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Cardiac arrhythmia: in vivo screening in the zebrafish to overcome complexity in drug discovery

Pages 619-632 | Published online: 21 May 2010

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Yanbin Zhao, Kun Zhang, Patrick Sips & Calum A. MacRae. (2019) Screening drugs for myocardial disease in vivo with zebrafish: an expert update. Expert Opinion on Drug Discovery 14:4, pages 343-353.
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Articles from other publishers (27)

Calum A. MacRaeRandall T. Peterson. (2023) Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology. Annual Review of Pharmacology and Toxicology 63:1, pages 43-64.
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Sébastien Gauvrit, Jaclyn Bossaer, Joyce Lee & Michelle M. Collins. (2022) Modeling Human Cardiac Arrhythmias: Insights from Zebrafish. Journal of Cardiovascular Development and Disease 9:1, pages 13.
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Nicholas Francoeur & Rwik Sen. (2021) Advances in Cardiac Development and Regeneration Using Zebrafish as a Model System for High-Throughput Research. Journal of Developmental Biology 9:4, pages 40.
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Jianhong Xia, Zhongxuan Meng, Hongyue Ruan, Wenguang Yin, Yiming Xu & Tiejun Zhang. (2020) Heart Development and Regeneration in Non-mammalian Model Organisms. Frontiers in Cell and Developmental Biology 8.
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Jussep Salgado-Almario, Manuel Vicente, Pierre Vincent, Beatriz Domingo & Juan Llopis. (2020) Mapping Calcium Dynamics in the Heart of Zebrafish Embryos with Ratiometric Genetically Encoded Calcium Indicators. International Journal of Molecular Sciences 21:18, pages 6610.
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Joycelyn K. Yip, Michael Harrison, Jessi Villafuerte, G. Esteban Fernandez, Andrew P. Petersen, Ching-Ling Lien & Megan L. McCain. (2020) Extended culture and imaging of normal and regenerating adult zebrafish hearts in a fluidic device. Lab on a Chip 20:2, pages 274-284.
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Massimo M. Santoro, Monica Beltrame, Daniela Panáková, Arndt F. Siekmann, Natascia Tiso, Marina Venero Galanternik, Hyun Min Jung & Brant M. Weinstein. (2019) Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research. Frontiers in Cell and Developmental Biology 7.
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Elena Sommariva, Ilaria Stadiotti, Gianluca L. Perrucci, Claudio Tondo & Giulio Pompilio. (2017) Cell models of arrhythmogenic cardiomyopathy: advances and opportunities. Disease Models & Mechanisms 10:7, pages 823-835.
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Bo Chen, Zhu-Qing Gao, Ying Liu, Yang-Min Zheng, Ying Han, Jing-Pu Zhang & Chang-Qin Hu. (2017) Embryo and Developmental Toxicity of Cefazolin Sodium Impurities in Zebrafish. Frontiers in Pharmacology 8.
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Carles Cornet, Simone Calzolari, Rafael Miñana-Prieto, Sylvia Dyballa, Els van Doornmalen, Helma Rutjes, Thierry Savy, Davide D’Amico & Javier Terriente. (2017) ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish. International Journal of Molecular Sciences 18:4, pages 864.
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Daniel Brown, Leigh Samsa, Li Qian & Jiandong Liu. (2016) Advances in the Study of Heart Development and Disease Using Zebrafish. Journal of Cardiovascular Development and Disease 3:2, pages 13.
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Sai-Wang Seto, Hosen Kiat, Simon M.Y. Lee, Alan Bensoussan, Yu-Ting Sun, Maggie P.M. Hoi & Dennis Chang. (2015) Zebrafish models of cardiovascular diseases and their applications in herbal medicine research. European Journal of Pharmacology 768, pages 77-86.
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Naveen L. Pereira, Daniel J. Sargent, Michael E. Farkouh & Charanjit S. Rihal. (2015) Genotype-based clinical trials in cardiovascular disease. Nature Reviews Cardiology 12:8, pages 475-487.
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Natalie Mesens. 2014. Predictive Toxicology. Predictive Toxicology 217 240 .
Sebastian Pieperhoff, Kathryn S. Wilson, James Baily, Kim de Mora, Sana Maqsood, Sharron Vass, Jonathan Taylor, Jorge Del-Pozo, Calum A. MacRae, John J. Mullins & Martin A. Denvir. (2014) Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture. PLoS ONE 9:5, pages e96771.
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Pallavi Sharma, Supriya Sharma, Vikram Patial, Damanpreet Singh & Yogendra Shantaram Padwad. (2014) Zebrafish (Danio rerio): A potential model for nephroprotective drug screening. Clinical Queries: Nephrology 3:2-4, pages 97-105.
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Pushkar Kulkarni, Girish Hari Chaudhari, Vijaykumar Sripuram, Rakesh Kumar Banote, Krishna Tulasi Kirla, Razia Sultana, Pallavi Rao, Srinivas Oruganti & Kiranam Chatti. (2014) Oral dosing in adult zebrafish: Proof-of-concept using pharmacokinetics and pharmacological evaluation of carbamazepine. Pharmacological Reports 66:1, pages 179-183.
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Sundeep Singh Dhillon, Éva Dóró, István Magyary, Stuart Egginton, Attila Sík & Ferenc Müller. (2013) Optimisation of Embryonic and Larval ECG Measurement in Zebrafish for Quantifying the Effect of QT Prolonging Drugs. PLoS ONE 8:4, pages e60552.
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Girish Hari Chaudhari, Keerthana Sarma Chennubhotla, Kiranam Chatti & Pushkar Kulkarni. (2013) Optimization of the adult zebrafish ECG method for assessment of drug-induced QTc prolongation. Journal of Pharmacological and Toxicological Methods 67:2, pages 115-120.
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Randall T. Peterson & Calum A. MacRae. (2013) Changing the scale and efficiency of chemical warfare countermeasure discovery using the zebrafish. Drug Discovery Today: Disease Models 10:1, pages e37-e42.
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Shunren Xia, Yongxu Zhu, Xiaoyin Xu & Weiming Xia. (2013) Computational techniques in zebrafish image processing and analysis. Journal of Neuroscience Methods 213:1, pages 6-13.
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Antonio Feula, Sundeep S. Dhillon, Rama Byravan, Mandeep Sangha, Ronald Ebanks, Mariwan A. Hama Salih, Neil Spencer, Louise Male, Istvan Magyary, Wei-Ping Deng, Ferenc Müller & John S. Fossey. (2013) Synthesis of azetidines and pyrrolidines via iodocyclisation of homoallyl amines and exploration of activity in a zebrafish embryo assay. Organic & Biomolecular Chemistry 11:31, pages 5083.
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Cristina Santoriello & Leonard I. Zon. (2012) Hooked! Modeling human disease in zebrafish. Journal of Clinical Investigation 122:7, pages 2337-2343.
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Alan L. Harvey. 2012. Plant Bioactives and Drug Discovery. Plant Bioactives and Drug Discovery 489 498 .
Christopher A. Lipinski. 2012. Designing Multi-Target Drugs. Designing Multi-Target Drugs 86 93 .
Randall T. PetersonCalum A. MacRae. (2012) Systematic Approaches to Toxicology in the Zebrafish. Annual Review of Pharmacology and Toxicology 52:1, pages 433-453.
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Donald Wlodkowic, Khashayar Khoshmanesh, Jin Akagi, David E. Williams & Jonathan M. Cooper. (2011) Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms. Cytometry Part A 79A:10, pages 799-813.
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