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Expert Opinion on Drug Discovery Volume 6, 2011 - Issue 5
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The design and screening of drugs to prevent acquired sensorineural hearing loss

Debashree MukherjeaSouthern Illinois University, School of Medicine, Department of Surgery, P.O. Box 19653, Springfield, IL 62794-9653, USA
, PhD (Research Assistant Professor) ,
Leonard P RybakSouthern Illinois University, School of Medicine, Departments of Surgery and Pharmacology, P.O. Box 19653, Springfield, IL 62794-9653, [email protected]
, MD PhD (Professor) ,
Kelly E SheehanSouthern Illinois University, School of Medicine, Department of Surgery, P.O. Box 19653, Springfield, IL 62794-9653, USA
, BS,
Tejbeer KaurSouthern Illinois University, School of Medicine, Department of Pharmacology, P.O. Box 19653, Springfield, IL 62794-9653, USA
, MS,
Vickram RamkumarSouthern Illinois University, School of Medicine, Department of Pharmacology, P.O. Box 19653, Springfield, IL 62794-9653, USA
, PhD,
Sarvesh JajooSouthern Illinois University, School of Medicine, Department of Pharmacology, P.O. Box 19653, Springfield, IL 62794-9653, USA
, PhD &
Sandeep ShethSouthern Illinois University, School of Medicine, Department of Pharmacology, P.O. Box 19653, Springfield, IL 62794-9653, USA
, MS show all
Pages 491-505 | Published online: 15 Mar 2011

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Xu Liu, Mingshuang Li, Hugh Smyth & Feng Zhang. (2018) Otic drug delivery systems: formulation principles and recent developments. Drug Development and Industrial Pharmacy 44:9, pages 1395-1408.
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Parvaneh Nasezadeh, Farshad Shahi, Mohammadjavad Fridoni, Enayatollah Seydi, Morteza Izadi & Ahmad Salimi. (2017) Moderate O3/O2 therapy enhances enzymatic and non-enzymatic antioxidant in brain and cochlear that protects noise-induced hearing loss. Free Radical Research 51:9-10, pages 828-837.
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Hui Cai, Xingxing Wen, Lu Wen, Nicola Tirelli, Xiao Zhang, Yue Zhang, Huanpeng Su, Fan Yang & Gang Chen. (2014) Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration. International Journal of Nanomedicine 9, pages 5591-5601.
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Wei Liu, Chuyi Yu, Miaomiao Wang, Youyou He, Zhongjie Guo, Jin He, Ru Jiang, Qin Xu, Jianming Liang & Shengzheng Wang. (2023) Discovery of Platinum IV –Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents . Journal of Medicinal Chemistry 66:12, pages 8066-8085.
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Lino E. Bertagnoli, Richard Seist, Shelley Batts & Konstantina M. Stankovic. (2023) Potential Ototoxicity of Insulin-like Growth Factor 1 Receptor Signaling Inhibitors: An In Silico Drug Repurposing Study of the Regenerating Cochlear Neuron Transcriptome. Journal of Clinical Medicine 12:10, pages 3485.
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Peipei Li, Ziyi Liu, Jinpeng Wang, Xiuli Bi, Yu Xiao, Ruifeng Qiao, Xuanchen Zhou, Siwei Guo, Peifeng Wan, Miao Chang, Guodong Hong, Zhangsuo Liu, Xia Ming, Jiangang Gao & Xiaolong Fu. (2022) Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice. The FASEB Journal 36:6.
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Jianxin Bao, Segun Light Jegede, John W. Hawks, Bethany Dade, Qiang Guan, Samantha Middaugh, Ziyu Qiu, Anna Levina & Tsung-Heng Tsai. (2022) Detecting Cochlear Synaptopathy Through Curvature Quantification of the Auditory Brainstem Response. Frontiers in Cellular Neuroscience 16.
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Nicole K. Febles, Mark A. Bauer, Bo Ding, Xiaoxia Zhu, Nathan D. Gallant & Robert D. Frisina. (2022) A combinatorial approach to protect sensory tissue against cisplatin-induced ototoxicity. Hearing Research 415, pages 108430.
