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Expert Opinion on Drug Discovery Volume 7, 2012 - Issue 1
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Identifying and characterizing promiscuous targets: Implications for virtual screening

Violeta I Pérez-Nueno INRIA Nancy – Grand Est, 615 rue du Jardin Botanique, 54506 Vandoeuvre-lès-Nancy, France+33 3 83593045; +33 3 83413079; [email protected]; [email protected]
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David W Ritchie INRIA Nancy – Grand Est, 615 rue du Jardin Botanique, 54506 Vandoeuvre-lès-Nancy, France+33 3 83593045; +33 3 83413079; [email protected]; [email protected]
Pages 1-17 | Published online: 08 Nov 2011

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Sarah Naomi Bolz & Michael Schroeder. (2023) Promiscuity in drug discovery on the verge of the structural revolution: recent advances and future chances. Expert Opinion on Drug Discovery 18:9, pages 973-985.
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Violeta I Pérez-Nueno. (2015) Using quantitative systems pharmacology for novel drug discovery. Expert Opinion on Drug Discovery 10:12, pages 1315-1331.
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Articles from other publishers (11)

Mahendra Awale & Jean-Louis Reymond. (2015) Similarity Mapplet: Interactive Visualization of the Directory of Useful Decoys and ChEMBL in High Dimensional Chemical Spaces. Journal of Chemical Information and Modeling 55:8, pages 1509-1516.
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Céline M. Labbé, Julien Rey, David Lagorce, Marek Vavruša, Jérome Becot, Olivier Sperandio, Bruno O. Villoutreix, Pierre Tufféry & Maria A. Miteva. (2015) MTiOpenScreen: a web server for structure-based virtual screening. Nucleic Acids Research 43:W1, pages W448-W454.
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Michael J. Keiser. 2015. Antitargets and Drug Safety. Antitargets and Drug Safety 19 44 .
H. Zhang, B. Zou, F. Du, K. Xu & M. Li. (2014) Reporting Sodium Channel Activity Using Calcium Flux: Pharmacological Promiscuity of Cardiac Nav1.5. Molecular Pharmacology 87:2, pages 207-217.
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Douglas B. Kell & Royston Goodacre. (2014) Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery. Drug Discovery Today 19:2, pages 171-182.
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Anat Levit, Thijs Beuming, Goran Krilov, Woody Sherman & Masha Y. Niv. (2013) Predicting GPCR Promiscuity Using Binding Site Features. Journal of Chemical Information and Modeling 54:1, pages 184-194.
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Douglas B. Kell. (2013) Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it. FEBS Journal 280:23, pages 5957-5980.
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Arnaud S. Karaboga, Jesús M. Planesas, Florent Petronin, Jordi Teixidó, Michel Souchet & Violeta I. Pérez-Nueno. (2013) Highly SpecIfic and Sensitive Pharmacophore Model for Identifying CXCR4 Antagonists. Comparison with Docking and Shape-Matching Virtual Screening Performance. Journal of Chemical Information and Modeling 53:5, pages 1043-1056.
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Douglas B. Kell, Paul D. Dobson, Elizabeth Bilsland & Stephen G. Oliver. (2013) The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Discovery Today 18:5-6, pages 218-239.
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Antonio Macchiarulo, Andrea Carotti, Marco Cellanetti, Roccaldo Sardella & Antimo Gioiello. (2013) Navigations of chemical space to further the understanding of polypharmacology in human nuclear receptors. MedChemComm 4:1, pages 216-227.
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Jesús M. Planesas, Violeta I. Pérez-Nueno, José I. Borrell & Jordi Teixidó. (2012) Impact of the CXCR4 structure on docking-based virtual screening of HIV entry inhibitors. Journal of Molecular Graphics and Modelling 38, pages 123-136.
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