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Expert Opinion on Drug Discovery Volume 2, 2007 - Issue 9
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Reviews

Novel 8-heterocyclyl xanthine derivatives in drug development – an update

Pier G Baraldi Università di Ferrara, Dipartimento di Scienze Farmaceutiche, 44100 Ferrara, Italy +39 0532 455921; +39 0532 455953; [email protected]
,
Francesca Fruttarolo Università di Ferrara, Dipartimento di Scienze Farmaceutiche, 44100 Ferrara, Italy +39 0532 455921; +39 0532 455953; [email protected]
, PhD,
Mojgan A Tabrizi Università di Ferrara, Dipartimento di Scienze Farmaceutiche, 44100 Ferrara, Italy +39 0532 455921; +39 0532 455953; [email protected]
, PhD,
Romeo Romagnoli Università di Ferrara, Dipartimento di Scienze Farmaceutiche, 44100 Ferrara, Italy +39 0532 455921; +39 0532 455953; [email protected]
, PhD &
Delia Preti Università di Ferrara, Dipartimento di Scienze Farmaceutiche, 44100 Ferrara, Italy +39 0532 455921; +39 0532 455953; [email protected]
, PhD
Pages 1161-1183 | Published online: 29 Aug 2007

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Irene Giorgi & Paola Nieri. (2008) Therapeutic potential of A1 adenosine receptor ligands: a survey of recent patent literature. Expert Opinion on Therapeutic Patents 18:7, pages 677-691.
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Articles from other publishers (11)

Nivedita Singh, Akhtar Hussain Malik, Parameswar Krishnan Iyer & Sanjukta Patra. (2021) Diversifying the xanthine scaffold for potential phosphodiesterase 9A inhibitors: synthesis and validation. Medicinal Chemistry Research 30:6, pages 1199-1219.
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Daniel Marx, Lukas M. Wingen, Gregor Schnakenburg, Christa E. Müller & Matthias S. Scholz. (2019) Fast, Efficient, and Versatile Synthesis of 6-amino-5-carboxamidouracils as Precursors for 8-Substituted Xanthines. Frontiers in Chemistry 7.
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David F. Carrageta, Tânia R. Dias, Ivana Jarak, Marco G. Alves, Pedro F. Oliveira, Mietha M. Van der Walt, Gisella Terre'Blanche, Mariana P. Monteiro & Branca M. Silva. (2018) 8-(3-phenylpropyl)-1,3,7-triethylxanthine is a synthetic caffeine substitute with stronger metabolic modulator activity. Toxicology in Vitro 53, pages 114-120.
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Nivedita Singh, Ashwinee Kumar Shreshtha, M.S. Thakur & Sanjukta Patra. (2018) Xanthine scaffold: scope and potential in drug development. Heliyon 4:10, pages e00829.
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David F. Carrageta, Tânia R. Dias, Marco G. Alves, Pedro F. Oliveira, Mariana P. Monteiro & Branca M. Silva. (2018) Anti-obesity potential of natural methylxanthines. Journal of Functional Foods 43, pages 84-94.
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João Monteiro, Marco Alves, Pedro Oliveira & Branca Silva. (2016) Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks. Molecules 21:8, pages 974.
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Mietha M. Van der Walt & Gisella Terre’Blanche. (2015) 1,3,7-Triethyl-substituted xanthines—possess nanomolar affinity for the adenosine A1 receptor. Bioorganic & Medicinal Chemistry 23:20, pages 6641-6649.
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Alaa M. Hayallah, Walid A. Elgaher, Ola I. Salem & Abdel Alim M. Abdel Alim. (2011) Design and synthesis of some new theophylline derivatives with bronchodilator and antibacterial activities. Archives of Pharmacal Research 34:1, pages 3-21.
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Pier Giovanni Baraldi, Mojgan Aghazadeh Tabrizi, Francesca Fruttarolo, Romeo Romagnoli & Delia Preti. (2009) Recent improvements in the development of A2B adenosine receptor agonists. Purinergic Signalling 5:1, pages 3-19.
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Pier Giovanni Baraldi, Mojgan Aghazadeh Tabrizi, Francesca Fruttarolo, Romeo Romagnoli & Delia Preti. (2008) Recent improvements in the development of A2B adenosine receptor agonists. Purinergic Signalling 4:4, pages 287-303.
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Bas Groenendaal, Eelco Ruijter, Frans J. J. de Kanter, Martin Lutz, Anthony L. Spek & Romano V. A. Orru. (2008) Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones. Organic & Biomolecular Chemistry 6:17, pages 3158.
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