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Min Dong, Anna V Rodriguez, Chelsea A Blankenship, Gary McPhail, Alexander A Vinks & Lisa L Hunter. (2021) Pharmacokinetic modelling to predict risk of ototoxicity with intravenous tobramycin treatment in cystic fibrosis. Journal of Antimicrobial Chemotherapy 76:11, pages 2923-2931.
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Nomfundo F. Moroe & Katijah Khoza-Shangase. (2020) Recent advances in hearing conservation programmes: A systematic review. South African Journal of Communication Disorders 67:2.
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Aadil Rasheed, Maliha Ghaffar & Hina Salahuddin. 2020. 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine. 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine 391 399 .
Alphonse Umugire, Sungsu Lee, Dami Kim, Munyoung Choi, Hyung-Seok Kim & Hyong-Ho Cho. (2019) Avenanthramide-C prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress. Cell Death Discovery 5:1.
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Triloke Ranjan Lakshman, Jolly Deb, Ivy Ghosh, Subhash Sarkar & Tapan Kanti Paine. (2019) Combining anti-inflammatory and anti-proliferative activities in ternary metal-NSAID complexes of a polypyridylamine ligand. Inorganica Chimica Acta 486, pages 663-668.
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R. Glueckert, L. Johnson Chacko, H. Rask-Andersen, W. Liu, S. Handschuh & A. Schrott-Fischer. (2018) Anatomical basis of drug delivery to the inner ear. Hearing Research 368, pages 10-27.
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So Young Kim, Gaon Jung, Ye Ji Shim & Ja-Won Koo. (2018) The Novel Peptide Vaccine GV1001 Protects Hearing in a Kanamycin-induced Ototoxicity Mouse Model. Otology & Neurotology 39:8, pages e731-e737.
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Shin Hye Kim, Gaon Jung, Sangjae Kim & Ja-Won Koo. (2018) Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide-Treated Mice. Frontiers in Cellular Neuroscience 12.
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Zichen Xu, Weiwei Hu, Zhimei Wang & Shaohua Gou. (2017) Platinum(IV) prodrugs multiply targeting genomic DNA, histone deacetylases and PARP-1. European Journal of Medicinal Chemistry 141, pages 211-220.
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Xiaochao Huang, Rizhen Huang, Shaohua Gou, Zhimei Wang, Zhixin Liao & Hengshan Wang. (2017) Platinum(IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance. Bioorganic & Medicinal Chemistry 25:17, pages 4686-4700.
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Lipika Ray, Manish Kumar Pal & Ratan Singh Ray. (2017) Synergism of co-delivered nanosized antioxidants displayed enhanced anticancer efficacy in human colon cancer cell lines. Bioactive Materials 2:2, pages 82-95.
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Feihong Chen, Xinyi Wang, Xiufeng Jin, Jian Zhao & Shaohua Gou. (2017) Oxidative DNA double strand breaks and autophagy in the antitumor effect of sterically hindered platinum(II) complexes in NSCLCs. Oncotarget 8:19, pages 30933-30955.
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Daniel Bodmer, Adrijana Perkovic, Marijana Sekulic-Jablanovic, Matthew B. Wright & Vesna Petkovic. (2016) Pasireotide prevents nuclear factor of activated T cells nuclear translocation and acts as a protective agent in aminoglycoside-induced auditory hair cell loss. Journal of Neurochemistry 139:6, pages 1113-1123.
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Xiaochao Huang, Rizhen Huang, Shaohua Gou, Zhimei Wang, Zhixin Liao & Hengshan Wang. (2016) Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action. Bioconjugate Chemistry 27:9, pages 2132-2148.
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Arzu Tatar, Sener Tasdemir, Ibrahim Sahin, Ceyda Bozoglu, Haktan Bagis Erdem, Ozgur Yoruk & Abdulgani Tatar. (2015) Mitochondrial DNA deletions in patients with chronic suppurative otitis media. European Archives of Oto-Rhino-Laryngology 273:9, pages 2473-2479.
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Tobias Reichenbach. 2016. Blast Injury Science and Engineering. Blast Injury Science and Engineering 307 314 .
