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Expert Opinion on Drug Discovery Volume 7, 2012 - Issue 7
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Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections

Xiaoyong ZhangProfessor, Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany+49 201 7233530; +49 201 7235929; [email protected]; [email protected]
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Anke KraftProfessor, Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany+49 201 7233530; +49 201 7235929; [email protected]; [email protected]
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Ruth BroeringDepartment of Gastroenterology and Hepatology, University Hospital of Essen, Essen, Germany
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Joerg F SchlaakDepartment of Gastroenterology and Hepatology, University Hospital of Essen, Essen, Germany
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Ulf DittmerProfessor, Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany+49 201 7233530; +49 201 7235929; [email protected]; [email protected]
&
Mengji LuProfessor, Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany+49 201 7233530; +49 201 7235929; [email protected]; [email protected]
Pages 597-611 | Published online: 19 May 2012

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Keye Du, Jia Liu, Ruth Broering, Xiaoyong Zhang, Dongliang Yang, Ulf Dittmer & Mengji Lu. (2018) Recent advances in the discovery and development of TLR ligands as novel therapeutics for chronic HBV and HIV infections. Expert Opinion on Drug Discovery 13:7, pages 661-670.
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Ge Yang, Pin Wan, Yaru Zhang, Qiaoru Tan, Muhammad Suhaib Qudus, Zhaoyang Yue, Wei Luo, Wen Zhang, Jianhua Ouyang, Yongkui Li & Jianguo Wu. (2022) Innate Immunity, Inflammation, and Intervention in HBV Infection. Viruses 14:10, pages 2275.
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Yan Yan, Yuanwang Qiu, Chantsalmaa Davgadorj & Chunfu Zheng. (2022) Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection. Frontiers in Cellular and Infection Microbiology 12.
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Sheikh Mohammad Fazle Akbar, Mamun AL-Mahtab, Sakirul Khan, Osamu Yoshida & Yoichi Hiasa. (2022) “Elimination of Hepatitis by 2030”: Present Realities and Future Projections. Infectious Diseases & Immunity 2:1, pages 3-8.
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Yang Gao, Narayan Nepal & Shi-Zhu Jin. (2021) Toll-like receptors and hepatitis C virus infection. Hepatobiliary & Pancreatic Diseases International 20:6, pages 521-529.
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Sheikh Mohammad Fazle Akbar, Mamun Al Mahtab, Julio Cesar Aguilar, Md. Helal Uddin, Md. Sakirul Islam Khan, Osamu Yoshida, Eduardo Penton, Guillen Nieto Gerardo & Yoichi Hiasa. (2021) Exploring evidence-based innovative therapy for the treatment of chronic HBV infection: experimental and clinical. Exploration of Medicine.
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Zhongji Meng, Yuanyuan Chen & Mengji Lu. (2020) Advances in Targeting the Innate and Adaptive Immune Systems to Cure Chronic Hepatitis B Virus Infection. Frontiers in Immunology 10.
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Wei Zhu, Hongyan Liu & Xiaoyong Zhang. (2019) Toward Curative Immunomodulation Strategies for Chronic Hepatitis B Virus Infection. ACS Infectious Diseases 5:5, pages 703-712.
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Pei-Yi Su & Chiaho Shih. 2019. Viral Hepatitis in Children. Viral Hepatitis in Children 211 227 .
Yong Lin, Xuan Huang, Jun Wu, Jia Liu, Mingfa Chen, Zhiyong Ma, Ejuan Zhang, Yan Liu, Shunmei Huang, Qian Li, Xiaoyong Zhang, Jinlin Hou, Dongliang Yang, Mengji Lu & Yang Xu. (2018) Pre-Activation of Toll-Like Receptor 2 Enhances CD8+ T-Cell Responses and Accelerates Hepatitis B Virus Clearance in the Mouse Models. Frontiers in Immunology 9.
