Advanced search
Publication Cover
Expert Opinion on Drug Discovery Volume 2, 2007 - Issue 7
Submit an article Journal homepage
229
Views
16
CrossRef citations to date
0
Altmetric
Reviews

Phosphodiesterase 10A inhibitors as a novel therapeutic approach for schizophrenia

Judith A Siuciak CNS Discovery, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA; Neuroscience Discovery Biology, Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA [email protected]
, PhD &
Christine A Strick CNS Discovery, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
, PhD
Pages 1001-1009 | Published online: 08 Aug 2007

Citations (16)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

A. K. Halder, S. A. Amin, T. Jha & S. Gayen. (2017) Insight into the structural requirements of pyrimidine-based phosphodiesterase 10A (PDE10A) inhibitors by multiple validated 3D QSAR approaches. SAR and QSAR in Environmental Research 28:3, pages 253-273.
Read now

Articles from other publishers (15)

Harsh S. Amin, Palak K. Parikh & Manjunath D. Ghate. (2021) Medicinal chemistry strategies for the development of phosphodiesterase 10A (PDE10A) inhibitors - An update of recent progress. European Journal of Medicinal Chemistry 214, pages 113155.
Crossref
Fredrik Svensson, Andreas Bender & David Bailey. (2017) Fragment-Based Drug Discovery of Phosphodiesterase Inhibitors. Journal of Medicinal Chemistry 61:4, pages 1415-1424.
Crossref
Yu-Wen Li, Matthew A. Seager, Trevor Wojcik, Karen Heman, Thaddeus F. Molski, Alda Fernandes, Shaun Langdon, Annapurna Pendri, Samuel Gerritz, Yuan Tian, Yang Hong, Lizbeth Gallagher, James R. Merritt, Chongwu Zhang, Ryan Westphal, Robert Zaczek, John E. Macor, Joanne J. Bronson & Nicholas J. Lodge. (2016) Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy. Neuropharmacology 102, pages 121-135.
Crossref
William D. Shipe, Steven S. Sharik, James C. Barrow, Georgia B. McGaughey, Cory R. Theberge, Jason M. Uslaner, Youwei Yan, John J. Renger, Sean M. Smith, Paul J. Coleman & Christopher D. Cox. (2015) Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis. Journal of Medicinal Chemistry 58:19, pages 7888-7894.
Crossref
Philip G. Jones, Michael C. Hewitt, John E. Campbell, Maria S. Quinton, Sharon Engel, Robert Lew, Una Campbell & Douglas F. Burdi. (2015) Pharmacological evaluation of a novel phosphodiesterase 10A inhibitor in models of antipsychotic activity and cognition. Pharmacology Biochemistry and Behavior 135, pages 46-52.
Crossref
Wataru Hamaguchi, Naoyuki Masuda, Satoshi Miyamoto, Yasuhiro Shiina, Shigetoshi Kikuchi, Takuma Mihara, Hiroyuki Moriguchi, Hiroshi Fushiki, Yoshihiro Murakami, Yasushi Amano, Kazuya Honbou & Kouji Hattori. (2015) Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition. Bioorganic & Medicinal Chemistry 23:2, pages 297-313.
Crossref
Christophe Plisson, David Weinzimmer, Steen Jakobsen, Sridhar Natesan, Cristian Salinas, Shu-Fei Lin, David Labaree, Ming-Qiang Zheng, Nabeel Nabulsi, Tiago Reis Marques, Shitij Kapur, Eiji Kawanishi, Takeaki Saijo, Roger N. Gunn, Richard E. Carson & Eugenii A. Rabiner. (2014) Phosphodiesterase 10A PET Radioligand Development Program: From Pig to Human. Journal of Nuclear Medicine 55:4, pages 595-601.
Crossref
Wataru HamaguchiNaoyuki MasudaKiyohiro SamizuTakuma MiharaKaori TakamaToshihiro Watanabe. (2014) Synthesis and <i>in Vivo</i> Evaluation of Novel Quinoline Derivatives as Phosphodiesterase 10A Inhibitors. Chemical and Pharmaceutical Bulletin 62:12, pages 1200-1213.
Crossref
Florence ThibautB. Millet, F. Le Jeune, M. Vérin, J.-M. Batail, G. Robert, D. Drapier & N. Jaafari. 2014. Apport des neurosciences à la psychiatrie clinique. Apport des neurosciences à la psychiatrie clinique 159 172 .
Wataru Hamaguchi, Naoyuki Masuda, Mai Isomura, Satoshi Miyamoto, Shigetoshi Kikuchi, Yasushi Amano, Kazuya Honbou, Takuma Mihara & Toshihiro Watanabe. (2013) Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition. Bioorganic & Medicinal Chemistry 21:24, pages 7612-7623.
Crossref
Junfeng Li, Hongjun Jin, Haiying Zhou, Justin Rothfuss & Zhude Tu. (2013) Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A. MedChemComm 4:2, pages 443.
Crossref
Uta Funke, Winnie Deuther-Conrad, Gregor Schwan, Aurélie Maisonial, Matthias Scheunemann, Steffen Fischer, Achim Hiller, Detlef Briel & Peter Brust. (2012) Radiosynthesis and Radiotracer Properties of a 7-(2-[18F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET. Pharmaceuticals 5:2, pages 169-188.
Crossref
Christophe Plisson, Cristian Salinas, David Weinzimmer, David Labaree, Shu-Fei Lin, Yu-Shin Ding, Steen Jakobsen, Paul W. Smith, Kawanishi Eiji, Richard E. Carson, Roger N. Gunn & Eugenii A. Rabiner. (2011) Radiosynthesis and in vivo evaluation of [11C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A. Nuclear Medicine and Biology 38:6, pages 875-884.
Crossref
Gregor J. Macdonald & José Manuel Bartolomé. 2010. 37 80 .
Florence Sotty, Liliana P. Montezinho, Björn Steiniger-Brach & Jacob Nielsen. (2009) Phosphodiesterase 10A inhibition modulates the sensitivity of the mesolimbic dopaminergic system to d-amphetamine: involvement of the D 1 -regulated feedback control of midbrain dopamine neurons . Journal of Neurochemistry 109:3, pages 766-775.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.