Tal Teitz, Asli N. Goktug, Taosheng Chen & Jian Zuo. 2016. Auditory and Vestibular Research. Auditory and Vestibular Research 419 430 .
Margaret A. Kenna. (2015) Acquired Hearing Loss in Children. Otolaryngologic Clinics of North America 48:6, pages 933-953.
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Naila El Kechai, Florence Agnely, Elisabeth Mamelle, Yann Nguyen, Evelyne Ferrary & Amélie Bochot. (2015) Recent advances in local drug delivery to the inner ear. International Journal of Pharmaceutics 494:1, pages 83-101.
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Jian Tang, Yi Qian, Hui Li, Benjamin J. Kopecky, Dalian Ding, Henry C. Ou, Rhonda DeCook, Xiaojie Chen, Zhenyu Sun, Megan Kobel & Jianxin Bao. (2015) Canertinib induces ototoxicity in three preclinical models. Hearing Research 328, pages 59-66.
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Takatoshi Karasawa & Peter S. Steyger. (2015) An integrated view of cisplatin-induced nephrotoxicity and ototoxicity. Toxicology Letters 237:3, pages 219-227.
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Jeong-Im Woo, Sung-Hee Kil, Sejo Oh, Yoo-Jin Lee, Raekil Park, David J. Lim & Sung K. Moon. (2015) IL-10/HMOX1 Signaling Modulates Cochlear Inflammation via Negative Regulation of MCP-1/CCL2 Expression in Cochlear Fibrocytes. The Journal of Immunology 194:8, pages 3953-3961.
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Wilma Neumann, Brenda C. Crews, Menyhárt B. Sárosi, Cristina M. Daniel, Kebreab Ghebreselasie, Matthias S. Scholz, Lawrence J. Marnett & Evamarie Hey-Hawkins. (2015) Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance. ChemMedChem 10:1, pages 183-192.
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Chunjie Tian, Yeon Ju Kim, Hye Jin Lim, Young Sun Kim, Hun Yi Park & Yun-Hoon Choung. (2014) Red ginseng delays age-related hearing and vestibular dysfunction in C57BL/6 mice. Experimental Gerontology 57, pages 224-232.
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Joshua R. Gold & Victoria M. Bajo. (2014) Insult-induced adaptive plasticity of the auditory system. Frontiers in Neuroscience 8.
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J-S Park, I Jou & S M Park. (2014) Attenuation of noise-induced hearing loss using methylene blue. Cell Death & Disease 5:4, pages e1200-e1200.
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G. Polony, V. Humli, R. Andó, M. Aller, T. Horváth, A. Harnos, L. Tamás, E.S. Vizi & T. Zelles. (2014) Protective effect of rasagiline in aminoglycoside ototoxicity. Neuroscience 265, pages 263-273.
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Yüksel Olgun, Günay Kırkım, Efsun Kolatan, Müge Kıray, Alper Bagrıyanık, Aybüke Olgun, Deniz Cakır Kızmazoglu, Hülya Ellıdokuz, Bulent Serbetcıoglu, Zekiye Altun, Safiye Aktas, Osman Yılmaz & Enis Alpin Günerı. (2013) Friend or foe? Effect of oral resveratrol on cisplatin ototoxicity. The Laryngoscope 124:3, pages 760-766.
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Rakesh K. Pathak, Sean Marrache, Joshua H. Choi, Trenton B. Berding & Shanta Dhar. (2014) The Prodrug Platin- A : Simultaneous Release of Cisplatin and Aspirin . Angewandte Chemie International Edition 53:7, pages 1963-1967.
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Rakesh K. Pathak, Sean Marrache, Joshua H. Choi, Trenton B. Berding & Shanta Dhar. (2014) The Prodrug Platin‐ A : Simultaneous Release of Cisplatin and Aspirin . Angewandte Chemie 126:7, pages 1994-1998.
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Hongzhuo Liu, Jinsong Hao & Kevin S. Li. (2013) Current strategies for drug delivery to the inner ear. Acta Pharmaceutica Sinica B 3:2, pages 86-96.
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Debashree Mukherjea & Leonard P Rybak. (2011) Pharmacogenomics of cisplatin-induced ototoxicity. Pharmacogenomics 12:7, pages 1039-1050.
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