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Expert Opinion on Drug Discovery Volume 2, 2007 - Issue 7
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Aurora kinase targeted therapeutics in oncology: past, present and future

Daruka Mahadevan Arizona Cancer Center, Tucson, AZ, 85724, USA +1 520 626 0191; +1 520 626 2255; [email protected]
, MD, PhD &
Sunni Beeck Arizona Cancer Center, Tucson, AZ, 85724, USA +1 520 626 0191; +1 520 626 2255; [email protected]
Pages 1011-1026 | Published online: 08 Aug 2007

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Myke R Green, Joseph E Woolery & Daruka Mahadevan. (2011) Update on aurora kinase targeted therapeutics in oncology. Expert Opinion on Drug Discovery 6:3, pages 291-307.
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Articles from other publishers (15)

Jing Zhang, Qing Qiao, Hong Xu, Ru Zhou & Xinzhe Liu. (2022) Human cell polyploidization: The good and the evil. Seminars in Cancer Biology 81, pages 54-63.
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Mandeep Singh, Lakshay Malhotra, Md Anzarul Haque, Mukesh Kumar, Alexander Tikhomirov, Valeria Litvinova, Alexander M. Korolev, A.S. Ethayathulla, Uddipan Das, Andrey E. Shchekotikhin & Punit Kaur. (2021) Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B. Biochimie 182, pages 152-165.
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Soon Young Shin, Seunghyun Ahn, Hyuk Yoon, Hyeryoung Jung, Yearam Jung, Dongsoo Koh, Young Han Lee & Yoongho Lim. (2016) Colorectal anticancer activities of polymethoxylated 3-naphthyl-5-phenylpyrazoline-carbothioamides. Bioorganic & Medicinal Chemistry Letters 26:17, pages 4301-4309.
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Gerald S. Falchook, Christel C. Bastida & Razelle Kurzrock. (2015) Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress. Seminars in Oncology 42:6, pages 832-848.
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Julien Defaux, Maud Antoine, Marc Le Borgne, Tilmann Schuster, Irene Seipelt, Babette Aicher, Michael Teifel, Eckhard Günther, Matthias Gerlach & Pascal Marchand. (2013) Discovery of 7‐Aryl‐Substituted (1,5‐Naphthyridin‐4‐yl)ureas as Aurora Kinase Inhibitors. ChemMedChem 9:1, pages 217-232.
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Soon Young Shin, Hyuk Yoon, Doseok Hwang, Seunghyun Ahn, Dong-Wook Kim, Dongsoo Koh, Young Han Lee & Yoongho Lim. (2013) Benzochalcones bearing pyrazoline moieties show anti-colorectal cancer activities and selective inhibitory effects on aurora kinases. Bioorganic & Medicinal Chemistry 21:22, pages 7018-7024.
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Andrew F. Slatter, Spencer Campbell & Richard M. Angell. (2013) Development of a Fluorescence Intensity Assay for the Mitotic Serine/Threonine Protein Kinase Aurora-A. SLAS Discovery 18:2, pages 219-225.
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Gu He, Minghua Qiu, Rui Li, Liang Ouyang, Fengbo Wu, Xiangrong Song, Li Cheng, Mingli Xiang & Luoting Yu. (2012) Multicomplex-Based Pharmacophore-Guided 3D-QSAR Studies of N-Substituted 2?-(Aminoaryl)Benzothiazoles as Aurora-A Inhibitors. Chemical Biology & Drug Design 79:6, pages 960-971.
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Aixia Yan, Liyu Wang, Shuyu Xu & Jun Xu. (2011) Aurora-A kinase inhibitor scaffolds and binding modes. Drug Discovery Today 16:5-6, pages 260-269.
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Teresa Sardon, Roland A Pache, Amelie Stein, Henrik Molina, Isabelle Vernos & Patrick Aloy. (2010) Uncovering new substrates for Aurora A kinase. EMBO reports 11:12, pages 977-984.
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Donald J. AbrahamRobert H. Bradbury. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 295 344 .
Mary Ann Hardwicke, Catherine A. Oleykowski, Ramona Plant, Jamin Wang, Qiaoyin Liao, Katherine Moss, Ken Newlander, Jerry L. Adams, Dashyant Dhanak, Jingsong Yang, Zhihong Lai, David Sutton & Denis Patrick. (2009) GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models. Molecular Cancer Therapeutics 8:7, pages 1808-1817.
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Teresa Sardon, Thomas Cottin, Jing Xu, Athanassios Giannis & Isabelle Vernos . (2009) Development and Biological Evaluation of a Novel Aurora A Kinase Inhibitor. ChemBioChem 10:3, pages 464-478.
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Hui-Yuan Wang, Lin-Li Li, Zhi-Xing Cao, Shi-Dong Luo, Yu-Quan Wei & Sheng-Yong Yang. (2009) A Specific Pharmacophore Model of Aurora B Kinase Inhibitors and Virtual Screening Studies Based on it. Chemical Biology & Drug Design 73:1, pages 115-126.
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Xiao-Qiang Deng, Hui-Yuan Wang, Ying-Lan Zhao, Ming-Li Xiang, Pei-Du Jiang, Zhi-Xing Cao, Yu-Zhu Zheng, Shi-Dong Luo, Luo-Ting Yu, Yu-Quan Wei & Sheng-Yong Yang. (2008) Pharmacophore Modelling and Virtual Screening for Identification of New Aurora-A Kinase Inhibitors. Chemical Biology & Drug Design 71:6, pages 533-539.
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