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Expert Opinion on Drug Discovery Volume 7, 2012 - Issue 10
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The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors

Yoshio HamadaFaculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, Chuo-ku, Kobe 650-8586, Japan;Kyoto Pharmaceutical University, Center for Frontier Research in Medicinal Science, Yamashina-ku, Kyoto 607-8412, [email protected]
&
Yoshiaki KisoFaculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, Chuo-ku, Kobe 650-8586, Japan;Kyoto Pharmaceutical University, Center for Frontier Research in Medicinal Science, Yamashina-ku, Kyoto 607-8412, [email protected];Nagahama Institute of Bio-Science and Technology, Laboratory of Peptide Science, Tamura-cho, Nagahama 526-0829, Japan
Pages 903-922 | Published online: 08 Aug 2012

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Siddharth Yadav, Shahzaib Ahamad, Dinesh Gupta & Puniti Mathur. (2023) Lead optimization, pharmacophore development and scaffold design of protein kinase CK2 inhibitors as potential COVID-19 therapeutics. Journal of Biomolecular Structure and Dynamics 41:5, pages 1811-1827.
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Yoshio Hamada & Yoshiaki Kiso. (2013) Advances in the identification of β-secretase inhibitors. Expert Opinion on Drug Discovery 8:6, pages 709-731.
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Yoshio Hamada & Zyta M. Ziora. 2020. Peptide Synthesis. Peptide Synthesis 215 223 .
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Marleen Häring, Sujay Kumar Nandi, Julio Rodríguez-López, Debasish Haldar, Víctor S. Martín, Antonio Diego Lozano-Gorrín, César Saldías & David Díaz Díaz. (2019) 5-(1 H -1,2,3-Triazol-5-yl)isophthalic Acid: A Versatile Ligand for the Synthesis of New Supramolecular Metallogels . ACS Omega 4:1, pages 2111-2117.
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Atanu Panja & Kumaresh Ghosh. (2019) Triazole-amide isosteric pyridine-based supramolecular gelators in metal ion and biothiol sensing with excellent performance in adsorption of heavy metal ions and picric acid from water. New Journal of Chemistry 43:2, pages 934-945.
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Yoshio Hamada & Yoshiaki Kiso. (2016) New directions for protease inhibitors directed drug discovery. Biopolymers 106:4, pages 563-579.
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Yoshio Hamada. (2016) Novel prodrugs with a spontaneous cleavable guanidine moiety. Bioorganic & Medicinal Chemistry Letters 26:7, pages 1685-1689.
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Yoshio Hamada. (2016) A novel N-terminal degradation reaction of peptides via N-amidination. Bioorganic & Medicinal Chemistry Letters 26:7, pages 1690-1695.
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Peter W. Glunz, Xuhong Cheng, Daniel L. Cheney, Carolyn A. Weigelt, Anzhi Wei, Joseph M. Luettgen, Pancras C. Wong, Ruth R. Wexler & E. Scott Priestley. (2015) Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors. Bioorganic & Medicinal Chemistry Letters 25:10, pages 2169-2173.
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Yoshio Hamada, Naoko Miyamoto & Yoshiaki Kiso. (2015) Novel β-amyloid aggregation inhibitors possessing a turn mimic. Bioorganic & Medicinal Chemistry Letters 25:7, pages 1572-1576.
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Rasha H. Alghamdi, Paul O'Reilly, Chunyu Lu, James Gomes, Thomas A. Lagace & Ajoy Basak. (2015) LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153–421): Design, synthesis and biochemical evaluation. European Journal of Medicinal Chemistry 92, pages 890-907.
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Jürgen Bachl, Judith Mayr, Francisco J. Sayago, Carlos Cativiela & David Díaz Díaz. (2015) Amide–triazole isosteric substitution for tuning self-assembly and incorporating new functions into soft supramolecular materials. Chemical Communications 51:25, pages 5294-5297.
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John L. Magnani. 2015. Glycoscience: Biology and Medicine. Glycoscience: Biology and Medicine 1517 1522 .
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G.E. Schiltz. 2014. Comprehensive Organic Synthesis II. Comprehensive Organic Synthesis II 555 572 .
John L. Magnani. 2021. Glycoscience: Biology and Medicine. Glycoscience: Biology and Medicine 1 6 .
Kenji Suzuki, Yoshio Hamada, Jeffrey-Tri Nguyen & Yoshiaki Kiso. (2013) Novel BACE1 inhibitors with a non-acidic heterocycle at the P1′ position. Bioorganic & Medicinal Chemistry 21:21, pages 6665-6673.
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Yoshio Hamada. (2013) The Significance of Quantum Chemical Interactions for Medicinal Science and Design of β-Secretase Inhibitors創薬研究における量子化学的相互作用の重要性とβ-secretase阻害剤の設計. YAKUGAKU ZASSHI 133:10, pages 1113-1120.
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Hiroyuki Konno, Yoshihiro Sema, Manabu Ishii, Yasunao Hattori, Kazuto Nosaka & Kenichi Akaji. (2013) Practical synthesis of peptide C-terminal aldehyde on a solid support. Tetrahedron Letters 54:36, pages 4848-4850.
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Nicholas A. Meanwell. 2015. Tactics in Contemporary Drug Design. Tactics in Contemporary Drug Design 283 381 .

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