechanisms of antichagasic action excluding DNA-bonding in vivo?. European Journal of Medicinal Chemistry 46:7, pages 2639-2651.
Crossref
John Spencer, Jahangir Amin, Minghua Wang, Graham Packham, Sharifah S. Syed Alwi, Graham J. Tizzard, Simon J. Coles, Ronald M. Paranal, James E. Bradner & Tom D. Heightman. (2011) Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors. ACS Medicinal Chemistry Letters 2:5, pages 358-362.
Crossref
L. W. Lawrence Woo, Christian Bubert, Atul Purohit & Barry V. L. Potter. (2010) Hybrid Dual Aromatase-Steroid Sulfatase Inhibitors with Exquisite Picomolar Inhibitory Activity. ACS Medicinal Chemistry Letters 2:3, pages 243-247.
Crossref
Jérémy Ricci, Minkyu Kim, Won-Yoon Chung, Kwang-Kyun Park & Mankil Jung. (2011) Discovery of Artemisinin-Glycolipid Hybrids as Anti-oral Cancer Agents. CHEMICAL & PHARMACEUTICAL BULLETIN 59:12, pages 1471-1475.
Crossref
Jérémy Ricci, Jeehyun Park, Won-Yoon Chung, Kwang-Kyun Park & Mankil Jung. (2010) Concise synthesis and antiangiogenic activity of artemisinin–glycolipid hybrids on chorioallantoic membranes. Bioorganic & Medicinal Chemistry Letters 20:22, pages 6858-6860.
Crossref
L. W. Lawrence WooToby JacksonAurélien PuteyGyles CozierPhilip LeonardK. Ravi AcharyaSurinder K. ChanderAtul PurohitMichael J. ReedBarry V. L. Potter. (2010) Highly Potent First Examples of Dual Aromatase−Steroid Sulfatase Inhibitors based on a Biphenyl Template. Journal of Medicinal Chemistry 53:5, pages 2155-2170.
Crossref

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