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Dipanwita Das, Isha Sengupta, Neelakshi Sarkar, Ananya Pal, Debraj Saha, Manikankana Bandopadhyay, Chandrima Das, Jimmy Narayan, Shivaram Prasad Singh, Sekhar Chakrabarti & Runu Chakravarty. (2017) Anti-hepatitis B virus (HBV) response of imiquimod based toll like receptor 7 ligand in hbv-positive human hepatocelluar carcinoma cell line. BMC Infectious Diseases 17:1.
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Jinke Pang, Geng Zhang, Yong Lin, Zhanglian Xie, Hongyan Liu, Libo Tang, Mengji Lu, Ran Yan, Haitao Guo, Jian Sun, Jinlin Hou & Xiaoyong Zhang. (2017) Transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis B virus replication. Scientific Reports 7:1.
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M.A. Tomai & J.P. Vasilakos. 2017. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 149 162 .
Haley Ward, Lydia Tang, Bhawna Poonia & Shyam Kottilil. (2016) Treatment of hepatitis B virus: an update. Future Microbiology 11:12, pages 1581-1597.
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Chiaho Shih, Shu-Fan Chou, Ching-Chun Yang, Jyun-Yuan Huang, Gansukh Choijilsuren & Ren-Shiang Jhou. (2016) Control and Eradication Strategies of Hepatitis B Virus. Trends in Microbiology 24:9, pages 739-749.
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Zhongji Meng, Xiaoyong Zhang, Rongjuan Pei, Ejuan Zhang, Thekla Kemper, Jörg Vollmer, Heather L. Davis, Dieter Glebe, Wolfram Gerlich, Michael Roggendorf & Mengji Lu. (2016) Combination therapy including CpG oligodeoxynucleotides and entecavir induces early viral response and enhanced inhibition of viral replication in a woodchuck model of chronic hepadnaviral infection. Antiviral Research 125, pages 14-24.
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Elisabetta Loggi, Giovanni Vitale, Fabio Conti, Mauro Bernardi & Pietro Andreone. (2015) Chronic hepatitis B: Are we close to a cure?. Digestive and Liver Disease 47:10, pages 836-841.
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Zuxiong Huang, Jun Ge, Jinke Pang, Hongyan Liu, Jinjun Chen, Baolin Liao, Xuan Huang, Daming Zuo, Jian Sun, Mengji Lu, Xiaoyong Zhang & Jinlin Hou. (2015) Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy. Antiviral Research 118, pages 10-19.
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Hong-Yan Liu. (2015) Innate immune recognition of hepatitis B virus. World Journal of Hepatology 7:21, pages 2319.
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Emily Funk, Shyam Kottilil, Bruce Gilliam & Rohit Talwani. (2014) Tickling the TLR7 to cure viral hepatitis. Journal of Translational Medicine 12:1.
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Mark Thursz. (2013) Basis of HBV persistence and new treatment options. Hepatology International 8:S2, pages 486-491.
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Nelson C. Di Paolo. (2014) Recognition of Human Oncogenic Viruses by Host Pattern-Recognition Receptors. Frontiers in Immunology 5.
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Rama Kapoor & Shyam Kottilil. (2014) Strategies to eliminate HBV infection. Future Virology 9:6, pages 565-585.
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Rong-Juan Pei. (2014) Control of hepatitis B virus replication by interferons and Toll-like receptor signaling pathways. World Journal of Gastroenterology 20:33, pages 11618.
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Masao Omata & Tatsuo KandaValérie Martel-LaferrièreDouglas Dieterich. 2013. Emerging Therapeutic Options for Hepatitis C. Emerging Therapeutic Options for Hepatitis C 46 56 .
Elisa T Helbig, Bastian Opitz & Leif E Sander. (2013) Adjuvant immunotherapies as a novel approach to bacterial infections. Immunotherapy 5:4, pages 365-381.
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Mirjam B. Zeisel, Joachim Lupberger, Isabel Fofana & Thomas F. Baumert. (2013) Host-targeting agents for prevention and treatment of chronic hepatitis C – Perspectives and challenges. Journal of Hepatology 58:2, pages 375-384.
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Stephanos J. Hadziyannis, Dimitrios Vassilopoulos & Emilia Hadziyannis. 2013. Antiviral Agents. Antiviral Agents 247 291 .

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